Daniel Shao Weng Tan

A phase II study of nimotuzumab (TheraCim-hR3) concurrent with cisplatin/radiotherapy in patients with locally advanced head and neck squamous cell carcinoma.

Authors:

Mei-Kim Ang Jose Enrique Montoya Ekkasit Tharavichitkul Cindy Lim Terence Tan Lan Ying Wang Joseph Wee Yoke-Lim Soong Kam-Weng Fong Quan Sing Ng Daniel Shao-Weng Tan Chee-Keong Toh Eng-Huat Tan Wan-Teck Lim

Head Neck 2021 Feb 5. Epub 2021 Feb 5.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

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February 2021

A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC).

Authors:

Joo-Leng Low Dawn Pingxi Lau Xiaoqian Zhang Xue-Lin Kwang Neha Rohatgi Jane Vin Chan Fui-Teen Chong Stephen Qi Rong Wong Hui-Sun Leong Matan Thangavelu Thangavelu Shivaji Rikka Anders Martin Jacobsen Skanderup Daniel Shao Weng Tan Giridharan Periyasamy Judice Lie Yong Koh N Gopalakrishna Iyer Ramanuj DasGupta

EBioMedicine 2021 Jan 30;64:103220. Epub 2021 Jan 30.

Laboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore. Electronic address:

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January 2021

Experimental and bioinformatics considerations in cancer application of single cell genomics.

Authors:

Joanna Hui Juan Tan Say Li Kong Joyce A Tai Huay Mei Poh Fei Yao Yee Yen Sia Edwin Kok Hao Lim Angela Maria Takano Daniel Shao-Weng Tan Asif Javed Axel M Hillmer

Comput Struct Biotechnol J 2021 23;19:343-354. Epub 2020 Dec 23.

Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.

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December 2020

Phase 1/2 study of ceritinib in Chinese patients with advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer previously treated with crizotinib: Results from ASCEND-6.

Authors:

Yi-Long Wu Yuankai Shi Daniel Shao Weng Tan Liu Xiaoqing Ying Cheng Jianying Zhou Tong Tong An You Lu Bo Zhu Chunxue Bai Vanessa Q Passos Yvonne Y Lau Liao Xun Li Zhang

Lung Cancer 2020 12 5;150:240-246. Epub 2020 Nov 5.

Sun Yat-Sen University Cancer Center, Guangzhou, China.

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December 2020

Partial absence of PD-1 expression by tumor-infiltrating EBV-specific CD8 T cells in EBV-driven lymphoepithelioma-like carcinoma.

Authors:

Yannick Simoni Etienne Becht Shamin Li Chiew Yee Loh Joe Poh Sheng Yeong Tony Kiat Hon Lim Angela Takano Daniel Shao Weng Tan Evan W Newell

Clin Transl Immunology 2020 9;9(9):e1175. Epub 2020 Sep 9.

Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA.

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September 2020

Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial.

Lancet Respir Med 2020 11 29;8(11):1132-1143. Epub 2020 May 29.

National Taiwan University Hospital, Taipei, Taiwan.

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November 2020

Recommendations to improve the clinical adoption of NGS-based cancer diagnostics in Singapore.

Authors:

David Shao-Peng Tan Daniel Shao-Weng Tan Iain Bee Huat Tan Benedict Yan Su Pin Choo Wee Joo Chng William Ying Khee Hwang

Asia Pac J Clin Oncol 2020 Aug 16;16(4):222-231. Epub 2020 Apr 16.

Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

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August 2020

Genomic landscape of lung adenocarcinoma in East Asians.

Nat Genet 2020 02 3;52(2):177-186. Epub 2020 Feb 3.

Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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February 2020

Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).

Authors:

Pei Yuan Fong Sze Huey Tan Darren Wan Teck Lim Eng Huat Tan Quan Sing Ng Kiattisa Sommat Daniel Shao Weng Tan Mei Kim Ang

PLoS One 2019 20;14(11):e0224665. Epub 2019 Nov 20.

Division of Medical Oncology, National Cancer Centre, Singapore.

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April 2020

Ceritinib plus Nivolumab in Patients with Advanced ALK-Rearranged Non-Small Cell Lung Cancer: Results of an Open-Label, Multicenter, Phase 1B Study.

Authors:

Enriqueta Felip Filippo G de Braud Michela Maur Herbert H Loong Alice Tsang Shaw Johan F Vansteenkiste Thomas John Geoffrey Liu Martijn P Lolkema Giovanni Selvaggi Vanessa Giannone Pilar Cazorla Jason Baum O Alejandro Balbin Luojun Victor Wang Yvonne Y Lau Jeffrey W Scott Daniel Shao-Weng Tan

J Thorac Oncol 2020 03 18;15(3):392-403. Epub 2019 Oct 18.

National Cancer Centre Singapore, Singapore.

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March 2020

Addressing cellular heterogeneity in tumor and circulation for refined prognostication.

Authors:

Su Bin Lim Trifanny Yeo Wen Di Lee Ali Asgar S Bhagat Swee Jin Tan Daniel Shao Weng Tan Wan-Teck Lim Chwee Teck Lim

Proc Natl Acad Sci U S A 2019 09 15;116(36):17957-17962. Epub 2019 Aug 15.

NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, 117456 Singapore, Singapore;

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September 2019

Publisher Correction: Methionine is a metabolic dependency of tumor-initiating cells.

Nat Med 2019 Jun;25(6):1022

Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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June 2019

Methionine is a metabolic dependency of tumor-initiating cells.

Nat Med 2019 05 6;25(5):825-837. Epub 2019 May 6.

Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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May 2019

Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures.

Authors:

Say Li Kong Huipeng Li Joyce A Tai Elise T Courtois Huay Mei Poh Dawn Pingxi Lau Yu Xuan Haw Narayanan Gopalakrishna Iyer Daniel Shao Weng Tan Shyam Prabhakar Dave Ruff Axel M Hillmer

Clin Chem 2019 02 6;65(2):272-281. Epub 2018 Dec 6.

Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore;

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February 2019

Effects of Single Nucleotide Polymorphisms on the Binding of Afatinib to EGFR: A Potential Patient Stratification Factor Revealed by Modeling Studies.

Authors:

Srinivasaraghavan Kannan Daniel Shao-Weng Tan Chandra Shekhar Verma

J Chem Inf Model 2019 01 10;59(1):309-315. Epub 2018 Dec 10.

Bioinformatics Institute (A*STAR) , 30 Biopolis Street, 07-01 matrix , Singapore 138671 , Singapore.

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January 2019

A Decade of Never-smokers Among Lung Cancer Patients-Increasing Trend and Improved Survival.

Authors:

Chee-Keong Toh Whee-Sze Ong Wan-Teck Lim Daniel Shao-Weng Tan Quan-Sing Ng Ravindran Kanesvaran Wei-Jie Seow Mei-Kim Ang Eng-Huat Tan

Clin Lung Cancer 2018 09 17;19(5):e539-e550. Epub 2018 Mar 17.

Division of Medical Oncology, National Cancer Centre, Singapore.

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September 2018

Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women.

Authors:

Wen Yee Chay Li Lian Kwok Wen Ning Tiong Sai Sakktee Krisna Kiat Hon Lim N Gopalkrishna Iyer Liang Kee Goh Daniel Shao-Weng Tan

Int J Gynecol Cancer 2018 03;28(3):428-436

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March 2018

Phase 1b Trial of Ficlatuzumab, a Humanized Hepatocyte Growth Factor Inhibitory Monoclonal Antibody, in Combination With Gefitinib in Asian Patients With NSCLC.

Authors:

Eng-Huat Tan Wan-Teck Lim Myung-Ju Ahn Quan-Sing Ng Jin Seok Ahn Daniel Shao-Weng Tan Jong-Mu Sun May Han Francis C Payumo Krista McKee Wei Yin Marc Credi Shefali Agarwal Jaroslaw Jac Keunchil Park

Clin Pharmacol Drug Dev 2018 06 18;7(5):532-542. Epub 2018 Jan 18.

Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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June 2018

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.

Authors:

Suhail Ahmed Kabeer Rasheed Hui Sun Leong Manikandan Lakshmanan Anandhkumar Raju Dhivya Dadlani Fui-Teen Chong Nicholas B Shannon Ravisankar Rajarethinam Thakshayeni Skanthakumar Ern Yu Tan Jacqueline Siok Gek Hwang Kok Hing Lim Daniel Shao-Weng Tan Paolo Ceppi Mei Wang Vinay Tergaonkar Patrick J Casey N Gopalakrishna Iyer

Oncogene 2018 03 19;37(10):1340-1353. Epub 2017 Dec 19.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.

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March 2018

Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.

Authors:

Srinivasaraghavan Kannan Mohan R Pradhan Garima Tiwari Wei-Chong Tan Balram Chowbay Eng Huat Tan Daniel Shao-Weng Tan Chandra Verma

Sci Rep 2017 05 8;7(1):1540. Epub 2017 May 8.

Bioinformatics Institute (A*STAR), 30 Biopolis Street, 07-01 matrix, Singapore, 138671, Singapore.

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May 2017

Metronomic chemotherapy: A relook at its basis and rationale.

Authors:

Tanujaa Rajasekaran Quan-Sing Ng Daniel Shao-Weng Tan Wan-Teck Lim Mei-Kim Ang Chee-Keong Toh Balram Chowbay Ravindran Kanesvaran Eng-Huat Tan

Cancer Lett 2017 03 18;388:328-333. Epub 2016 Dec 18.

Division of Medical Oncology, National Cancer Centre, Singapore. Electronic address:

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March 2017

Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small Cell Lung Cancer.

Authors:

Ying Swan Ho Lian Yee Yip Nurhidayah Basri Vivian Su Hui Chong Chin Chye Teo Eddy Tan Kah Ling Lim Gek San Tan Xulei Yang Si Yong Yeo Mariko Si Yue Koh Anantham Devanand Angela Takano Eng Huat Tan Daniel Shao Weng Tan Tony Kiat Hon Lim

Sci Rep 2016 10 14;6:35110. Epub 2016 Oct 14.

Department of Pathology Singapore General Hospital 20 College Road, Academia, Level 10, Singapore 169856, Singapore.

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October 2016

Imaging features of renal complications after crizotinib treatment for non-small-cell lung cancer: a case report.

Authors:

Wan Ying Chan Mei-Kim Ang Daniel Shao Weng Tan Wan Lin Koh Jin Wei Kwek

Radiol Case Rep 2016 Sep 18;11(3):245-7. Epub 2016 May 18.

Division of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, 169610 Singapore.

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September 2016

Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression.

Nat Commun 2016 06 21;7:11702. Epub 2016 Jun 21.

Genome Institute of Singapore, Singapore 138672, Singapore.

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June 2016

Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK-Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External Controls.

Authors:

Daniel Shao-Weng Tan António Araújo Jie Zhang James Signorovitch Zheng-Yi Zhou Xiaopeng Cai Geoffrey Liu

J Thorac Oncol 2016 09 8;11(9):1550-7. Epub 2016 Jun 8.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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September 2016

Advances in systemic treatment for nasopharyngeal carcinoma.

Authors:

Wan-Ling Tan Eng-Huat Tan Darren Wan-Teck Lim Quan-Sing Ng Daniel Shao-Weng Tan Amit Jain Mei-Kim Ang

Chin Clin Oncol 2016 Apr;5(2):21

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

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April 2016

Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer.

Authors:

Chye Ling Tan Tse Hui Lim Tony Kh Lim Daniel Shao-Weng Tan Yong Wei Chua Mei Kim Ang Brendan Pang Chwee Teck Lim Angela Takano Alvin Soon-Tiong Lim Man Chun Leong Wan-Teck Lim

Oncotarget 2016 Apr;7(17):23251-62

Department of Medical Oncology, National Cancer Center Singapore, Singapore.

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April 2016

Single-cell profiling approaches to probing tumor heterogeneity.

Authors:

Bee Luan Khoo Parthiv Kant Chaudhuri Naveen Ramalingam Daniel Shao Weng Tan Chwee Teck Lim Majid Ebrahimi Warkiani

Int J Cancer 2016 07 16;139(2):243-55. Epub 2016 Feb 16.

BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore.

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July 2016

Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.

PLoS One 2015 8;10(5):e0123587. Epub 2015 May 8.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Cancer Therapeutics Research Laboratory, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore; Cancer Stem Cell Biology, Genome Institute of Singapore, Singapore, Singapore.

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February 2016

Metronomic vinorelbine (oral) in combination with sorafenib in advanced non-small cell lung cancer.

Authors:

Eng Huat Tan Daniel Shao Weng Tan Wen Yun Li Benjamin Haaland Mei Kim Ang Noan Min Chau Chee Keong Toh Iain Bee Huat Tan Tong San Koh Choon Hua Thng Balram Chowbay Kam Man Hui Wan Teck Lim Quan Sing Ng

Lung Cancer 2015 Jun 13;88(3):289-96. Epub 2015 Apr 13.

Department of Medical Oncology, National Cancer Centre, Singapore. Electronic address:

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June 2015

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