Daniel G Tenen

Daniel G Tenen

UNVERIFIED PROFILE

Are you Daniel G Tenen?   Register this Author

Register author
Daniel G Tenen

Daniel G Tenen

Publications by authors named "Daniel G Tenen"

Are you Daniel G Tenen?   Register this Author

100Publications

2916Reads

41Profile Views

NanoVar: accurate characterization of patients' genomic structural variants using low-depth nanopore sequencing.

Genome Biol 2020 Mar 3;21(1):56. Epub 2020 Mar 3.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore, 117599, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-020-01968-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055087PMC
March 2020

High-speed automatic characterization of rare events in flow cytometric data.

PLoS One 2020 11;15(2):e0228651. Epub 2020 Feb 11.

Public Health Dynamics Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228651PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012421PMC
February 2020

DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells.

Nucleic Acids Res 2019 08;47(14):7460-7475

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698669PMC
August 2019

Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation.

Bioorg Med Chem Lett 2019 Aug 20;29(16):2286-2289. Epub 2019 Jun 20.

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2019.06.024DOI Listing
August 2019

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer.

Theranostics 2019 14;9(21):6157-6174. Epub 2019 Aug 14.

Cancer Science Institute Singapore, National University of Singapore, MD6, #12-01, 14 Medical Drive, Singapore 117599.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.35805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735519PMC
August 2019

Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA.

Redox Biol 2019 06 14;24:101168. Epub 2019 Mar 14.

School of Biological Sciences, Nanyang Technological University, 637551, Singapore; Institute of Molecular and Cell Biology, A*STAR, 138673, Singapore; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, 17177, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2019.101168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439307PMC
June 2019

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.

Leukemia 2018 10 26;32(10):2138-2151. Epub 2018 Mar 26.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-018-0110-4DOI Listing
October 2018

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα.

Molecules 2018 Aug 3;23(8). Epub 2018 Aug 3.

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules23081938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222906PMC
August 2018

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Cancer Cell 2018 06;33(6):1111-1127.e5

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191185PMC
June 2018

The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?

PLoS Genet 2017 01 12;13(1):e1006505. Epub 2017 Jan 12.

Division of Hematology and Oncology, Leipzig University Hospital, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1006505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5230742PMC
January 2017

Targeting SALL4 by entinostat in lung cancer.

Oncotarget 2016 Nov;7(46):75425-75440

Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.12251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342750PMC
November 2016

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Gastroenterology 2016 10 1;151(4):637-650.e10. Epub 2016 Jul 1.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2016.06.043DOI Listing
October 2016

SALL4, the missing link between stem cells, development and cancer.

Gene 2016 Jun 16;584(2):111-9. Epub 2016 Feb 16.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, New Research Building Room 652D, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823161PMC
June 2016

The second hit of DNA methylation.

Mol Cell Oncol 2016 May 29;3(3):e1093690. Epub 2015 Oct 29.

Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; ADIENNE, Lugano, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23723556.2015.1093690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909463PMC
May 2016

The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.

J Immunol 2016 Jan 25;196(1):244-55. Epub 2015 Nov 25.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215; Broad Institute of MIT and Harvard, Cambridge, MA 02142; and Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1403099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684978PMC
January 2016

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Cell Stem Cell 2015 Nov 24;17(5):611-23. Epub 2015 Sep 24.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Cancer Science Institute, National University of Singapore, Singapore, 117599. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2015.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636971PMC
November 2015

A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation.

J Biomol Screen 2015 Oct 24;20(9):1150-9. Epub 2015 Jun 24.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1087057115592220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575897PMC
October 2015

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.

Nat Cell Biol 2015 Oct 21;17(10):1327-38. Epub 2015 Sep 21.

Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb3240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772727PMC
October 2015

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

J Exp Med 2015 Sep 24;212(10):1551-69. Epub 2015 Aug 24.

Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0XY, England, UK Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK

View Article

Download full-text PDF

Source
http://jem.rupress.org/content/212/10/1551.full.pdf
Web Search
http://www.jem.org/lookup/doi/10.1084/jem.20141661
Publisher Site
http://dx.doi.org/10.1084/jem.20141661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577832PMC
September 2015

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.

Blood 2015 Aug 18;126(9):1086-94. Epub 2015 Jun 18.

Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore; Department of Biochemistry and Department of Pediatrics, Duke University School of Medicine, Durham, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-09-598540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598194PMC
August 2015

Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells.

Cancer Cell 2015 May;27(5):671-81

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Cancer Science Institute, National University of Singapore, Singapore 119077, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447336PMC
May 2015

Dissecting the role of aberrant DNA methylation in human leukaemia.

Nat Commun 2015 May 22;6:7091. Epub 2015 May 22.

1] Harvard Medical School, Boston, Massachusetts 02115, USA [2] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA [3] Cancer Science Institute, National University of Singapore, Singapore 66123, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms8091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443494PMC
May 2015

Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.

Cancer Sci 2015 Mar 12;106(3):227-36. Epub 2015 Feb 12.

Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.12593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373983PMC
March 2015

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.

Nat Commun 2014 Dec 18;5:5872. Epub 2014 Dec 18.

1] Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan [2] JST, CREST, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490789PMC
December 2014

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.

Blood 2014 Oct 3;124(15):2391-9. Epub 2014 Sep 3.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA; Cancer Science Institute, National University of Singapore, Singapore; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-01-550855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192750PMC
October 2014

Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.

Blood 2014 Jun 25;123(24):3760-9. Epub 2014 Apr 25.

Moores University California San Diego Cancer Center, Biomedical Science Graduate Program, and Division of Biological Sciences, University of California San Diego, La Jolla, CA; Department of Pathology, University of California San Diego, La Jolla, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-08-521252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055923PMC
June 2014

RNA editome imbalance in hepatocellular carcinoma.

Cancer Res 2014 Mar 20;74(5):1301-6. Epub 2014 Feb 20.

Authors' Affiliations: Cancer Science Institute of Singapore, National University of Singapore, Singapore; and Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-3485DOI Listing
March 2014

Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.

Cell Stem Cell 2013 Dec 10;13(6):754-68. Epub 2013 Oct 10.

Stem Cell Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK; Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2013.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878573PMC
December 2013

DNMT1-interacting RNAs block gene-specific DNA methylation.

Nature 2013 Nov 9;503(7476):371-6. Epub 2013 Oct 9.

1] Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA [3] Università Cattolica del Sacro Cuore, Institute of Hematology, L.go A. Gemelli 8, Rome 00168, Italy [4].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870304PMC
November 2013

SALL4 is a key transcription regulator in normal human hematopoiesis.

Transfusion 2013 May 31;53(5):1037-49. Epub 2012 Aug 31.

Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1537-2995.2012.03888.x
Publisher Site
http://dx.doi.org/10.1111/j.1537-2995.2012.03888.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653586PMC
May 2013

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

Nat Cell Biol 2013 Apr 17;15(4):385-94. Epub 2013 Mar 17.

Harvard Stem Cell Institute, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781213PMC
April 2013

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.

Blood 2013 Feb 3;121(8):1413-21. Epub 2013 Jan 3.

Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-04-424275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578956PMC
February 2013

Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.

J Clin Invest 2012 Aug 17;122(8):2955-66. Epub 2012 Jul 17.

Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI43354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408728PMC
August 2012

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Blood 2011 Dec 19;118(25):6544-52. Epub 2011 Oct 19.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-11-317909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242717PMC
December 2011

CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis.

Am J Respir Crit Care Med 2011 Sep 3;184(6):687-98. Epub 2011 Jun 3.

The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201011-1764OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208601PMC
September 2011

PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.

Nat Med 2010 May 25;16(5):580-5, 1p following 585. Epub 2010 Apr 25.

Molecular Oncology Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.2122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039870PMC
May 2010

Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences.

Biochem Biophys Res Commun 2010 Mar 10;393(3):498-503. Epub 2010 Feb 10.

Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948238PMC
March 2010

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.

J Clin Oncol 2009 Feb 15;27(4):619-28. Epub 2008 Dec 15.

University of Münster, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2008.17.9812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645860PMC
February 2009