Publications by authors named "Daniela Filippo"

3 Publications

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Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers.

EBioMedicine 2021 May 9;67:103357. Epub 2021 May 9.

División Infectología, Hospital General de Agudos Dr. Juan A. Fernández, Av. Cerviño 3356, CABA C1425, Argentina.

Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype and function of circulating neutrophils from children with COVID-19.

Methods: An observational study including 182 children with COVID-19, 21 children with multisystem inflammatory syndrome (MIS-C), and 40 healthy children was performed in Buenos Aires, Argentina. Neutrophil phenotype was analyzed by flow cytometry in blood samples. Cytokine production, plasma levels of IgG antibodies directed to the spike protein of SARS-CoV-2 and citrullinated histone H3 were measured by ELISA. Cell-free DNA was quantified by fluorometry.

Findings: Compared with healthy controls, neutrophils from children with COVID-19 showed a lower expression of CD11b, CD66b, and L-selectin but a higher expression of the activation markers HLA-DR, CD64 and PECAM-1 and the inhibitory receptors LAIR-1 and PD-L1. No differences in the production of cytokines and NETs were observed. Interestingly, the expression of CD64 in neutrophils and the serum concentration of IgG antibodies directed to the spike protein of SARS-CoV-2 distinguished asymptomatic from mild and moderate COVID-19.

Interpretation: Acute lung injury is a prominent feature of severe COVID-19 in adults. A low expression of adhesion molecules together with a high expression of inhibitory receptors in neutrophils from children with COVID-19 might prevent tissue infiltration by neutrophils preserving lung function.

Funding: This study was supported by the Ministry of Science and Technology (National Agency for Scientific and Technological Promotion, IP-COVID-19-0277 and PMO BID PICT 2018-2548), and University of Buenos Aires from Argentina (20020170100573BA).
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http://dx.doi.org/10.1016/j.ebiom.2021.103357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153212PMC
May 2021

Highly Cited Papers at the Spanish Domestic Level.

Front Res Metr Anal 2021 22;6:651991. Epub 2021 Apr 22.

Department of Library and Information Science, Carlos III University of Madrid (UC3M), Getafe, Spain.

This paper presents a methodological proposal based on the identification of highly cited papers (HCPs) at domestic-level in the Spanish Public University System (SUPE), in order to find the most outstanding publications in the local context. The principal aim is to detect different activity and impact profiles among Spanish universities and differentiate those institutions that play a more significant role. To determine which and how many are the highly cited papers at the domestic level (HCP-DL) collected in the Web of Science, three citation thresholds (1, 5, and 10%) were established. Thematic classification in Incites/Essential Science Indicators areas is used. The results show a preponderance of HCPs in the field of Space Science, while the polytechnic universities have high visibility in the Computer Science area. It has been observed that the presence of HCPs in a given area is involved with universities specialized in teaching and research activities. In absolute terms, the big non-specialized universities are major producers of HCPs and hold the leading positions in our results. However, when efficiency is analyzed in relative terms, some small, specialized universities reveal themselves to be more efficient at producing HCPs (% of HCPs or citations per HCP). We think that this methodology, due to its simplicity, its ease of calculation, and the knowledge it provides, can be very useful to analyze the national systems of any country, in order to know the impact and visibility of the research carried out in its scientific institutions or research areas.
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http://dx.doi.org/10.3389/frma.2021.651991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101551PMC
April 2021

[Bibliometry of collaboration and impact of the Revista de Biología Tropical (Web of Science 2003-2012)].

Rev Biol Trop 2016 03;64(1):147-56

The activity analysis of a scientific journal is relevant to know the evolution of its characteristics over time. In this paper, results of a bibliometric study of the Revista de Biología Tropical/International Journal of Tropical Biology and Conservation (Costa Rica) are presented. The goal of this study was to describe the main characteristics of its scientific production, and analyze its level of collaboration and its impact between the years 2003-2012. Data was derived from the Web of Science (Thomson-Reuters), and the relationship among authors and coauthors, institutions and countries, and their links with the citations received were analyzed for that period. Descriptive statistics about production (number of documents per year, institution and country), collaboration (authorship index, collaboration among institutions and countries) and impact (IF, position in JCR and number of citations received) were collected. Results showed that the journal has published 1 473 papers in this period, in similar proportions English and Spanish. Mexico, Costa Rica, Venezuela and Colombia are the most common countries of origin, with the Universidad of Costa Rica, Universidad Autónoma de Mexico and the University of Puerto Rico as the most common leader institutions. Collaboration between authors, institutions and countries has shown an increasing trend over the last decade. The co-author index was 3.07 per document, 63 % of publications included 2 or more institutions, and 22 % of the papers were product of international collaboration. The most common collaboration link was between Costa Rica and the United States of America. The impact factor has been oscillating during this last decade, reaching a maximum in 2012 (IF JCR = 0.553). Besides, 10 % of the most cited papers concentrated half of the citations received by the journal, and have a very high number of citations, compared with the journal mean. The main countries that cite the journal were USA, Brazil, Mexico, Argentina and Costa Rica. Data showed an increasing collaboration between authors, institutions and countries, and a direct relationship between the increase of this collaboration and the received impact.
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http://dx.doi.org/10.15517/rbt.v64i1.18241DOI Listing
March 2016