Daniel G Anderson

Daniel G Anderson

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Daniel G Anderson

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Biomaterials for Personalized Cell Therapy.

Adv Mater 2019 Sep 9:e1902005. Epub 2019 Sep 9.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201902005DOI Listing
September 2019

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation.

Nat Biotechnol 2019 Sep 30. Epub 2019 Sep 30.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0247-3DOI Listing
September 2019

mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo.

Mol Ther 2019 Aug 18;27(8):1415-1423. Epub 2019 May 18.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698250PMC
August 2019

Identification of cell cycle-targeting microRNAs through genome-wide screens.

Cell Cycle 2017 14;16(23):2241-2248. Epub 2017 Nov 14.

a Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2017.1380132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788471PMC
July 2019

CRISPR-Cas: a tool for cancer research and therapeutics.

Nat Rev Clin Oncol 2019 05;16(5):281-295

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41571-019-0166-8DOI Listing
May 2019

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation 2019 May;139(19):2238-2255

Center for Pulmonary Vascular Biology and Medicine, Center for Metabolism and Mitochondrial Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (Q.Y., Y.-Y.T., Y.T., J.Z., V.N., M.K.C., J.P., W.S., J.S., M.R., M.S., N.K., T.S., M.Z., N.F., S.S., S.Y.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519484PMC
May 2019

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.

Mol Cell 2019 05 19;74(3):508-520.e4. Epub 2019 Mar 19.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193010
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http://dx.doi.org/10.1016/j.molcel.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724735PMC
May 2019

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.

Mol Ther 2019 Apr 19;27(4):710-728. Epub 2019 Feb 19.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453548PMC
April 2019

Strategies, design, and chemistry in siRNA delivery systems.

Adv Drug Deliv Rev 2019 Apr 15;144:133-147. Epub 2019 May 15.

Deparment of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, Department of Chemistry, Institute for Medical Engineering and Science, and Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2019.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745264PMC
April 2019

Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

Proc Natl Acad Sci U S A 2019 03 26;116(11):4861-4870. Epub 2019 Feb 26.

David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1815909116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421446PMC
March 2019

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium.

Adv Mater 2019 Feb 4;31(8):e1805116. Epub 2019 Jan 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201805116DOI Listing
February 2019

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.

Angew Chem Int Ed Engl 2018 10 14;57(41):13582-13586. Epub 2018 Sep 14.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://doi.wiley.com/10.1002/anie.201809056
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http://dx.doi.org/10.1002/anie.201809056DOI Listing
October 2018

Poly(β-amino ester)-co-poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo.

Adv Healthc Mater 2018 07 14;7(14):e1800249. Epub 2018 May 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adhm.201800249DOI Listing
July 2018

Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery.

Adv Mater 2018 Jul 5:e1801151. Epub 2018 Jul 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

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http://doi.wiley.com/10.1002/adma.201801151
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http://dx.doi.org/10.1002/adma.201801151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320729PMC
July 2018

Engineering circular RNA for potent and stable translation in eukaryotic cells.

Nat Commun 2018 07 6;9(1):2629. Epub 2018 Jul 6.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-018-05096-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035260PMC
July 2018

Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles.

Sci Adv 2018 06 27;4(6):eaar8409. Epub 2018 Jun 27.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/sciadv.aar8409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021147PMC
June 2018

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling.

Cell Death Dis 2018 05 24;9(6):632. Epub 2018 May 24.

Department of Cell, Developmental and Cancer Biology, Department of Radiation Medicine, Oregon Health and Sciences University (OHSU), 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.

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http://dx.doi.org/10.1038/s41419-018-0690-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967305PMC
May 2018

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

Nat Chem Biol 2018 03 29;14(3):311-316. Epub 2018 Jan 29.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902734PMC
March 2018

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Mol Ther Nucleic Acids 2018 Mar 21;10:55-63. Epub 2017 Nov 21.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734870PMC
March 2018

Surface tension-assisted additive manufacturing.

Nat Commun 2018 03 22;9(1):1184. Epub 2018 Mar 22.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St Cambridge, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1038/s41467-018-03391-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864961PMC
March 2018

Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents.

Methods Mol Biol 2017 ;1521:153-166

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/978-1-4939-6588-5_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541997PMC
January 2018

Engineered 3D-printed artificial axons.

Sci Rep 2018 01 11;8(1):478. Epub 2018 Jan 11.

Biosystems & Micromechanics Interdisciplinary Research Group (BioSyM), Singapore-MIT Alliance in Research & Technology (SMART), Singapore, Singapore.

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http://dx.doi.org/10.1038/s41598-017-18744-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765144PMC
January 2018

Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.

J Am Heart Assoc 2018 01 30;7(3). Epub 2018 Jan 30.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University, New Haven, CT

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http://dx.doi.org/10.1161/JAHA.117.007501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850249PMC
January 2018

Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction.

J Tissue Eng Regen Med 2017 10 3;11(10):2763-2773. Epub 2016 Jun 3.

Plastic Surgery Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/term.2171DOI Listing
October 2017

Glucose-responsive insulin by molecular and physical design.

Nat Chem 2017 09;9(10):937-943

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nchem.2857DOI Listing
September 2017

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

J Clin Invest 2017 Aug 10;127(8):3039-3051. Epub 2017 Jul 10.

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI93182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531423PMC
August 2017

Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures.

Expert Opin Drug Deliv 2017 07 14;14(7):851-864. Epub 2016 Oct 14.

a David H. Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , MA , USA.

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https://www.tandfonline.com/doi/full/10.1080/17425247.2016.1
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http://dx.doi.org/10.1080/17425247.2016.1244187DOI Listing
July 2017

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins.

Nucleic Acids Res 2017 Jul;45(13):7602-7614

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/nar/gkx546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570165PMC
July 2017

Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression.

Proc Natl Acad Sci U S A 2017 07 10;114(30):E6147-E6156. Epub 2017 Jul 10.

Department of Neurological Surgery, Brain Tumor Research Institute, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1701911114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544292PMC
July 2017

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Biomaterials 2017 06 7;128:147-159. Epub 2017 Mar 7.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.03.008DOI Listing
June 2017

Delivery technologies for genome editing.

Nat Rev Drug Discov 2017 Jun 24;16(6):387-399. Epub 2017 Mar 24.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/doifinder/10.1038/nrd.2016.280
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http://dx.doi.org/10.1038/nrd.2016.280DOI Listing
June 2017

Advances in the delivery of RNA therapeutics: from concept to clinical reality.

Genome Med 2017 06 27;9(1):60. Epub 2017 Jun 27.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1186/s13073-017-0450-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485616PMC
June 2017

Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks.

Adv Mater 2017 May 15;29(19). Epub 2017 Mar 15.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201605947DOI Listing
May 2017

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.

Gastroenterology 2017 04 10;152(5):1161-1173.e1. Epub 2016 Dec 10.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts; Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204228PMC
April 2017

Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice.

Gastroenterology 2017 04 11;152(5):1151-1160. Epub 2017 Jan 11.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368009PMC
April 2017

Microfluidic Fabrication of Colloidal Nanomaterials-Encapsulated Microcapsules for Biomolecular Sensing.

Nano Lett 2017 03 6;17(3):2015-2020. Epub 2017 Feb 6.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b00026DOI Listing
March 2017

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy.

Nano Lett 2017 03 5;17(3):1326-1335. Epub 2016 Dec 5.

Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/acs.nanolett.6b03329
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http://dx.doi.org/10.1021/acs.nanolett.6b03329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523404PMC
March 2017

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

Sci Rep 2017 03 21;7(1):252. Epub 2017 Mar 21.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1038/s41598-017-00193-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427874PMC
March 2017

A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.

Adv Healthc Mater 2017 Feb 15;6(4). Epub 2016 Dec 15.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adhm.201601091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322155PMC
February 2017

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.

Proc Natl Acad Sci U S A 2017 02 6;114(8):2060-2065. Epub 2017 Feb 6.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1620874114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338412PMC
February 2017

Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.

Adv Drug Deliv Rev 2016 12 26;107:367-392. Epub 2016 Jun 26.

David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2016.06.012DOI Listing
December 2016

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo.

Biomaterials 2016 12 25;109:78-87. Epub 2016 Sep 25.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267554PMC
December 2016

Supramolecular PEGylation of biopharmaceuticals.

Proc Natl Acad Sci U S A 2016 12 28;113(50):14189-14194. Epub 2016 Nov 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1616639113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167179PMC
December 2016

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.

Nat Commun 2016 11 25;7:13597. Epub 2016 Nov 25.

Department of Cell, Developmental and Cancer Biology, Department of Radiation Medicine, Oregon Health and Science University, Portland, Oregon 97229, USA.

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http://dx.doi.org/10.1038/ncomms13597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133658PMC
November 2016

Materials for non-viral intracellular delivery of messenger RNA therapeutics.

J Control Release 2016 10 21;240:227-234. Epub 2015 Dec 21.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139, USA; Department of Anesthesiology, Boston Children's Hospital, Boston, 02122, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, 02139, USA; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.12.032DOI Listing
October 2016

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling.

Nat Cell Biol 2016 10 5;18(10):1043-53. Epub 2016 Sep 5.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/ncb3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301150PMC
October 2016

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs.

Angew Chem Int Ed Engl 2016 10 30;55(44):13808-13812. Epub 2016 Sep 30.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/anie.201608450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279893PMC
October 2016

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.

Proc Natl Acad Sci U S A 2016 10 4;113(43):E6639-E6648. Epub 2016 Oct 4.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, & Harvard, Cambridge, MA 02139; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Howard Hughes Medical Institute, Chevy Chase, MD 20815

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http://dx.doi.org/10.1073/pnas.1606050113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086995PMC
October 2016

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circ Res 2016 Sep 21;119(7):853-64. Epub 2016 Jul 21.

From the Center for Systems Biology, Department of Imaging (H.B.S., M.H., T.H., G.C., Y.S., Y.I., B.T., R.W., F.K.S., M.N.) and Cardiovascular Research Center (M.N.), Massachusetts General Hospital and Harvard Medical School, Boston; Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MS (K.J.L.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (M.B.M., P.L.); Department of Cardiology and Angiology I, Heart Center Freiburg University, Germany (T.H.); Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA (O.F.K., J.E.D., D.G.A.); David H. Koch Institute for Integrative Cancer Research (O.F.K., J.E.D., D.G.A.) and Department of Chemical Engineering (D.G.A.), Massachusetts Institute of Technology, Cambridge; Alnylam Pharmaceuticals, Cambridge, MA (A.B., K.F.); and Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378496PMC
September 2016

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Biomacromolecules 2016 09 26;17(9):2830-8. Epub 2016 Aug 26.

Department of Chemical Engineering, Institute for Medical Engineering and Science, Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.biomac.6b00615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464089PMC
September 2016

Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation.

J Leukoc Biol 2016 08 10;100(2):253-60. Epub 2016 Mar 10.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Harvard-Massachusetts Institute of Technology Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

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http://dx.doi.org/10.1189/jlb.1HI0615-248RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945357PMC
August 2016

An elastic second skin.

Nat Mater 2016 08 9;15(8):911-8. Epub 2016 May 9.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nmat4635DOI Listing
August 2016

Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications.

Angew Chem Int Ed Engl 2016 08 1;55(33):9529-33. Epub 2016 Jul 1.

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201602748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245870PMC
August 2016

Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.

Langmuir 2016 08 17;32(34):8743-7. Epub 2016 Aug 17.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.langmuir.5b04755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242094PMC
August 2016

Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion.

Biomater Sci 2016 Aug;4(9):1381-91

Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. morgan.alexander.nottingham.ac.uk.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038343PMC
http://dx.doi.org/10.1039/c6bm00214eDOI Listing
August 2016

Spatial Control of Gene Expression by Nanocarriers Using Heparin Masking and Ultrasound-Targeted Microbubble Destruction.

ACS Nano 2016 08 29;10(8):7267-78. Epub 2016 Jul 29.

Department of Chemical Engineering, MIT , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsnano.6b01199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240524PMC
August 2016

Smart approaches to glucose-responsive drug delivery.

J Drug Target 2015 ;23(7-8):651-5

a David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge , MA , USA .

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http://dx.doi.org/10.3109/1061186X.2015.1055749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450160PMC
July 2016

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose.

Proc Natl Acad Sci U S A 2016 07 5;113(29):E4133-42. Epub 2016 Jul 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1600299113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961123PMC
July 2016

Neutrophil Responses to Sterile Implant Materials.

PLoS One 2015 10;10(9):e0137550. Epub 2015 Sep 10.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, 02115, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137550PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565661PMC
May 2016

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.

J Hepatol 2016 Apr 30;64(4):899-907. Epub 2015 Nov 30.

Skolkovo Institute of Science and Technology, Skolkovo 143025, Russia; Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 119991, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381270PMC
April 2016

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.

Adv Mater 2016 Apr 18;28(15):2939-43. Epub 2016 Feb 18.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201505822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245883PMC
April 2016

Poly(Limonene Thioether) Scaffold for Tissue Engineering.

Adv Healthc Mater 2016 Apr 18;5(7):813-21. Epub 2016 Feb 18.

Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adhm.201500892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828277PMC
April 2016

MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation.

Nat Commun 2016 Apr 12;7:11268. Epub 2016 Apr 12.

Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale University School of Medicine, 300 George Street, 7th Floor, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1038/ncomms11268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832062PMC
April 2016

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.

Nano Lett 2016 Feb 13;16(2):842-8. Epub 2016 Jan 13.

David H. Koch Institute for Integrative Cancer Research, ‡Department of Chemical Engineering, §Department of Biology, and ∥Institute for Medical Engineering and Science, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.nanolett.5b02428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278877PMC
February 2016

Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.

Adv Mater 2016 Jan 5;28(1):86-91. Epub 2015 Nov 5.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201502902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825176PMC
January 2016

High Throughput Layer-by-Layer Films for Extracting Film Forming Parameters and Modulating Film Interactions with Cells.

ACS Appl Mater Interfaces 2016 Jan 12;8(3):2255-61. Epub 2016 Jan 12.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , 500 Main Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsami.5b11081DOI Listing
January 2016

Ultrasound-mediated gastrointestinal drug delivery.

Sci Transl Med 2015 Oct;7(310):310ra168

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa5937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825174PMC
October 2015

Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

Hum Gene Ther 2015 Jul;26(7):432-42

2 RNA Therapeutics Institute and Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, Massachusetts.

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http://dx.doi.org/10.1089/hum.2015.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509492PMC
July 2015

Accelerating the Translation of Nanomaterials in Biomedicine.

ACS Nano 2015 Jul 26;9(7):6644-54. Epub 2015 Jun 26.

⬢Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, United States.

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http://dx.doi.org/10.1021/acsnano.5b03569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227554PMC
July 2015

Precision cancer mouse models through genome editing with CRISPR-Cas9.

Genome Med 2015 9;7(1):53. Epub 2015 Jun 9.

RNA Therapeutics Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605 USA.

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http://dx.doi.org/10.1186/s13073-015-0178-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460969PMC
June 2015

A versatile reporter system for CRISPR-mediated chromosomal rearrangements.

Genome Biol 2015 May 28;16:111. Epub 2015 May 28.

RNA Therapeutics Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1186/s13059-015-0680-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465146PMC
May 2015