Daniel W Hommes

Daniel W Hommes

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Daniel W Hommes

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Standardization of mesenchymal stromal cell therapy for perianal fistulizing Crohn's disease.

Eur J Gastroenterol Hepatol 2018 10;30(10):1148-1154

Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0000000000001208DOI Listing
October 2018

Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Inflammatory Bowel Disease.

Clin Pharmacokinet 2018 09;57(9):1075-1106

Department of Gastroenterology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.

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http://dx.doi.org/10.1007/s40262-018-0639-4DOI Listing
September 2018

A Multi-Level Fit-Based Quality Improvement Initiative to Improve Colorectal Cancer Screening in a Managed Care Population.

Clin Transl Gastroenterol 2018 09 4;9(8):177. Epub 2018 Sep 4.

The Vatche & Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41424-018-0046-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120887PMC
September 2018

Using insurance claims to predict and improve hospitalizations and biologics use in members with inflammatory bowel diseases.

J Biomed Inform 2018 05 3;81:93-101. Epub 2018 Apr 3.

UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; UCLA Departments of Psychiatry, Neurology, Radiology, Psychology, Biomedical Physics and Bioengineering, and California Nanosystems Institute, Los Angeles, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15320464183005
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http://dx.doi.org/10.1016/j.jbi.2018.03.015DOI Listing
May 2018

Defining a Patient Population With Cirrhosis: An Automated Algorithm With Natural Language Processing.

J Clin Gastroenterol 2016 Nov/Dec;50(10):889-894

Divisions of *Digestive Diseases †General Internal Medicine, David Geffen School of Medicine at UCLA ‡UCLA Office of Health Informatics & Analytics, UCLA Health, Los Angeles, CA.

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http://dx.doi.org/10.1097/MCG.0000000000000583DOI Listing
November 2017

The impact of value-based healthcare for inflammatory bowel diseases on healthcare utilization: a pilot study.

Eur J Gastroenterol Hepatol 2017 Mar;29(3):331-337

aCenter for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases Center, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles bGehr Family Center for Implementation Science, Division of Geriatric, Hospital, Palliative and General Internal Medicine, Department of Medicine, Keck School of Medicine cLeonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles dAnthem Blue Cross, Woodland Hills, California eAbbVie, North Chicago, Illinois, USA fDepartment of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0000000000000782DOI Listing
March 2017

Short article: Absence of serological rheumatoid arthritis biomarkers in inflammatory bowel disease patients with arthropathies.

Eur J Gastroenterol Hepatol 2017 Mar;29(3):345-348

Departments of aGastroenterology and Hepatology bRheumatology, Leiden University Medical Center, Leiden, The Netherlands cCenter for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles dInova Diagnostics, San Diego, California, USA.

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http://dx.doi.org/10.1097/MEG.0000000000000805DOI Listing
March 2017

Value redefined for inflammatory bowel disease patients: a choice-based conjoint analysis of patients' preferences.

Qual Life Res 2017 02 31;26(2):455-465. Epub 2016 Aug 31.

Division of Digestive Diseases, Center for Inflammatory Bowel Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s11136-016-1398-zDOI Listing
February 2017

Is Stem Cell Therapy Ready for Prime Time in Treatment of Inflammatory Bowel Diseases?

Gastroenterology 2017 Feb 11;152(2):389-397.e2. Epub 2016 Nov 11.

Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.11.003DOI Listing
February 2017

Development and Validation of an Inflammatory Bowel Diseases Monitoring Index for Use With Mobile Health Technologies.

Clin Gastroenterol Hepatol 2016 12 18;14(12):1742-1750.e7. Epub 2015 Nov 18.

UCLA Center for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1016/j.cgh.2015.10.035DOI Listing
December 2016

Etrolizumab for ulcerative colitis: the new kid on the block?

Expert Opin Biol Ther 2016 ;16(4):567-72

a Division of Digestive Disease , University of California Los Angeles , Los Angeles , CA , USA.

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http://dx.doi.org/10.1517/14712598.2016.1158807DOI Listing
October 2016

Employment status, difficulties at work and quality of life in inflammatory bowel disease patients.

Eur J Gastroenterol Hepatol 2016 Oct;28(10):1130-6

aCoronel Institute of Occupational Health bDepartment of Medical Psychology, Academic Medical Center cDepartment of Gastroenterology, Sint Lucas Andreas Hospital, Amsterdam dDepartment of Clinical and Health Psychology, Utrecht University, Utrecht eDepartment of Clinical Psychology fDepartment of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands gDepartment of Medicine, Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1097/MEG.0000000000000685DOI Listing
October 2016

Anti-TNF-α therapies for the treatment of Crohn's disease: the past, present and future.

Expert Opin Investig Drugs 2016 8;25(2):129-43. Epub 2016 Jan 8.

a Center for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases, David Geffen School of Medicine , University of California , Los Angeles , USA.

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http://dx.doi.org/10.1517/13543784.2016.1126247DOI Listing
September 2016

Identification of Circulating MicroRNA Signatures in Crohn's Disease Using the Nanostring nCounter Technology.

Inflamm Bowel Dis 2016 09;22(9):2063-9

*Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; †College of Arts and Science, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom; and ‡Center for Systems Biomedicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000883DOI Listing
September 2016

Informatics-Based Discovery of Disease-Associated Immune Profiles.

PLoS One 2016;11(9):e0163305. Epub 2016 Sep 26.

Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036861PMC
September 2016

Intraluminal Injection of Mesenchymal Stromal Cells in Spheroids Attenuates Experimental Colitis.

J Crohns Colitis 2016 Aug 19;10(8):953-64. Epub 2016 Feb 19.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1093/ecco-jcc/jjw047DOI Listing
August 2016

Stem cell-based therapies in inflammatory bowel disease: promises and pitfalls.

Therap Adv Gastroenterol 2016 Jul 25;9(4):533-47. Epub 2016 Apr 25.

Department of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/1756283X16642190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913333PMC
July 2016

Stem cells: HSCT for Crohn's disease: work in progress or a bridge too far?

Nat Rev Gastroenterol Hepatol 2016 Mar 17;13(3):128-30. Epub 2016 Feb 17.

UCLA Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, 10945 Le Conte Avenue #2338E, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nrgastro.2016.22DOI Listing
March 2016

Assessment of Circulating MicroRNAs for the Diagnosis and Disease Activity Evaluation in Patients with Ulcerative Colitis by Using the Nanostring Technology.

Inflamm Bowel Dis 2015 Nov;21(11):2533-9

*Center for Systems Biomedicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; †Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; ‡Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and §Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000547DOI Listing
November 2015

Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.

Cell Mol Gastroenterol Hepatol 2015 Nov;1(6):610-630

IBD Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA ; Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico ; Division of Surgery, School of Medicine, University of Crete, Heraklion, Crete, Greece.

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http://dx.doi.org/10.1016/j.jcmgh.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610032PMC
November 2015

Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media.

Sci Rep 2015 Nov 13;5:16570. Epub 2015 Nov 13.

Center for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases Center, David Geffen School of Medicine, UCLA, Los Angeles, California.

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http://dx.doi.org/10.1038/srep16570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643287PMC
November 2015

Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.

Gastroenterology 2015 Oct 25;149(4):918-27.e6. Epub 2015 Jun 25.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1053/j.gastro.2015.06.014DOI Listing
October 2015

Predicting Endoscopic Disease Activity in Crohn's Disease: A New and Validated Noninvasive Disease Activity Index (The Utrecht Activity Index).

Inflamm Bowel Dis 2015 Oct;21(10):2453-9

*Department of Internal Medicine and Gastroenterology, Tergooi Hospital, Hilversum, the Netherlands; †Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; ‡Department of Gastroenterology, VU Medical Center, Amsterdam, the Netherlands; §Department of Gastroenterology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; ‖Center for Inflammatory Bowel Diseases, UCLA Health System, Los Angeles, California; ¶Department of Gastroenterology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; **Department of Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands; and ††Department of Gastroenterology, Meander Medical Center, Amersfoort, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000507DOI Listing
October 2015

Presenteeism in Inflammatory Bowel Diseases: A Hidden Problem with Significant Economic Impact.

Inflamm Bowel Dis 2015 Jul;21(7):1623-30

*UCLA Center for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and †Center for Inflammatory Bowel Diseases, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/MIB.0000000000000399DOI Listing
July 2015

Value-based health care for inflammatory bowel diseases.

J Crohns Colitis 2015 May 16;9(5):421-7. Epub 2015 Feb 16.

Center for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases Center, David Geffen School of Medicine, University of California Los Angeles, USA

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http://dx.doi.org/10.1093/ecco-jcc/jjv036DOI Listing
May 2015

A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium.

Inflamm Bowel Dis 2015 May;21(5):996-1005

*Center for Systems Biomedicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; †Pediatric IBD Center, MassGeneral Hospital for Children, Boston, Massachusetts; ‡Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; and §Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402238PMC
May 2015

How does a gastroenterologist show value?

Clin Gastroenterol Hepatol 2015 Mar 28;13(3):616-7. Epub 2014 Oct 28.

Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1016/j.cgh.2014.10.024DOI Listing
March 2015

A nationwide 2010-2012 analysis of U.S. health care utilization in inflammatory bowel diseases.

Inflamm Bowel Dis 2014 Oct;20(10):1747-53

*UCLA Center for Inflammatory Bowel Diseases, Melvin and Bren Simon Digestive Diseases Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; †Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands; ‡Qforma Inc., Santa Fe, New Mexico; and §Department of Surgery, and ‖Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000139DOI Listing
October 2014

Repurposing miltefosine for the treatment of immune-mediated disease?

J Pharmacol Exp Ther 2014 Aug 15;350(2):189-95. Epub 2014 May 15.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands (A.P.V., M.E.W., G.R.v.d.B.); Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands (A.P.V., D.W.H.); Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands (M.P.P.); and Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, California (D.W.H.)

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http://dx.doi.org/10.1124/jpet.113.212654DOI Listing
August 2014

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Gastroenterology 2014 Jul 3;147(1):196-208.e13. Epub 2014 Apr 3.

Department of Gastroenterology and Hepatology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2014.03.052DOI Listing
July 2014

Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.

Gut 2014 Feb 13;63(2):310-6. Epub 2013 Feb 13.

Tytgat Institute for Liver & Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, , Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2012-304216DOI Listing
February 2014

Anti-TNF antibodies in inflammatory bowel disease: do we finally know how it works?

Curr Drug Targets 2013 Nov;14(12):1421-32

10945 Le Conte Avenue, Ueberoth Building #2338E Los Angeles, California 90095, USA.

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http://dx.doi.org/10.2174/13894501113149990164DOI Listing
November 2013

A rapid assay for on-site monitoring of infliximab trough levels: a feasibility study.

Anal Bioanal Chem 2013 Sep 9;405(23):7367-75. Epub 2013 Jul 9.

Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20 Bldg 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-013-7154-0DOI Listing
September 2013

Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions.

J Crohns Colitis 2013 Aug 13;7(7):534-41. Epub 2012 Sep 13.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1016
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http://dx.doi.org/10.1016/j.crohns.2012.08.009DOI Listing
August 2013

Miltefosine suppresses inflammation in a mouse model of inflammatory bowel disease.

Inflamm Bowel Dis 2013 Aug;19(9):1974-82

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, the Netherlands.

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http://pdfs.journals.lww.com/ibdjournal/2013/08000/Miltefosi
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MIB.0b013e3182917a2bDOI Listing
August 2013

IBD: Antibodies to anti-TNF therapy--consequences for IBD management.

Nat Rev Gastroenterol Hepatol 2013 Aug 2;10(8):446-8. Epub 2013 Jul 2.

Center for Inflammatory Bowel Diseases, University of California Los Angeles, 10945 Le Conte Avenue, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/nrgastro.2013.118DOI Listing
August 2013

Stem cell therapy in inflammatory bowel disease: which, when and how?

Curr Opin Gastroenterol 2013 Jul;29(4):384-90

Department of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1097/MOG.0b013e328361f763DOI Listing
July 2013

Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2.

J Immunol 2013 Jun 20;190(12):6589-95. Epub 2013 May 20.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1202898DOI Listing
June 2013

Mucosal schwann cell hamartoma in ulcerative colitis: diagnosis and clinical relevance.

Gastroenterol Hepatol (N Y) 2013 Mar;9(3):185-6

Center for Inflammatory Bowel Diseases, University of California at Los Angeles, Los Angeles, California ; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745210PMC
March 2013

Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease.

J Allergy (Cairo) 2012 20;2012:187408. Epub 2012 Sep 20.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1155/2012/187408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459229PMC
October 2012

Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse.

Gastroenterology 2012 Jun 24;142(7):1493-503.e6. Epub 2012 Feb 24.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S001650851200248
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http://dx.doi.org/10.1053/j.gastro.2012.02.034DOI Listing
June 2012

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro.

Inflamm Bowel Dis 2012 Mar 20;18(3):401-8. Epub 2011 Sep 20.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/ibd.21818DOI Listing
March 2012

Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease.

Clin Imaging 2011 Sep-Oct;35(5):360-5

Department of Radiology, Academic Medical Center, University of Amsterdam, 1105 AZ, The Netherlands.

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http://dx.doi.org/10.1016/j.clinimag.2010.09.003DOI Listing
January 2012

Neutralizing antibodies against adeno-associated viruses in inflammatory bowel disease patients: implications for gene therapy.

Inflamm Bowel Dis 2011 Dec 2;17(12):2436-42. Epub 2011 Mar 2.

Research and Development, Amsterdam Molecular Therapeutics (AMT) B.V., Amsterdam, the Netherlands; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/ibd.21673DOI Listing
December 2011

Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease.

J Crohns Colitis 2011 Dec 12;5(6):543-9. Epub 2011 Jun 12.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.crohns.2011.05.004DOI Listing
December 2011

Gene and cell therapy based treatment strategies for inflammatory bowel diseases.

World J Gastrointest Pathophysiol 2011 Dec;2(6):114-22

Department of Research and Development, Amsterdam Molecular Therapeutics BV, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.4291/wjgp.v2.i6.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240904PMC
December 2011

IBD and arthropathies: a practical approach to its diagnosis and management.

Gut 2011 Oct 6;60(10):1426-35. Epub 2011 May 6.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/gut.2010.228866DOI Listing
October 2011

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer.

World J Gastrointest Oncol 2011 Jun;3(6):79-98

Alexandra MJ Langers, Hein W Verspaget, Daniel W Hommes, Cornelis FM Sier, Department of Gastroenterology and Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.4251/wjgo.v3.i6.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124635PMC
June 2011

Histomorphometric analysis reveals reduced bone mass and bone formation in patients with quiescent Crohn's disease.

Gastroenterology 2011 Jan 18;140(1):116-23. Epub 2010 Sep 18.

Department of Endocrinology, VU University Medical Center, Research Institute MOVE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2010.09.007DOI Listing
January 2011

Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner.

Gastroenterology 2011 Jan 16;140(1):221-30. Epub 2010 Oct 16.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2010.10.008DOI Listing
January 2011

The joint-gut axis in inflammatory bowel diseases.

J Crohns Colitis 2010 Sep 30;4(3):257-68. Epub 2009 Nov 30.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.crohns.2009.11.005DOI Listing
September 2010

Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases.

J Immunol 2010 Jul 26;185(1):653-9. Epub 2010 May 26.

Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901129
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http://dx.doi.org/10.4049/jimmunol.0901129DOI Listing
July 2010

5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes.

Inflamm Bowel Dis 2010 Mar;16(3):379-89

Department of Gastroenterology and Hepatology, and Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ibd.21086DOI Listing
March 2010

Quality of web-based information on inflammatory bowel diseases.

Inflamm Bowel Dis 2009 Dec 21;15(12):1891-6. Epub 2009 May 21.

Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ibd.20976DOI Listing
December 2009

Update on genetics in inflammatory disease.

Best Pract Res Clin Gastroenterol 2009 ;23(2):233-43

Department of Gastroenterology and Hepatology, Leiden University Medical Center, C4-12 Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.bpg.2009.02.005DOI Listing
July 2009

Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands.

Steroids 2008 Oct 14;73(9-10):1025-9. Epub 2007 Dec 14.

Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.steroids.2007.12.002DOI Listing
October 2008

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.

Eur J Cancer 2008 Sep 6;44(13):1904-13. Epub 2008 Aug 6.

Department of Gastroenterology-Hepatology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2008.06.031DOI Listing
September 2008

Are we ready for top-down therapy for inflammatory bowel diseases: pro.

Expert Rev Gastroenterol Hepatol 2007 Dec;1(2):243-8

Erasmus Medical Center, Department of Gastroenterology and Hepatology, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1586/17474124.1.2.243DOI Listing
December 2007

The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.

Gastroenterology 2007 Oct 14;133(4):1272-81. Epub 2007 Aug 14.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2007.08.021DOI Listing
October 2007

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.

Immunity 2007 Oct 4;27(4):660-9. Epub 2007 Oct 4.

Department of Cell Biology and Histology, Academic Medical Centre of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130700443
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http://dx.doi.org/10.1016/j.immuni.2007.08.013DOI Listing
October 2007