Publications by authors named "Daniel S Peeper"

81Publications

Rational Cancer Treatment Combinations: An Urgent Clinical Need.

Mol Cell 2020 06;78(6):1002-1018

Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.05.031DOI Listing
June 2020

Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux.

Mol Cell Proteomics 2020 02 26;19(2):261-277. Epub 2019 Nov 26.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

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http://dx.doi.org/10.1074/mcp.RA119.001800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000121PMC
February 2020

High-Throughput Assessment of Kinome-wide Activation States.

Cell Syst 2019 10 11;9(4):366-374.e5. Epub 2019 Sep 11.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, the Netherlands; Mass Spectrometry and Proteomics Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838672PMC
October 2019

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Cancer Cell 2018 02;33(2):322-336.e8

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Germany.

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http://dx.doi.org/10.1016/j.ccell.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977991PMC
February 2018

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.

Nature 2017 10 4;550(7675):270-274. Epub 2017 Oct 4.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature24037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640985PMC
October 2017

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.

Genome Res 2017 10 15;27(10):1634-1644. Epub 2017 Sep 15.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1101/gr.225763.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630027PMC
October 2017

Phenotypic diversity drives paracrine drug tolerance.

EMBO Mol Med 2017 08;9(8):987-989

Department of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.15252/emmm.201707956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538330PMC
August 2017

MITF: More Interesting Traits, Folks!

Pigment Cell Melanoma Res 2016 May 31;29(3):263-5. Epub 2016 Mar 31.

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http://dx.doi.org/10.1111/pcmr.12476DOI Listing
May 2016

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.

Oncotarget 2015 Dec;6(41):43146-61

Department of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.6454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791222PMC
December 2015

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

Proc Natl Acad Sci U S A 2015 Oct 12;112(43):13308-11. Epub 2015 Oct 12.

Department of Molecular Oncology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands; Cancer Genomics.nl, 3584 CG Utrecht, The Netherlands; Foundation Hubrecht Organoid Technology (HUB), 3584 CT, Utrecht, The Netherlands; Department of Medical Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands

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http://dx.doi.org/10.1073/pnas.1516689112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629330PMC
October 2015

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence.

Carcinogenesis 2015 Nov 8;36(11):1263-74. Epub 2015 Sep 8.

Division of Molecular Oncology and

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http://dx.doi.org/10.1093/carcin/bgv124DOI Listing
November 2015

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

J Proteome Res 2015 Oct 8;14(10):4332-41. Epub 2015 Sep 8.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.5b00529DOI Listing
October 2015

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

J Proteome Res 2015 Jul 2;14(7):2906-14. Epub 2015 Jun 2.

†Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.5b00236
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http://dx.doi.org/10.1021/acs.jproteome.5b00236DOI Listing
July 2015

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

Pigment Cell Melanoma Res 2015 May 6;28(3):307-17. Epub 2015 Apr 6.

Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/pcmr.12364DOI Listing
May 2015

Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy.

Cancer Res 2014 Nov 15;74(21):5937-41. Epub 2014 Oct 15.

Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1174DOI Listing
November 2014

Cancer drug resistance: old concept, novel solutions required.

Authors:
Daniel S Peeper

Mol Oncol 2014 Sep 7;8(6):1064-6. Epub 2014 Aug 7.

Netherlands Cancer Institute, Division of Molecular Oncology, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528613PMC
September 2014

Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence.

Mol Cell Proteomics 2014 Aug 24;13(8):2089-100. Epub 2014 Jun 24.

From the ‡Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands; §Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, The Netherlands;

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http://dx.doi.org/10.1074/mcp.M113.035436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125739PMC
August 2014

Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma.

Pigment Cell Melanoma Res 2014 Jul 14;27(4):640-52. Epub 2014 May 14.

Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1111/pcmr.12248
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http://dx.doi.org/10.1111/pcmr.12248DOI Listing
July 2014

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

Nature 2013 Jun 19;498(7452):109-12. Epub 2013 May 19.

Division of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature12154DOI Listing
June 2013

Ageing: Old cells under attack.

Authors:
Daniel S Peeper

Nature 2011 Nov 9;479(7372):186-7. Epub 2011 Nov 9.

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http://dx.doi.org/10.1038/479186aDOI Listing
November 2011

Oncogene-induced senescence and melanoma: where do we stand?

Authors:
Daniel S Peeper

Pigment Cell Melanoma Res 2011 Dec;24(6):1107-11

Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1111/j.1755-148X.2011.00933.x
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http://dx.doi.org/10.1111/j.1755-148X.2011.00933.xDOI Listing
December 2011

Evidence of oncogene-induced senescence in thyroid carcinogenesis.

Endocr Relat Cancer 2011 Dec 1;18(6):743-57. Epub 2011 Dec 1.

Molecular Mechanisms Unit, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation-Istituto Nazionale dei Tumori, Via G. Amadeo, 42 20133 Milan, Italy.

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http://dx.doi.org/10.1530/ERC-11-0240DOI Listing
December 2011

C/EBPβ: lost beyond translation.

Authors:
Daniel S Peeper

EMBO J 2011 Sep 14;30(18):3663-4. Epub 2011 Sep 14.

Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/emboj.2011.288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173799PMC
September 2011

Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.

EMBO J 2011 May 29;30(9):1753-65. Epub 2011 Mar 29.

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/emboj.2011.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102000PMC
May 2011

Functional characterization of human cancer-derived TRKB mutations.

PLoS One 2011 Feb 17;6(2):e16871. Epub 2011 Feb 17.

Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016871PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040757PMC
February 2011

The essence of senescence.

Genes Dev 2010 Nov;24(22):2463-79

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1971610
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http://dx.doi.org/10.1101/gad.1971610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975923PMC
November 2010

PICS-ure this: prosenescence therapy?

Authors:
Daniel S Peeper

Cancer Cell 2010 Mar;17(3):219-20

The Netherlands Cancer Institute, Division of Molecular Genetics, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.ccr.2010.02.028DOI Listing
March 2010

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

Carcinogenesis 2010 Feb 25;31(2):201-7. Epub 2009 Nov 25.

Division of Molecular Genetics, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgp296DOI Listing
February 2010

Metastasis mechanisms.

Biochim Biophys Acta 2009 Dec 14;1796(2):293-308. Epub 2009 Aug 14.

Division of Molecular Genetics, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.bbcan.2009.07.006DOI Listing
December 2009

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.

PLoS One 2009 14;4(5):e5542. Epub 2009 May 14.

Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005542PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677661PMC
August 2009

A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.

Mol Cell Biol 2009 Jul 4;29(13):3722-37. Epub 2009 May 4.

Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1128/MCB.01164-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698746PMC
July 2009

Ras and pRb: the relationship gets yet more intimate.

Authors:
Daniel S Peeper

Cancer Cell 2009 Apr;15(4):243-5

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ccr.2009.03.007DOI Listing
April 2009

Senescence-messaging secretome: SMS-ing cellular stress.

Nat Rev Cancer 2009 Feb 9;9(2):81-94. Epub 2009 Jan 9.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/nrc2560DOI Listing
February 2009

Deregulating EMT and senescence: double impact by a single twist.

Cancer Cell 2008 Jul;14(1):5-7

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ccr.2008.06.012DOI Listing
July 2008

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Cell 2008 Jun;133(6):1019-31

Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cell.2008.03.039DOI Listing
June 2008

Cellular senescence in vivo: a barrier to tumorigenesis.

Curr Opin Cell Biol 2008 Apr 18;20(2):150-5. Epub 2008 Mar 18.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ceb.2008.01.007DOI Listing
April 2008

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis.

Cancer Res 2007 Jul;67(13):6221-9

Division of Molecular Genetics, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0121DOI Listing
July 2007

KLF4, p21 and context-dependent opposing forces in cancer.

Nat Rev Cancer 2006 Jan;6(1):11-23

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrc1780DOI Listing
January 2006

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene.

Nat Cell Biol 2005 Nov;7(11):1074-82

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb1314DOI Listing
November 2005

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective.

Cancer Res 2005 Aug;65(16):7033-6

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0709DOI Listing
August 2005

BRAFE600-associated senescence-like cell cycle arrest of human naevi.

Nature 2005 Aug;436(7051):720-4

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature03890DOI Listing
August 2005

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB.

Nature 2004 Aug;430(7003):1034-9

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.

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http://dx.doi.org/10.1038/nature02765DOI Listing
August 2004

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest.

Cancer Cell 2002 Jul;2(1):55-65

Division of Molecular Carcinogenesis, Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s1535-6108(02)00085-5DOI Listing
July 2002

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

Nat Cell Biol 2002 Feb;4(2):148-53

Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb742DOI Listing
February 2002