Daniel J Dumont

Daniel J Dumont

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Daniel J Dumont

Daniel J Dumont

Publications by authors named "Daniel J Dumont"

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Tie2 signalling through Erk1/2 regulates TLR4 driven inflammation.

Cell Signal 2018 11 2;51:211-221. Epub 2018 Aug 2.

The Arthur and Sonia Labatt Brain Tumour Research Centre and Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2018.08.001DOI Listing
November 2018

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Crit Care 2017 Nov 13;21(1):274. Epub 2017 Nov 13.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Infectious Diseases and Pulmonary Medicine, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1186/s13054-017-1851-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683375PMC
November 2017

Pharmacological Tie2 activation in kidney transplantation.

World J Transplant 2016 Sep;6(3):573-82

Kristina Thamm, Florence Njau, Joon-Keun Park, Hermann Haller, Sascha David, Department of Nephrology and Hypertension, Medical School Hannover, 30625 Hannover, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036127PMC
http://dx.doi.org/10.5500/wjt.v6.i3.573DOI Listing
September 2016

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):2472-7. Epub 2016 Feb 16.

Center for Vascular Biology Research and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1519467113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780619PMC
March 2016

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.

Sci Rep 2016 Feb 25;6:22111. Epub 2016 Feb 25.

Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany.

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http://dx.doi.org/10.1038/srep22111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766468PMC
February 2016

Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.

BMC Cancer 2014 Aug 26;14:614. Epub 2014 Aug 26.

Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-14-614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159535PMC
August 2014

Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes.

J Surg Res 2014 Mar 7;187(1):43-52. Epub 2013 Oct 7.

Department of Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute at St. Michael's Hospital, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00224804130090
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http://dx.doi.org/10.1016/j.jss.2013.09.035DOI Listing
March 2014

Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development.

PLoS One 2013 14;8(1):e52197. Epub 2013 Jan 14.

Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544876PMC
July 2013

The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.

Crit Care 2011 31;15(5):R261. Epub 2011 Oct 31.

Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, Münster 48149 Germany.

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http://dx.doi.org/10.1186/cc10523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334812PMC
June 2013

Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.

PLoS One 2012 25;7(9):e43568. Epub 2012 Sep 25.

Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458045PMC
April 2013

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited.

Acta Neuropathol 2012 Dec 11;124(6):763-75. Epub 2012 Nov 11.

Institute of Neurology (Edinger Institute), Frankfurt University Medical School, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00401-012-1066-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508273PMC
December 2012

Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.

Blood 2011 Nov 25;118(18):5050-9. Epub 2011 Aug 25.

Edinger Institute/Institute of Neurology, Frankfurt University Medical School, Frankfurt, Germany.

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http://dx.doi.org/10.1182/blood-2011-03-343293DOI Listing
November 2011

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats.

BMC Neurol 2010 Nov 15;10:114. Epub 2010 Nov 15.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1471-2377-10-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020671PMC
November 2010

Tyrosine phosphorylation of Grb14 by Tie2.

Cell Commun Signal 2010 Oct 25;8:30. Epub 2010 Oct 25.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1478-811X-8-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978215PMC
October 2010

Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections.

J Biomed Opt 2010 Mar-Apr;15(2):026018

University of Toronto, Department of Physics, Institute for Optical Sciences, Department of Chemical and Physical Sciences, 3359 Mississauga Road North, Mississauga, Ontario, L5L 1C6 Canada.

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http://dx.doi.org/10.1117/1.3382908DOI Listing
September 2010

Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature.

BMC Dev Biol 2010 Jun 28;10:72. Epub 2010 Jun 28.

Sunnybrook Research Institute University of Toronto 2075 Bayview Avenue Toronto, Ontario M4N 3M5, Canada.

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http://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-21
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http://dx.doi.org/10.1186/1471-213X-10-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909156PMC
June 2010

Differential proteomic analysis of lymphatic, venous, and arterial endothelial cells extracted from bovine mesenteric vessels.

Proteomics 2010 Apr;10(8):1658-72

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://doi.wiley.com/10.1002/pmic.200900594
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http://dx.doi.org/10.1002/pmic.200900594DOI Listing
April 2010

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.

Biochem J 2009 Oct 12;423(3):375-80. Epub 2009 Oct 12.

Division of Molecular and Cellular Biology Research, Sunnybrook Research Institute, Toronto, Ontario, Canada, M4N 3M5.

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http://dx.doi.org/10.1042/BJ20091010DOI Listing
October 2009

The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice.

J Exp Med 2009 Sep 8;206(10):2221-34. Epub 2009 Sep 8.

Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada.

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http://dx.doi.org/10.1084/jem.20090389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757882PMC
September 2009

Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1.

Histochem Cell Biol 2009 Aug 8;132(2):225-37. Epub 2009 May 8.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Research Building, S-218, Toronto, ON, M4N 3M5, Canada.

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http://dx.doi.org/10.1007/s00418-009-0603-3DOI Listing
August 2009

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.

J Leukoc Biol 2008 Jul 1;84(1):59-67. Epub 2008 May 1.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1189/jlb.0607347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178502PMC
July 2008

Angiopoietin-2 impairs revascularization after limb ischemia.

Circ Res 2007 07 31;101(1):88-96. Epub 2007 May 31.

Institute of Neurology, Frankfurt University Medical School, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.106.143594DOI Listing
July 2007

Lymphangiogenesis following obstruction of large postnodal lymphatics in sheep.

Microvasc Res 2007 May 26;73(3):214-23. Epub 2006 Dec 26.

Neuroscience Research Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1016/j.mvr.2006.11.003DOI Listing
May 2007

Cell-based angiopoietin-1 gene therapy for acute lung injury.

Am J Respir Crit Care Med 2007 May 22;175(10):1014-26. Epub 2007 Feb 22.

St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada.

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http://dx.doi.org/10.1164/rccm.200609-1370OCDOI Listing
May 2007

Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2.

BMC Cell Biol 2007 Mar 6;8:10. Epub 2007 Mar 6.

Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2121-8-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828055PMC
March 2007

Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization.

J Cell Sci 2006 Sep 8;119(Pt 17):3551-60. Epub 2006 Aug 8.

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Research Building, S-218, Toronto, Ontario M4N 3M5, Canada.

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http://dx.doi.org/10.1242/jcs.03077DOI Listing
September 2006

Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.

Blood 2006 Aug 25;108(4):1260-6. Epub 2006 Apr 25.

Deprtment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-09-01
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http://dx.doi.org/10.1182/blood-2005-09-012807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895873PMC
August 2006

Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and blood vessel architecture.

Biochem Biophys Res Commun 2006 Jul 4;345(4):1299-307. Epub 2006 May 4.

Divisions of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.bbrc.2006.04.149DOI Listing
July 2006

Gene expression analysis of Tek/Tie2 signaling.

Physiol Genomics 2005 Jul 17;22(2):257-67. Epub 2005 May 17.

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00063.2005DOI Listing
July 2005

Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.

Mol Cell Biol 2005 Jun;25(11):4693-702

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Rm. 982, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1128/MCB.25.11.4693-4702.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140648PMC
June 2005

Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes.

J Comp Neurol 2005 Feb;482(3):244-56

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario M4N 3M5, Canada.

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http://doi.wiley.com/10.1002/cne.20422
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http://dx.doi.org/10.1002/cne.20422DOI Listing
February 2005

Functional inhibition of secreted angiopoietin: a novel role for angiopoietin 1 in coronary vessel patterning.

Biochem Biophys Res Commun 2004 Oct;323(3):937-46

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1016/j.bbrc.2004.08.185DOI Listing
October 2004

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.

Cancer Biol Ther 2004 Apr 29;3(4):402-5. Epub 2004 Apr 29.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.4161/cbt.3.4.735DOI Listing
April 2004

Angiopoietin 1 expression levels in the myocardium direct coronary vessel development.

Dev Dyn 2004 Mar;229(3):500-9

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/dvdy.10479DOI Listing
March 2004

Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.

J Biol Chem 2003 Aug 30;278(32):30170-9. Epub 2003 May 30.

Division of Molecular and Cellular Biology, Sunnybrook and Women's College Health Sciences Centre, Toronto M4N 3M5, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301339200
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http://dx.doi.org/10.1074/jbc.M301339200DOI Listing
August 2003

Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide.

Am J Pathol 2003 Jun;162(6):1927-36

Terrence Donnelly Heart Center and Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868142PMC
http://dx.doi.org/10.1016/S0002-9440(10)64326-XDOI Listing
June 2003

A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.

Mol Cell Biol 2003 Apr;23(8):2658-68

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario M4N 3M5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152553PMC
http://dx.doi.org/10.1128/mcb.23.8.2658-2668.2003DOI Listing
April 2003

A role for survivin in chemoresistance of endothelial cells mediated by VEGF.

Proc Natl Acad Sci U S A 2002 Apr 26;99(7):4349-54. Epub 2002 Mar 26.

Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada M4N 3M5.

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http://dx.doi.org/10.1073/pnas.072586399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123651PMC
April 2002

The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.

Semin Cell Dev Biol 2002 Feb;13(1):19-27

Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario, Canada M4N 3M5.

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http://dx.doi.org/10.1006/scdb.2001.0288DOI Listing
February 2002