Daniel Hartl

Daniel Hartl

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Daniel Hartl

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Limits to Compensatory Mutations: Insights from Temperature-Sensitive Alleles.

Mol Biol Evol 2019 09;36(9):1874-1883

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

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http://dx.doi.org/10.1093/molbev/msz110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735812PMC
September 2019

Chimeric dihydrofolate reductases display properties of modularity and biophysical diversity.

Protein Sci 2019 Jul 30;28(7):1359-1367. Epub 2019 May 30.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/pro.3646DOI Listing
July 2019

Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance.

Genetics 2019 06 23;212(2):565-575. Epub 2019 Apr 23.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138.

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http://dx.doi.org/10.1534/genetics.119.302138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553834PMC
June 2019

Reply to Velavan et al.: Polymorphisms of in natural populations: Implications for functional significance.

Proc Natl Acad Sci U S A 2019 Jun;116(26):12613-12614

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1907920116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601244PMC
June 2019

Mutations in actin-binding protein coronin confer reduced artemisinin susceptibility.

Proc Natl Acad Sci U S A 2018 12 12;115(50):12799-12804. Epub 2018 Nov 12.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1812317115
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http://dx.doi.org/10.1073/pnas.1812317115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294886PMC
December 2018

Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission.

PLoS Comput Biol 2018 01 9;14(1):e1005923. Epub 2018 Jan 9.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777656PMC
January 2018

Genome-Wide Association Studies of Drug-Resistance Determinants.

Trends Parasitol 2017 03 27;33(3):214-230. Epub 2016 Oct 27.

The Broad Institute of MIT and Harvard, Infectious Disease Initiative, Cambridge, MA, USA; Harvard University, Organismic and Evolutionary Biology, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.pt.2016.10.001DOI Listing
March 2017

Mosquito Vectors and the Globalization of Plasmodium falciparum Malaria.

Annu Rev Genet 2016 Nov 3;50:447-465. Epub 2016 Oct 3.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; email:

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http://dx.doi.org/10.1146/annurev-genet-120215-035211DOI Listing
November 2016

A New Take on John Maynard Smith's Concept of Protein Space for Understanding Molecular Evolution.

PLoS Comput Biol 2016 Oct 13;12(10):e1005046. Epub 2016 Oct 13.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063322PMC
October 2016

Neighboring genes for DNA-binding proteins rescue male sterility in Drosophila hybrids.

Proc Natl Acad Sci U S A 2016 07 29;113(29):E4200-7. Epub 2016 Jun 29.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1608337113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961176PMC
July 2016

Genotypic Context and Epistasis in Individuals and Populations.

Cell 2016 Jul;166(2):279-287

Department of Organismic and Evolutionary Biology, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.06.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948997PMC
July 2016

Direct Gamete Sequencing Reveals No Evidence for Segregation Distortion in House Mouse Hybrids.

PLoS One 2015 29;10(6):e0131933. Epub 2015 Jun 29.

Department of Organismic & Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America; Howard Hughes Medical Institute, Department of Molecular & Cellular Biology, Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131933PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487504PMC
April 2016

Biophysical principles predict fitness landscapes of drug resistance.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):E1470-8. Epub 2016 Feb 29.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1601441113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801265PMC
March 2016

Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.

PLoS Comput Biol 2016 Jan 25;12(1):e1004710. Epub 2016 Jan 25.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726534PMC
January 2016

A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax.

Malar J 2016 Jan 25;15:40. Epub 2016 Jan 25.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1186/s12936-016-1090-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727274PMC
January 2016

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria.

J Vis Exp 2015 Nov 10(105):e52839. Epub 2015 Nov 10.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; School of Nursing and Health Sciences, Simmons College.

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http://dx.doi.org/10.3791/52839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692701PMC
November 2015

Behavioral idiosyncrasy reveals genetic control of phenotypic variability.

Proc Natl Acad Sci U S A 2015 May 7;112(21):6706-11. Epub 2015 May 7.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138; Rowland Institute at Harvard, Cambridge, MA 02142; and Center for Brain Science, Harvard University, Cambridge, MA 02138.

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http://dx.doi.org/10.1073/pnas.1503830112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450409PMC
May 2015

Natural selection constrains neutral diversity across a wide range of species.

PLoS Biol 2015 Apr 10;13(4):e1002112. Epub 2015 Apr 10.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge Massachusetts, United States of America.

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http://dx.plos.org/10.1371/journal.pbio.1002112
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http://dx.doi.org/10.1371/journal.pbio.1002112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393120PMC
April 2015

Recurrent bottlenecks in the malaria life cycle obscure signals of positive selection.

Parasitology 2015 Feb 20;142 Suppl 1:S98-S107. Epub 2014 Feb 20.

Department of Organismic and Evolutionary Biology,Harvard University,Cambridge, MA 02138,USA.

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http://dx.doi.org/10.1017/S0031182014000067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139472PMC
February 2015

What can we learn from fitness landscapes?

Authors:
Daniel L Hartl

Curr Opin Microbiol 2014 Oct 13;21:51-7. Epub 2014 Oct 13.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254422PMC
October 2014

Positive selection drives faster-Z evolution in silkmoths.

Evolution 2014 Aug 6;68(8):2331-42. Epub 2014 Jun 6.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138.

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http://dx.doi.org/10.1111/evo.12449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122604PMC
August 2014

The roles of cis- and trans-regulation in the evolution of regulatory incompatibilities and sexually dimorphic gene expression.

Genome Res 2014 Jan 16;24(1):84-95. Epub 2013 Sep 16.

Department of Biology, University of Rochester, Rochester, New York 14627, USA;

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http://dx.doi.org/10.1101/gr.156414.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875864PMC
January 2014

Genome-wide gene expression effects of sex chromosome imprinting in Drosophila.

G3 (Bethesda) 2014 Jan 10;4(1):1-10. Epub 2014 Jan 10.

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.

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http://g3journal.org/lookup/doi/10.1534/g3.113.008029
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http://dx.doi.org/10.1534/g3.113.008029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887524PMC
January 2014

Genetic incompatibilities are widespread within species.

Nature 2013 Dec 6;504(7478):135-7. Epub 2013 Nov 6.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature12678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844467PMC
December 2013

Malaria life cycle intensifies both natural selection and random genetic drift.

Proc Natl Acad Sci U S A 2013 Dec 20;110(50):20129-34. Epub 2013 Nov 20.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.

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http://dx.doi.org/10.1073/pnas.1319857110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864301PMC
December 2013

Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease.

Proc Natl Acad Sci U S A 2013 Nov 21;110(46):18572-7. Epub 2013 Oct 21.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.

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http://dx.doi.org/10.1073/pnas.1318211110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831948PMC
November 2013

Accessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax.

J Mol Evol 2013 Sep 27;77(3):81-91. Epub 2013 Sep 27.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA,

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http://link.springer.com/10.1007/s00239-013-9582-z
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http://dx.doi.org/10.1007/s00239-013-9582-zDOI Listing
September 2013

Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis.

Genetics 2013 Jul 1;194(3):609-18. Epub 2013 May 1.

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1534/genetics.113.150805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697967PMC
July 2013

DNA-binding specificity changes in the evolution of forkhead transcription factors.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):12349-54. Epub 2013 Jul 8.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1310430110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725104PMC
July 2013

Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.

Genome Biol Evol 2013 ;5(1):255-66

Department of Organismic and Evolutionary Biology, Harvard University, MA, USA.

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http://dx.doi.org/10.1093/gbe/evt005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595022PMC
June 2013

Population genomics of inversion polymorphisms in Drosophila melanogaster.

PLoS Genet 2012 20;8(12):e1003056. Epub 2012 Dec 20.

Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527211PMC
May 2013

Novel genes from formation to function.

Int J Evol Biol 2012 3;2012:821645. Epub 2012 Jul 3.

Centro de Biologia Ambiental (CBA), Faculdade de Ciências da Universidade de Lisboa, 1749 Lisboa, Portugal.

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https://www.hindawi.com/archive/2012/821645/
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http://dx.doi.org/10.1155/2012/821645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395120PMC
August 2012

Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila.

Proc Natl Acad Sci U S A 2012 Jun 4;109(25):9941-6. Epub 2012 Jun 4.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1207367109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382510PMC
June 2012

Chimeric genes as a source of rapid evolution in Drosophila melanogaster.

Mol Biol Evol 2012 Feb 18;29(2):517-29. Epub 2011 Jul 18.

Department of Organismic and Evolutionary Biology, Harvard University, USA.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/msr184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350314PMC
February 2012

Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster.

Genome Biol Evol 2011 ;3:1014-24

Department of Organismic and Evolutionary Biology, Harvard University, USA.

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http://dx.doi.org/10.1093/gbe/evr023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227403PMC
January 2012

James F. Crow and the art of teaching and mentoring.

Authors:
Daniel L Hartl

Genetics 2011 Dec;189(4):1129-33

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1534/genetics.111.135160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241436PMC
December 2011

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection.

Nat Genet 2011 Dec 18;44(1):101-5. Epub 2011 Dec 18.

Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534735PMC
December 2011

Model transcriptional networks with continuously varying expression levels.

BMC Evol Biol 2011 Dec 19;11:363. Epub 2011 Dec 19.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1186/1471-2148-11-363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270072PMC
December 2011

Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum.

PLoS One 2011 23;6(5):e19636. Epub 2011 May 23.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019636PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100297PMC
November 2011

Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila.

Proc Natl Acad Sci U S A 2011 Oct 3;108(41):17046-51. Epub 2011 Oct 3.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1114690108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193250PMC
October 2011

The evolutionary landscape of antifolate resistance in Plasmodium falciparum.

J Genet 2011 Aug;90(2):187-90

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212943PMC
http://dx.doi.org/10.1007/s12041-011-0072-zDOI Listing
August 2011

Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation.

PLoS Genet 2011 Apr 21;7(4):e1001376. Epub 2011 Apr 21.

Department of Biology, Texas A&M University, College Station, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080856PMC
April 2011

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):680-5. Epub 2010 Dec 27.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1017570108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021021PMC
January 2011

Compensatory mutations restore fitness during the evolution of dihydrofolate reductase.

Mol Biol Evol 2010 Dec 24;27(12):2682-90. Epub 2010 Jun 24.

Department of Organismic and Evolutionary Biology, Harvard University, MA, USA.

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http://dx.doi.org/10.1093/molbev/msq160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981517PMC
December 2010

Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes".

BMC Evol Biol 2010 Dec 14;10:385. Epub 2010 Dec 14.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1186/1471-2148-10-385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020225PMC
December 2010

Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome.

Mol Biol Evol 2010 Sep 28;27(9):2198-209. Epub 2010 Apr 28.

Department of Organismic and Evolutionary Biology, Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1093/molbev/msq108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922621PMC
September 2010

Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster.

Genetics 2010 Sep 15;186(1):109-18. Epub 2010 Jun 15.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1534/genetics.110.118109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940279PMC
September 2010

Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict.

Proc Natl Acad Sci U S A 2010 Sep 23;107(36):15826-31. Epub 2010 Aug 23.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1010383107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936610PMC
September 2010

Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster.

Proc Natl Acad Sci U S A 2010 Jun 1;107(24):10943-8. Epub 2010 Jun 1.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1006503107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890713PMC
June 2010

Colloquium papers: Adaptive landscapes and protein evolution.

Proc Natl Acad Sci U S A 2010 Jan 30;107 Suppl 1:1747-51. Epub 2009 Sep 30.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0906192106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868285PMC
January 2010

Recurrent selection on the Winters sex-ratio genes in Drosophila simulans.

Genetics 2010 Jan 6;184(1):253-65. Epub 2009 Nov 6.

Department of Biology, University of Rochester, Rochester, New York 14627, USA.

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http://dx.doi.org/10.1534/genetics.109.109587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815921PMC
January 2010

Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways.

Mol Biol Evol 2009 Nov 14;26(11):2455-62. Epub 2009 Jul 14.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/molbev/msp151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912465PMC
November 2009

Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

Proc Natl Acad Sci U S A 2009 Jul 8;106(29):12025-30. Epub 2009 Jul 8.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0905922106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715478PMC
July 2009

Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1.

Proc Natl Acad Sci U S A 2009 Mar 11;106(13):5348-52. Epub 2009 Mar 11.

Department of Biology, Virginia Commonwealth University, 1000 West Cary Street, Room 126, Richmond, VA 23284-2012, USA.

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http://dx.doi.org/10.1073/pnas.0900878106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664016PMC
March 2009

Formation and longevity of chimeric and duplicate genes in Drosophila melanogaster.

Genetics 2009 Jan 17;181(1):313-22. Epub 2008 Nov 17.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1534/genetics.108.091538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621179PMC
January 2009

Optimization of gene expression by natural selection.

Proc Natl Acad Sci U S A 2009 Jan 12;106(4):1133-8. Epub 2009 Jan 12.

Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0812009106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633540PMC
January 2009

Accelerated evolution of resistance in multidrug environments.

Proc Natl Acad Sci U S A 2008 Sep 8;105(37):13977-81. Epub 2008 Sep 8.

Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0805965105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544564PMC
September 2008

Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression.

Proc Natl Acad Sci U S A 2008 Sep 12;105(38):14471-6. Epub 2008 Sep 12.

Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0805160105
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http://dx.doi.org/10.1073/pnas.0805160105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567206PMC
September 2008

Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila.

Mol Biol Evol 2008 Aug 13;25(8):1639-50. Epub 2008 May 13.

Section of Evolutionary Biology, Department of Biology, University of Munich, 82152 Munich, Germany.

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http://dx.doi.org/10.1093/molbev/msn111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727381PMC
August 2008

Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila.

Mol Biol Evol 2008 Aug 13;25(8):1631-8. Epub 2008 May 13.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/molbev/msn112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734129PMC
August 2008

Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae.

Mol Ecol 2008 Jun 18;17(12):2985-97. Epub 2008 Apr 18.

Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1111/j.1365-294X.2008.03765.xDOI Listing
June 2008

Overdispersion of the molecular clock varies between yeast, Drosophila and mammals.

Genetics 2008 Jun 27;179(2):977-84. Epub 2008 May 27.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1534/genetics.108.089185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429890PMC
June 2008

Patterns of polymorphism in genomic regions flanking three highly polymorphic surface antigens in Plasmodium falciparum.

Mol Biochem Parasitol 2008 May 15;159(1):1-6. Epub 2007 Dec 15.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016668510700339
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http://dx.doi.org/10.1016/j.molbiopara.2007.12.004DOI Listing
May 2008

Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax.

Gene 2008 Feb 15;410(1):105-12. Epub 2008 Jan 15.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.gene.2007.11.022DOI Listing
February 2008

Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences.

Science 2008 Jan;319(5859):91-3

Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1148861DOI Listing
January 2008

Malaria: a peek at the var variorum.

Trends Parasitol 2007 Dec 30;23(12):563-5. Epub 2007 Oct 30.

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

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http://linkinghub.elsevier.com/retrieve/pii/S147149220700258
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http://dx.doi.org/10.1016/j.pt.2007.08.022DOI Listing
December 2007

A portrait of copy-number polymorphism in Drosophila melanogaster.

Proc Natl Acad Sci U S A 2007 Dec 4;104(50):19920-5. Epub 2007 Dec 4.

Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0709888104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148398PMC
December 2007

A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor.

PLoS Biol 2007 Nov;5(11):e292

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0050292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062475PMC
November 2007

A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.

PLoS Biol 2007 Nov;5(11):e293

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0050293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062476PMC
November 2007

Genome organization and gene expression shape the transposable element distribution in the Drosophila melanogaster euchromatin.

PLoS Genet 2007 Nov 10;3(11):e210. Epub 2007 Oct 10.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.0030210
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098804PMC
November 2007

Mutational reversions during adaptive protein evolution.

Mol Biol Evol 2007 Aug 7;24(8):1608-10. Epub 2007 Jun 7.

Department of Organismic and Evolutionary Biology, Harvard University, MA, USA.

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http://dx.doi.org/10.1093/molbev/msm118DOI Listing
August 2007

Genetic properties influencing the evolvability of gene expression.

Science 2007 Jul 24;317(5834):118-21. Epub 2007 May 24.

Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1140247DOI Listing
July 2007

Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population.

Mol Biol Evol 2007 Apr 22;24(4):939-47. Epub 2007 Jan 22.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard University, USA.

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http://dx.doi.org/10.1093/molbev/msm013DOI Listing
April 2007

Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia.

J Infect Dis 2007 Apr 6;195(8):1218-26. Epub 2007 Mar 6.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1086/512685DOI Listing
April 2007

Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila.

Proc Natl Acad Sci U S A 2007 Apr 4;104(16):6504-10. Epub 2007 Apr 4.

Department of Mathematics, Washington University, St. Louis, MO 63130, USA.

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http://dx.doi.org/10.1073/pnas.0701572104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871816PMC
April 2007

Mud sticks: on the alleged falsification of Mendel's data.

Genetics 2007 Mar;175(3):975-9

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1840063PMC
March 2007

Systems-level analysis and evolution of the phototransduction network in Drosophila.

Proc Natl Acad Sci U S A 2007 Feb 20;104(9):3283-8. Epub 2007 Feb 20.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0611402104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805570PMC
February 2007

Epigenetic memory at malaria virulence genes.

Proc Natl Acad Sci U S A 2007 Jan 5;104(3):899-902. Epub 2007 Jan 5.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0609084103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764221PMC
January 2007