SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33595175 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 17 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1751-553X [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 17 ) ) [Title] => International journal of laboratory hematology [ISOAbbreviation] => Int J Lab Hematol ) [ArticleTitle] => The effect of DOAC-Stop on several oral and parenteral anticoagulants. [ELocationID] => 10.1111/ijlh.13487 [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Riva [ForeName] => Nicoletta [Initials] => N [Identifier] => https://orcid.org/0000-0002-8922-8823 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Vella [ForeName] => Kevin [Initials] => K [Identifier] => https://orcid.org/0000-0002-0826-1921 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hickey [ForeName] => Kieron [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gatt [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Perfusion Services, Mater Dei Hospital, Msida, Malta. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grima [ForeName] => Charlie [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Perfusion Services, Mater Dei Hospital, Msida, Malta. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zammit [ForeName] => Daniel [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ageno [ForeName] => Walter [Initials] => W [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine and Surgery, University of Insubria, Varese, Italy. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kitchen [ForeName] => Steve [Initials] => S [Identifier] => https://orcid.org/0000-0003-4790-1159 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Makris [ForeName] => Michael [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gatt [ForeName] => Alex [Initials] => A [Identifier] => https://orcid.org/0000-0002-4314-048X [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. ) [1] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Letter ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 17 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Int J Lab Hematol [NlmUniqueID] => 101300213 [ISSNLinking] => 1751-5521 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => direct oral anticoagulants [1] => heparin [2] => thrombin generation [3] => thromboelastography [4] => warfarin ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 12 [Day] => 16 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 12 [Day] => 31 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 01 [Day] => 29 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 17 [Hour] => 8 [Minute] => 56 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 18 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 18 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33595175 [1] => 10.1111/ijlh.13487 ) ) ) ) [1] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30418134 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 12 [Day] => 25 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 03 [Day] => 09 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 2385-2070 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 17 [Issue] => 3 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 05 ) ) [Title] => Blood transfusion = Trasfusione del sangue [ISOAbbreviation] => Blood Transfus ) [ArticleTitle] => Fibrinogen measurement in liver disease: validation of the functional fibrinogen thromboelastography assay and a novel mathematical predictive model. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 237-246 ) [ELocationID] => 10.2450/2018.0105-18 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Fibrinogen is produced in the liver and tends to be reduced in liver cirrhosis. Quantitative and qualitative tests exist to measure fibrinogen. We aimed to validate the functional fibrinogen thromboelastography assay (FF-TEG) and propose a new model to estimate fibrinogen levels via the Clauss method (Clauss) using data from a prothrombin time-derived fibrinogen assay (PT-Fg) in patients with liver cirrhosis. [1] => Clauss, PT-Fg, fibrinogen antigen (Fib-Ag) and FF-TEG were studied in 55 patients with liver cirrhosis (26 with Child-Turcotte-Pugh [CTP]-A disease, 14 with CTP-B and 15 CTP-C) and 20 healthy individuals. [2] => The results of all four assays correlated strongly with each other, but gave significantly different mean levels in all cohorts. PT-Fg gave the highest levels whereas the Clauss gave the lowest levels. The FF-TEG performed well with results which were in between the Clauss and the PT-Fg. Significant differences were only observed between CTP-A and CTP-C for the Clauss, PT-Fg and Fib-Ag but not functional fibrinogen level. We devised a simple linear regression model in order to estimate Clauss from the PT-Fg. [3] => The results of the FF-TEG correlate well with those of routine fibrinogen assays in patients with liver cirrhosis. However, the FF-TEG assay does not discriminate between early and late stages of disease, pointing to a preserved fibrin clot strength in cirrhosis. Through linear regression models, fibrinogen levels can be accurately estimated using the Clauss method based on fibrinogen levels obtained in the cheaper PT-Fg. ) ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rizzo [ForeName] => Kirsty [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Faculty of Health Sciences, University of Malta, Tal-Qroqq, Msida, Malta. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Vella [ForeName] => Kevin [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Laboratory, Department of Pathology, "Mater Dei" Hospital, Msida, Malta. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zammit [ForeName] => Daniel [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Laboratory, Department of Pathology, "Mater Dei" Hospital, Msida, Malta. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gatt [ForeName] => Peter [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Perfusion Services, Department of Cardiac Surgery, "Mater Dei" Hospital, Msida, Malta. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grima [ForeName] => Charlie [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Perfusion Services, Department of Cardiac Surgery, "Mater Dei" Hospital, Msida, Malta. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Inguanez [ForeName] => Monique Borg [Initials] => MB [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Statistics and Operations Research, University of Malta, Tal-Qroqq, Msida, Malta. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gerada [ForeName] => Jurgen [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Gastroenterology, "Mater Dei" Hospital, Msida, Malta. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ellul [ForeName] => Pierre [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Gastroenterology, "Mater Dei" Hospital, Msida, Malta. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Vassallo [ForeName] => Mario [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Gastroenterology, "Mater Dei" Hospital, Msida, Malta. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Azzopardi [ForeName] => Neville [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Gastroenterology, "Mater Dei" Hospital, Msida, Malta. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Pocock [ForeName] => James [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Gastroenterology, "Mater Dei" Hospital, Msida, Malta. ) ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gatt [ForeName] => Alex [Initials] => A [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Coagulation Laboratory, Department of Pathology, "Mater Dei" Hospital, Msida, Malta. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Pathology, University of Malta, Tal-Qroqq, Msida, Malta. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Clinical Trial [1] => Journal Article [2] => Validation Study ) ) [ArticleDate] => 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SimpleXMLElement Object ( [ArticleId] => 19135704 ) ) [4] => SimpleXMLElement Object ( [Citation] => Ann Clin Biochem. 2004 Nov;41(Pt 6):430-40 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 15588432 ) ) [5] => SimpleXMLElement Object ( [Citation] => Arterioscler Thromb. 1992 Jul;12(7):780-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 1616903 ) ) [6] => SimpleXMLElement Object ( [Citation] => Shock. 2013 Jan;39(1):45-9 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23247121 ) ) [7] => SimpleXMLElement Object ( [Citation] => Semin Thromb Hemost. 2008 Nov;34(8):772-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19214915 ) ) [8] => SimpleXMLElement Object ( [Citation] => Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Sep;156(3):260-1 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 22660203 ) ) [9] => SimpleXMLElement Object ( [Citation] => J Vasc Interv Radiol. 2016 Nov;27(11):1665-1674 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 27595469 ) ) [10] => SimpleXMLElement Object ( [Citation] => Int J Lab Hematol. 2015 Aug;37(4):459-65 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25377182 ) ) [11] => SimpleXMLElement Object ( [Citation] => Br J Haematol. 2003 May;121(3):396-404 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 12716361 ) ) [12] => SimpleXMLElement Object ( [Citation] => Thromb Haemost. 2008 Dec;100(6):1106-10 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19132237 ) ) [13] => SimpleXMLElement Object ( [Citation] => J Clin Pathol. 1982 Jun;35(6):667-72 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 7085917 ) ) [14] => SimpleXMLElement Object ( [Citation] => Dis Markers. 2015;2015:468596 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25960593 ) ) [15] => SimpleXMLElement Object ( [Citation] => J Clin Invest. 1978 Feb;61(2):535-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 621288 ) ) [16] => SimpleXMLElement Object ( [Citation] => Haemophilia. 2008 Nov;14(6):1151-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 19141154 ) ) [17] => SimpleXMLElement Object ( [Citation] => J Thromb Haemost. 2010 Sep;8(9):1994-2000 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20546119 ) ) [18] => SimpleXMLElement Object ( [Citation] => Thromb Res. 2010 Dec;126(6):e428-33 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 20947138 ) ) [19] => SimpleXMLElement Object ( [Citation] => Gastroenterol Hepatol (N Y). 2012 Aug;8(8):513-20 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 23293564 ) ) [20] => SimpleXMLElement Object ( [Citation] => Hypertension. 2001 Nov;38(5):1199-203 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 11711523 ) ) [21] => SimpleXMLElement Object ( [Citation] => J Clin Invest. 1971 Aug;50(8):1690-701 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 5163179 ) ) [22] => SimpleXMLElement Object ( [Citation] => J Clin Lab Anal. 2014 Nov;28(6):465-8 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 24659250 ) ) [23] => SimpleXMLElement Object ( [Citation] => J Hepatol. 2011 Dec;55(6):1415-27 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 21718668 ) ) [24] => SimpleXMLElement Object ( [Citation] => Thromb Res. 2015 Jun;135(6):1124-30 [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => 25900310 ) ) ) ) ) ) [2] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 30093507 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2018 [Month] => 10 [Day] => 29 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 12 [Day] => 10 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1472-4146 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 71 [Issue] => 11 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 [Month] => Nov ) ) [Title] => Journal of clinical pathology [ISOAbbreviation] => J Clin Pathol ) [ArticleTitle] => Biomarkers for the diagnosis of venous thromboembolism: D-dimer, thrombin generation, procoagulant phospholipid and soluble P-selectin. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1015-1022 ) [ELocationID] => 10.1136/jclinpath-2018-205293 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => The diagnostic algorithm for venous thromboembolism (VTE) currently involves a composite of pre-test probability, D-dimer and imaging. Other laboratory tests, however, may assist in the identification of patients with VTE. [1] => To assess the accuracy of different coagulation tests (D-dimer, thrombin generation, phospholipid-dependent (PPL) clotting time, soluble P-selectin (sP-selectin)) as biomarkers of acute VTE. [2] => Random samples arriving at the Coagulation Laboratory at Mater Dei Hospital (Msida, Malta) from the Accident and Emergency Department with a request for D-dimer measurement were collected between August 2015 and February 2016. The following tests were performed: Innovance D-dimer (Siemens Healthcare Diagnostics), HemosIL D-dimer HS (Instrumentation Laboratory), thrombin generation (using the calibrated automated thrombogram), STA Procoag PPL (Diagnostica Stago) and sP-selectin (Affymetrix; eBioscience). VTE was objectively confirmed by compression ultrasonography, CT pulmonary angiography or ventilation/perfusion lung scan. [3] => 100 samples were collected (33 with VTE). A strong positive linear correlation was found between the two D-dimer tests (r=0.97, p<0.001). Patients with VTE showed significantly higher sP-selectin concentrations compared with patients without VTE (75.7 ng/mL vs 53.0 ng/mL, p<0.001). In the random forest plot, the two D-dimer assays showed the highest variable importance, followed by sP-selectin. A sP-selectin cut-off of 74.8 ng/mL was associated with 72.7% sensitivity and 78.2% specificity for acute VTE in our cohort. [4] => Our results confirmed D-dimer as the main biomarker of VTE and speculated a role for sP-selectin. The impact of thrombin generation was limited and no role emerged for the PPL clotting time. These observations need to be confirmed in large management studies. ) [CopyrightInformation] => © Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Riva [ForeName] => Nicoletta [Initials] => N [Identifier] => http://orcid.org/0000-0002-8922-8823 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Vella [ForeName] => Kevin [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hickey [ForeName] => Kieron [Initials] => K [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bertù [ForeName] => Lorenza [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine and Surgery, University of Insubria, Varese, Italy. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zammit [ForeName] => Daniel [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Spiteri [ForeName] => Silvana [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kitchen [ForeName] => Steve [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Makris [ForeName] => Michael [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Sheffield Haemophilia and Thrombosis Centre, University of Sheffield, Sheffield, UK. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ageno [ForeName] => Walter [Initials] => W [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine and Surgery, University of Insubria, Varese, Italy. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gatt [ForeName] => Alex [Initials] => A [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta alexander.gatt@um.edu.mt. ) [1] => SimpleXMLElement Object ( [Affiliation] => Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Comparative Study [1] => Evaluation Study [2] => Journal Article ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2018 [Month] => 08 [Day] => 09 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => J Clin Pathol [NlmUniqueID] => 0376601 [ISSNLinking] => 0021-9746 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Biomarkers ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Fibrin Fibrinogen Degradation Products ) 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[DescriptorName] => Computed Tomography Angiography ) [6] => SimpleXMLElement Object ( [DescriptorName] => Female ) [7] => SimpleXMLElement Object ( [DescriptorName] => Fibrin Fibrinogen Degradation Products [QualifierName] => analysis ) [8] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [9] => SimpleXMLElement Object ( [DescriptorName] => Male ) [10] => SimpleXMLElement Object ( [DescriptorName] => Malta ) [11] => SimpleXMLElement Object ( [DescriptorName] => Middle Aged ) [12] => SimpleXMLElement Object ( [DescriptorName] => P-Selectin [QualifierName] => blood ) [13] => SimpleXMLElement Object ( [DescriptorName] => Perfusion Imaging ) [14] => SimpleXMLElement Object ( [DescriptorName] => Phospholipids [QualifierName] => blood ) [15] => SimpleXMLElement Object ( [DescriptorName] => Predictive Value of Tests ) [16] => SimpleXMLElement Object ( [DescriptorName] => Reproducibility of Results ) [17] => SimpleXMLElement Object ( [DescriptorName] => Thrombin [QualifierName] => metabolism ) [18] => SimpleXMLElement Object ( [DescriptorName] => Ultrasonography ) [19] => SimpleXMLElement Object ( [DescriptorName] => Venous Thromboembolism [QualifierName] => Array ( [0] => blood [1] => diagnosis [2] => diagnostic imaging ) ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => biomarkers [1] => diagnosis [2] => venous thromboembolism ) ) [CoiStatement] => Competing interests: None declared. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2018 [Month] => 05 [Day] => 25 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2018 [Month] => 07 [Day] => 03 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2018 [Month] => 07 [Day] => 16 ) [3] => SimpleXMLElement 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[@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1472-4146 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 69 [Issue] => 7 [PubDate] => SimpleXMLElement Object ( [Year] => 2016 [Month] => Jul ) ) [Title] => Journal of clinical pathology [ISOAbbreviation] => J Clin Pathol ) [ArticleTitle] => A feasibility study on the effects of Triton X-100 for the in vitro inactivation of Ebola virus on haematological assays. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 637-42 ) [ELocationID] => 10.1136/jclinpath-2015-203331 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => The aim of this study was to check the effect of Triton X-100 on various, commonly used haematology test parameters. [1] => Anonymised blood samples were treated with 10 µL of 10% Triton X-100 per 1 mL of blood. Treated and untreated samples were tested in parallel for blood film morphology, complete blood counts (CBCs), flow cytometry, blood grouping and antibody screens. Samples were also taken in 3.2% citrate tubes for coagulation test analyses. [2] => Statistical differences were noted in all CBC parameters apart from the mean cell volume, eosinophil and basophil counts. Platelet counts were significantly different with an apparent rise after the addition of Triton X-100. Samples were noted to have a high red cell fragmentation index. Immunological platelet counting methods using flow cytometry and fluorescent methods showed no significant differences and gave reliable results. Neither flow cytometry for T-cell subsets nor blood grouping/antibody screens were affected by Triton X-100. However, coagulation samples were severely haemolysed prohibiting analysis. [3] => We have demonstrated that the addition of Triton X-100 to haematology blood samples impacts mainly on platelet counts and coagulation studies due to haemolysis. The platelet count is spuriously raised probably due to the presence of red cell fragments. The latter can be circumvented by the use of immunological platelet counting technology. ) [CopyrightInformation] => Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mifsud [ForeName] => Antoinette [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Peelen [ForeName] => Daphne [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta VU University Amsterdam, Amsterdam, The Netherlands. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Brincat [ForeName] => Patricia [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Abela [ForeName] => Sylvana [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Debattista [ForeName] => Neville [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Hospital Blood Bank, Mater Dei Hospital, Msida, Malta. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Laspina [ForeName] => Stefan [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Hospital Blood Bank, Mater Dei Hospital, Msida, Malta. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zammit [ForeName] => Daniel [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Camilleri [ForeName] => David J [Initials] => DJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gatt [ForeName] => Alex [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Haematology, Mater Dei Hospital, Msida, Malta. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2015 [Month] => 12 [Day] => 15 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => J Clin Pathol [NlmUniqueID] => 0376601 [ISSNLinking] => 0021-9746 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => SimpleXMLElement Object ( [RegistryNumber] => 9002-93-1 [NameOfSubstance] => Octoxynol ) ) [CitationSubset] => Array ( [0] => AIM [1] => IM ) [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Blood Coagulation [QualifierName] => drug effects ) [1] => SimpleXMLElement Object ( [DescriptorName] => Blood Platelets [QualifierName] => drug effects ) [2] => SimpleXMLElement Object ( [DescriptorName] => Ebolavirus [QualifierName] => drug effects ) [3] => SimpleXMLElement Object ( [DescriptorName] => Erythrocyte Indices ) [4] => SimpleXMLElement Object ( [DescriptorName] => Feasibility Studies ) [5] => SimpleXMLElement Object ( [DescriptorName] => Flow Cytometry ) [6] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [7] => SimpleXMLElement Object ( [DescriptorName] => Octoxynol [QualifierName] => pharmacology ) [8] => SimpleXMLElement Object ( [DescriptorName] => Platelet Count ) [9] => SimpleXMLElement Object ( [DescriptorName] => Virus Inactivation [QualifierName] => drug effects ) ) ) [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => CELL COUNTING [1] => COAGULATION [2] => FLOW CYTOMETRY [3] => HAEMATOLOGY [4] => PLATELETS ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2015 [Month] => 08 [Day] => 10 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2015 [Month] => 11 [Day] => 12 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2015 [Month] => 12 [Day] => 17 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2015 [Month] => 12 [Day] => 17 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2017 [Month] => 2 [Day] => 7 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 26670745 [1] => jclinpath-2015-203331 [2] => 10.1136/jclinpath-2015-203331 ) ) ) ) ) ) Daniel Zammit | PubFacts

Publications by authors named "Daniel Zammit"

4Publications

The effect of DOAC-Stop on several oral and parenteral anticoagulants.

Int J Lab Hematol 2021 Feb 17. Epub 2021 Feb 17.

Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

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February 2021