Publications by authors named "Daniel J Rader"

100Publications

Teaching Old Drugs New Tricks: Statins for COVID-19?

Cell Metab 2020 08;32(2):145-147

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402379PMC
August 2020

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.

J Am Coll Cardiol 2020 Jun;75(22):2769-2780

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346975PMC
June 2020

COVID-19 outcomes and the human genome.

Genet Med 2020 07 12;22(7):1175-1177. Epub 2020 May 12.

Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41436-020-0832-3DOI Listing
July 2020

Systematically Sifting Big Data to Identify Novel Causal Genes for Human Traits.

Cell Metab 2020 Apr;31(4):658-659

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.03.013DOI Listing
April 2020

Antisense oligonucleotides for atherosclerotic disease.

Nat Med 2020 04;26(4):471-472

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41591-020-0835-2DOI Listing
April 2020

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

Kidney Int 2020 May 17;97(5):1032-1041. Epub 2020 Feb 17.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2020.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265573PMC
May 2020

Genetics of Postlingual Sensorineural Hearing Loss.

Laryngoscope 2020 Apr 3. Epub 2020 Apr 3.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/lary.28646DOI Listing
April 2020

Trends and Factors Associated With Insurer Approval of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Prescriptions.

Value Health 2020 02 13;23(2):209-216. Epub 2019 Nov 13.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jval.2019.08.011DOI Listing
February 2020

Polygenic Risk Scores and Coronary Artery Disease: Ready for Prime Time?

Circulation 2020 Feb 24;141(8):637-640. Epub 2020 Feb 24.

Department of Medicine (M.G.L., D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044770DOI Listing
February 2020

The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes.

PLoS One 2020 13;15(2):e0228931. Epub 2020 Feb 13.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228931PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018061PMC
June 2020

Prospective Genotyping to Guide Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Pragmatic Randomized Clinical Trial.

Circ Genom Precis Med 2020 02 12;13(1):e002640. Epub 2020 Jan 12.

Cardiovascular Medicine Division (W.M., A.N., C.C., K. Maslowski, G.C., T.K., S.A., J.H., R.L.W., H.C.H., D.M.K., J.G.), University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1161/CIRCGEN.119.002640DOI Listing
February 2020

Annual Report on Sex in Preclinical Studies: Publications in 2018.

Arterioscler Thromb Vasc Biol 2020 01 23;40(1):e1-e9. Epub 2019 Dec 23.

From the Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington (H.S.L., A.D.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192230PMC
January 2020

Familial Chylomicronemia Syndrome With a Novel Homozygous LPL Mutation Identified in Three Siblings in Their 50s.

Ann Intern Med 2020 Apr 19;172(7):500-502. Epub 2019 Nov 19.

University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania (R.L.D.).

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http://dx.doi.org/10.7326/L19-0568DOI Listing
April 2020

Enhancing Atherosclerosis Regression in Diabetic Mice Through Apo AI (Apolipoprotein AI).

Authors:
Daniel J Rader

Circulation 2019 10 30;140(14):1185-1187. Epub 2019 Sep 30.

Departments of Genetics, Medicine, and Pediatrics, and the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040369DOI Listing
October 2019

A regression framework to uncover pleiotropy in large-scale electronic health record data.

J Am Med Inform Assoc 2019 10;26(10):1083-1090

Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1093/jamia/ocz084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748812PMC
October 2019

Polygenic Risk Scores in Familial Hypercholesterolemia.

J Am Coll Cardiol 2019 07;74(4):523-525

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jacc.2019.06.006DOI Listing
July 2019

Effect of Access to Prescribed PCSK9 Inhibitors on Cardiovascular Outcomes.

Circ Cardiovasc Qual Outcomes 2019 08 23;12(8):e005404. Epub 2019 Jul 23.

Departments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.J.R.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005404DOI Listing
August 2019

FBN1 Coding Variants and Nonsyndromic Aortic Disease.

Circ Genom Precis Med 2019 06 18;12(6):e002454. Epub 2019 Jun 18.

Medicine (K.H., D.J.R., R.E.P.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002454DOI Listing
June 2019

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver.

Am J Hum Genet 2019 07 13;105(1):89-107. Epub 2019 Jun 13.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612522PMC
July 2019

Association of serum androgens and coronary artery calcium scores in women.

Fertil Steril 2019 09 11;112(3):586-593. Epub 2019 Jun 11.

Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2019.04.024DOI Listing
September 2019

Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD.

Am J Kidney Dis 2019 06 25;73(6):827-836. Epub 2019 Jan 25.

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; The Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1053/j.ajkd.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615056PMC
June 2019

Genomic Risk Stratification Predicts All-Cause Mortality After Cardiac Catheterization.

Circ Genom Precis Med 2018 11;11(11):e002352

Department of Surgery (R.J., S.M.D.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCGEN.118.002352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310018PMC
November 2018

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics.

Mol Ther 2019 01 15;27(1):188-199. Epub 2018 Nov 15.

Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183050
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http://dx.doi.org/10.1016/j.ymthe.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319316PMC
January 2019

SLCO1B1 and Statin Therapy.

Circ Genom Precis Med 2018 09;11(9):e002320

Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.T, D.J.R).

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http://dx.doi.org/10.1161/CIRCGEN.118.002320DOI Listing
September 2018

Reporting Sex and Sex Differences in Preclinical Studies.

Arterioscler Thromb Vasc Biol 2018 10;38(10):e171-e184

From the Department of Physiology, Saha Cardiovascular Research Center, University of Kentucky, Lexington (H.S.L., A.D.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207213PMC
October 2018

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci.

Am J Hum Genet 2018 09 23;103(3):377-388. Epub 2018 Aug 23.

Cardiovascular Institute, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128252PMC
September 2018

Apolipoprotein A-I Infusion Therapies for Coronary Disease: Two Outs in the Ninth Inning and Swinging for the Fences.

Authors:
Daniel J Rader

JAMA Cardiol 2018 09;3(9):799-801

Department of Genetics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at University of Pennsylvania, Philadelphia.

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2018.2168DOI Listing
September 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 06 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0133-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136836PMC
June 2018

High density lipoprotein cholesterol and cancer: Marker or causative?

Prog Lipid Res 2018 07 4;71:54-69. Epub 2018 Jun 4.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.plipres.2018.06.001DOI Listing
July 2018

Response by Daugherty et al to Letter Regarding Article, "Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Council".

Arterioscler Thromb Vasc Biol 2018 06;38(6):e101-e102

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität (LMU) and German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance.

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http://dx.doi.org/10.1161/ATVBAHA.118.310988DOI Listing
June 2018

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

N Engl J Med 2018 03;378(12):1096-1106

From the Regeneron Genetics Center (N.S.A.-H., A.H.L., C.S., S. McCarthy, C.O., J.S.P., S.B., N.G., S. Mukherjee, A.E.L., E.D.F., J.P., I.B.B., A.R.S., J.G.R., J.D.O., O.G., T.M.T., A.B., F.E.D.) and Regeneron Pharmaceuticals (X. Cheng, Y.X., P.S., Y.L., D.E., S.Y.K., B.Z., W.O., A.J.M., G.D.Y., J.G.), Tarrytown, NY; the University of Texas Southwestern Medical Center at Dallas, Dallas (J.K., S.S., H.H.H., J.C.C.); and Geisinger Health System, Danville (G.C.W., A.N.S., M.D.S., X. Chu, J.Z.L., U.L.M., D.J.C., C.D.S., T.M.), and Perelman School of Medicine, University of Pennsylvania, Philadelphia (M.D.F., A.S., S.M.D., D.J.R.) - both in Pennsylvania.

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http://dx.doi.org/10.1056/NEJMoa1712191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668033PMC
March 2018

Angiopoietin-like protein 4: A therapeutic target for triglycerides and coronary disease?

J Clin Lipidol 2018 May - Jun;12(3):583-587. Epub 2018 Feb 2.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jacl.2018.01.012DOI Listing
September 2019

Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease.

Kidney Int 2018 06 8;93(6):1397-1408. Epub 2018 Mar 8.

Department of Hypertension, Medical University of Lodz, Lodz, Poland.

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http://dx.doi.org/10.1016/j.kint.2017.12.011DOI Listing
June 2018

New Therapeutic Approaches for Familial Hypercholesterolemia.

Annu Rev Med 2018 01;69:113-131

Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: ,

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http://dx.doi.org/10.1146/annurev-med-051215-030943DOI Listing
January 2018

Prior Authorization Requirements for Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Across US Private and Public Payers.

Circ Cardiovasc Qual Outcomes 2018 01;11(1):e003939

From the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (Dr Doshi, J.T. Puckett, Dr Parmacek, and Dr Rader) and the Leonard Davis Institute of Health Economics, Philadelphia (Dr Doshi).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.117.003939DOI Listing
January 2018

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100.

Circ Res 2018 02 4;122(4):568-582. Epub 2018 Jan 4.

From the Division of Cardiology (J.A., L.G., H.W., E.A.F.), Department of Medicine (J.A., L.G., H.W., E.A.F.), and Marc and Ruti Bell Program in Vascular Biology (J.A., E.A.F., L.G, H.W.), NYU School of Medicine; Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.S., D.J.R.); Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York (J.M.-M., S.K., A.M.C.); and Department of Biological Sciences, University of Pittsburgh, PA (J.L.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815905PMC
February 2018

HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics.

Curr Cardiol Rep 2017 11 4;19(12):132. Epub 2017 Nov 4.

Perelman School of Medicine at the University of Pennsylvania, 11-162 TRC, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11886-017-0940-0DOI Listing
November 2017

Interrogation of the Atherosclerosis-Associated (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.

Arterioscler Thromb Vasc Biol 2018 01 2;38(1):76-82. Epub 2017 Nov 2.

From the Cardiovascular Institute (X.W., E.E.P., D.J.R., K.M.), Department of Medicine (X.W., E.E.P., D.J.R., K.M.), and Department of Genetics (X.W., E.E.P., D.J.R., K.M.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Harvard Medical School, Boston, MA (A.R., D.T.P.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746470PMC
January 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators.

Arterioscler Thromb Vasc Biol 2018 01 19;38(1):164-173. Epub 2017 Oct 19.

From the Perelman School of Medicine (C.K.Y.), Department of Systems Pharmacology and Translational Therapeutics (T.X., R.K.A.), Program in Translational Biomechanics, Institute of Translational Medicine and Therapeutics (T.X., R.K.A.), and Departments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine (D.J.R.), University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/ATVBAHA.117.310237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881588PMC
January 2018

mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion.

J Clin Invest 2017 Nov 16;127(11):4207-4215. Epub 2017 Oct 16.

Institute for Diabetes, Obesity, and Metabolism, and.

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http://dx.doi.org/10.1172/JCI96036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663357PMC
November 2017

Trials and Tribulations of CETP Inhibitors.

Circ Res 2018 01 10;122(1):106-112. Epub 2017 Oct 10.

From the Division of Molecular Medicine, Department of Medicine, Columbia University, New York (A.R.T.); and Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.J.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756107PMC
January 2018

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

Am J Hum Genet 2017 Oct 21;101(4):489-502. Epub 2017 Sep 21.

Department of Genetics, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630162PMC
October 2017

New insights into the role of glycosylation in lipoprotein metabolism.

Curr Opin Lipidol 2017 Dec;28(6):502-506

aDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands bDepartments of Genetics and Medicine, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000461DOI Listing
December 2017

Can changes in the plasma lipidome help explain the cardiovascular benefits of the Mediterranean diet?

Am J Clin Nutr 2017 Oct 13;106(4):965-966. Epub 2017 Sep 13.

Departments of Medicine,

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http://dx.doi.org/10.3945/ajcn.117.165886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611787PMC
October 2017

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.

Arterioscler Thromb Vasc Biol 2017 11 7;37(11):2156-2160. Epub 2017 Sep 7.

From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York (H.Z., J.S., M.A.H., C.X., R.C.B., M.P.R.); Irving Institute for Clinical and Translational Research, Columbia University, New York (H.J., M.P.R.); Cardiovascular Institute, Perelman School of Medicine (W.L.), Division of Translational Medicine and Human Genetics, Departments of Genetics and Medicine, Perelman School of Medicine (J.T., J.B., M.C.P., D.J.R.), and Metabolic Tracer Resource, Institute for Diabetes, Obesity and Metabolism, Department of Medicine (J.M.), University of Pennsylvania, Philadelphia; and Department of Pathology and Immunology, Washington University in St. Louis, MO (B.R.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659288PMC
November 2017

Polygenic determinants in extremes of high-density lipoprotein cholesterol.

J Lipid Res 2017 11 4;58(11):2162-2170. Epub 2017 Sep 4.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

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http://dx.doi.org/10.1194/jlr.M079822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665671PMC
November 2017

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Nat Genet 2017 Oct 4;49(10):1450-1457. Epub 2017 Sep 4.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224PMC
October 2017

Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity.

Arterioscler Thromb Vasc Biol 2017 10 31;37(10):1956-1962. Epub 2017 Aug 31.

From the Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom (A.L.K., V.C., N.G.D.M., C.P.N., M.D.M., N.J.S.); German Heart Center, Technische Universität, Munich, Germany (B.M.K., C.H.); Department for Internal Medicine I, St. Josefs-Hospital, Wiesbaden, Germany (B.M.K.); German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany (C.H.); and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.J.R.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627541PMC
October 2017

Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).

Arterioscler Thromb Vasc Biol 2017 10 24;37(10):1971-1978. Epub 2017 Aug 24.

From the Division of General Internal Medicine, Department of Medicine (A.B.), Division of Vascular Surgery (S.M.D.), Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics (A.H.A., D.X., D.S., J.C.), Department of Genetics (D.S., D.J.R.), Department of Medicine (D.J.R.), Department of Pediatrics (D.J.R.), The Penn Cardiovascular Institute (D.J.R.), and Institute for Translational Medicine and Therapeutics (D.J.R.), University of Pennsylvania, Philadelphia; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA (S.M.D.); Department of Medicine, Los Angeles Biomedical Research Institute at Harbor, University of California-Los Angles (M.J.B.); Division of Research, Kaiser Permanente Northern California, Oakland, CA (A.S.G.); Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (J.H.); Division of Nephrology, Department of Medicine, University of Illinois at Chicago (J.P.L.); Department of Medicine, University of Michigan, Ann Arbor (A.O.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (W.S.P.); Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD (W.S.P.); Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH (M.R.); Division of Cardiology, Department of Medicine, (M.P.R.) and Irving Institute for Clinical and Translational Research (M.P.R.), Columbia University, New York, NY; and Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (R.R.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620129PMC
October 2017

Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome.

J Clin Lipidol 2017 Sep - Oct;11(5):1192-1200.e3. Epub 2017 Jul 8.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.06.018DOI Listing
May 2018