Publications by authors named "Daniel J Drucker"

100Publications

Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease.

Mol Metab 2020 Sep 25:101090. Epub 2020 Sep 25.

Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101090DOI Listing
September 2020

Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans.

Nat Commun 2020 07 28;11(1):3766. Epub 2020 Jul 28.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41467-020-17556-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387453PMC
July 2020

The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.

Mol Metab 2020 Sep 7;39:101008. Epub 2020 May 7.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, ON, M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283165PMC
September 2020

Coronavirus Infections and Type 2 Diabetes-Shared Pathways with Therapeutic Implications.

Authors:
Daniel J Drucker

Endocr Rev 2020 06;41(3)

From the Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mt. Sinai Hospital, University of Toronto, Toronto Ontario, Canada.

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http://dx.doi.org/10.1210/endrev/bnaa011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184382PMC
June 2020

Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion.

Mol Metab 2020 07 9;37:100990. Epub 2020 Apr 9.

Department of Medicine and the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molmet.2020.100990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200938PMC
July 2020

The Discovery of GLP-2 and Development of Teduglutide for Short Bowel Syndrome.

Authors:
Daniel J Drucker

ACS Pharmacol Transl Sci 2019 Apr 1;2(2):134-142. Epub 2019 Mar 1.

Department of Medicine, the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1021/acsptsci.9b00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088900PMC
April 2019

Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.

JCI Insight 2020 Apr 23;5(8). Epub 2020 Apr 23.

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/jci.insight.136907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205439PMC
April 2020

Advances in oral peptide therapeutics.

Authors:
Daniel J Drucker

Nat Rev Drug Discov 2020 04 17;19(4):277-289. Epub 2019 Dec 17.

Department of Medicine and Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41573-019-0053-0DOI Listing
April 2020

Proglucagon-Derived Peptides, Glucose-Dependent Insulinotropic Polypeptide, and Dipeptidyl Peptidase-4-Mechanisms of Action in Adipose Tissue.

Endocrinology 2020 01;161(1)

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto ON, Canada.

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http://dx.doi.org/10.1210/endocr/bqz029DOI Listing
January 2020

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension.

Arterioscler Thromb Vasc Biol 2020 01 21;40(1):145-158. Epub 2019 Nov 21.

From the Center for Cardiology (J.H., K. Frenis, K. Filippou, M.D., S.K., F.P., S.K.-S., M.O., P.W. T.M., A.D., S.S.), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1161/atv.0000615456.97862.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946108PMC
January 2020

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.

Cell Metab 2019 11 24;30(5):963-975.e7. Epub 2019 Oct 24.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.10.001DOI Listing
November 2019

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.

Cell Metab 2019 11 5;30(5):976-986.e3. Epub 2019 Sep 5.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.08.009DOI Listing
November 2019

Physiological roles of the GIP receptor in murine brown adipose tissue.

Mol Metab 2019 10 10;28:14-25. Epub 2019 Aug 10.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822254PMC
October 2019

Localization of Glucagon-Like Peptide-2 Receptor Expression in the Mouse.

Endocrinology 2019 08;160(8):1950-1963

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2019-00398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656427PMC
August 2019

Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action.

Cell Rep 2019 06;27(11):3371-3384.e3

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 2J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.055DOI Listing
June 2019

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Mol Metab 2019 04 5;22:37-48. Epub 2019 Feb 5.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437632PMC
April 2019

GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9.

Nat Metab 2019 Jan 19;1(1):58-69. Epub 2018 Nov 19.

The Research Center for Digestive Tract and Liver Diseases, Tel-Aviv Sourasky Medical Center and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1038/s42255-018-0001-zDOI Listing
January 2019

Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition.

Cell Metab 2019 02 1;29(2):320-334.e5. Epub 2018 Nov 1.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, LTRI, 600 University Avenue TCP5-1004, Toronto, ON M5G 1X5, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 2J7, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183063
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http://dx.doi.org/10.1016/j.cmet.2018.10.001DOI Listing
February 2019

Insulin Secretion Depends on Intra-islet Glucagon Signaling.

Cell Rep 2018 10;25(5):1127-1134.e2

NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.celrep.2018.10.018DOI Listing
October 2018

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.

Diabetes 2018 11 27;67(11):2157-2166. Epub 2018 Aug 27.

Comprehensive Diabetes Center and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

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http://dx.doi.org/10.2337/db18-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198333PMC
November 2018

The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications.

Authors:
Daniel J Drucker

Diabetes 2018 09;67(9):1710-1719

Department of Medicine, Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/dbi18-0008DOI Listing
September 2018

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy.

Mol Metab 2018 10 9;16:45-54. Epub 2018 Jun 9.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157461PMC
October 2018

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.

Diabetes 2018 09 20;67(9):1773-1782. Epub 2018 Jun 20.

Comprehensive Diabetes Center and Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

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http://dx.doi.org/10.2337/db17-1502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110317PMC
September 2018

Precision medicine in the management of type 2 diabetes.

Lancet Diabetes Endocrinol 2018 11 23;6(11):891-900. Epub 2018 Apr 23.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183005
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http://dx.doi.org/10.1016/S2213-8587(18)30052-4DOI Listing
November 2018

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1.

Authors:
Daniel J Drucker

Cell Metab 2018 04;27(4):740-756

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Mailbox 39, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.03.001DOI Listing
April 2018

Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling.

Stem Cells Int 2018 8;2018:5284963. Epub 2018 Feb 8.

Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1155/2018/5284963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822806PMC
February 2018

GLP-1 Receptor Expression Within the Human Heart.

Endocrinology 2018 04;159(4):1570-1584

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1210/en.2018-00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939638PMC
April 2018

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

Cell Metab 2018 02 21;27(2):450-460.e6. Epub 2017 Dec 21.

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.11.003DOI Listing
February 2018

Discovery, characterization, and clinical development of the glucagon-like peptides.

J Clin Invest 2017 Dec 1;127(12):4217-4227. Epub 2017 Dec 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1172/JCI97233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707151PMC
December 2017

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Mol Metab 2017 11 1;6(11):1339-1349. Epub 2017 Sep 1.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173060
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http://dx.doi.org/10.1016/j.molmet.2017.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681270PMC
November 2017

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Cell Rep 2017 Oct;21(5):1160-1168

INSERM LNC UMR 1231, 21000 Dijon, France; University Bourgogne Franche-Comté, LNC UMR 1231, 21000 Dijon, France; LipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne Franche-Comté, 21000 Dijon, France; AgroSup Dijon, 21000 Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.008DOI Listing
October 2017

Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors.

Circulation 2017 Aug;136(9):849-870

From Diabetes Center Bochum-Hattingen, St Josef-Hospital, Ruhr-University Bochum, Germany (M.A.N., J.J.M., M.A.E.A.); Department of Medicine, University of North Carolina, Chapel Hill (M.A.C.); and Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt Sinai Hospital, University of Toronto, Ontario, Canada (D.J.D.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028136DOI Listing
August 2017

Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α in Patients With Type 2 Diabetes.

Diabetes Care 2017 08 26;40(8):1073-1081. Epub 2017 May 26.

Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/dc17-0061DOI Listing
August 2017

Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport.

Mol Metab 2017 03 17;6(3):245-255. Epub 2017 Jan 17.

Department of Medicine, University of Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324020PMC
March 2017

β-Cell Inactivation of Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.

Diabetes 2017 06 2;66(6):1626-1635. Epub 2017 Mar 2.

Lunenfeld-Tanenbaum Research Institute, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db17-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860191PMC
June 2017

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.

Cell Metab 2017 01 10;25(1):152-165. Epub 2016 Nov 10.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 2J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.007DOI Listing
January 2017

Vascular Biology of Glucagon Receptor Superfamily Peptides: Mechanistic and Clinical Relevance.

Endocr Rev 2016 12 12;37(6):554-583. Epub 2016 Oct 12.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada.

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http://dx.doi.org/10.1210/er.2016-1078DOI Listing
December 2016

Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice.

Mol Metab 2016 Aug 22;5(8):725-730. Epub 2016 Jun 22.

Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021674PMC
August 2016

Never Waste a Good Crisis: Confronting Reproducibility in Translational Research.

Authors:
Daniel J Drucker

Cell Metab 2016 09;24(3):348-360

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.08.006DOI Listing
September 2016

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy.

Cell Metab 2016 09 1;24(3):510-519. Epub 2016 Sep 1.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061124PMC
http://dx.doi.org/10.1016/j.cmet.2016.08.003DOI Listing
September 2016

The Cardiovascular Biology of Glucagon-like Peptide-1.

Authors:
Daniel J Drucker

Cell Metab 2016 07 23;24(1):15-30. Epub 2016 Jun 23.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.009DOI Listing
July 2016

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.

Diabetes 2016 Mar 15;65(3):742-54. Epub 2015 Dec 15.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db15-1224DOI Listing
March 2016

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology.

Authors:
Daniel J Drucker

J Clin Endocrinol Metab 2016 Mar 9;101(3):778-86. Epub 2015 Dec 9.

Department of Medicine, Mt. Sinai Hospital, University of Toronto and the Lunenfeld-Tanenbaum Research Institute, Toronto, Canada M5G 1X5.

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http://dx.doi.org/10.1210/jc.2015-3449DOI Listing
March 2016

The past 10 years-new hormones, new functions, new endocrine organs.

Nat Rev Endocrinol 2015 Nov 1;11(11):681-6. Epub 2015 Sep 1.

Baker IDI Heart and Diabetes Institute, Epidemiology &Clinical Diabetes, 99 Commercial Road, Melbourne, VIC 3004, Australia.

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http://dx.doi.org/10.1038/nrendo.2015.142DOI Listing
November 2015

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

N Engl J Med 2015 Sep 19;373(10):895-907. Epub 2015 Aug 19.

From Beth Israel Deaconess Medical Center and Hebrew SeniorLife, Gerontology Division, Harvard Medical School, Boston (M.C., Y.-H.H.); Massachusetts Institute of Technology (MIT) Computer Science and Artificial Intelligence Laboratory (M.C., G.Q., W.M., N.A.A., M.K.), and Broad Institute of MIT and Harvard, Cambridge (M.C., G.Q., W.M., M.K.); Clinical Cooperation Group "Nutrigenomics and Type 2 Diabetes," Helmholtz Center Munich (M.C., H.H.), and Else Kröner-Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, ZIEL-Institute for Food and Health, Technische Universität München (M.C., V.G., I.S.S., H.H.), Munich, Germany; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, and Hormone Laboratory, Haukeland University Hospital, Bergen, Norway (S.N.D., C.H., G.M.); Program in Developmental and Stem Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto (K.-H.K., V.P., J.L., C.-C.H.), and Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital (J.L.B., D.J.D.), Toronto; and the Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden (P.-A.S.).

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http://dx.doi.org/10.1056/NEJMoa1502214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959911PMC
September 2015

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.

Diabetes 2015 Nov 7;64(11):3798-807. Epub 2015 Jul 7.

Institut de recherches cliniques de Montréal, Montreal, QC, Canada Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada Division of Experimental Medicine, McGill University, Montreal, QC, Canada Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada Département de Médecine, Université de Montréal, Montreal, QC, Canada

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http://diabetes.diabetesjournals.org/content/early/2015/06/3
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http://www.glucagon.com/pdfs/Oropeza3798.full.pdf
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613972PMC
November 2015

Islet α cells and glucagon--critical regulators of energy homeostasis.

Nat Rev Endocrinol 2015 Jun 7;11(6):329-38. Epub 2015 Apr 7.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, TCP5-1004, Toronto, ON M5G 1X5, Canada.

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http://www.nature.com/articles/nrendo.2015.51
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http://dx.doi.org/10.1038/nrendo.2015.51DOI Listing
June 2015

Oxyntomodulin regulates resetting of the liver circadian clock by food.

Elife 2015 Mar 30;4:e06253. Epub 2015 Mar 30.

Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

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http://dx.doi.org/10.7554/eLife.06253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426666PMC
March 2015

GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.

Cell Metab 2015 Mar;21(3):379-91

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G1X5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.02.005DOI Listing
March 2015

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R.

Diabetes 2015 Jul 3;64(7):2537-49. Epub 2015 Mar 3.

Department of Medicine, Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada

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http://dx.doi.org/10.2337/db14-1577DOI Listing
July 2015

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.

Mol Metab 2015 Feb 29;4(2):132-43. Epub 2014 Nov 29.

Department of Laboratory Medicine and Pathobiology, Department of Medicine, Toronto, Ontario, Canada ; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada ; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molmet.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314543PMC
February 2015

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

FASEB J 2015 Jun 12;29(6):2268-80. Epub 2015 Feb 12.

*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763871PMC
June 2015

Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior.

Neuropsychopharmacology 2015 Jul 11;40(8):1969-78. Epub 2015 Feb 11.

Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839521PMC
July 2015

Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 Banting Lecture.

Authors:
Daniel J Drucker

Diabetes 2015 Feb;64(2):317-26

Department of Medicine, Mount Sinai Hospital and the Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db14-1514DOI Listing
February 2015

Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic peptide in hypertensive subjects with type 2 diabetes.

Diabetes Care 2015 Jan 20;38(1):132-9. Epub 2014 Nov 20.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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January 2015

Ghrelin Is a Novel Regulator of GLP-1 Secretion.

Diabetes 2015 May 20;64(5):1513-21. Epub 2014 Nov 20.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db14-1176DOI Listing
May 2015

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis.

Diabetes 2015 Mar 2;64(3):1046-56. Epub 2014 Oct 2.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db14-0883DOI Listing
March 2015

Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors.

Endocr Rev 2014 Dec 12;35(6):992-1019. Epub 2014 Sep 12.

Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada.

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December 2014

Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.

PLoS One 2014 13;9(6):e96863. Epub 2014 Jun 13.

SAAD centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine, Northern Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057070PMC
October 2015

Cardiovascular actions of incretin-based therapies.

Circ Res 2014 May;114(11):1788-803

From the Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.301958DOI Listing
May 2014

N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway.

J Biol Chem 2014 Jun 17;289(23):15927-41. Epub 2014 Apr 17.

From the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada and the Departments of Molecular Genetics, Laboratory Medicine and Pathology, and Medicine, University of Toronto, Toronto, Ontario M5R 0A3, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047366PMC
June 2014

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.

Mol Metab 2014 Apr 11;3(2):191-201. Epub 2013 Dec 11.

Center for Hypothalamic Research, Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953682PMC
April 2014

Oxyntomodulin increases intrinsic heart rate through the glucagon receptor.

Physiol Rep 2013 Oct 20;1(5):e00112. Epub 2013 Oct 20.

Department of Biology, Williams College Williamstown, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841047PMC
October 2013

Microbial modulation of energy availability in the colon regulates intestinal transit.

Cell Host Microbe 2013 Nov;14(5):582-90

Wallenberg Laboratory/Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Gothenburg 40530, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg 41345, Sweden.

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November 2013

Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway.

Diabetes 2014 Feb 1;63(2):471-82. Epub 2013 Nov 1.

INSERM UMR866-LabEx LipSTIC, Faculté de Médecine, Université de Bourgogne, Dijon, France.

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http://dx.doi.org/10.2337/db13-0903DOI Listing
February 2014

Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2.

Annu Rev Physiol 2014 25;76:561-83. Epub 2013 Oct 25.

Department of Medicine, Mount Sinai Hospital, Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1X5; email: ,

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September 2014

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.

Kidney Int 2014 Mar 23;85(3):579-89. Epub 2013 Oct 23.

Division of Endocrinology, Metabolism and Geriatric Medicine, Akita University Graduate School of Medicine, Akita, Japan.

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http://dx.doi.org/10.1038/ki.2013.427DOI Listing
March 2014

Metabolic disease puts up a fight: are diet and exercise helpful for the heart?

Nat Med 2013 Oct;19(10):1216-7

Department of Medicine, Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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October 2013

Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls.

Authors:
Daniel J Drucker

Diabetes 2013 Oct 1;62(10):3316-23. Epub 2013 Jul 1.

Department of Medicine, Mt. Sinai Hospital, Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/db13-0822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781450PMC
October 2013

Pharmacology, physiology, and mechanisms of incretin hormone action.

Cell Metab 2013 Jun 16;17(6):819-837. Epub 2013 May 16.

Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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June 2013

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.

Nat Med 2013 May 31;19(5):567-75. Epub 2013 Mar 31.

Department of Medicine, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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May 2013

Emerging combinatorial hormone therapies for the treatment of obesity and T2DM.

Nat Rev Endocrinol 2013 Jul 12;9(7):425-33. Epub 2013 Mar 12.

Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue TCP5-1004, Toronto M5G 1X5, ON, Canada.

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July 2013

Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency.

Diabetes 2013 Jul 22;62(7):2380-5. Epub 2013 Feb 22.

Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.2337/db12-1498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712071PMC
July 2013

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose.

Am J Physiol Endocrinol Metab 2013 Apr 22;304(7):E677-85. Epub 2013 Jan 22.

Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827, USA.

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April 2013

Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.

Diabetes 2013 Apr 16;62(4):1196-205. Epub 2012 Nov 16.

Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/db11-1605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609565PMC
April 2013