Publications by authors named "Daniel D Von Hoff"

100Publications

Phase 1 Clinical Trials in the Elderly: Enrollment Challenges.

J Adv Pract Oncol 2020 Jul 1;11(5):494-501. Epub 2020 Jul 1.

HonorHealth Research Institute, Scottsdale, Arizona.

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July 2020

Single-Cell Sequencing in Precision Medicine.

Cancer Treat Res 2019 ;178:237-252

Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, USA.

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June 2019

Triptolide and Its Derivatives as Cancer Therapies.

Trends Pharmacol Sci 2019 05 8;40(5):327-341. Epub 2019 Apr 8.

Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, USA. Electronic address:

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May 2019

NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors.

Eur J Cancer 2019 02 14;108:78-87. Epub 2019 Jan 14.

National Health Research Institutes - National Institute of Cancer Research, No. 367, Sheng-Li Road, Tainan, 70456, Taiwan.

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February 2019

Quality of life in metastatic pancreatic cancer patients receiving liposomal irinotecan plus 5-fluorouracil and leucovorin.

Eur J Cancer 2019 01 17;106:24-33. Epub 2018 Nov 17.

Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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January 2019

Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.

PLoS One 2017 25;12(8):e0183871. Epub 2017 Aug 25.

Molecular Medicine Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America.

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October 2017

Tumor-Treating Fields: A Fourth Modality in Cancer Treatment.

Clin Cancer Res 2018 01 1;24(2):266-275. Epub 2017 Aug 1.

Virginia G. Piper Cancer Center Clinical Trials, HonorHealth Research Institute, Scottsdale, Arizona.

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January 2018

Pancreatic Cancer: "A Riddle Wrapped in a Mystery inside an Enigma".

Clin Cancer Res 2017 Apr;23(7):1629-1637

HonorHealth, Scottsdale, Arizona and TGen, Phoenix, Arizona.

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April 2017

Tumor Reduction in Primary and Metastatic Pancreatic Cancer Lesions With nab-Paclitaxel and Gemcitabine: An Exploratory Analysis From a Phase 3 Study.

Pancreas 2017 02;46(2):203-208

From the *Medizinische Klinik und Poliklinik II, University of Würzburg, Würzburg, Germany; †Mayo Clinic, Scottsdale, AZ; ‡Prince of Wales Hospital, Sydney, New South Wales, Australia; §Celgene Corporation, Summit, NJ; and ∥Translational German Research Institute and Honor Health Research Institute, Scottsdale, AZ.

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February 2017

Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells.

PLoS One 2016 28;11(10):e0165586. Epub 2016 Oct 28.

Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America.

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June 2017

Hypoxia-activated prodrugs in the treatment of advanced pancreatic adenocarcinoma.

Anticancer Drugs 2017 02;28(2):127-132

aVirginia G Piper Cancer Center Clinical Trials, HonorHealth Research Institute bDepartment of Internal Medicine, Division of Hematology-Oncology, Mayo Clinic Cancer Center, Scottsdale cClinical Translational Research Division, Translational Genomics Research Institute (TGen), Phoenix dDepartment of Internal Medicine, Division of Hematology Oncology, University of Arizona Cancer Center eDepartment of Internal Medicine, University of Arizona, Tucson, Arizona fDepartment of Molecular Medicine, Centre for Individualized Medicine, Rochester, Minnesota, USA gDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

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February 2017

Dose modification and efficacy of nab-paclitaxel plus gemcitabine vs. gemcitabine for patients with metastatic pancreatic cancer: phase III MPACT trial.

J Gastrointest Oncol 2016 Jun;7(3):469-78

1 Medizinische Universität Wien, Wien, Austria ; 2 Division of Hematology/Oncology, Mayo Clinic, Scottsdale, Arizona, USA ; 3 BC Cancer Agency, Vancouver, British Columbia, Canada ; 4 Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain ; 5 Prince of Wales Hospital, Sydney, NSW, Australia ; 6 Hôpital Beaujon, Clichy, France ; 7 Universitätsklinikum Würzburg, Würzburg, Germany ; 8 Celgene Corporation, Summit, New Jersey, USA ; 9 Celgene Corporation, Boudry, Switzerland ; 10 Translational Genomics Research Institute and Honor Health, Scottsdale, Arizona, USA.

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June 2016

Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.

Lancet 2016 Feb 29;387(10018):545-557. Epub 2015 Nov 29.

National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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February 2016

Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review.

World J Gastrointest Oncol 2015 Sep;7(9):132-40

Erkut Borazanci, Daniel D Von Hoff, HonorHealth Research Institute, Virginia G. Piper Cancer Center, Scottsdale, AZ 85258, United States.

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September 2015

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

N Engl J Med 2015 Jul;373(5):428-37

From Memorial Sloan Kettering Cancer Center (W.D.T., J.H.H.) and Weill Cornell Medical College (W.D.T.) - both in New York; University of California, Los Angeles, Medical Center, Los Angeles (Z.A.W., B.C., A.S.S.), Plexxikon, Berkeley (P.N.I., C.Z., J.Z., G.H., Y.Z., E.A.B., G.V., L.S., P.S., H.N., M.J.K., A.M., G.T., R.S., C.G., B.L.W., P.H., K.N., H.H.H., P.S.L., S.T.-S., G.B.), and Stanford University School of Medicine, Stanford (M.R.) - all in California; Evergreen Hematology and Oncology, Spokane, WA (S.P.A.); University of Pennsylvania School of Medicine, Philadelphia (A.P.S.); Rocky Mountain Cancer Centers, Denver (A.L.C.); Dana-Farber Cancer Institute (G.I.S., A.J.W.) and Massachusetts General Hospital (E.L.K.) - both in Boston; Vanderbilt University Medical Center, Nashville (V.L.K., I.P.); Virginia G. Piper Cancer Center at Scottsdale Healthcare-Translational Genomics Research Institute (TGen), Scottsdale, AZ (D.D.V.H., G.J.W., R.K.R.); and Spire Sciences, Boca Raton, FL (C.P.).

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July 2015

Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer: Normalization, Not Destruction.

Cancer J 2015 Jul-Aug;21(4):299-306

From the Clinical Translational Research Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ.

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May 2016

Use of mechanistic models to integrate and analyze multiple proteomic datasets.

Biophys J 2015 Apr;108(7):1819-1829

Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, Arizona; Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico. Electronic address:

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April 2015

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer.

Clin Cancer Res 2015 Aug 18;21(15):3561-8. Epub 2015 Feb 18.

Clinical Translational Research Division, The Translational Genomics Research Institute, Phoenix, Arizona.

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August 2015

nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial.

J Natl Cancer Inst 2015 Feb 31;107(2). Epub 2015 Jan 31.

Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia (DG); Royal Victoria Regional Health Centre, Barrie, ON, Canada (RHEM); Hôpital Beaujon, Clichy, France (PH); Klinikum Grosshadern, University of Munich, Munich, Germany (VH); Universitätsklinikum Würzburg, Würzburg, Germany (VK); Hospital Clinico San Carlos, Madrid, Spain (JS); Medizinische Universität Wien, Wien, Austria (WS); Ospedale Niguarda Ca' Granda, Milan, Italy (SS); Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain (JT); Hôpital Saint Antoine, Paris, France (LT); Azienda Ospedaliera Universitaria Integrata and University of Verona, Verona, Italy (GT); Hôpital Erasme, Brussels, Belgium (JLVL); Royal Hobart Hospital, Hobart, Australia (RY); Celgene Corporation, Summit, NJ (DNP); Celgene Corporation, Summit, NJ (BL); Celgene Corporation, Boudry, Switzerland (AR); Virginia G. Piper Cancer Center at Scottsdale Healthcare/TGen, Scottsdale, AZ (DDVH).

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February 2015

Prognostic factors of survival in a randomized phase III trial (MPACT) of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic pancreatic cancer.

Oncologist 2015 Feb 12;20(2):143-50. Epub 2015 Jan 12.

Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain; Division of Oncology, University of Washington, Seattle, Washington, USA; Department of Oncology/Hematology, Sarah Cannon Research Institute, Nashville, Tennessee, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Oncology, Peninsula Oncology Centre, Monash University, Frankston, Victoria, Australia; Division of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA; Division of Clinical Oncology, Medizinische Universität Wien, Vienna, Austria; Mayo Clinic, Scottsdale, Arizona, USA; Department of Oncology, Prince of Wales Hospital, Randwick, New South Wales, Sydney, Australia; Celgene Corporation, Summit, New Jersey, USA; Department of Oncology, Virginia G. Piper Cancer Center at Scottsdale Healthcare/TGen, Scottsdale, Arizona, USA.

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February 2015

Comprehensive tumor profiling identifies numerous biomarkers of drug response in cancers of unknown primary site: analysis of 1806 cases.

Oncotarget 2014 Dec;5(23):12440-7

Translational Genomic Research Institute and Virginia G Piper Cancer Center, Phoenix, United States of America.

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December 2014

Nab-paclitaxel and gemcitabine for the treatment of patients with metastatic pancreatic cancer.

Expert Rev Gastroenterol Hepatol 2014 Sep 31;8(7):739-47. Epub 2014 May 31.

Translational Genomics Research Institute, Phoenix, AZ, USA.

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September 2014

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.

Cancer Discov 2014 Aug 29;4(8):905-13. Epub 2014 May 29.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute;

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August 2014

Taxanes: impact on pancreatic cancer.

Anticancer Drugs 2014 May;25(5):584-92

aDepartment of Medicine, University of Washington, Seattle, Washington bTranslational Genomics Research Institute (TGen)/Virginia Piper Cancer Center, Scottsdale, Arizona, USA.

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May 2014

Discrimination between adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysis.

J Proteome Res 2014 Feb 12;13(2):395-407. Epub 2013 Dec 12.

Complex Carbohydrate Research Center, ‡Chemistry Department, and §Department of Biochemistry and Molecular Biology, University of Georgia , Athens, Georgia 30602, United States.

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February 2014

A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges.

PLoS One 2013 30;8(10):e76438. Epub 2013 Oct 30.

Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare (VGPCC), Scottsdale, Arizona, United States of America ; The Translational Genomics Research Institute, Phoenix, Arizona, United States of America.

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August 2014

Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.

N Engl J Med 2013 Oct 16;369(18):1691-703. Epub 2013 Oct 16.

From the Translational Genomics Research Institute, Phoenix, and Virginia G. Piper Cancer Center, Scottsdale - both in Arizona (D.D.V.H., R.K.R.); Cancer Specialists, Fort Myers, FL (T.E.); Arena Oncology Associates, Lake Success (F.P.A.), and Roswell Park Cancer Institute, Buffalo (W.W.M.) - both in New York; University of Washington, Seattle (E.G.C.); Sarah Cannon Research Institute-Tennessee Oncology, Nashville (J. Infante); Princess Margaret Hospital, Toronto (M.M.); Atlanta Cancer Care (T.S.) and Georgia Cancer Specialists (M.N.S.) - both in Atlanta; Blokhin Cancer Research Center, Moscow (S.A.T.); Southern Health, East Bentleigh, VIC (M.H.), Prince of Wales Hospital, Sydney (D.G.), and Bionomics, Thebarton, SA (J. Iglesias) - all in Australia; San Raffaele Scientific Institute, Milan (M.R.); Tom Baker Cancer Centre, Calgary, AB, Canada (S.D.); Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (D.L.); University of Pittsburgh Medical Center, Pittsburgh (N.B.); Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona (J.T.); Centro Integral Oncológico Clara Campal, Madrid (M.H.); University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium (E.V.C.); and Celgene, Summit, NJ (X.W., M.F.R.).

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October 2013

Targeting the nucleolus for cancer-specific activation of p53.

Drug Discov Today 2014 Mar 28;19(3):259-65. Epub 2013 Aug 28.

The Translational Genomics Research Institute, 445 N. Fifth Street, Phoenix, AZ 85004, USA. Electronic address:

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March 2014

Isolation and characterization of muscle fatigue substance with anti-tumor activities.

J Cancer 2013 9;4(4):343-9. Epub 2013 May 9.

Division of Clinical Translational Research, Translational Genomics Research Institute, Scottsdale, Arizona, USA.

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May 2013

Identification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs.

BMC Genomics 2013 May 4;14:302. Epub 2013 May 4.

Translational Genomics Research Institute, Neurogenomics Division, Phoenix, AZ 85004, USA.

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May 2013

SnapShot: pancreatic cancer.

Cancer Cell 2013 Mar;23(3):424-424.e1

Translational Genomics Research Institute, Phoenix, AZ 85004, USA.

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March 2013

Clonal evolution and therapeutic resistance in solid tumors.

Front Pharmacol 2013 28;4. Epub 2013 Jan 28.

The Translational Genomics Research Institute Scottsdale, AZ, USA ; Mayo Clinic Arizona Scottsdale, AZ, USA.

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February 2013

Tumor-stromal interactions in pancreatic cancer.

Crit Rev Oncog 2013 ;18(1-2):135-51

Clinical Translational Research Division, The Translational Genomics Research Institute (TGEN), Phoenix, Arizona 85004, USA.

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July 2013

Genomic analysis and selected molecular pathways in rare cancers.

Phys Biol 2012 Dec 29;9(6):065004. Epub 2012 Nov 29.

Norris Comprehensive Cancer Center, Division of Medical Oncology, University of Southern California, Los Angeles, CA, USA.

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December 2012

Characterization of a membrane-active anti-tumor agent, UA8967.

Invest New Drugs 2013 Jun 23;31(3):576-86. Epub 2012 Nov 23.

University of Arizona Cancer Center, 1515 N. Campbell Ave, Rm 4963C, Tucson, AZ 85724-5024, USA.

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June 2013

Determinants of patient screen failures in Phase 1 clinical trials.

Invest New Drugs 2013 Jun 8;31(3):774-9. Epub 2012 Nov 8.

Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, 10510 N 92nd St. Ste 200, Scottsdale, AZ, 85258, USA.

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June 2013

Translational therapeutic opportunities in ductal adenocarcinoma of the pancreas.

Clin Cancer Res 2012 Aug;18(16):4249-56

Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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August 2012