Daniel J Brat

Daniel J Brat

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Daniel J Brat

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Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion.

FASEB J 2019 Aug 9:fj201802610RR. Epub 2019 Aug 9.

Regenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.

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http://dx.doi.org/10.1096/fj.201802610RRDOI Listing
August 2019

cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates.

Brain Pathol 2019 07 22;29(4):469-472. Epub 2019 May 22.

Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bpa.12732DOI Listing
July 2019

Data Sets for the Reporting of Tumors of the Central Nervous System.

Arch Pathol Lab Med 2019 Jun 20. Epub 2019 Jun 20.

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Dr Louis); the Department of Pathology, Amsterdam Universities Medical Center/VUmc CCA Brain Tumor Center, Amsterdam, the Netherlands (Dr Wesseling); the Department of Pathology, Princess Máxima Center for Pediatric Oncology, and University Medical Center Utrecht, Utrecht, the Netherlands (Dr Wesseling); Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, United Kingdom (Dr Brandner); the Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom (Dr Brandner); the Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (Dr Brat); the Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee (Dr Ellison); the Department of Radiology, Oncology and Anatomic Pathology, University La Sapienza, Rome, Italy (Dr Giangaspero); IRCCS Neuromed, Pozzilli, Isernia, Italy (Dr Giangaspero); the Department of Pathology, University of Louisville School of Medicine, Louisville, Kentucky (Dr Hattab); the Department of Laboratory Medicine & Pathobiology, The Hospital for Sick Children, Toronto, Ontario, Canada (Dr Hawkins); Project Management Office, Royal College of Pathologists of Australasia, Sydney, Australia (Ms Judge); the Departments of Pathology, Neurology, and Neurosurgery, University of Colorado, Aurora (Dr Kleinschmidt-DeMasters); the Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan (Dr Komori); the Department of Pathology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan (Dr Komori); Alfred Anatomical Pathology and NNF, Victorian Brain Bank, Carlton, Victoria, Australia (Dr McLean); Institute of Neuropathology, University Hospital Münster, Münster, Germany (Dr Paulus); Division of Neuropathology, Department of Pathology, University of California, San Francisco (Dr Perry); the Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany (Dr Reifenberger); German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany (Dr Reifenberger); the Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (Dr Weller); and the Department of Histopathology, Addenbrookes Hospital, Cambridge, United Kingdom (Dr Rous); ICCR Steering Group Representative (Dr Rous).

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http://dx.doi.org/10.5858/arpa.2018-0565-OADOI Listing
June 2019

What Every Neuropathologist Needs to Know: Update on cIMPACT-NOW.

J Neuropathol Exp Neurol 2019 Apr;78(4):294-296

Department of Pathology, Northwestern Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1093/jnen/nlz012DOI Listing
April 2019

Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.

Cancer Res 2019 Mar 10;79(6):1085-1097. Epub 2018 Dec 10.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0482DOI Listing
March 2019

Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer's disease.

NPJ Aging Mech Dis 2019 22;5. Epub 2019 Jan 22.

1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA USA.

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http://dx.doi.org/10.1038/s41514-018-0033-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342990PMC
January 2019

(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.

Biol Psychiatry 2018 10 6;84(7):488-498. Epub 2017 Nov 6.

Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Department of Neurology, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Free Radical and Radiation Biology Program, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Pappajohn Biomedical Institute, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Interdisciplinary Graduate Program in Human Toxicology, Department of Occupational and Environmental Health, University of Iowa College of Public Health, Iowa City, Iowa; Iowa City VA Health Care System, Iowa City, Iowa; Weill Cornell Autism Research Program, Weill Cornell Medical College New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415524PMC
October 2018

[F]Fluciclovine PET discrimination between high- and low-grade gliomas.

EJNMMI Res 2018 Jul 25;8(1):67. Epub 2018 Jul 25.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1841 Clifton Rd. NE, 2nd floor, Atlanta, GA, 30329, USA.

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http://dx.doi.org/10.1186/s13550-018-0415-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060188PMC
July 2018

Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.

Adv Anat Pathol 2018 May;25(3):143-171

Department of Pathology, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1097/PAP.0000000000000186DOI Listing
May 2018

TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.

Sci Rep 2018 05 8;8(1):7248. Epub 2018 May 8.

Department of Biomedical Informatics, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1038/s41598-018-25337-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940855PMC
May 2018

Meningioma With Tyrosine-Rich Crystalloids: A Case Report and Review of the Literature.

Int J Surg Pathol 2018 Apr 17;26(2):157-160. Epub 2017 Aug 17.

3 Mount Sinai Beth Israel Hospital, New York, NY, USA.

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http://dx.doi.org/10.1177/1066896917727100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794632PMC
April 2018

Predicting cancer outcomes from histology and genomics using convolutional networks.

Proc Natl Acad Sci U S A 2018 03 12;115(13):E2970-E2979. Epub 2018 Mar 12.

Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA 30322;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1717139115
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http://dx.doi.org/10.1073/pnas.1717139115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879673PMC
March 2018

Practical Diagnostic Approach to the Presence of Hyphae in Neuropathology Specimens With Three Illustrative Cases.

Am J Clin Pathol 2018 Jan;149(2):98-104

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1093/ajcp/aqx144DOI Listing
January 2018

Progesterone improves neurocognitive outcomes following therapeutic cranial irradiation in mice.

Horm Behav 2017 11 18;96:21-30. Epub 2017 Sep 18.

Brain Research Laboratory, Department of Emergency Medicine, 1365 B Clifton Rd NE, Suite 5100, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yhbeh.2017.08.004DOI Listing
November 2017

Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy.

Results Probl Cell Differ 2017 ;61:401-421

Departments of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/978-3-319-53150-2_18DOI Listing
July 2017

Development of a Framework for Large Scale Three-Dimensional Pathology and Biomarker Imaging and Spatial Analytics.

AMIA Jt Summits Transl Sci Proc 2017 26;2017:75-84. Epub 2017 Jul 26.

Department of Biomedical Informatics, Emory University, Atlanta, GA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543358PMC
July 2017

Chordoid glioma of the third ventricle: report of a rapidly progressive case.

J Neurooncol 2017 05 18;132(3):487-495. Epub 2017 Mar 18.

Departments of Pathology and Laboratory Medicine, Emory University Hospital, H-195, 1364 Clifton Rd. NE, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/s11060-017-2399-7DOI Listing
May 2017

DYNAMIC REGISTRATION FOR GIGAPIXEL SERIAL WHOLE SLIDE IMAGES.

Proc IEEE Int Symp Biomed Imaging 2017 Apr 19;2017:424-428. Epub 2017 Jun 19.

Department of Biomedical Informatics, Emory University, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1109/ISBI.2017.7950552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550903PMC
April 2017

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.

Mol Oncol 2017 03 15;11(3):280-294. Epub 2017 Feb 15.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1002/1878-0261.12034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332279PMC
March 2017

Genomic Analysis in the Practice of Surgical Neuropathology: The Emory Experience.

Arch Pathol Lab Med 2017 Mar;141(3):355-365

From the Departments of Pathology and Laboratory Medicine (Drs Neill, Saxe, Rossi, Schniederjan, and Brat) and Radiation Oncology (Dr Rossi), Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia; and the Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia (Dr Schniederjan).

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http://dx.doi.org/10.5858/arpa.2016-0276-SAIDOI Listing
March 2017

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.

eNeuro 2016 Mar-Apr;3(2). Epub 2016 Mar 31.

Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242; Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, New York 10065; Department of Neurology, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242; Department of Free Radical and Radiation Biology Program, Department of Radiation Oncology Holden Comprehensive Cancer Center, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242; Department of Veteran Affairs, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.

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http://dx.doi.org/10.1523/ENEURO.0006-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819284PMC
December 2016

EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform.

FASEB J 2016 12 29;30(12):4098-4108. Epub 2016 Aug 29.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia;

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http://dx.doi.org/10.1096/fj.201600550RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102110PMC
December 2016

Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study.

Neuro Oncol 2016 10 22;18(10):1442-50. Epub 2016 Mar 22.

Departments of Pediatrics (R.I.J.), Pathology (R.L.H.) and Neurosurgery (I.F.P.), University of Pittsburgh School of Medicine, Pittsburgh, PA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland (K.J.C.); Children's Oncology Group, Operations Office, Monrovia, California (A.B., M.D.K.); Department of Preventive Medicine, University of Southern California, Los Angeles, California (M.D.K, S.P.E.); Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland (P.C.B.); Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (M.K.R.); Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia (D.J.B.); Department of Mathematics and Statistics, California State University, Long Beach, California (T.Z.); Maurer Family Cancer Care Center, Bowling Green, Ohio (R.S.L.)

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http://dx.doi.org/10.1093/neuonc/now038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035517PMC
October 2016

Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004-2012, varying).

J Neurooncol 2016 10 14;130(1):31-42. Epub 2016 Jul 14.

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Wearn 152, Cleveland, OH, 44106, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071143PMC
http://dx.doi.org/10.1007/s11060-016-2217-7DOI Listing
October 2016

Assessing the Effects of Software Platforms on Volumetric Segmentation of Glioblastoma.

J Neuroimaging Psychiatry Neurol 2016 20;1(2):64-72. Epub 2016 Jul 20.

Departments of Biomedical Informatics and Neurology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.17756/jnpn.2016-008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870135PMC
July 2016

TNFRSF10C copy number variation is associated with metastatic colorectal cancer.

J Gastrointest Oncol 2016 Jun;7(3):306-14

1 Department of Radiation Oncology, 2 Winship Cancer Institute, Emory University, GA, USA ; 3 Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA ; 4 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA ; 5 Department of Pathology and Laboratory Medicine, 6 Department of Biomedical Informatics, 7 Department of Biostatistics and Bioinformatics, 8 Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.21037/jgo.2015.11.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880759PMC
June 2016

Glioblastoma: biology, genetics, and behavior.

Authors:
Daniel J Brat

Am Soc Clin Oncol Educ Book 2012 :102-7

From the Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.14694/EdBook_AM.2012.32.102DOI Listing
April 2016

Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.

Cancer Res 2016 04 18;76(8):2443-52. Epub 2016 Feb 18.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873416PMC
April 2016

Robust Cell Segmentation for Histological Images of Glioblastoma.

Proc IEEE Int Symp Biomed Imaging 2016 Apr 16;2016:1041-1045. Epub 2016 Jun 16.

Department of Computer Science, Stony Brook University, Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1109/ISBI.2016.7493444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382998PMC
April 2016

Defining neoplastic diseases differently: An emerging paradigm from The Cancer Genome Atlas lower-grade gliomas project.

Mol Cell Oncol 2016 Mar 29;3(2):e1074333. Epub 2015 Jul 29.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine , Atlanta, GA 30322.

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http://dx.doi.org/10.1080/23723556.2015.1074333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905393PMC
March 2016

Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups.

Acta Neuropathol Commun 2016 Jan 13;4. Epub 2016 Jan 13.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA, 30307, USA.

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http://dx.doi.org/10.1186/s40478-015-0270-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711079PMC
January 2016

Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment.

Chin J Cancer 2016 Jan 12;35:12. Epub 2016 Jan 12.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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https://cancercommun.biomedcentral.com/articles/10.1186/s408
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http://dx.doi.org/10.1186/s40880-015-0071-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711065PMC
January 2016

Biomarker-driven diagnosis of diffuse gliomas.

Mol Aspects Med 2015 Nov 21;45:87-96. Epub 2015 May 21.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2015.05.002DOI Listing
November 2015

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Tumors of the Central Nervous System.

Arch Pathol Lab Med 2015 Sep 2;139(9):1087-93. Epub 2015 Feb 2.

From the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia (Dr Brat); the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Dr Cagle); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Dillon); the Department of Pathology, Indiana University Medical Center, Indianapolis (Dr Hattab); the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr McLendon); Cancer Registry, Saint Agnes Hospital, Baltimore, Maryland (Ms Miller); and the Department of Oncology, Mayo Clinic, Rochester, Minnesota (Dr Buckner).

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http://dx.doi.org/10.5858/arpa.2014-0588-CPDOI Listing
September 2015

P53 tumor suppression network in cancer epigenetics.

Methods Mol Biol 2015 ;1238:597-605

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/978-1-4939-1804-1_31DOI Listing
July 2015

Bilateral optic neuropathy after erythematous rash. Bilateral anterior optic neuropathy due to RMSF.

J Neuroophthalmol 2015 Jun;35(2):201-4

Departments of Neurology (SMN, JDS) and Ophthalmology, Jones Eye Institute (SMN, JGC), University of Arkansas for Medical Sciences, Little Rock, Arkansas; Central Arkansas Veterans Healthcare System (SMN, JDS, JGC), Little Rock, Arkansas; Veterans Healthcare System of the Ozarks (KYS), Fayetteville, Arkansas; Departments of Radiology and Imaging Sciences (PAH) and Pathology (DJB), Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1097/WNO.0000000000000261DOI Listing
June 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Molecular genetics of gliomas.

Cancer J 2014 Jan-Feb;20(1):66-72

From the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PPO.0000000000000020DOI Listing
May 2015

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

Nature 2015 May;521(7552):E1-4

1] Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA [2] Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA [3] Veterans Affairs, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA [4] Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature14444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684952PMC
May 2015

Novel genotype-phenotype associations in human cancers enabled by advanced molecular platforms and computational analysis of whole slide images.

Lab Invest 2015 Apr 19;95(4):366-76. Epub 2015 Jan 19.

1] Department of Biomedical Informatics, Emory University, Atlanta, GA, USA [2] Winship Cancer Institute, Emory University, Atlanta, GA, USA [3] Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.

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http://www.nature.com/articles/labinvest2014153
Publisher Site
http://dx.doi.org/10.1038/labinvest.2014.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465352PMC
April 2015

AUTOMATED CELL SEGMENTATION WITH 3D FLUORESCENCE MICROSCOPY IMAGES.

Proc IEEE Int Symp Biomed Imaging 2015 Apr;2015:1212-1215

Department of Biomedical Informatics, Emory University, Atlanta, GA, 30322, USA ; Department of Pathology, Emory University, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1109/ISBI.2015.7164091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578315PMC
April 2015

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.

Genome Res 2015 Mar 3;25(3):316-27. Epub 2015 Feb 3.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;

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http://dx.doi.org/10.1101/gr.180612.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352879PMC
March 2015

Cancer stem cell division: when the rules of asymmetry are broken.

Stem Cells Dev 2015 Feb 18;24(4):405-16. Epub 2014 Dec 18.

1 Department of Pathology and Laboratory Medicine, Emory University , Atlanta, Georgia .

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http://dx.doi.org/10.1089/scd.2014.0442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313409PMC
February 2015

Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.

Adv Anat Pathol 2015 Jan;22(1):50-8

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1097/PAP.0000000000000048DOI Listing
January 2015

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1107-12. Epub 2015 Jan 12.

Department of Epidemiology and Biostatistics, Department of Pathology, and Department of Gastrointestinal Surgery, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1422640112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313862PMC
January 2015

Analysis of graft survival in a trial of stem cell transplant in ALS.

Ann Clin Transl Neurol 2014 Nov 22;1(11):900-8. Epub 2014 Oct 22.

Department of Neurology, Emory University School of Medicine Atlanta, Georgia ; Department of Pathology and Laboratory Medicine, Emory University School of Medicine Atlanta, Georgia.

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http://dx.doi.org/10.1002/acn3.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265061PMC
November 2014

The descriptive epidemiology of atypical teratoid/rhabdoid tumors in the United States, 2001-2010.

Neuro Oncol 2014 Oct 20;16(10):1392-9. Epub 2014 May 20.

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (Q.T.O., Y.C., H.G., Y.W., J.S.B.-S.); Central Brain Tumor Registry of the United States, Hinsdale, Illinois (Q.T.O., Y.C., H.G., Y.W., C.K., J.S.B.-S.); Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio (P.M.d.B.); The Ohio State University, Columbus, Ohio (A.O.); Case Western Reserve University, Cleveland, Ohio (P.F.); Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio (M.L.C.); Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Hospital, Atlanta, Georgia (D.J.B.).

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http://dx.doi.org/10.1093/neuonc/nou090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165422PMC
October 2014

Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma.

Cancer Res 2014 Aug 19;74(16):4536-48. Epub 2014 Jun 19.

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia. Department of Biomedical Informatics, Emory University, Atlanta, Georgia. Winship Cancer Institute, Emory University, Atlanta, Georgia.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-3703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134737PMC
August 2014

Machine-based morphologic analysis of glioblastoma using whole-slide pathology images uncovers clinically relevant molecular correlates.

PLoS One 2013 13;8(11):e81049. Epub 2013 Nov 13.

Center for Comprehensive Informatics, Emory University, Atlanta, Georgia, United States of America ; Department of Biomedical Informatics, Emory University, Atlanta, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081049PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827469PMC
July 2014

The role of neuropathology in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.

J Neurooncol 2014 Jul 15;118(3):461-78. Epub 2014 Apr 15.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA,

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http://link.springer.com/10.1007/s11060-013-1331-z
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July 2014

Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy.

Neurosurgery 2014 Jun;74(6):569-84; discussion 584-5

Departments of *Neurosurgery, ‡Neurology, §Pathology, and ¶Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia; ‖Interventional MRI Program, Emory University Hospital, Atlanta, Georgia; #Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia; **Department of Neurology, University of Washington School of Medicine, Seattle, Washington; ††Visualase, Inc., Houston, Texas.

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http://dx.doi.org/10.1227/NEU.0000000000000343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151501PMC
June 2014

Outcomes and patterns of failure for grade 2 meningioma treated with reduced-margin intensity modulated radiation therapy.

Int J Radiat Oncol Biol Phys 2014 Apr;88(5):1004-10

Department of Radiation Oncology, Emory University, Atlanta, Georgia; Winship Cancer Institute, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1016/j.ijrobp.2013.12.037DOI Listing
April 2014

P14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway.

Cancer Res 2014 Mar 7;74(5):1371-8. Epub 2014 Jan 7.

Authors' Affiliations: Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery; Departments of Pathology and Laboratory Medicine and Hematology and Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947444PMC
March 2014

The modern pathologist: lab data deliverer, interpreter, and diagnostician.

Authors:
Daniel J Brat

J Neuroophthalmol 2014 Mar;34(1):1-2

Department of Pathology and Laboratory Medicine, Emory University Hospital, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1097/WNO.0000000000000097DOI Listing
March 2014

Pituitary carcinoma in situ.

Endocr Pract 2013 May-Jun;19(3):e69-73

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.4158/EP12351.CRDOI Listing
February 2014

Acute monocular visual loss in an elderly woman: a neuro-ophthalmologic emergency.

J Neuroophthalmol 2013 Dec;33(4):390-3

Departments of Ophthalmology (MSV, JD), Neurology (MSV), and Neurosurgery (MSV), University of Alabama at Birmingham, Birmingham, Alabama; and Departments of Radiology (PAH) and Pathology and Laboratory Medicine (DJB), Emory University, Atlanta, Georgia.

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December 2013

Cancer Digital Slide Archive: an informatics resource to support integrated in silico analysis of TCGA pathology data.

J Am Med Inform Assoc 2013 Nov-Dec;20(6):1091-8. Epub 2013 Jul 25.

Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1136/amiajnl-2012-001469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822112PMC
December 2013

Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.

Clin Cancer Res 2013 Sep 17;19(18):4951-60. Epub 2013 Jul 17.

Authors' Affiliations: Emory University School of Medicine, Departments of Biomedical Informatics and Pathology and Laboratory Medicine,Center for Comprehensive Informatics, Winship Cancer Institute, Emory University; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia; Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan; Department of Pathology, Case Western Reserve University, Cleveland, Ohio; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Pathology, Duke University Medical Center, Durham, North Carolina; Department of Pathology, Ohio State University, Columbus, Ohio; Department of Pathology, University of North Carolina, Chapel Hill, North Carolina; and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865611PMC
September 2013

Blockade of glioma proliferation through allosteric inhibition of JAK2.

Sci Signal 2013 Jul 9;6(283):ra55. Epub 2013 Jul 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1126/scisignal.2003900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772155PMC
July 2013

Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry.

Am J Surg Pathol 2013 May;37(5):763-71

Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Emory University School of Medicine, 1001 Johnson Ferry Rd NE, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1097/PAS.0b013e31827bf4ccDOI Listing
May 2013

A high-performance spatial database based approach for pathology imaging algorithm evaluation.

J Pathol Inform 2013 14;4. Epub 2013 Mar 14.

Department of Biomedical Informatics, Emory University, USA ; Center for Comprehensive Informatics, Emory University, USA.

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http://dx.doi.org/10.4103/2153-3539.108543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624706PMC
April 2013

Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants.

Mod Pathol 2013 Mar 5;26(3):315-26. Epub 2012 Oct 5.

Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1038/modpathol.2012.173DOI Listing
March 2013

P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.

J Clin Invest 2012 Apr 1;122(4):1283-95. Epub 2012 Mar 1.

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1172/JCI38596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314443PMC
April 2012

Oncogenic regulation of tissue factor and thrombosis in cancer.

Thromb Res 2012 Apr;129 Suppl 1:S46-9

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/S0049-3848(12)70015-4DOI Listing
April 2012

The use of neuroimaging to guide the histologic diagnosis of central nervous system lesions.

Adv Anat Pathol 2012 Mar;19(2):97-107

Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1097/PAP.0b013e318248b747DOI Listing
March 2012

Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.

Sci Transl Med 2012 Mar;4(127):127ra36

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003016DOI Listing
March 2012

MORPHOLOGICAL SIGNATURES AND GENOMIC CORRELATES IN GLIOBLASTOMA.

Proc IEEE Int Symp Biomed Imaging 2011 Mar:1624-1627

Center for Comprehensive Informatics, Emory University, Atlanta, GA 30322.

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http://dx.doi.org/10.1109/ISBI.2011.5872714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241612PMC
March 2011