Dr  Daniel Seifu, PhD - University of Global Health Equity - Associate professor

Dr Daniel Seifu

PhD

University of Global Health Equity

Associate professor

Kigali, Kigali | Rwanda

Main Specialties: Biology, Chemical Pathology

Additional Specialties: Medical biochemist

ORCID logohttps://orcid.org/0000-0003-1490-4441

Dr  Daniel Seifu, PhD - University of Global Health Equity - Associate professor

Dr Daniel Seifu

PhD

Introduction

Primary Affiliation: University of Global Health Equity - Kigali, Kigali , Rwanda

Specialties:

Additional Specialties:

Research Interests:


View Dr Daniel Seifu’s Resume / CV

Education

Feb 2018
Diploma to teach in higher education
Diploma
medical education
Jan 2011
Addis Ababa University/Karoliniska institute
PhD
Medical Biochemistry
Jun 2000
University of MADRAS , India
MSc
Biochemistry
Jun 1998
University of New Delhi , India
BSc(Hons)
Biochemistry

Experience

Mar 2017
investigation of predisposing and genetic driving factor for aggressive nature of Ethiopian breast cancer
PI
Thematic research grant from Addis Ababa University
Feb 2013
Clinico-epidemiological characterization of breast cancer in Ethiopia
PI
Thematic research grant from Addis Ababa University

Publications

10Publications

514Reads

21Profile Views

10PubMed Central Citations

Vitamin D Status and Association of Genetic Polymorphism to Risk of Breast Cancer in Ethiopia.

Nutrients 2019 Jan 29;11(2). Epub 2019 Jan 29.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden.

Emerging evidence associates vitamin D deficiency and vitamin D receptor () genetic variations with risk for breast cancer. This study investigated the prevalence of vitamin D deficiency and its association with tumor characteristics and the implications of genetic variations for risk of breast cancer in Ethiopia. This unmatched case?control study involved 392 female breast cancer patients and 193 controls. The plasma 25-hydroxyvitamin D (25(OH)D?) level was quantified in chemotherapy-naïve ( = 112) and tamoxifen-treated patients ( = 89). Genotyping for the common variant alleles rs7975232 (I), rs2228570 (I), and rs731236 (I) was done. Eighty-six percent of the patients were vitamin D deficient (<50 nmol/L). Chemotherapy-naïve breast cancer patients had a higher prevalence of vitamin D deficiency (91.9% vs. 78.3%) compared to the tamoxifen-treated group ( < 0.001). The prevalence of severe vitamin D deficiency (<25 nmol/L) was significantly higher in chemotherapy-naïve (41.1%) than tamoxifen-treated (11.2%) patients. Vitamin D deficiency was not significantly associated with tumor characteristics or genotype. The rs2228570 genotype was associated with increased risk of breast cancer (OR = 1.44, 95% confidence interval = 1.01-2.06). Our result indicates that rs2228570 might be a moderate risk factor for breast cancer development in the Ethiopian population. The high prevalence of severe vitamin D deficiency in treatment-naïve breast cancer patients indicates the need for nutritional supplementation of vitamin D at the time of chemotherapy initiation.

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http://dx.doi.org/10.3390/nu11020289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412905PMC
January 2019
3 Reads
3.148 Impact Factor

Breast cancer in Ethiopia: evidence for geographic difference in the distribution of molecular subtypes in Africa.

BMC Womens Health 2018 02 14;18(1):40. Epub 2018 Feb 14.

Dept of Laboratory Medicine, Faculty of Medicine and Health, Orebro University, Orebro, Sweden.

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http://dx.doi.org/10.1186/s12905-018-0531-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813361PMC
February 2018
13 Reads
1.660 Impact Factor

Lipid Peroxidation and Altered Antioxidant Profiles with Pediatric HIV Infection and Antiretroviral Therapy in Addis Ababa, Ethiopia.

J Trop Pediatr 2017 06;63(3):196-202

Department of Biochemistry, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

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http://dx.doi.org/10.1093/tropej/fmw076DOI Listing
June 2017
25 Reads
0.860 Impact Factor

Efavirenz and ritonavir-boosted lopinavir use exhibited elevated markers of atherosclerosis across age groups in people living with HIV in Ethiopia.

J Biomech 2016 09 21;49(13):2584-2592. Epub 2016 May 21.

Department of Pediatrics and Child Health, Addis Ababa University, Addis Ababa, Ethiopia.

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http://dx.doi.org/10.1016/j.jbiomech.2016.05.018DOI Listing
September 2016
36 Reads
2 Citations
2.751 Impact Factor

Establishment of reference intervals of thyroid function tests from cord blood of neonates in two selected hospitals, Addis Ababa, Ethiopia.

BMC Pediatr 2016 08 2;16:118. Epub 2016 Aug 2.

Department of Biochemistry, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

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http://dx.doi.org/10.1186/s12887-016-0654-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969665PMC
August 2016
100 Reads
1.920 Impact Factor

Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin Zymography.

Mol Biotechnol 2016 Jan;58(1):56-64

Oncology Division, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1007/s12033-015-9903-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712114PMC
January 2016
118 Reads
1 Citation
1.880 Impact Factor

Top co-authors

Wondwossen Amogne
Wondwossen Amogne

Karolinska Institutet

4
Rudolph L Gleason
Rudolph L Gleason

Georgia Institute of Technology

4
Alexander W Caulk
Alexander W Caulk

The George W. Woodruff School of Mechanical Engineering

3
Eyasu Makonnen
Eyasu Makonnen

Addis Ababa University

2
Eleni Aklillu
Eleni Aklillu

Karolinska Institutet

2
Alan Fotoohi
Alan Fotoohi

Karolinska University Hospital

2
Getnet Yimer
Getnet Yimer

Karolinska Institutet

2
Rawleigh Howe
Rawleigh Howe

Armauer Hansen Research Institute

2
Abebe Bekele
Abebe Bekele

Addis Ababa University

2
Mathewos Assefa
Mathewos Assefa

Addis Ababa University

2