Daniel L Kaufman

Daniel L Kaufman

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Daniel L Kaufman

Daniel L Kaufman

Publications by authors named "Daniel L Kaufman"

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32Publications

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Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the A obesity-associated gene.

Sci Rep 2019 Mar 12;9(1):4269. Epub 2019 Mar 12.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States.

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http://dx.doi.org/10.1038/s41598-019-38905-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414670PMC
March 2019

A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human -Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells.

J Diabetes Res 2019 26;2019:5783545. Epub 2019 Feb 26.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1155/2019/5783545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413367PMC
February 2019

Homotaurine, a safe blood-brain barrier permeable GABA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis.

Sci Rep 2018 11 8;8(1):16555. Epub 2018 Nov 8.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.

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http://www.nature.com/articles/s41598-018-32733-3
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http://dx.doi.org/10.1038/s41598-018-32733-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224391PMC
November 2018

Repurposing Lesogaberan to Promote Human Islet Cell Survival and -Cell Replication.

J Diabetes Res 2017 5;2017:6403539. Epub 2017 Sep 5.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1155/2017/6403539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605788PMC
June 2018

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication.

Sci Rep 2017 03 23;7(1):374. Epub 2017 Mar 23.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1038/s41598-017-00515-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428733PMC
March 2017

γ-Aminobutyric acid regulates both the survival and replication of human β-cells.

Diabetes 2013 Nov 30;62(11):3760-5. Epub 2013 Aug 30.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.2337/db13-0931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806626PMC
November 2013

Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

J Neurosci Res 2013 Oct 1;91(10):1292-302. Epub 2013 Aug 1.

Department of Molecular and Medical Pharmacology, the David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1002/jnr.23253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800426PMC
October 2013

Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.

J Neuroimmunol 2012 Jun 12;247(1-2):1-8. Epub 2012 Apr 12.

Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California-Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2012.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776040PMC
June 2012

Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice.

PLoS One 2011 22;6(9):e25337. Epub 2011 Sep 22.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178649PMC
February 2012

Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice.

PLoS One 2011 22;6(9):e25338. Epub 2011 Sep 22.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178643PMC
February 2012

Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis.

Autoimmunity 2011 Sep 23;44(6):465-70. Epub 2011 May 23.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.3109/08916934.2011.571223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787624PMC
September 2011

Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.

Diabetes 2011 May 25;60(5):1383-92. Epub 2011 Mar 25.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.2337/db10-0907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292311PMC
May 2011

Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves.

Immunol Lett 2011 Mar 23;135(1-2):118-23. Epub 2010 Oct 23.

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA.

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http://dx.doi.org/10.1016/j.imlet.2010.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776043PMC
March 2011

A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth.

PLoS One 2011 Mar 31;6(3):e18439. Epub 2011 Mar 31.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069096PMC
March 2011

BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.

PLoS One 2011 Jan 31;6(1):e16610. Epub 2011 Jan 31.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031604PMC
January 2011

Antigen-based therapy for the treatment of type 1 diabetes.

Diabetes 2009 Sep;58(9):1939-46

Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California, USA.

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http://dx.doi.org/10.2337/db09-0451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731536PMC
September 2009

Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid.

J Med Chem 2008 Aug 4;51(15):4834-8. Epub 2008 Jul 4.

Department of Phytochemistry, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, PR China.

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http://dx.doi.org/10.1021/jm800167uDOI Listing
August 2008

Long-term monitoring of transplanted islets using positron emission tomography.

Mol Ther 2006 Dec 18;14(6):851-6. Epub 2006 Sep 18.

Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.1016/j.ymthe.2006.08.007DOI Listing
December 2006

Noninvasive imaging of islet grafts using positron-emission tomography.

Proc Natl Acad Sci U S A 2006 Jul;103(30):11294-9

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1735, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0603909103
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http://dx.doi.org/10.1073/pnas.0603909103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544080PMC
July 2006

B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice.

J Immunol 2006 Feb;176(4):2654-61

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 90095, USA.

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http://dx.doi.org/10.4049/jimmunol.176.4.2654DOI Listing
February 2006

Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.

J Immunol 2005 Aug;175(3):1991-9

Department of Molecular and Medical Pharmacology, University of California, School of Medicine, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.4049/jimmunol.175.3.1991DOI Listing
August 2005

A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.

Diabetes 2004 Oct;53(10):2574-80

Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.2337/diabetes.53.10.2574DOI Listing
October 2004

Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model.

J Immunol 2004 Oct;173(8):5298-304

Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90095, USA.

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http://dx.doi.org/10.4049/jimmunol.173.8.5298DOI Listing
October 2004

Bioluminescent monitoring of islet graft survival after transplantation.

Mol Ther 2004 Mar;9(3):428-35

Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.1016/j.ymthe.2004.01.008DOI Listing
March 2004

Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens.

Cell Immunol 2003 Aug;224(2):74-85

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1735, USA.

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http://dx.doi.org/10.1016/j.cellimm.2003.08.007DOI Listing
August 2003

Murder mysteries in type 1 diabetes.

Authors:
Daniel L Kaufman

Nat Med 2003 Feb;9(2):161-2

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http://dx.doi.org/10.1038/nm0203-161DOI Listing
February 2003

Antigen-based immunotherapy drives the precocious development of autoimmunity.

J Immunol 2002 Dec;169(11):6564-9

Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90095, USA.

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http://dx.doi.org/10.4049/jimmunol.169.11.6564DOI Listing
December 2002