Publications by authors named "Daniela C Zarnescu"

39Publications

Think globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity.

J Cell Biol 2020 Dec;219(12)

Molecular and Cellular Biology, University of Arizona, Tucson AZ.

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http://dx.doi.org/10.1083/jcb.202010172DOI Listing
December 2020

Mutations disrupting neuritogenesis genes confer risk for cerebral palsy.

Nat Genet 2020 10 28;52(10):1046-1056. Epub 2020 Sep 28.

Pediatric Movement Disorders Program, Division of Pediatric Neurology, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ, USA.

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http://dx.doi.org/10.1038/s41588-020-0695-1DOI Listing
October 2020

To Be or Not To Be…Toxic-Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration?

Front Mol Biosci 2019 10;6:154. Epub 2020 Jan 10.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, United States.

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http://dx.doi.org/10.3389/fmolb.2019.00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965497PMC
January 2020

-2019 PLOS Genetics Research Prize: Fruit fly school - language and dialects for communicating a threat.

PLoS Genet 2019 09 12;15(9):e1008381. Epub 2019 Sep 12.

Departments of Molecular and Cellular Biology, Neuroscience and Neurology, University of Arizona, Tucson, Arizona, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741850PMC
September 2019

Lost in Translation: Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases.

Adv Neurobiol 2018 ;20:283-301

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.1007/978-3-319-89689-2_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530776PMC
October 2018

Dynamic duo - FMRP and TDP-43: Regulating common targets, causing different diseases.

Brain Res 2018 08 30;1693(Pt A):37-42. Epub 2018 Apr 30.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, United States; Department of Neuroscience, University of Arizona, Tucson, AZ, United States; Department of Neurology, University of Arizona, Tucson AZ, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183022
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http://dx.doi.org/10.1016/j.brainres.2018.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997554PMC
August 2018

Endocytosis regulates TDP-43 toxicity and turnover.

Nat Commun 2017 12 12;8(1):2092. Epub 2017 Dec 12.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721, USA.

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http://dx.doi.org/10.1038/s41467-017-02017-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727062PMC
December 2017

Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.

Circulation 2018 02 3;137(6):605-618. Epub 2017 Nov 3.

Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program (M.C., S.M.N., C.C., A.A.W., C.C.G.)

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809294PMC
February 2018

Metabolic Dysregulation in Amyotrophic Lateral Sclerosis: Challenges and Opportunities.

Curr Genet Med Rep 2017 Jun 28;5(2):108-114. Epub 2017 Apr 28.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721.

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http://link.springer.com/10.1007/s40142-017-0123-8
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http://dx.doi.org/10.1007/s40142-017-0123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647833PMC
June 2017

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.

Cell Rep 2017 Oct;21(1):110-125

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; Department of Neurology, University of Arizona, Tucson, AZ 85721, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679478PMC
October 2017

Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.

Front Cell Neurosci 2017 17;11:243. Epub 2017 Aug 17.

Department of Molecular and Cellular Biology, University of ArizonaTucson, AZ, United States.

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00
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http://dx.doi.org/10.3389/fncel.2017.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562674PMC
August 2017

A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes.

PLoS Genet 2016 11 17;12(11):e1006419. Epub 2016 Nov 17.

Departments of Molecular and Cellular Biology, Neuroscience and Neurology, University of Arizona, Tucson, Arizona.

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http://dx.doi.org/10.1371/journal.pgen.1006419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147772PMC
November 2016

Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein.

PLoS One 2015 16;10(11):e0142836. Epub 2015 Nov 16.

Department of Molecular and Cellular Biology The University of Arizona, Tucson, Arizona, 85721, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142836PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646288PMC
June 2016

PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Hum Mol Genet 2015 Sep 30;24(18):5154-73. Epub 2015 Jun 30.

Department of Cell Biology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA,

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550816PMC
September 2015

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.

Hum Mol Genet 2015 Mar 28;24(6):1741-54. Epub 2014 Nov 28.

Department of Molecular and Cellular Biology, Department of Neuroscience Department of Neurology, University of Arizona, Tucson, AZ 85721, USA

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http://dx.doi.org/10.1093/hmg/ddu587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381760PMC
March 2015

Fragile hearts: new insights into translational control in cardiac muscle.

Trends Cardiovasc Med 2013 Nov 10;23(8):275-81. Epub 2013 Apr 10.

Department of Molecular and Cellular Biology, the Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2013.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142197PMC
November 2013

Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain.

Brain Res 2012 Jun 27;1462:151-61. Epub 2012 Mar 27.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1016/j.brainres.2012.03.042DOI Listing
June 2012

Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.

Circ Res 2011 Jul 9;109(3):262-71. Epub 2011 Jun 9.

Department of Cellular and Molecular Medicine, University of Arizona, 1656 East Mabel, Tucson, AZ 85724, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.111.24424
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http://dx.doi.org/10.1161/CIRCRESAHA.111.244244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163600PMC
July 2011

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

Hum Mol Genet 2011 Jun 26;20(12):2308-21. Epub 2011 Mar 26.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1093/hmg/ddr124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098735PMC
June 2011

Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells.

Genesis 2011 Jun 31;49(6):424-40. Epub 2011 May 31.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1002/dvg.20745DOI Listing
June 2011

Fragile X protein controls neural stem cell proliferation in the Drosophila brain.

Hum Mol Genet 2010 Aug 26;19(15):3068-79. Epub 2010 May 26.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1093/hmg/ddq213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901145PMC
August 2010

The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila.

J Cell Sci 2010 Jan;123(Pt 2):277-85

Department of Biology, Department of Biochemistry and Molecular Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1242/jcs.056853DOI Listing
January 2010

Ferrying wingless across the synaptic cleft.

Cell 2009 Oct;139(2):229-31

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1016/j.cell.2009.09.032DOI Listing
October 2009

Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary.

Dev Biol 2009 Jun 21;330(1):83-92. Epub 2009 Mar 21.

Department of Molecular and Cellular Biology, Life Sciences South, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.03.011DOI Listing
June 2009

Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.

BMC Syst Biol 2008 Nov 25;2:101. Epub 2008 Nov 25.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.

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http://dx.doi.org/10.1186/1752-0509-2-101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610033PMC
November 2008

Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons.

Mol Cell Neurosci 2008 Oct 28;39(2):170-9. Epub 2008 Jun 28.

Department of Molecular and Cellular Biology, University of Arizona, Tucson AZ 85721, USA.

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http://dx.doi.org/10.1016/j.mcn.2008.06.012DOI Listing
October 2008

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Nat Chem Biol 2008 Apr 9;4(4):256-63. Epub 2008 Mar 9.

Department of Human Genetics, Emory University School of Medicine, 615 Michael Street Suite 300, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/nchembio.78DOI Listing
April 2008

Born again at the synapse: a new function for the anaphase promoting complex/cyclosome.

Dev Cell 2004 Dec;7(6):777-8

Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Room 400, Atlanta, GA 30322 USA.

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http://dx.doi.org/10.1016/j.devcel.2004.11.011DOI Listing
December 2004

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.

Nat Neurosci 2004 Feb 4;7(2):113-7. Epub 2004 Jan 4.

Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/nn1174DOI Listing
February 2004

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.

Neuron 2003 Aug;39(5):739-47

Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/s0896-6273(03)00533-6DOI Listing
August 2003