Daniel Christ

Daniel Christ

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Daniel Christ

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Systematic functional identification of cancer multi-drug resistance genes.

Genome Biol 2020 Feb 7;21(1):27. Epub 2020 Feb 7.

The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life & Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1186/s13059-020-1940-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006212PMC
February 2020

GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.

Int J Obes (Lond) 2019 12 31;43(12):2370-2380. Epub 2019 May 31.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1038/s41366-019-0365-5DOI Listing
December 2019

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity.

Immunol Rev 2019 11 26;292(1):61-75. Epub 2019 Sep 26.

Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1111/imr.12808DOI Listing
November 2019

Protein A superantigen: structure, engineering and molecular basis of antibody recognition.

Protein Eng Des Sel 2019 Oct 22. Epub 2019 Oct 22.

Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1093/protein/gzz026DOI Listing
October 2019

Expression of Human VH Single Domains as Fc Fusions in Mammalian Cells.

Methods Mol Biol 2019 ;1953:121-136

Immunology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-4939-9145-7_8DOI Listing
July 2019

Selection of Antibody Fragments Against Structured DNA by Phage Display.

Methods Mol Biol 2018 ;1827:197-209

Garvan Institute of Medical Research, Sydney, NSW, Australia.

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http://link.springer.com/10.1007/978-1-4939-8648-4_11
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http://dx.doi.org/10.1007/978-1-4939-8648-4_11DOI Listing
April 2019

Expression of IgG Monoclonals with Engineered Immune Effector Functions.

Methods Mol Biol 2018 ;1827:313-334

Garvan Institute of Medical Research, Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-4939-8648-4_16DOI Listing
April 2019

Human Antibody Bispecifics through Phage Display Selection.

Biochemistry 2019 04 22;58(13):1701-1704. Epub 2019 Mar 22.

Garvan Institute of Medical Research , 384 Victoria Road , Darlinghurst, Sydney , New South Wales 2010 , Australia.

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http://dx.doi.org/10.1021/acs.biochem.9b00037DOI Listing
April 2019

Next-Generation Sequencing of Antibody Display Repertoires.

Front Immunol 2018 2;9:118. Epub 2018 Feb 2.

Garvan Institute of Medical Research, Sydney, NSW, Australia.

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http://dx.doi.org/10.3389/fimmu.2018.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810246PMC
March 2019

Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis.

ACS Chem Biol 2019 03 21;14(3):554-561. Epub 2019 Feb 21.

Garvan Institute of Medical Research , Darlinghurst , New South Wales , Australia.

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http://dx.doi.org/10.1021/acschembio.9b00116DOI Listing
March 2019

Crystal structure of duck egg lysozyme isoform II (DEL-II).

BMC Struct Biol 2018 08 22;18(1):10. Epub 2018 Aug 22.

Immunology Division, Garvan Institute of Medical Research, 384 Victoria Road, Darlinghurst, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1186/s12900-018-0090-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103880PMC
August 2018

I-motif DNA structures are formed in the nuclei of human cells.

Nat Chem 2018 06 23;10(6):631-637. Epub 2018 Apr 23.

Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/s41557-018-0046-3DOI Listing
June 2018

Transient expression of human antibodies in mammalian cells.

Nat Protoc 2018 Jan 14;13(1):99-117. Epub 2017 Dec 14.

Garvan Institute of Medical Research, Sydney, Australia.

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http://dx.doi.org/10.1038/nprot.2017.126DOI Listing
January 2018

Structural basis of antigen recognition: crystal structure of duck egg lysozyme.

Acta Crystallogr D Struct Biol 2017 Nov 25;73(Pt 11):910-920. Epub 2017 Oct 25.

Immunology Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1107/S2059798317013730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683014PMC
November 2017

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes.

Cell Rep 2017 Nov;21(6):1624-1638

Department of Immunology, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, Department of Medicine, University of New South Wales, Sydney, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.044DOI Listing
November 2017

IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.

J Immunol 2017 10 23;199(7):2366-2376. Epub 2017 Aug 23.

Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia; and

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http://dx.doi.org/10.4049/jimmunol.1700335DOI Listing
October 2017

Structural reconstruction of protein ancestry.

Proc Natl Acad Sci U S A 2017 04 29;114(15):3897-3902. Epub 2017 Mar 29.

Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia;

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http://dx.doi.org/10.1073/pnas.1613477114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393204PMC
April 2017

Circumventing the stability-function trade-off in an engineered FN3 domain.

Protein Eng Des Sel 2016 Nov;29(11):541-550

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.

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http://dx.doi.org/10.1093/protein/gzw046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081044PMC
November 2016

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.

J Exp Med 2016 06 13;213(7):1255-65. Epub 2016 Jun 13.

Department of Immunology, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, NSW 2010, Australia

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http://dx.doi.org/10.1084/jem.20151978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925023PMC
June 2016

Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis.

Protein Eng Des Sel 2015 Oct 15;28(10):445-50. Epub 2015 Apr 15.

Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia Faculty of Medicine, St Vincent's Clinical School, The University of New South Wales, Darlinghurst, Sydney, NSW 2010, Australia

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http://dx.doi.org/10.1093/protein/gzv021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661788PMC
October 2015

Challenges and opportunities for non-antibody scaffold drugs.

Drug Discov Today 2015 Oct 7;20(10):1271-83. Epub 2015 Sep 7.

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia; The University of New South Wales, Faculty of Medicine, St Vincent's Clinical School, Darlinghurst, Sydney, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.09.004DOI Listing
October 2015

Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies.

J Biol Chem 2015 May 3;290(19):11905-17. Epub 2015 Mar 3.

From the Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia and the Faculty of Medicine, St. Vincent's Clinical School, University of New South Wales, Darlinghurst, Sydney, New South Wales 2010, Australia

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http://dx.doi.org/10.1074/jbc.M114.614842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424330PMC
May 2015

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

Immunity 2015 May 12;42(5):890-902. Epub 2015 May 12.

Immunology Division, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Australia, Darlinghurst, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.04.010DOI Listing
May 2015

Identification of aggregation inhibitors of the human antibody light chain repertoire by phage display.

Protein Eng Des Sel 2014 Oct 22;27(10):405-9. Epub 2014 Jul 22.

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia The University of New South Wales, Faculty of Medicine, St Vincent's Clinical School, Darlinghurst, Sydney, NSW 2010, Australia

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http://dx.doi.org/10.1093/protein/gzu026DOI Listing
October 2014

Bispecific antibodies with native chain structure.

Nat Biotechnol 2014 Feb;32(2):136-7

Garvan Institute of Medical Research and at the University of New South Wales, Faculty of Medicine, Darlinghurst, Sydney, Australia.

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http://dx.doi.org/10.1038/nbt.2812DOI Listing
February 2014

Stability engineering of the human antibody repertoire.

FEBS Lett 2014 Jan 28;588(2):269-77. Epub 2013 Nov 28.

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia; The University of New South Wales, Faculty of Medicine, St Vincent's Clinical School, Darlinghurst, Sydney, NSW 2010, Australia.

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http://doi.wiley.com/10.1016/j.febslet.2013.11.029
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http://dx.doi.org/10.1016/j.febslet.2013.11.029DOI Listing
January 2014

Rapid prediction of expression and refolding yields using phage display.

Protein Eng Des Sel 2013 Oct 19;26(10):671-4. Epub 2013 May 19.

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1093/protein/gzt019DOI Listing
October 2013

Purification of molecular machines and nanomotors using phage-derived monoclonal antibody fragments.

Methods Mol Biol 2013 ;996:203-17

CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain.

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http://dx.doi.org/10.1007/978-1-62703-354-1_12DOI Listing
September 2013

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells.

Nat Immunol 2013 May 17;14(5):446-53. Epub 2013 Mar 17.

Immunological Diseases Division, Garvan Institute of Medical Research, Darlinghurst, Australia.

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http://www.nature.com/articles/ni.2555
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http://dx.doi.org/10.1038/ni.2555DOI Listing
May 2013

Selection of human VH single domains with improved biophysical properties by phage display.

Methods Mol Biol 2012 ;911:383-97

Garvan Institute of Medical Research, Darlinghurst/Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-61779-968-6_23DOI Listing
December 2012

Generation of human single domain antibody repertoires by Kunkel mutagenesis.

Methods Mol Biol 2012 ;907:195-209

Garvan Institute of Medical Research, Darlinghurst/Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-61779-974-7_10DOI Listing
December 2012

General strategy for the generation of human antibody variable domains with increased aggregation resistance.

Proc Natl Acad Sci U S A 2012 Jul 27;109(27):10879-84. Epub 2012 Jun 27.

Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1202866109
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http://dx.doi.org/10.1073/pnas.1202866109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390889PMC
July 2012

Expression of high-affinity human antibody fragments in bacteria.

Nat Protoc 2012 Feb 2;7(2):364-73. Epub 2012 Feb 2.

Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.

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https://vetbiotech.um.ac.ir/parameters/vetbiotech/filemanage
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http://www.nature.com/doifinder/10.1038/nprot.2011.448
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http://dx.doi.org/10.1038/nprot.2011.448DOI Listing
February 2012

A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.

Immunity 2011 Apr;34(4):602-15

Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.immuni.2011.01.021DOI Listing
April 2011

Expression, purification and characterization of recombinant interleukin-21.

J Immunol Methods 2010 Oct 25;362(1-2):185-9. Epub 2010 Aug 25.

Garvan Institute of Medical Research, Darlinghurst/Sydney, Australia.

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http://dx.doi.org/10.1016/j.jim.2010.08.008DOI Listing
October 2010

Sequence determinants of protein aggregation in human VH domains.

Protein Eng Des Sel 2009 Mar 28;22(3):217-20. Epub 2008 Oct 28.

Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.

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http://dx.doi.org/10.1093/protein/gzn059DOI Listing
March 2009

Selection of human antibody fragments by phage display.

Nat Protoc 2007 ;2(11):3001-8

Garvan Institute of Medical Research, 384 Victoria Road, Darlinghurst, Sydney New South Wales 2010, Australia.

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http://dx.doi.org/10.1038/nprot.2007.448DOI Listing
February 2008

Engineering Escherichia coli heat-resistance by synthetic gene amplification.

Protein Eng Des Sel 2008 Feb 5;21(2):121-5. Epub 2008 Jan 5.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1093/protein/gzm085DOI Listing
February 2008

Thermodynamically stable aggregation-resistant antibody domains through directed evolution.

J Mol Biol 2008 Feb 4;376(4):926-31. Epub 2007 Nov 4.

Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.jmb.2007.10.075DOI Listing
February 2008

Repertoires of aggregation-resistant human antibody domains.

Protein Eng Des Sel 2007 Aug 24;20(8):413-6. Epub 2007 Aug 24.

Laboratory of Molecular Biology, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1093/protein/gzm037DOI Listing
August 2007

Identification of protein domains by shotgun proteolysis.

J Mol Biol 2006 Apr 13;358(2):364-71. Epub 2006 Feb 13.

Division for Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 1TQ, UK.

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http://dx.doi.org/10.1016/j.jmb.2006.01.057DOI Listing
April 2006

Identification of functional similarities between proteins using directed evolution.

Proc Natl Acad Sci U S A 2003 Nov 22;100(23):13202-6. Epub 2003 Oct 22.

Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.2134365100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263750PMC
November 2003