Publications by authors named "Daniel E Speiser"

100Publications

COVID-19: Mechanisms of Vaccination and Immunity.

Vaccines (Basel) 2020 Jul 22;8(3). Epub 2020 Jul 22.

International Immunology Centre, Anhui Agricultural University, Hefei 230036, China.

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http://dx.doi.org/10.3390/vaccines8030404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564472PMC
July 2020

The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.

Nat Immunol 2020 Sep 13;21(9):1034-1045. Epub 2020 Jul 13.

Department of Dermatology, CHUV University Hospital, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41590-020-0721-6DOI Listing
September 2020

Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b by combinatorial peptide library screening.

Mol Immunol 2020 09 6;125:43-50. Epub 2020 Jul 6.

Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2020.06.025DOI Listing
September 2020

Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination.

Hum Vaccin Immunother 2020 Apr 29:1-8. Epub 2020 Apr 29.

Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne , Epalinges, Switzerland.

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http://dx.doi.org/10.1080/21645515.2020.1750249DOI Listing
April 2020

Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma.

Cancer Immunol Res 2020 04 4;8(4):556-564. Epub 2020 Feb 4.

Department of Oncology UNIL CHUV and Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0504DOI Listing
April 2020

Minimal immune response to booster vaccination against Yellow Fever associated with pre-existing antibodies.

Vaccine 2020 02 31;38(9):2172-2182. Epub 2020 Jan 31.

Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2020.01.045DOI Listing
February 2020

Analysis of cancer cell-intrinsic immune regulation in response to CD8+ T cell attack.

Methods Enzymol 2020 1;631:443-466. Epub 2019 Aug 1.

Department of Oncology, University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.05.035DOI Listing
August 2019

Intratumoral CD8 T cells with stem cell-like properties: Implications for cancer immunotherapy.

Sci Transl Med 2019 10;11(515)

Department of Oncology, University of Lausanne, Ch. des Boveresses 155, CH-1066 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/scitranslmed.aay6863DOI Listing
October 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201970107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350392PMC
October 2019

Defining 'T cell exhaustion'.

Nat Rev Immunol 2019 11 30;19(11):665-674. Epub 2019 Sep 30.

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.1038/s41577-019-0221-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286441PMC
November 2019

Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma.

Front Immunol 2019 6;10:2115. Epub 2019 Sep 6.

Department of Oncology, Lausanne University Hospital Center (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.3389/fimmu.2019.02115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742971PMC
October 2020

Virus-like particles for vaccination against cancer.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2020 01 27;12(1):e1579. Epub 2019 Aug 27.

Department of BioMedical Research, Immunology RIA, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/wnan.1579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916610PMC
January 2020

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts.

PLoS Biol 2019 07 15;17(7):e3000072. Epub 2019 Jul 15.

Center for Immunity and Infection Lausanne, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.3000072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657915PMC
July 2019

Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.

Exp Gerontol 2019 09 14;124:110633. Epub 2019 Jun 14.

Clinical Immunology Department, Center of Molecular Immunology, 216 St, corner 15, PO box 16040, Atabey, Havana, Cuba.

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http://dx.doi.org/10.1016/j.exger.2019.110633DOI Listing
September 2019

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients.

J Exp Med 2019 05 11;216(5):1091-1107. Epub 2019 Apr 11.

Institute of Bioengineering and Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.1084/jem.20181618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504224PMC
May 2019

Circulating CD56 NK cells inversely correlate with survival of melanoma patients.

Sci Rep 2019 03 14;9(1):4487. Epub 2019 Mar 14.

Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1038/s41598-019-40933-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418246PMC
March 2019

The C-terminal extension landscape of naturally presented HLA-I ligands.

Proc Natl Acad Sci U S A 2018 05 30;115(20):5083-5088. Epub 2018 Apr 30.

Ludwig Institute for Cancer Research, Department of Fundamental Oncology, University of Lausanne, 1066 Epalinges, Switzerland;

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http://dx.doi.org/10.1073/pnas.1717277115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960288PMC
May 2018

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data.

Elife 2017 11 13;6. Epub 2017 Nov 13.

Ludwig Centre for Cancer Research, Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.7554/eLife.26476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718706PMC
November 2017

More T Cells versus Better T Cells in Patients with Breast Cancer.

Cancer Discov 2017 10;7(10):1062-1064

Department of Oncology and Ludwig Cancer Research, University of Lausanne, Switzerland.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0858DOI Listing
October 2017

Tumor infiltrating lymphocytes in lymph node metastases of stage III melanoma correspond to response and survival in nine patients treated with ipilimumab at the time of stage IV disease.

Cancer Immunol Immunother 2018 01 11;67(1):39-45. Epub 2017 Sep 11.

Department of Dermatology/Allergology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland.

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http://dx.doi.org/10.1007/s00262-017-2061-4DOI Listing
January 2018

TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency.

JCI Insight 2017 Jul 20;2(14). Epub 2017 Jul 20.

Department of Oncology, Lausanne University Hospital Center (CHUV) and University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1172/jci.insight.92570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518551PMC
July 2017

Heterogeneity assessment of functional T cell avidity.

Sci Rep 2017 03 13;7:44320. Epub 2017 Mar 13.

Ludwig Cancer Research Center, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/srep44320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347081PMC
March 2017

Broad and Conserved Immune Regulation by Genetically Heterogeneous Melanoma Cells.

Cancer Res 2017 04 19;77(7):1623-1636. Epub 2017 Jan 19.

Ludwig Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2680DOI Listing
April 2017

T memory stem cells in health and disease.

Nat Med 2017 01;23(1):18-27

Experimental Hematology Unit, Division of Immunology Transplantation and Infectious Diseases, Leukemia Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/nm.4241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354775PMC
January 2017

Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer.

Oncoimmunology 2016 19;5(11):e1231292. Epub 2016 Sep 19.

Department of Dermatology and Allergology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; Institute of Immunobiolology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1080/2162402X.2016.1231292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139632PMC
September 2016

Rapid and Continued T-Cell Differentiation into Long-term Effector and Memory Stem Cells in Vaccinated Melanoma Patients.

Clin Cancer Res 2017 07 21;23(13):3285-3296. Epub 2016 Nov 21.

Department of Oncology, Lausanne University Hospital Center (CHUV) and University of Lausanne, Epalinges, Switzerland.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-16-1708DOI Listing
July 2017

Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?

J Immunother 2016 Nov/Dec;39(9):379-382

Departments of *Oncology ‡Ophthalmology #Dermatology/Allergology **Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen †Department of Oncology, Hospital Grabs, Grabs §Ludwig Cancer Research Center, University of Lausanne, Lausanne ∥Department of Dermatology ¶Private Ophthalmic Practice in Cooperation with the Skin Cancer Unit, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1097/CJI.0000000000000143DOI Listing
December 2017

A Well-Controlled Experimental System to Study Interactions of Cytotoxic T Lymphocytes with Tumor Cells.

Front Immunol 2016 30;7:326. Epub 2016 Aug 30.

Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Epalinges , Switzerland.

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http://dx.doi.org/10.3389/fimmu.2016.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003846PMC
September 2016

Regulatory circuits of T cell function in cancer.

Nat Rev Immunol 2016 10 16;16(10):599-611. Epub 2016 Aug 16.

Department of Oncology, Ludwig Cancer Research, University of Lausanne, Biopole 3 - 02DB92, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1038/nri.2016.80DOI Listing
October 2016

Anticancer Teamwork: Cross-Presenting Dendritic Cells Collaborate with Therapeutic Monoclonal Antibodies.

Cancer Discov 2016 Jan;6(1):17-9

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Canada. Department of Oncology and Ludwig Center for Cancer Research, University of Lausanne, Switzerland.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1366DOI Listing
January 2016

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens.

Front Immunol 2015 18;6:582. Epub 2015 Nov 18.

Department of Oncology, Lausanne University Hospital Center (CHUV), University of Lausanne , Epalinges , Switzerland ; Ludwig Center for Cancer Research, University of Lausanne , Epalinges , Switzerland.

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http://dx.doi.org/10.3389/fimmu.2015.00582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649060PMC
December 2015

Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans.

Genom Data 2015 Sep 2;5:297-301. Epub 2015 Jul 2.

Ludwig Cancer Center, University of Lausanne, Switzerland ; Department of Oncology, Lausanne University Hospital (CHUV), Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S22135960150013
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http://dx.doi.org/10.1016/j.gdata.2015.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583680PMC
September 2015

Inhibitory Receptors Beyond T Cell Exhaustion.

Front Immunol 2015 26;6:310. Epub 2015 Jun 26.

Ludwig Cancer Research Center, University of Lausanne , Lausanne , Switzerland ; Department of Oncology, Lausanne University Hospital (CHUV) , Lausanne , Switzerland.

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http://dx.doi.org/10.3389/fimmu.2015.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481276PMC
July 2015

Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion.

EMBO J 2015 Aug 2;34(15):2042-58. Epub 2015 Jul 2.

Centre d'Immunologie de Marseille-Luminy (CIML), UM2 Aix-Marseille Université, Marseille Cedex 9, France INSERM U1104, Marseille, France CNRS UMR7280, Marseille, France

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http://dx.doi.org/10.15252/embj.201490786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551351PMC
August 2015

From T cell "exhaustion" to anti-cancer immunity.

Biochim Biophys Acta 2016 Jan 27;1865(1):49-57. Epub 2015 Jun 27.

Ludwig Cancer Research Center and Department of Oncology, Clinical Tumor Biology & Immunotherapy Group, Lausanne University Hospital Center (CHUV) and University of Lausanne, Route de la Corniche 9A, CH-1066 Epalinges, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2015.06.007DOI Listing
January 2016

Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence.

J Immunol 2015 Jul 22;195(1):356-66. Epub 2015 May 22.

Department of Oncology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland; and Ludwig Center for Cancer Research, University of Lausanne, CH-1011 Lausanne, Switzerland

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http://www.jimmunol.org/content/early/2015/05/22/jimmunol.14
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1403145
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http://dx.doi.org/10.4049/jimmunol.1403145DOI Listing
July 2015

Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination.

Sci Transl Med 2015 Apr;7(282):282ra48

Ludwig Cancer Center, University of Lausanne, Epalinges CH-1066, Switzerland. Department of Oncology, University Hospital of Lausanne (Centre Hospitalier Universitaire Vaudois), Lausanne CH-1011, Switzerland.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aaa3700DOI Listing
April 2015

Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells.

Cancer Res 2015 May 25;75(10):1983-91. Epub 2015 Mar 25.

Department of Oncology, Lausanne University Hospital Center and University of Lausanne, Lausanne, Switzerland. Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland.

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http://cancerres.aacrjournals.org/content/75/10/1983.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-3516DOI Listing
May 2015

Cancer immunotherapy drives implementation science in oncology.

Hum Vaccin Immunother 2014 ;10(11):3107-10

a Ludwig Cancer Research Center; Department of Oncology; Faculty of Biology and Medicine ; University of Lausanne ; Lausanne , Switzerland.

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http://dx.doi.org/10.4161/21645515.2014.983000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514085PMC
October 2015

Classification of current anticancer immunotherapies.

Oncotarget 2014 Dec;5(24):12472-508

Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. INSERM, U1138, Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Pôle de Biologie, Hôpital Européen Georges Pompidou (HEGP), AP-HP, Paris, France.

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https://lirias.kuleuven.be/bitstream/123456789/502976/1/2998
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http://oncotarget.com/abstract/2998
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350348PMC
http://dx.doi.org/10.18632/oncotarget.2998DOI Listing
December 2014

Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma.

Cancer Immunol Res 2014 Dec 2;2(12):1148-53. Epub 2014 Oct 2.

Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0143DOI Listing
December 2014

T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

Nat Rev Immunol 2014 11 26;14(11):768-74. Epub 2014 Sep 26.

Swiss Vaccine Research Institute, Centre des laboratoires d'Epalinges, 1066 Epalinges, Switzerland, and the Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.

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http://www.nature.com/articles/nri3740
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November 2014

Deciphering the unusual HLA-A2/Melan-A/MART-1-specific TCR repertoire in humans.

Eur J Immunol 2014 Sep;44(9):2567-70

Ludwig Cancer Research Center, Department of Oncology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/eji.201445004DOI Listing
September 2014

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.

Front Immunol 2013 19;4:455. Epub 2013 Dec 19.

Clinical Tumor Biology and Immunotherapy Unit, Department of Oncology, Ludwig Center for Cancer Research, Lausanne University Hospital (CHUV) , Lausanne , Switzerland.

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http://journal.frontiersin.org/article/10.3389/fimmu.2013.00
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867683PMC
January 2014

Mobilizing and evaluating anticancer T cells: pitfalls and solutions.

Expert Rev Vaccines 2013 Nov 16;12(11):1325-40. Epub 2013 Oct 16.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada.

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http://www.tandfonline.com/doi/full/10.1586/14760584.2013.84
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November 2013

Clinical Implications of CD8+ T-cell infiltration in frequent and rare cancers.

J Invest Dermatol 2013 Aug;133(8):1929-32

Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/jid.2013.90DOI Listing
August 2013

Molecular insights for optimizing T cell receptor specificity against cancer.

Front Immunol 2013 19;4:154. Epub 2013 Jun 19.

Department of Oncology, Lausanne University Hospital Center (CHUV), University of Lausanne , Lausanne , Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685811PMC
June 2013

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

Nat Immunol 2013 Jun 5;14(6):603-10. Epub 2013 May 5.

Swiss Vaccine Research Institute, Epalinges, Switzerland.

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June 2013

Hit parade for adoptive cell transfer therapy: the best T cells for superior clinical responses.

Authors:
Daniel E Speiser

Cancer Discov 2013 Apr;3(4):379-81

Department of Oncology and Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0064DOI Listing
April 2013

SHP-1 phosphatase activity counteracts increased T cell receptor affinity.

J Clin Invest 2013 Mar 8;123(3):1044-56. Epub 2013 Feb 8.

Department of Oncology, Lausanne University Hospital Center and University of Lausanne, Lausanne, Switzerland.

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http://www.jci.org/articles/view/65325
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http://dx.doi.org/10.1172/JCI65325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582132PMC
March 2013

Conference scene: Immune signatures in the tumor and beyond.

Immunotherapy 2012 Aug;4(8):761-72

Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, PA, USA.

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http://dx.doi.org/10.2217/imt.12.70DOI Listing
August 2012

CpG-ODN-induced sustained expression of BTLA mediating selective inhibition of human B cells.

J Mol Med (Berl) 2013 Feb 19;91(2):195-205. Epub 2012 Aug 19.

INSERM U1068, Centre de Recherche en Cancérologie de Marseille, Marseille, 13009, France.

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http://dx.doi.org/10.1007/s00109-012-0943-7DOI Listing
February 2013

A stepwise protocol to coat aAPC beads prevents out-competition of anti-CD3 mAb and consequent experimental artefacts.

J Immunol Methods 2012 Nov 31;385(1-2):90-5. Epub 2012 Jul 31.

Clinical Tumor Biology and Immunotherapy Unit, Ludwig Center for Cancer Research of the University of Lausanne, CH-1011 Lausanne, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S002217591200228
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November 2012

Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma.

Int J Cancer 2013 Feb 3;132(3):E85-93. Epub 2012 Oct 3.

Department of Otolaryngology and Head and Neck Surgery, University Hospital CHUV, Lausanne, Switzerland.

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http://doi.wiley.com/10.1002/ijc.27728
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February 2013