Daniel Schrimpf

Daniel Schrimpf

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Daniel Schrimpf

Daniel Schrimpf

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Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Authors:
Annika K Wefers Damian Stichel Daniel Schrimpf Roland Coras Mélanie Pages Arnault Tauziède-Espariat Pascale Varlet Daniel Schwarz Figen Söylemezoglu Ute Pohl José Pimentel Jochen Meyer Ekkehard Hewer Anna Japp Abhijit Joshi David E Reuss Annekathrin Reinhardt Philipp Sievers M Belén Casalini Azadeh Ebrahimi Kristin Huang Christian Koelsche Hu Liang Low Olinda Rebelo Dina Marnoto Albert J Becker Ori Staszewski Michel Mittelbronn Martin Hasselblatt Jens Schittenhelm Edmund Cheesman Ricardo Santos de Oliveira Rosane Gomes P Queiroz Elvis Terci Valera Volkmar H Hans Andrey Korshunov Adriana Olar Keith L Ligon Stefan M Pfister Zane Jaunmuktane Sebastian Brandner Ruth G Tatevossian David W Ellison Thomas S Jacques Mrinalini Honavar Eleonora Aronica Maria Thom Felix Sahm Andreas von Deimling David T W Jones Ingmar Blumcke David Capper

Acta Neuropathol 2020 Jan 28;139(1):193-209. Epub 2019 Sep 28.

Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1007/s00401-019-02078-wDOI Listing
January 2020

YAP1-fusions in pediatric NF2-wildtype meningioma.

Authors:
Philipp Sievers Jason Chiang Daniel Schrimpf Damian Stichel Nagarajan Paramasivam Martin Sill Tenzin Gayden Belen Casalini David E Reuss James Dalton Kristian W Pajtler Daniel Hänggi Christel Herold-Mende Elisabeth Rushing Andrey Korshunov Christian Mawrin Michael Weller Matthias Schlesner Wolfgang Wick Nada Jabado David T W Jones Stefan M Pfister Andreas von Deimling David W Ellison Felix Sahm

Acta Neuropathol 2020 Jan 16;139(1):215-218. Epub 2019 Nov 16.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02095-9DOI Listing
January 2020

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.

Authors:
Felix K F Kommoss Damian Stichel Daniel Schrimpf Mark Kriegsmann Basile Tessier-Cloutier Aline Talhouk Jessica N McAlpine Kenneth T E Chang Dominik Sturm Stefan M Pfister Laura Romero-Pérez Thomas Kirchner Thomas G P Grünewald Rolf Buslei Hans-Peter Sinn Gunhild Mechtersheimer Peter Schirmacher Dietmar Schmidt Hans-Anton Lehr Felix Sahm David G Huntsman C Blake Gilks Friedrich Kommoss Andreas von Deimling Christian Koelsche

J Cancer Res Clin Oncol 2020 Jan 25;146(1):97-104. Epub 2019 Nov 25.

Department of Pathology, Institute of Pathology, Heidelberg University Hospital, INF 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00432-019-03093-wDOI Listing
January 2020

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.

Authors:
Damian Stichel Daniel Schrimpf Belén Casalini Jochen Meyer Annika K Wefers Philipp Sievers Andrey Korshunov Christian Koelsche David E Reuss Annekathrin Reinhardt Azadeh Ebrahimi Francisco Fernández-Klett Tobias Kessler Dominik Sturm Jonas Ecker Till Milde Christel Herold-Mende Olaf Witt Stefan M Pfister Wolfgang Wick David T W Jones Andreas von Deimling Felix Sahm

Acta Neuropathol 2019 Nov 5;138(5):827-835. Epub 2019 Jul 5.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02039-3DOI Listing
November 2019

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation.

Authors:
Philipp Sievers Daniel Schrimpf Damian Stichel David E Reuss Martin Hasselblatt Christian Hagel Ori Staszewski Jürgen Hench Stephan Frank Sebastian Brandner Andrey Korshunov Wolfgang Wick Stefan M Pfister Guido Reifenberger Andreas von Deimling Felix Sahm David T W Jones

Acta Neuropathol 2019 Nov 15. Epub 2019 Nov 15.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02097-7DOI Listing
November 2019

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.

Authors:
Andrey Korshunov Konstantin Okonechnikov Felix Sahm Marina Ryzhova Damian Stichel Daniel Schrimpf David R Ghasemi Kristian W Pajtler Manila Antonelli Vittoria Donofrio Angela Mastronuzzi Sabrina Rossi Francesca Diomedi Camassei Anna Maria Buccoliero Christine Haberler Irene Slavc Sonika Dahiya Belen Casalini Philipp Sievers Jochen Meyer Ella Kumirova Olga Zheludkova Andrey Golanov David T W Jones Stefan M Pfister Marcel Kool Andreas von Deimling

Acta Neuropathol 2019 Nov 28. Epub 2019 Nov 28.

Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02102-zDOI Listing
November 2019

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities.

Authors:
Annekathrin Reinhardt Damian Stichel Daniel Schrimpf Christian Koelsche Annika K Wefers Azadeh Ebrahimi Philipp Sievers Kristin Huang M Belén Casalini Francisco Fernández-Klett Abigail Suwala Michael Weller Dorothee Gramatzki Joerg Felsberg Guido Reifenberger Albert Becker Volkmar H Hans Marco Prinz Ori Staszewski Till Acker Hildegard Dohmen Christian Hartmann Werner Paulus Katharina Heß Benjamin Brokinkel Jens Schittenhelm Rolf Buslei Martina Deckert Christian Mawrin Ekkehard Hewer Ute Pohl Zane Jaunmuktane Sebastian Brandner Andreas Unterberg Daniel Hänggi Michael Platten Stefan M Pfister Wolfgang Wick Christel Herold-Mende Andrey Korshunov David E Reuss Felix Sahm David T W Jones David Capper Andreas von Deimling

Acta Neuropathol Commun 2019 Oct 28;7(1):163. Epub 2019 Oct 28.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-019-0801-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816155PMC
October 2019

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1.

Authors:
Philipp Sievers Romain Appay Daniel Schrimpf Damian Stichel David E Reuss Annika K Wefers Annekathrin Reinhardt Roland Coras Viktoria C Ruf Simone Schmid Karin de Stricker Henning B Boldt Bjarne Winther Kristensen Jeanette Krogh Petersen Benedicte P Ulhøi Maria Gardberg Eleonora Aronica Martin Hasselblatt Wolfgang Brück Franck Bielle Karima Mokhtari Benoît Lhermitte Wolfgang Wick Christel Herold-Mende Daniel Hänggi Sebastian Brandner Felice Giangaspero David Capper Elisabeth Rushing Pieter Wesseling Stefan M Pfister Dominique Figarella-Branger Andreas von Deimling Felix Sahm David T W Jones

Acta Neuropathol 2019 Sep 27;138(3):497-504. Epub 2019 Jun 27.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02038-4DOI Listing
September 2019

Molecular progression of SHH-activated medulloblastomas.

Authors:
Andrey Korshunov Konstantin Okonechnikov Felix Sahm Marina Ryzhova Damian Stichel Philipp Sievers Jochen Meyer Daniel Schrimpf Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Stefan M Pfister Andreas von Deimling Marcel Kool

Acta Neuropathol 2019 Aug 27;138(2):327-330. Epub 2019 Apr 27.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02022-yDOI Listing
August 2019

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.

Authors:
Nagarajan Paramasivam Daniel Hübschmann Umut H Toprak Naveed Ishaque Marian Neidert Daniel Schrimpf Damian Stichel David Reuss Philipp Sievers Annekathrin Reinhardt Annika K Wefers David T W Jones Zuguang Gu Johannes Werner Sebastian Uhrig Hans-Georg Wirsching Matthias Schick Melanie Bewerunge-Hudler Katja Beck Stephanie Brehmer Steffi Urbschat Marcel Seiz-Rosenhagen Daniel Hänggi Christel Herold-Mende Ralf Ketter Roland Eils Zvi Ram Stefan M Pfister Wolfgang Wick Michael Weller Rachel Grossmann Andreas von Deimling Matthias Schlesner Felix Sahm

Acta Neuropathol 2019 Aug 8;138(2):295-308. Epub 2019 May 8.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02008-wDOI Listing
August 2019

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles.

Authors:
Andrey Korshunov Felix Sahm Konstantin Okonechnikov Marina Ryzhova Damian Stichel Daniel Schrimpf Belen Casalini Philipp Sievers Jochen Meyer Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Stefan M Pfister Marcel Kool Andreas von Deimling

Acta Neuropathol 2019 Jun 2;137(6):1003-1015. Epub 2019 Mar 2.

Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-01981-6DOI Listing
June 2019

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.

Authors:
Yanghao Hou Jorge Pinheiro Felix Sahm David E Reuss Daniel Schrimpf Damian Stichel Belén Casalini Christian Koelsche Philipp Sievers Annika K Wefers Annekathrin Reinhardt Azadeh Ebrahimi Francisco Fernández-Klett Stefan Pusch Jochen Meier Leonille Schweizer Werner Paulus Marco Prinz Christian Hartmann Karl H Plate Guido Reifenberger Torsten Pietsch Pascale Varlet Mélanie Pagès Ulrich Schüller David Scheie Karin de Stricker Stephan Frank Jürgen Hench Bianca Pollo Sebastian Brandner Andreas Unterberg Stefan M Pfister David T W Jones Andrey Korshunov Wolfgang Wick David Capper Ingmar Blümcke Andreas von Deimling Luca Bertero

Acta Neuropathol 2019 May 13;137(5):837-846. Epub 2019 Feb 13.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-01969-2DOI Listing
May 2019

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas.

Authors:
Andrey Korshunov Felix Sahm Olga Zheludkova Andrey Golanov Damian Stichel Daniel Schrimpf Marina Ryzhova Alexander Potapov Antje Habel Jochen Meyer Peter Lichter David T W Jones Andreas von Deimling Stefan M Pfister Marcel Kool

Neuro Oncol 2019 02;21(2):214-221

Hopp Children's Cancer Center at the National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noy155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374763PMC
February 2019

Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre.

Authors:
Zane Jaunmuktane David Capper David T W Jones Daniel Schrimpf Martin Sill Monika Dutt Nirosha Suraweera Stefan M Pfister Andreas von Deimling Sebastian Brandner

Acta Neuropathol Commun 2019 02 20;7(1):24. Epub 2019 Feb 20.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0668-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381711PMC
February 2019

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype.

Authors:
Christian Koelsche Damian Stichel Klaus G Griewank Daniel Schrimpf David E Reuss Melanie Bewerunge-Hudler Christian Vokuhl Winand N M Dinjens Iver Petersen Michel Mittelbronn Adrian Cuevas-Bourdier Rolf Buslei Stefan M Pfister Uta Flucke Gunhild Mechtersheimer Thomas Mentzel Andreas von Deimling

Clin Sarcoma Res 2019 14;9. Epub 2019 Feb 14.

2Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Baden-Württemberg Germany.

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-019-0113-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375211PMC
February 2019

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p.

Authors:
Philipp Sievers Damian Stichel Thomas Hielscher Daniel Schrimpf Annekathrin Reinhardt Annika K Wefers David Reuss David T W Jones Melanie Bewerunge-Hudler Christian Hartmann Peter Baumgarten Hans-Georg Wirsching Bjarne Winther-Kristensen Benjamin Brokinkel Ralf Ketter Miguel Angel Idoate Gastearena Katrin Lamszus Marcel Seiz-Rosenhagen Christian Mawrin Patrick N Harter Jörg Felsberg Daniel Hänggi Christel Herold-Mende Anna Sophie Berghoff Michael Weller Stefan M Pfister Wolfgang Wick Guido Reifenberger Matthias Preusser Andreas von Deimling Felix Sahm

Acta Neuropathol 2018 12 31;136(6):975-978. Epub 2018 Oct 31.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-018-1924-x
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http://dx.doi.org/10.1007/s00401-018-1924-xDOI Listing
December 2018

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.

Authors:
Damian Stichel Azadeh Ebrahimi David Reuss Daniel Schrimpf Takahiro Ono Mitsuaki Shirahata Guido Reifenberger Michael Weller Daniel Hänggi Wolfgang Wick Christel Herold-Mende Manfred Westphal Sebastian Brandner Stefan M Pfister David Capper Felix Sahm Andreas von Deimling

Acta Neuropathol 2018 11 5;136(5):793-803. Epub 2018 Sep 5.

Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1905-0DOI Listing
November 2018

Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.

Authors:
Andrey Korshunov Lukas Chavez Tanvi Sharma Marina Ryzhova Daniel Schrimpf Damian Stichel David Capper Dominik Sturm Marcel Kool Antje Habel Bette K Kleinschmidt-DeMasters Marc Rosenblum Oksana Absalyamova Andrey Golanov Peter Lichter Stefan M Pfister David T W Jones Arie Perry Andreas von Deimling

Brain Pathol 2018 09 30;28(5):656-662. Epub 2017 Oct 30.

Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1111/bpa.12566DOI Listing
September 2018

Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling.

Authors:
Klaus G Griewank Christian Koelsche Johannes A P van de Nes Daniel Schrimpf Marco Gessi Inga Möller Antje Sucker Richard A Scolyer Michael E Buckland Rajmohan Murali Torsten Pietsch Andreas von Deimling Dirk Schadendorf

Clin Cancer Res 2018 09 11;24(18):4494-4504. Epub 2018 Jun 11.

Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0763DOI Listing
September 2018

Correction to: DNA methylation-based reclassification of olfactory neuroblastoma.

Authors:
David Capper Nils W Engel Damian Stichel Matt Lechner Stefanie Glöss Simone Schmid Christian Kölsche Daniel Schrimpf Judith Niesen Annika K Wefers David T W Jones Martin Sill Oliver Weigert Keith L Ligon Adriana Olar Arend Koch Martin Forster Sebastian Moran Oscar M Tirado Miguel Sáinz-Jaspeado Jaume Mora Manel Esteller Javier Alonso Xavier Garcia Del Muro Werner Paulus Jörg Felsberg Guido Reifenberger Markus Glatzel Stephan Frank Camelia M Monoranu Valerie J Lund Andreas von Deimling Stefan Pfister Rolf Buslei Julika Ribbat-Idel Sven Perner Volker Gudziol Matthias Meinhardt Ulrich Schüller

Acta Neuropathol 2018 09;136(3):505

Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-018-1887-yDOI Listing
September 2018

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.

Authors:
Annekathrin Reinhardt Damian Stichel Daniel Schrimpf Felix Sahm Andrey Korshunov David E Reuss Christian Koelsche Kristin Huang Annika K Wefers Volker Hovestadt Martin Sill Dorothee Gramatzki Joerg Felsberg Guido Reifenberger Arend Koch Ulrich-W Thomale Albert Becker Volkmar H Hans Marco Prinz Ori Staszewski Till Acker Hildegard Dohmen Christian Hartmann Wolf Mueller Muin S A Tuffaha Werner Paulus Katharina Heß Benjamin Brokinkel Jens Schittenhelm Camelia-Maria Monoranu Almuth Friederike Kessler Mario Loehr Rolf Buslei Martina Deckert Christian Mawrin Patricia Kohlhof Ekkehard Hewer Adriana Olar Fausto J Rodriguez Caterina Giannini Amulya A NageswaraRao Uri Tabori Nuno Miguel Nunes Michael Weller Ute Pohl Zane Jaunmuktane Sebastian Brandner Andreas Unterberg Daniel Hänggi Michael Platten Stefan M Pfister Wolfgang Wick Christel Herold-Mende David T W Jones Andreas von Deimling David Capper

Acta Neuropathol 2018 08 21;136(2):273-291. Epub 2018 Mar 21.

Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1837-8DOI Listing
August 2018

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

Authors:
Andrey Korshunov Felix Sahm Damian Stichel Daniel Schrimpf Marina Ryzhova Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Andreas von Deimling Stefan M Pfister Marcel Kool

Acta Neuropathol 2018 08 22;136(2):303-313. Epub 2018 Mar 22.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1840-0DOI Listing
August 2018

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information.

Authors:
Christian Koelsche Wolfgang Hartmann Daniel Schrimpf Damian Stichel Susanne Jabar Andreas Ranft David E Reuss Felix Sahm David T W Jones Melanie Bewerunge-Hudler Marcel Trautmann Thomas Klingebiel Christian Vokuhl Manfred Gessler Eva Wardelmann Iver Petersen Daniel Baumhoer Uta Flucke Cristina Antonescu Manel Esteller Stefan Fröhling Marcel Kool Stefan M Pfister Gunhild Mechtersheimer Uta Dirksen Andreas von Deimling

Mod Pathol 2018 08 23;31(8):1246-1256. Epub 2018 Mar 23.

Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41379-018-0045-3DOI Listing
August 2018

DNA methylation-based reclassification of olfactory neuroblastoma.

Authors:
David Capper Nils W Engel Damian Stichel Matt Lechner Stefanie Glöss Simone Schmid Christian Koelsche Daniel Schrimpf Judith Niesen Annika K Wefers David T W Jones Martin Sill Oliver Weigert Keith L Ligon Adriana Olar Arend Koch Martin Forster Sebastian Moran Oscar M Tirado Miguel Sáinz-Jaspeado Jaume Mora Manel Esteller Javier Alonso Xavier Garcia Del Muro Werner Paulus Jörg Felsberg Guido Reifenberger Markus Glatzel Stephan Frank Camelia M Monoranu Valerie J Lund Andreas von Deimling Stefan Pfister Rolf Buslei Julika Ribbat-Idel Sven Perner Volker Gudziol Matthias Meinhardt Ulrich Schüller

Acta Neuropathol 2018 08 5;136(2):255-271. Epub 2018 May 5.

Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-018-1854-7DOI Listing
August 2018

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

Authors:
Christian Koelsche Martin Mynarek Daniel Schrimpf Luca Bertero Jonathan Serrano Felix Sahm David E Reuss Yanghao Hou Daniel Baumhoer Christian Vokuhl Uta Flucke Iver Petersen Wolfgang Brück Stefan Rutkowski Sandro Casavilca Zambrano Juan Luis Garcia Leon Rosdali Yesenia Diaz Coronado Manfred Gessler Oscar M Tirado Jaume Mora Javier Alonso Xavier Garcia Del Muro Manel Esteller Dominik Sturm Jonas Ecker Till Milde Stefan M Pfister Andrey Korshunov Matija Snuderl Gunhild Mechtersheimer Ulrich Schüller David T W Jones Andreas von Deimling

Acta Neuropathol 2018 08 7;136(2):327-337. Epub 2018 Jun 7.

Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1871-6DOI Listing
August 2018

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

Authors:
David Capper Damian Stichel Felix Sahm David T W Jones Daniel Schrimpf Martin Sill Simone Schmid Volker Hovestadt David E Reuss Christian Koelsche Annekathrin Reinhardt Annika K Wefers Kristin Huang Philipp Sievers Azadeh Ebrahimi Anne Schöler Daniel Teichmann Arend Koch Daniel Hänggi Andreas Unterberg Michael Platten Wolfgang Wick Olaf Witt Till Milde Andrey Korshunov Stefan M Pfister Andreas von Deimling

Acta Neuropathol 2018 08 2;136(2):181-210. Epub 2018 Jul 2.

Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1879-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060790PMC
August 2018

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

Authors:
Philipp Sievers Damian Stichel Daniel Schrimpf Felix Sahm Christian Koelsche David E Reuss Annika K Wefers Annekathrin Reinhardt Kristin Huang Azadeh Ebrahimi Yanghao Hou Kristian W Pajtler Stefan M Pfister Martin Hasselblatt Walter Stummer Uta Schick Christian Hartmann Christian Hagel Ori Staszewski Guido Reifenberger Rudi Beschorner Roland Coras Kathy Keyvani Patricia Kohlhof Francesca Diomedi-Camassei Christel Herold-Mende Felice Giangaspero Elisabeth Rushing Caterina Giannini Andrey Korshunov David T W Jones Andreas von Deimling

Acta Neuropathol 2018 08 5;136(2):293-302. Epub 2018 Jul 5.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1882-3DOI Listing
August 2018

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.

Authors:
Lukas Bunse Stefan Pusch Theresa Bunse Felix Sahm Khwab Sanghvi Mirco Friedrich Dalia Alansary Jana K Sonner Edward Green Katrin Deumelandt Michael Kilian Cyril Neftel Stefanie Uhlig Tobias Kessler Anna von Landenberg Anna S Berghoff Kelly Marsh Mya Steadman Dongwei Zhu Brandon Nicolay Benedikt Wiestler Michael O Breckwoldt Ruslan Al-Ali Simone Karcher-Bausch Matthias Bozza Iris Oezen Magdalena Kramer Jochen Meyer Antje Habel Jessica Eisel Gernot Poschet Michael Weller Matthias Preusser Minou Nadji-Ohl Niklas Thon Michael C Burger Patrick N Harter Miriam Ratliff Richard Harbottle Axel Benner Daniel Schrimpf Jürgen Okun Christel Herold-Mende Sevin Turcan Stefan Kaulfuss Holger Hess-Stumpp Karen Bieback Daniel P Cahill Karl H Plate Daniel Hänggi Marion Dorsch Mario L Suvà Barbara A Niemeyer Andreas von Deimling Wolfgang Wick Michael Platten

Nat Med 2018 08 9;24(8):1192-1203. Epub 2018 Jul 9.

German Cancer Consortium (DKTK) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41591-018-0095-6DOI Listing
August 2018

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.

Authors:
Mitsuaki Shirahata Takahiro Ono Damian Stichel Daniel Schrimpf David E Reuss Felix Sahm Christian Koelsche Annika Wefers Annekathrin Reinhardt Kristin Huang Philipp Sievers Hiroaki Shimizu Hiroshi Nanjo Yusuke Kobayashi Yohei Miyake Tomonari Suzuki Jun-Ichi Adachi Kazuhiko Mishima Atsushi Sasaki Ryo Nishikawa Melanie Bewerunge-Hudler Marina Ryzhova Oksana Absalyamova Andrey Golanov Peter Sinn Michael Platten Christine Jungk Frank Winkler Antje Wick Daniel Hänggi Andreas Unterberg Stefan M Pfister David T W Jones Martin van den Bent Monika Hegi Pim French Brigitta G Baumert Roger Stupp Thierry Gorlia Michael Weller David Capper Andrey Korshunov Christel Herold-Mende Wolfgang Wick David N Louis Andreas von Deimling

Acta Neuropathol 2018 07 23;136(1):153-166. Epub 2018 Apr 23.

Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-018-1849-4
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http://dx.doi.org/10.1007/s00401-018-1849-4DOI Listing
July 2018

Integrated analysis of dynamic FET PET/CT parameters, histology, and methylation profiling of 44 gliomas.

Authors:
Manuel Röhrich Kristin Huang Daniel Schrimpf Nathalie L Albert Thomas Hielscher Andreas von Deimling Ulrich Schüller Antonia Dimitrakopoulou-Strauss Uwe Haberkorn

Eur J Nucl Med Mol Imaging 2018 07 7;45(9):1573-1584. Epub 2018 May 7.

Division of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00259-018-4009-0DOI Listing
July 2018

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation-the NCT Neuro Master Match (N2M2) pilot study.

Authors:
Elke Pfaff Tobias Kessler Gnana Prakash Balasubramanian Anne Berberich Daniel Schrimpf Antje Wick Jürgen Debus Andreas Unterberg Martin Bendszus Christel Herold-Mende David Capper Irini Schenkel Andreas Eisenmenger Susan Dettmer Benedikt Brors Michael Platten Stefan M Pfister Andreas von Deimling David T W Jones Wolfgang Wick Felix Sahm

Neuro Oncol 2018 05;20(6):826-837

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961072PMC
May 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers.

Authors:
Andrey Korshunov Daniel Schrimpf Marina Ryzhova Dominik Sturm Lukas Chavez Volker Hovestadt Tanvi Sharma Antje Habel Anna Burford Chris Jones Olga Zheludkova Ella Kumirova Christof M Kramm Andrey Golanov David Capper Andreas von Deimling Stefan M Pfister David T W Jones

Acta Neuropathol 2017 Sep 11;134(3):507-516. Epub 2017 Apr 11.

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-017-1710-1
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http://dx.doi.org/10.1007/s00401-017-1710-1DOI Listing
September 2017

Molecular Transition of an Adult Low-Grade Brain Tumor to an Atypical Teratoid/Rhabdoid Tumor Over a Time-Course of 14 Years.

Authors:
Yvonne Schweizer Zsolt Meszaros David T W Jones Christian Koelsche Miream Boudalil Petra Fiesel Daniel Schrimpf Rosario M Piro Stefanie Brehmer Andreas von Deimling Ulrich Kerl Marcel Seiz-Rosenhagen David Capper

J Neuropathol Exp Neurol 2017 Aug;76(8):655-664

Department of Neurosurgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (YS, SB, MSR); Department of Neurosurgery, Evangelisches Krankenhaus Bielefeld, Bielefeld, Germany (ZM); Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (DTWJ); Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany (CK, DS, AvD, DC); Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (CK, MB, PF, DS, AvD, DC); Institute of Computer Science, Freie Universität Berlin and Institute of Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany (RMP); Department of Neuroradiology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany (UK); and Department of Neuropathology, Charité Universitätsmedizin Berlin and German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany (DC).

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http://dx.doi.org/10.1093/jnen/nlx044DOI Listing
August 2017

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature.

Authors:
Felix Sahm Umut H Toprak Daniel Hübschmann Kortine Kleinheinz Ivo Buchhalter Martin Sill Damian Stichel Matthias Schick Melanie Bewerunge-Hudler Daniel Schrimpf Gelareh Zadeh Ken Aldape Christel Herold-Mende Katja Beck Ori Staszewski Marco Prinz Carmit Ben Harosh Roland Eils Dominik Sturm David T W Jones Stefan M Pfister Werner Paulus Zvi Ram Matthias Schlesner Rachel Grossman Andreas von Deimling

Acta Neuropathol 2017 07 4;134(1):155-158. Epub 2017 May 4.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-017-1715-9DOI Listing
July 2017

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.

Authors:
Felix Sahm Daniel Schrimpf Damian Stichel David T W Jones Thomas Hielscher Sebastian Schefzyk Konstantin Okonechnikov Christian Koelsche David E Reuss David Capper Dominik Sturm Hans-Georg Wirsching Anna Sophie Berghoff Peter Baumgarten Annekathrin Kratz Kristin Huang Annika K Wefers Volker Hovestadt Martin Sill Hayley P Ellis Kathreena M Kurian Ali Fuat Okuducu Christine Jungk Katharina Drueschler Matthias Schick Melanie Bewerunge-Hudler Christian Mawrin Marcel Seiz-Rosenhagen Ralf Ketter Matthias Simon Manfred Westphal Katrin Lamszus Albert Becker Arend Koch Jens Schittenhelm Elisabeth J Rushing V Peter Collins Stefanie Brehmer Lukas Chavez Michael Platten Daniel Hänggi Andreas Unterberg Werner Paulus Wolfgang Wick Stefan M Pfister Michel Mittelbronn Matthias Preusser Christel Herold-Mende Michael Weller Andreas von Deimling

Lancet Oncol 2017 05 15;18(5):682-694. Epub 2017 Mar 15.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30155-9DOI Listing
May 2017

Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases.

Authors:
Christian Koelsche Daniel Schrimpf Lars Tharun Eva Roth Dominik Sturm David T W Jones Eva-Kristin Renker Martin Sill Annika Baude Felix Sahm David Capper Melanie Bewerunge-Hudler Wolfgang Hartmann Andreas E Kulozik Iver Petersen Uta Flucke Hendrik W B Schreuder Reinhard Büttner Marc-André Weber Peter Schirmacher Christoph Plass Stefan M Pfister Andreas von Deimling Gunhild Mechtersheimer

Clin Sarcoma Res 2017 4;7. Epub 2017 May 4.

Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13569-017-0075-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418758PMC
May 2017

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.

Authors:
Stefan Pusch Sonja Krausert Viktoria Fischer Jörg Balss Martina Ott Daniel Schrimpf David Capper Felix Sahm Jessica Eisel Ann-Christin Beck Manfred Jugold Viktoria Eichwald Stefan Kaulfuss Olaf Panknin Hartmut Rehwinkel Katja Zimmermann Roman C Hillig Judith Guenther Luisella Toschi Roland Neuhaus Andrea Haegebart Holger Hess-Stumpp Markus Bauser Wolfgang Wick Andreas Unterberg Christel Herold-Mende Michael Platten Andreas von Deimling

Acta Neuropathol 2017 04 25;133(4):629-644. Epub 2017 Jan 25.

German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-017-1677-y
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April 2017

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas.

Authors:
Felix Sahm Andrey Korshunov Daniel Schrimpf Damian Stichel David T W Jones David Capper Christian Koelsche David Reuss Annekathrin Kratz Kristin Huang Annika K Wefers Matthias Schick Melanie Bewerunge-Hudler Michel Mittelbronn Michael Platten Daniel Hänggi Astrid Jeibmann Andreas Unterberg Christel Herold-Mende Stefan M Pfister Sebastian Brandner Wolfgang Wick Andreas von Deimling

Acta Neuropathol 2017 02 20;133(2):325-327. Epub 2016 Dec 20.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-016-1657-7DOI Listing
February 2017

SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature.

Authors:
Ross Mangum Elizabeth Varga Daniel R Boué David Capper Martin Benesch Jeffrey Leonard Diana S Osorio Christopher R Pierson Nicholas Zumberge Felix Sahm Daniel Schrimpf Stefan M Pfister Jonathan L Finlay

Childs Nerv Syst 2016 Dec 21;32(12):2439-2446. Epub 2016 Jul 21.

The Divisions of Hematology/Oncology/BMT, Neurosurgery and Neuropathology, the Departments of Pediatrics, Surgery and Pathology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.

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http://link.springer.com/10.1007/s00381-016-3185-0
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http://dx.doi.org/10.1007/s00381-016-3185-0DOI Listing
December 2016

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis.

Authors:
Martin Hasselblatt Christian Thomas Volker Hovestadt Daniel Schrimpf Pascal Johann Susanne Bens Florian Oyen Susanne Peetz-Dienhart Yvonne Crede Annika Wefers Hannes Vogel Markus J Riemenschneider Manila Antonelli Felice Giangaspero Marie Christine Bernardo Caterina Giannini Nasir Ud Din Arie Perry Kathy Keyvani Frank van Landeghem David Sumerauer Peter Hauser David Capper Andrey Korshunov David T W Jones Stefan M Pfister Reinhard Schneppenheim Reiner Siebert Michael C Frühwald Marcel Kool

Acta Neuropathol 2016 07 11;132(1):149-51. Epub 2016 Apr 11.

German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.

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http://link.springer.com/content/pdf/10.1007%2Fs00401-016-15
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http://link.springer.com/10.1007/s00401-016-1574-9
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http://dx.doi.org/10.1007/s00401-016-1574-9DOI Listing
July 2016

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.

Authors:
Felix Sahm Daniel Schrimpf David T W Jones Jochen Meyer Annekathrin Kratz David Reuss David Capper Christian Koelsche Andrey Korshunov Benedikt Wiestler Ivo Buchhalter Till Milde Florian Selt Dominik Sturm Marcel Kool Manuela Hummel Melanie Bewerunge-Hudler Christian Mawrin Ulrich Schüller Christine Jungk Antje Wick Olaf Witt Michael Platten Christel Herold-Mende Andreas Unterberg Stefan M Pfister Wolfgang Wick Andreas von Deimling

Acta Neuropathol 2016 06 15;131(6):903-10. Epub 2015 Dec 15.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-015-1519-8DOI Listing
June 2016

Methylation-based classification of benign and malignant peripheral nerve sheath tumors.

Authors:
Manuel Röhrich Christian Koelsche Daniel Schrimpf David Capper Felix Sahm Annekathrin Kratz Jana Reuss Volker Hovestadt David T W Jones Melanie Bewerunge-Hudler Albert Becker Joachim Weis Christian Mawrin Michel Mittelbronn Arie Perry Victor-Felix Mautner Gunhild Mechtersheimer Christian Hartmann Ali Fuat Okuducu Mirko Arp Marcel Seiz-Rosenhagen Daniel Hänggi Stefanie Heim Werner Paulus Jens Schittenhelm Rezvan Ahmadi Christel Herold-Mende Andreas Unterberg Stefan M Pfister Andreas von Deimling David E Reuss

Acta Neuropathol 2016 06 8;131(6):877-87. Epub 2016 Feb 8.

Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-016-1540-6DOI Listing
June 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

Authors:
Felix Sahm Daniel Schrimpf Adriana Olar Christian Koelsche David Reuss Juliane Bissel Annekathrin Kratz David Capper Sebastian Schefzyk Thomas Hielscher Qianghu Wang Erik P Sulman Sebastian Adeberg Arend Koch Ali Fuat Okuducu Stefanie Brehmer Jens Schittenhelm Albert Becker Benjamin Brokinkel Melissa Schmidt Theresa Ull Konstantinos Gousias Almuth Friederike Kessler Katrin Lamszus Jürgen Debus Christian Mawrin Yoo-Jin Kim Matthias Simon Ralf Ketter Werner Paulus Kenneth D Aldape Christel Herold-Mende Andreas von Deimling

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.

Authors:
Felix Sahm Frederick A Jakobiec Jochen Meyer Daniel Schrimpf Charles G Eberhart Volker Hovestadt David Capper Sander Lambo Marina Ryzhova Ulrich Schüller Olga Zheludkova Ella Kumirova Peter Lichter Andreas von Deimling David T W Jones Stefan M Pfister Marcel Kool Andrey Korshunov

Genes Chromosomes Cancer 2016 May 4;55(5):418-27. Epub 2016 Feb 4.

Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), and Department of Neuropathology University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22344DOI Listing
May 2016

Malignant Transformation of a Dysembryoplastic Neuroepithelial Tumor (DNET) Characterized by Genome-Wide Methylation Analysis.

Authors:
Dieter Henrik Heiland Ori Staszewski Martin Hirsch Waseem Masalha Pamela Franco Jürgen Grauvogel David Capper Daniel Schrimpf Horst Urbach Astrid Weyerbrock

J Neuropathol Exp Neurol 2016 Apr 27;75(4):358-65. Epub 2016 Feb 27.

From the Department of Neurosurgery (DHH, WM, PF, JG, AW), Department of Pathology, Institute of Neuropathology (OS), Department of Neurosurgery, Epilepsy Center (MH), and Department of Neuroradiology (HU), Medical Center - University of Freiburg, Freiburg, Germany; and Department of Neuropathology, University Heidelberg, Im Neuenheimer Feld 224 and German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany (DC, DS).

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http://dx.doi.org/10.1093/jnen/nlw007DOI Listing
April 2016

Synchronous pituitary adenoma and pituicytoma.

Authors:
Marian C Neidert Henning Leske Jan-Karl Burkhardt Spyros S Kollias David Capper Daniel Schrimpf Luca Regli Elisabeth J Rushing

Hum Pathol 2016 Jan 16;47(1):138-43. Epub 2015 Sep 16.

Department of Neuropathology, University Hospital Zurich, CH-8091 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2015.08.017DOI Listing
January 2016

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.

Authors:
Andrey Korshunov David Capper David Reuss Daniel Schrimpf Marina Ryzhova Volker Hovestadt Dominik Sturm Jochen Meyer Chris Jones Olga Zheludkova Ella Kumirova Andrey Golanov Marcel Kool Ulrich Schüller Michel Mittelbronn Martin Hasselblatt Jens Schittenhelm Guido Reifenberger Christel Herold-Mende Peter Lichter Andreas von Deimling Stefan M Pfister David T W Jones

Acta Neuropathol 2016 Jan;131(1):137-46

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http://link.springer.com/10.1007/s00401-015-1493-1
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http://dx.doi.org/10.1007/s00401-015-1493-1DOI Listing
January 2016

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities.

Authors:
David E Reuss Annekathrin Kratz Felix Sahm David Capper Daniel Schrimpf Christian Koelsche Volker Hovestadt Melanie Bewerunge-Hudler David T W Jones Jens Schittenhelm Michel Mittelbronn Elisabeth Rushing Matthias Simon Manfred Westphal Andreas Unterberg Michael Platten Werner Paulus Guido Reifenberger Joerg-Christian Tonn Kenneth Aldape Stefan M Pfister Andrey Korshunov Michael Weller Christel Herold-Mende Wolfgang Wick Sebastian Brandner Andreas von Deimling

Acta Neuropathol 2015 Sep 19;130(3):407-17. Epub 2015 Jun 19.

Department of Neuropathology, Institute of Pathology, University of Heidelberg, INF 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-015-1454-8DOI Listing
September 2015

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

Authors:
David E Reuss Yasin Mamatjan Daniel Schrimpf David Capper Volker Hovestadt Annekathrin Kratz Felix Sahm Christian Koelsche Andrey Korshunov Adriana Olar Christian Hartmann Jaap C Reijneveld Pieter Wesseling Andreas Unterberg Michael Platten Wolfgang Wick Christel Herold-Mende Kenneth Aldape Andreas von Deimling

Acta Neuropathol 2015 Jun 12;129(6):867-73. Epub 2015 May 12.

Department of Neuropathology, Institute of Pathology, University of Heidelberg, INF 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-015-1438-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500039PMC
June 2015

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.

Authors:
Andrey Korshunov Marina Ryzhova Volker Hovestadt Sebastian Bender Dominik Sturm David Capper Jochen Meyer Daniel Schrimpf Marcel Kool Paul A Northcott Olga Zheludkova Till Milde Olaf Witt Andreas E Kulozik Guido Reifenberger Nada Jabado Arie Perry Peter Lichter Andreas von Deimling Stefan M Pfister David T W Jones

Acta Neuropathol 2015 May 10;129(5):669-78. Epub 2015 Mar 10.

Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-015-1405-4DOI Listing
May 2015

Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles.

Authors:
Christian Koelsche Volker Hovestadt David T W Jones David Capper Dominik Sturm Felix Sahm Daniel Schrimpf Sebastian Adeberg Katja Böhmer Christian Hagenlocher Gunhild Mechtersheimer Patricia Kohlhof Helmut Mühleisen Rudi Beschorner Christian Hartmann Anne Kristin Braczynski Michel Mittelbronn Rolf Buslei Albert Becker Alexander Grote Horst Urbach Ori Staszewski Marco Prinz Ekkehard Hewer Stefan M Pfister Andreas von Deimling David E Reuss

Brain Pathol 2015 Mar 15;25(2):202-8. Epub 2014 Dec 15.

Department of Neuropathology, Institute of Pathology, University Medical Center, Heidelberg, Germany; German Cancer Consortium (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/bpa.12228DOI Listing
March 2015

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.

Authors:
David E Reuss Felix Sahm Daniel Schrimpf Benedikt Wiestler David Capper Christian Koelsche Leonille Schweizer Andrey Korshunov David T W Jones Volker Hovestadt Michel Mittelbronn Jens Schittenhelm Christel Herold-Mende Andreas Unterberg Michael Platten Michael Weller Wolfgang Wick Stefan M Pfister Andreas von Deimling

Acta Neuropathol 2015 Jan 27;129(1):133-46. Epub 2014 Nov 27.

German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-014-1370-3DOI Listing
January 2015

Design of clinical studies: adaptive randomization and progression-free survival (PFS) as an endpoint in clinical studies of advanced non-small cell lung cancer (NSCLC).

Authors:
Daniel Schrimpf Christian Manegold Lothar R Pilz

Int J Clin Pharmacol Ther 2013 Jan;51(1):84-6

Deutsches Krebsforschungszentrum (DKFZ), Department of Biostatistics, Heidelberg, Germany.

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http://dx.doi.org/10.5414/cpp51084DOI Listing
January 2013

Adaptive randomization procedures for the web-based randomization system RANDI2.

Authors:
Daniel Schrimpf Lothar R Pilz

Int J Clin Pharmacol Ther 2012 Jan;50(1):85-6

German Cancer Research Center (DKFZ), Department of Biostatistics, Heidelberg, Germany.

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http://dx.doi.org/10.5414/cpp50085DOI Listing
January 2012