Publications by authors named "Daniel J Dumont"

54Publications

Tie2 signalling through Erk1/2 regulates TLR4 driven inflammation.

Authors:
Tracy L Smith Paul Van Slyke Nina Jones Daniel J Dumont C Jane McGlade

Cell Signal 2018 11 2;51:211-221. Epub 2018 Aug 2.

The Arthur and Sonia Labatt Brain Tumour Research Centre and Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2018.08.001DOI Listing
November 2018

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Authors:
Birgitt Gutbier Xiaohui Jiang Kristina Dietert Carolin Ehrler Jasmin Lienau Paul Van Slyke Harold Kim Van C Hoang Jason T Maynes Daniel J Dumont Achim D Gruber Norbert Weissmann Timothy J Mitchell Norbert Suttorp Martin Witzenrath

Crit Care 2017 Nov 13;21(1):274. Epub 2017 Nov 13.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Infectious Diseases and Pulmonary Medicine, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1186/s13054-017-1851-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683375PMC
November 2017

Pharmacological Tie2 activation in kidney transplantation.

Authors:
Kristina Thamm Florence Njau Paul Van Slyke Daniel J Dumont Joon-Keun Park Hermann Haller Sascha David

World J Transplant 2016 Sep;6(3):573-82

Kristina Thamm, Florence Njau, Joon-Keun Park, Hermann Haller, Sascha David, Department of Nephrology and Hypertension, Medical School Hannover, 30625 Hannover, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036127PMC
http://dx.doi.org/10.5500/wjt.v6.i3.573DOI Listing
September 2016

Vasculotide, an Angiopoietin-1 mimetic, ameliorates several features of experimental atopic dermatitis-like disease.

Authors:
Annie Bourdeau Paul Van Slyke Harold Kim Maribelle Cruz Tracy Smith Daniel J Dumont

BMC Res Notes 2016 May 28;9:289. Epub 2016 May 28.

Sunnybrook Research Institute, Toronto, ON, USA.

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http://dx.doi.org/10.1186/s13104-015-1817-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884390PMC
May 2016

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.

Authors:
Eva Rübig Jörg Stypmann Paul Van Slyke Daniel J Dumont Tilmann Spieker Konrad Buscher Stefan Reuter Tobias Goerge Hermann Pavenstädt Philipp Kümpers

Sci Rep 2016 Feb 25;6:22111. Epub 2016 Feb 25.

Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.

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http://dx.doi.org/10.1038/srep22111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766468PMC
February 2016

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Authors:
Chandra C Ghosh Sascha David Ruyang Zhang Anthony Berghelli Katelyn Milam Sarah J Higgins Jon Hunter Aditi Mukherjee Yongyue Wei Mei Tran Freeman Suber Lester Kobzik Kevin C Kain Shulin Lu Ansgar Santel Kiichiro Yano Prajna Guha Daniel J Dumont David C Christiani Samir M Parikh

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):2472-7. Epub 2016 Feb 16.

Center for Vascular Biology Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1519467113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780619PMC
March 2016

Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.

Authors:
Elina Korpela Darren Yohan Lee Cl Chin Anthony Kim Xiaoyong Huang Shachar Sade Paul Van Slyke Daniel J Dumont Stanley K Liu

BMC Cancer 2014 Aug 26;14:614. Epub 2014 Aug 26.

Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-14-614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159535PMC
August 2014

Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes.

Authors:
Sébastien Trop John C Marshall C David Mazer Milan Gupta Daniel J Dumont Annie Bourdeau Subodh Verma

J Surg Res 2014 Mar 7;187(1):43-52. Epub 2013 Oct 7.

Department of Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute at St. Michael's Hospital, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00224804130090
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http://dx.doi.org/10.1016/j.jss.2013.09.035DOI Listing
March 2014

Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development.

Authors:
Harold Kim Maribelle Cruz Annie Bourdeau Daniel J Dumont

PLoS One 2013 14;8(1):e52197. Epub 2013 Jan 14.

Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544876PMC
July 2013

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited.

Authors:
Karl H Plate Alexander Scholz Daniel J Dumont

Acta Neuropathol 2012 Dec 11;124(6):763-75. Epub 2012 Nov 11.

Institute of Neurology (Edinger Institute), Frankfurt University Medical School, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00401-012-1066-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508273PMC
December 2012

Inhibition of T cell protein tyrosine phosphatase enhances interleukin-18-dependent hematopoietic stem cell expansion.

Authors:
Annie Bourdeau Sébastien Trop Karen M Doody Daniel J Dumont Michel L Tremblay Michel L Tremblayef

Stem Cells 2013 Feb;31(2):293-304

Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/stem.1276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593175PMC
February 2013

Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.

Authors:
Michael Lekas Poli Lekas Shirley H J Mei Yupu Deng Daniel J Dumont Duncan J Stewart

PLoS One 2012 25;7(9):e43568. Epub 2012 Sep 25.

Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458045PMC
April 2013

Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.

Authors:
Qing Cai Marcela Brissova Rachel B Reinert Fong Cheng Pan Priyanka Brahmachary Marie Jeansson Alena Shostak Aramandla Radhika Greg Poffenberger Susan E Quaggin W Gray Jerome Daniel J Dumont Alvin C Powers

Dev Biol 2012 Jul 24;367(1):40-54. Epub 2012 Apr 24.

Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.ydbio.2012.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391601PMC
July 2012

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.

Authors:
Linda Chang Michela Noseda Michelle Higginson Michelle Ly Alexandre Patenaude Megan Fuller Alastair H Kyle Andrew I Minchinton Mira C Puri Daniel J Dumont Aly Karsan

Proc Natl Acad Sci U S A 2012 May 16;109(18):6993-8. Epub 2012 Apr 16.

Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1118512109
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http://dx.doi.org/10.1073/pnas.1118512109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345008PMC
May 2012

The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.

Authors:
Philipp Kumpers Faikah Gueler Sascha David Paul Van Slyke Daniel J Dumont Joon-Keun Park Clemens L Bockmeyer Samir M Parikh Hermann Pavenstadt Hermann Haller Nelli Shushakova

Crit Care 2011 31;15(5):R261. Epub 2011 Oct 31.

Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, Münster 48149 Germany.

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http://dx.doi.org/10.1186/cc10523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334812PMC
June 2013

Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.

Authors:
Alexander Scholz Victoria Lang Reinhard Henschler Marcus Czabanka Peter Vajkoczy Emmanouil Chavakis Janina Drynski Patrick N Harter Michel Mittelbronn Daniel J Dumont Karl H Plate Yvonne Reiss

Blood 2011 Nov 25;118(18):5050-9. Epub 2011 Aug 25.

Edinger Institute/Institute of Neurology, Frankfurt University Medical School, Frankfurt, Germany.

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http://dx.doi.org/10.1182/blood-2011-03-343293DOI Listing
November 2011

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats.

Authors:
Shahrzad Jalali Yuexi Huang Daniel J Dumont Kullervo Hynynen

BMC Neurol 2010 Nov 15;10:114. Epub 2010 Nov 15.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1471-2377-10-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020671PMC
November 2010

25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner.

Authors:
Vicky Pkh Nguyen Stephen H Chen Katerina Pizzuto Alyssa Cantarutti Alyssa Terminesi Cassandra Mendonca Daniel J Dumont

J Angiogenes Res 2010 Nov 11;2:24. Epub 2010 Nov 11.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, M4N 3M5, Canada.

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http://vascularcell.com/index.php/vc/article/view/10.1186-20
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http://dx.doi.org/10.1186/2040-2384-2-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991284PMC
November 2010

Tyrosine phosphorylation of Grb14 by Tie2.

Authors:
Celina Sturk Daniel J Dumont

Cell Commun Signal 2010 Oct 25;8:30. Epub 2010 Oct 25.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1478-811X-8-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978215PMC
October 2010

Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature.

Authors:
Harold Kim Vicky P K H Nguyen Tatiana V Petrova Maribelle Cruz Kari Alitalo Daniel J Dumont

BMC Dev Biol 2010 Jun 28;10:72. Epub 2010 Jun 28.

Sunnybrook Research Institute University of Toronto 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada.

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http://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-21
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http://dx.doi.org/10.1186/1471-213X-10-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909156PMC
June 2010

Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections.

Authors:
Adam Tuer Danielle Tokarz Nicole Prent Richard Cisek Jennifer Alami Daniel J Dumont Ludmila Bakueva John Rowlands Virginijus Barzda

J Biomed Opt 2010 Mar-Apr;15(2):026018

University of Toronto, Department of Physics, Institute for Optical Sciences, Department of Chemical and Physical Sciences, 3359 Mississauga Road North, Mississauga, Ontario, L5L 1C6 Canada.

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http://dx.doi.org/10.1117/1.3382908DOI Listing
September 2010

The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis.

Authors:
Gurpreet K Lakhanpal Laura M Vecchiarelli-Federico You-Jun Li Jiu-Wei Cui Monica L Bailey David E Spaner Daniel J Dumont Dwayne L Barber Yaacov Ben-David

Blood 2010 Jul 5;116(3):428-36. Epub 2010 May 5.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2009-10-250217DOI Listing
July 2010

Differential proteomic analysis of lymphatic, venous, and arterial endothelial cells extracted from bovine mesenteric vessels.

Authors:
Vicky P K H Nguyen George Hanna Natalie Rodrigues Katerina Pizzuto Eric Yang Paul Van Slyke Harold Kim Stephen H Chen Daniel J Dumont

Proteomics 2010 Apr;10(8):1658-72

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://doi.wiley.com/10.1002/pmic.200900594
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http://dx.doi.org/10.1002/pmic.200900594DOI Listing
April 2010

The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice.

Authors:
Lakshmi Kugathasan Julie Basu Ray Yupu Deng Effat Rezaei Daniel J Dumont Duncan J Stewart

J Exp Med 2009 Sep 8;206(10):2221-34. Epub 2009 Sep 8.

Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada.

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http://dx.doi.org/10.1084/jem.20090389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757882PMC
September 2009

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.

Authors:
Christina Wehrle Paul Van Slyke Daniel J Dumont

Biochem J 2009 Oct 12;423(3):375-80. Epub 2009 Oct 12.

Division of Molecular and Cellular Biology Research, Sunnybrook Research Institute, Toronto, Ontario, Canada, M4N 3M5.

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http://dx.doi.org/10.1042/BJ20091010DOI Listing
October 2009

Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1.

Authors:
Elena Bogdanovic Neil Coombs Daniel J Dumont

Histochem Cell Biol 2009 Aug 8;132(2):225-37. Epub 2009 May 8.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Research Building, S-218, Toronto, ON, M4N 3M5, Canada.

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http://dx.doi.org/10.1007/s00418-009-0603-3DOI Listing
August 2009

Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.

Authors:
Marja Lohela Hanna Heloterä Paula Haiko Daniel J Dumont Kari Alitalo

Am J Pathol 2008 Dec 6;173(6):1891-901. Epub 2008 Nov 6.

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.2353/ajpath.2008.080378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626399PMC
December 2008

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.

Authors:
Daniel Voskas Yael Babichev Ling S Ling Jennifer Alami Yuval Shaked Robert S Kerbel Brian Ciruna Daniel J Dumont

J Leukoc Biol 2008 Jul 1;84(1):59-67. Epub 2008 May 1.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1189/jlb.0607347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178502PMC
July 2008

Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth.

Authors:
John M L Ebos Christina R Lee Elena Bogdanovic Jennifer Alami Paul Van Slyke Giulio Francia Ping Xu Anthony J Mutsaers Daniel J Dumont Robert S Kerbel

Cancer Res 2008 Jan;68(2):521-9

Sunnybrook Health Sciences Centre, Molecular and Cellular Biology Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-3217DOI Listing
January 2008

Angiopoietin-2 impairs revascularization after limb ischemia.

Authors:
Yvonne Reiss Jasmin Droste Matthias Heil Silvia Tribulova Mirko HH Schmidt Wolfgang Schaper Daniel J Dumont Karl H Plate

Circ Res 2007 07 31;101(1):88-96. Epub 2007 May 31.

Institute of Neurology, Frankfurt University Medical School, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.106.143594DOI Listing
July 2007

Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2.

Authors:
Vicky P K H Nguyen Stephen H Chen Jason Trinh Harold Kim Brenda L Coomber Daniel J Dumont

BMC Cell Biol 2007 Mar 6;8:10. Epub 2007 Mar 6.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2121-8-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828055PMC
March 2007

Cell-based angiopoietin-1 gene therapy for acute lung injury.

Authors:
Sarah D McCarter Shirley H J Mei Patrick F H Lai Qiu Wang Zhang Colleen H Parker Renée S Suen Roberta D Hood Yidan D Zhao Yupu Deng Robin N N Han Daniel J Dumont Duncan J Stewart

Am J Respir Crit Care Med 2007 May 22;175(10):1014-26. Epub 2007 Feb 22.

St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada.

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http://dx.doi.org/10.1164/rccm.200609-1370OCDOI Listing
May 2007

Lymphangiogenesis following obstruction of large postnodal lymphatics in sheep.

Authors:
Azadeh Jila Harold Kim Vicky P K H Nguyen Daniel J Dumont John Semple Dianna Armstrong Eva Seto Miles Johnston

Microvasc Res 2007 May 26;73(3):214-23. Epub 2006 Dec 26.

Neuroscience Research Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1016/j.mvr.2006.11.003DOI Listing
May 2007

Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization.

Authors:
Elena Bogdanovic Vicky P K H Nguyen Daniel J Dumont

J Cell Sci 2006 Sep 8;119(Pt 17):3551-60. Epub 2006 Aug 8.

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Research Building, S-218, Toronto, Ontario M4N 3M5, Canada.

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http://dx.doi.org/10.1242/jcs.03077DOI Listing
September 2006

Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and blood vessel architecture.

Authors:
Alexandra L Haninec Daniel Voskas Andrew Needles Allison S Brown F Stuart Foster Daniel J Dumont

Biochem Biophys Res Commun 2006 Jul 4;345(4):1299-307. Epub 2006 May 4.

Divisions of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.bbrc.2006.04.149DOI Listing
July 2006

Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.

Authors:
Hanako Kobayashi Laura M DeBusk Yael O Babichev Daniel J Dumont Pengnian Charles Lin

Blood 2006 Aug 25;108(4):1260-6. Epub 2006 Apr 25.

Deprtment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-09-01
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http://dx.doi.org/10.1182/blood-2005-09-012807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895873PMC
August 2006

Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy.

Authors:
Kelly E Fathers Courtney M Stone Kanwal Minhas Jason J A Marriott Janice D Greenwood Daniel J Dumont Brenda L Coomber

Am J Pathol 2005 Dec;167(6):1753-62

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401061256
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613180PMC
http://dx.doi.org/10.1016/S0002-9440(10)61256-4DOI Listing
December 2005

Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.

Authors:
Isao Hamaguchi Tohru Morisada Masaki Azuma Kyoko Murakami Madoka Kuramitsu Takuo Mizukami Kazuyuki Ohbo Kazunari Yamaguchi Yuichi Oike Daniel J Dumont Toshio Suda

Blood 2006 Feb 11;107(3):1207-13. Epub 2005 Oct 11.

Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1182/blood-2005-05-1823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895914PMC
February 2006

Problems with co-funding in Canada.

Authors:
Mike Tyers Eric Brown David W Andrews John J M Bergeron Charles Boone Roderick Bremner Howard A Bussey James C Cross Julian E Davies Michel Desjardins John E Dick Daniel J Dumont Daniel Durocher Michael J Ellison G Brian Golding Michael W Gray Lea A Harrington Philip A Hieter Gerald Johnston David J Kelvin Brian E McCarry Stephen W Michnick Francis Ouellette Ron E Pearlman Linda J Z Penn Jerry Pelletier Richard A Rachubinski Paul S Rennie Daniela Rotin Robert Rottapel Ivan Sadowski Frank Sicheri Lou Siminovitch Nahum Sonenberg K W Michael Siu Michel L Tremblay Neil Winegarden Richard W Wozniak Gerard D Wright James R Woodgett

Science 2005 Jun;308(5730):1867

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http://dx.doi.org/10.1126/science.308.5730.1867bDOI Listing
June 2005

Gene expression analysis of Tek/Tie2 signaling.

Authors:
Stephen H Chen Yael Babichev Natalie Rodrigues Daniel Voskas Ling Ling Vicky P K H Nguyen Daniel J Dumont

Physiol Genomics 2005 Jul 17;22(2):257-67. Epub 2005 May 17.

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00063.2005DOI Listing
July 2005

Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.

Authors:
Kazunobu Tachibana Nina Jones Daniel J Dumont Mira C Puri Alan Bernstein

Mol Cell Biol 2005 Jun;25(11):4693-702

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Rm. 982, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1128/MCB.25.11.4693-4702.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140648PMC
June 2005

Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.

Authors:
Paul Van Slyke Mariano Loza Coll Zubin Master Harold Kim Jorge Filmus Daniel J Dumont

Mol Cell Biol 2005 May;25(9):3831-41

Sunnybrook and Women's Research Institute, 2075 Bayview Avenue, Research Building S-218, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1128/MCB.25.9.3831-3841.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084282PMC
May 2005

A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.

Authors:
Daniel Voskas Nina Jones Paul Van Slyke Celina Sturk Wing Chang Alex Haninec Yael Olya Babichev Jennifer Tran Zubin Master Stephen Chen Nicole Ward Maribelle Cruz Jamie Jones Robert S Kerbel Serge Jothy Lina Dagnino Jack Arbiser Giannoula Klement Daniel J Dumont

Am J Pathol 2005 Mar;166(3):843-55

Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602355PMC
http://dx.doi.org/10.1016/S0002-9440(10)62305-XDOI Listing
March 2005

Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes.

Authors:
Nicole L Ward Tracy Putoczki Karen Mearow Tammy L Ivanco Daniel J Dumont

J Comp Neurol 2005 Feb;482(3):244-56

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario M4N 3M5, Canada.

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http://doi.wiley.com/10.1002/cne.20422
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http://dx.doi.org/10.1002/cne.20422DOI Listing
February 2005

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.

Authors:
Yuval Shaked Francesco Bertolini Shan Man Michael S Rogers Dave Cervi Thomas Foutz Kimberley Rawn Daniel Voskas Daniel J Dumont Yaacov Ben-David Jack Lawler Jack Henkin Jim Huber Daniel J Hicklin Robert J D'Amato Robert S Kerbel

Cancer Cell 2005 Jan;7(1):101-11

Department of Molecular and Cellular Biology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario M3N 4M5, Canada.

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http://dx.doi.org/10.1016/j.ccr.2004.11.023DOI Listing
January 2005

Functional inhibition of secreted angiopoietin: a novel role for angiopoietin 1 in coronary vessel patterning.

Authors:
Nicole L Ward Paul Van Slyke Daniel J Dumont

Biochem Biophys Res Commun 2004 Oct;323(3):937-46

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1016/j.bbrc.2004.08.185DOI Listing
October 2004

Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.

Authors:
Nicole L Ward Alexandra L Haninec Paul Van Slyke John G Sled Celina Sturk R Mark Henkelman Ian R Wanless Daniel J Dumont

Am J Pathol 2004 Sep;165(3):889-99

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618608PMC
http://dx.doi.org/10.1016/S0002-9440(10)63351-2DOI Listing
September 2004

Angiopoietin 1 expression levels in the myocardium direct coronary vessel development.

Authors:
Nicole L Ward Paul Van Slyke Celina Sturk Maribelle Cruz Daniel J Dumont

Dev Dyn 2004 Mar;229(3):500-9

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/dvdy.10479DOI Listing
March 2004

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.

Authors:
Qi Niu Carole Perruzzi Daniel Voskas Jack Lawler Daniel J Dumont Laura E Benjamin

2004 Apr 29;3(4):402-5. Epub 2004 Apr 29.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.4161/cbt.3.4.735DOI Listing
April 2004

Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.

Authors:
Zubin Master Jennifer Tran Aseem Bishnoi Stephen H Chen John M L Ebos Paul Van Slyke Robert S Kerbel Daniel J Dumont

J Biol Chem 2003 Aug 30;278(32):30170-9. Epub 2003 May 30.

Division of Molecular and Cellular Biology, Sunnybrook and Women's College Health Sciences Centre, Toronto M4N 3M5, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301339200
Publisher Site
http://dx.doi.org/10.1074/jbc.M301339200DOI Listing
August 2003

Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide.

Authors:
Saeid Babaei Krystyna Teichert-Kuliszewska Qiuwang Zhang Nina Jones Daniel J Dumont Duncan J Stewart

Am J Pathol 2003 Jun;162(6):1927-36

Terrence Donnelly Heart Center and Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868142PMC
http://dx.doi.org/10.1016/S0002-9440(10)64326-XDOI Listing
June 2003

A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.

Authors:
Nina Jones Stephen H Chen Celina Sturk Zubin Master Jennifer Tran Robert S Kerbel Daniel J Dumont

Mol Cell Biol 2003 Apr;23(8):2658-68

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario M4N 3M5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152553PMC
http://dx.doi.org/10.1128/mcb.23.8.2658-2668.2003DOI Listing
April 2003

The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.

Authors:
Nicole L Ward Daniel J Dumont

Semin Cell Dev Biol 2002 Feb;13(1):19-27

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1006/scdb.2001.0288DOI Listing
February 2002

A role for survivin in chemoresistance of endothelial cells mediated by VEGF.

Authors:
Jennifer Tran Zubin Master Joanne L Yu Janusz Rak Daniel J Dumont Robert S Kerbel

Proc Natl Acad Sci U S A 2002 Apr 26;99(7):4349-54. Epub 2002 Mar 26.

Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada M4N 3M5.

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http://dx.doi.org/10.1073/pnas.072586399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123651PMC
April 2002