Daniel C Link

Daniel C Link

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TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow.

Stem Cell Reports 2019 Jul 13;13(1):48-60. Epub 2019 Jun 13.

Division of Oncology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8007, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626889PMC
July 2019

Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.

J Clin Invest 2019 04 30;129(7):2920-2931. Epub 2019 Apr 30.

Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1172/JCI124829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597218PMC
April 2019

Mechanisms of leukemic transformation in congenital neutropenia.

Authors:
Daniel C Link

Curr Opin Hematol 2019 Jan;26(1):34-40

Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447304PMC
January 2019

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.

N Engl J Med 2018 12 31;379(24):2330-2341. Epub 2018 Oct 31.

From the Division of Oncology, Department of Internal Medicine (M.J.C., A.A.P., M.P.R., C.A.M., E.C., N.M.H., L.D.W., J.S.W., S.E.H., D.C.L., M.J.W., P.W., T.J.L., J.F.D.), the McDonnell Genome Institute (A.A.P., C.A.M., M.O., C.C.F., R.S.F., L.D.W., T.J.L.), the Department of Pathology and Immunology (E.J.D., J.E.P.), and the Division of Biostatistics (J.D.B.), Washington University in St. Louis, St. Louis; the Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN (J.M.K.); the Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH (R.K.W.); and the Center for Cancer Research, Massachusetts General Hospital, Boston (T.A.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808777
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http://dx.doi.org/10.1056/NEJMoa1808777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322675PMC
December 2018

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

PLoS Biol 2018 11 2;16(11):e3000047. Epub 2018 Nov 2.

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.plos.org/10.1371/journal.pbio.3000047
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http://dx.doi.org/10.1371/journal.pbio.3000047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235378PMC
November 2018

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.

N Engl J Med 2018 Sep;379(11):1028-1041

From the Department of Pathology and Immunology (E.J.D.), the Department of Medicine, Division of Oncology (M.A.J., C.A.M., N.E., J.S., K.E., J.R., S.E.H., K.B., L.D.W., M.J.C., I.P., J.S.W., G.L.U., D.C.L., J.F.D., P.W., T.J.L., M.J.W.), the McDonnell Genome Institute (G.S.C., C.A.M., H.A., R.S.F., C.C.F., M.O.), the Department of Medicine, Division of Hospital Medicine (R.S.), and Siteman Biostatistics Shared Resource, Siteman Cancer Center (K.T.), Washington University School of Medicine in St. Louis, St. Louis; and Massachusetts General Hospital Cancer Center, Boston (T.A.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1804714
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http://dx.doi.org/10.1056/NEJMoa1804714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309244PMC
September 2018

Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.

Exp Hematol 2017 11 28;55:19-33. Epub 2017 Jul 28.

The McDonnell Genome Institute, Washington University, St. Louis, MO; Department of Medicine, Washington University, St. Louis, MO; Siteman Cancer Center, Washington University, St. Louis, MO; Department of Biomedical Engineering, Washington University, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772960PMC
November 2017

N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.

J Bone Miner Res 2017 Jun 29;32(6):1332-1342. Epub 2017 Mar 29.

Department of Internal Medicine, Division of Bone and Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.3112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466462PMC
June 2017

promotes leukemogenesis via .

Blood 2017 03;129(11):1409-1410

WASHINGTON UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2017-01-761544DOI Listing
March 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell 2017 02 16;168(5):801-816.e13. Epub 2017 Feb 16.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328582PMC
February 2017

Concise Review: The Malignant Hematopoietic Stem Cell Niche.

Stem Cells 2017 01 23;35(1):3-8. Epub 2016 Sep 23.

Departments of Medicine and Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/stem.2487DOI Listing
January 2017

Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells.

J Bone Miner Res 2016 11 14;31(11):2001-2007. Epub 2016 Jun 14.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.2877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523961PMC
November 2016

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

N Engl J Med 2016 11;375(21):2023-2036

the Department of Internal Medicine, Division of Oncology (J.S.W., L.D.W., G.L.U., A.G., M.H.T., I.P., R.R., T.A.F., K.E.S.-G., R.V., S.T.O., C.N.A., A.F.C., M.A.S., M.A.J., S.E.H., K.L., M.R.J., M.J.W., P.W., D.C.L., J.F.D., T.J.L.), and the Division of Biostatistics (J.D.B.), and the Department of Pathology and Immunology (E.J.D., B.T., Y.-S.L.), Washington University School of Medicine, and McDonnell Genome Institute, Washington University in St. Louis (A.A.P., C.A.M., C.C.F., M.O., R.S.F., R.K.W., L.D.W., T.J.L.) - both in St. Louis; the Departments of Internal Medicine (A.H., N.K., M.J.S., W.S.) and Pharmacy (R.W.K.), University of Chicago, Chicago; and the Department of Internal Medicine (T.A.G.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMoa1605949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217532PMC
November 2016

Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.

Front Endocrinol (Lausanne) 2016 30;7:87. Epub 2016 Jun 30.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Bone and Mineral Diseases Division, Washington University School of Medicine, St. Louis, MO, USA.

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http://journal.frontiersin.org/Article/10.3389/fendo.2016.00
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http://dx.doi.org/10.3389/fendo.2016.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928449PMC
July 2016

MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice.

PLoS One 2015 20;10(3):e0119304. Epub 2015 Mar 20.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119304PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368818PMC
February 2016

Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia.

Leuk Res 2015 Dec 1;39(12):1437-42. Epub 2015 Oct 1.

Division of Oncology, Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2015.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661095PMC
December 2015

The hematopoietic stem cell niche in homeostasis and disease.

Blood 2015 Nov 14;126(22):2443-51. Epub 2015 Oct 14.

Departments of Medicine and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-07-53
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http://dx.doi.org/10.1182/blood-2015-07-533588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661168PMC
November 2015

Acute ether lipid deficiency affects neutrophil biology in mice.

Cell Metab 2015 May;21(5):652-3

Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.04.018DOI Listing
May 2015

Osteoclasts are dispensable for hematopoietic progenitor mobilization by granulocyte colony-stimulating factor in mice.

Exp Hematol 2015 Feb 1;43(2):110-4.e1-2. Epub 2014 Nov 1.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323843PMC
February 2015

The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.

Curr Opin Hematol 2015 Jan;22(1):3-11

aDepartment of Medicine, University of Washington, Seattle, USA bDepartment of Molecular Hematopoiesis, Kinderklinik, MedizinischeHochschule, Hannover cInternal Medicine II, University Hospital, Tübingen, Tübingen, Germany dDepartment of Medicine, University of Washington, Severe Chronic Neutropenia International Registry, Seattle ePediatric Hematology Oncology, University of Michigan, Ann Arbor fPediatric Hematology Oncology, Saint Joseph's Children's Hospital, Paterson gDepartments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester hPediatric Hematology/Oncology, Fred Hutchinson Cancer Research Center, Seattle iBiostatistics Branch, National Cancer Institute at the National Institutes of Health, Division of Cancer Epidemiology & Genetics, Bethesda jDivision of Oncology, Washington University, St Louis, USA *Vahagn Makaryan and Cornelia Zeidler contributed equally to the writing of this article.

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http://dx.doi.org/10.1097/MOH.0000000000000105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380169PMC
January 2015

Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.

Cell Metab 2015 Jan;21(1):51-64

Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287274PMC
January 2015

Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nat Med 2014 Dec 19;20(12):1472-8. Epub 2014 Oct 19.

1] The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, USA. [2] Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA. [3] Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, USA. [4] Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nm.3733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313872PMC
December 2014

Megakaryocytes in the hematopoietic stem cell niche.

Nat Med 2014 Nov;20(11):1233-4

Department of Medicine, Washington University, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nm.3745DOI Listing
November 2014

Inherited bone marrow failure syndromes in adolescents and young adults.

Ann Med 2014 Sep 3;46(6):353-63. Epub 2014 Jun 3.

Department of Pediatrics, Washington University School of Medicine , St. Louis, MO , USA.

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http://dx.doi.org/10.3109/07853890.2014.915579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426964PMC
September 2014

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.

PLoS Genet 2014 Jul 10;10(7):e1004462. Epub 2014 Jul 10.

Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091781PMC
July 2014

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Cancer Cell 2014 Mar 6;25(3):379-92. Epub 2014 Mar 6.

The Genome Institute, Washington University, St. Louis, MO 63110, USA; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983786PMC
March 2014

Cellular complexity of the bone marrow hematopoietic stem cell niche.

Calcif Tissue Int 2014 Jan 8;94(1):112-24. Epub 2013 Oct 8.

Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA,

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http://dx.doi.org/10.1007/s00223-013-9805-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936515PMC
January 2014

Regulation of hematopoietic stem cells by bone marrow stromal cells.

Trends Immunol 2014 Jan 5;35(1):32-7. Epub 2013 Nov 5.

Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://www.cell.com/trends/immunology/pdf/S1471-4906(13)0015
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http://linkinghub.elsevier.com/retrieve/pii/S147149061300155
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http://dx.doi.org/10.1016/j.it.2013.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947365PMC
January 2014

Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.

Blood 2013 Oct 5;122(15):e44-51. Epub 2013 Sep 5.

Jane Anne Nohl Division of Hematology, Department of Medicine, University of Southern California, Los Angeles, CA;

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http://dx.doi.org/10.1182/blood-2013-03-488007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795465PMC
October 2013

Regulation of hematopoietic stem cell activity by inflammation.

Front Immunol 2013 19;4:204. Epub 2013 Jul 19.

Department of Pediatrics, Washington University School of Medicine , St. Louis, MO , USA.

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http://journal.frontiersin.org/article/10.3389/fimmu.2013.00
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http://dx.doi.org/10.3389/fimmu.2013.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715736PMC
July 2013

SNAREing a new cause of neutropenia.

Authors:
Daniel C Link

Blood 2013 Jun;121(25):4969-70

Washington University, USA.

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http://dx.doi.org/10.1182/blood-2013-05-498717DOI Listing
June 2013

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.

Nature 2013 Mar 24;495(7440):227-30. Epub 2013 Feb 24.

Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nature11926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600148PMC
March 2013

Osteocytes link bone maintenance to blood homeostasis.

Authors:
Daniel C Link

Blood 2013 Feb;121(6):867-8

Washington University, USA.

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http://dx.doi.org/10.1182/blood-2012-12-468637DOI Listing
February 2013

Molecular genetics of AML.

Authors:
Daniel C Link

Best Pract Res Clin Haematol 2012 Dec 23;25(4):409-14. Epub 2012 Oct 23.

Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8007, Saint Louis, MO 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152169261200080
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http://dx.doi.org/10.1016/j.beha.2012.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513694PMC
December 2012

Enhancing hematopoietic growth factor performance.

Nat Med 2012 Dec;18(12):1740-1

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http://dx.doi.org/10.1038/nm.3022DOI Listing
December 2012

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.

Blood 2012 Jul 9;120(2):295-302. Epub 2012 Feb 9.

Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2011-09-377457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398761PMC
July 2012

Regulation of neutrophil trafficking from the bone marrow.

Cell Mol Life Sci 2012 May 2;69(9):1415-23. Epub 2011 Nov 2.

Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://link.springer.com/10.1007/s00018-011-0870-8
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http://dx.doi.org/10.1007/s00018-011-0870-8DOI Listing
May 2012

Genomics of AML: clinical applications of next-generation sequencing.

Hematology Am Soc Hematol Educ Program 2011 ;2011:30-5

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.30DOI Listing
April 2012

A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice.

Exp Hematol 2011 Dec 10;39(12):1136-43. Epub 2011 Sep 10.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Mo., USA.

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http://dx.doi.org/10.1016/j.exphem.2011.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221305PMC
December 2011

Niche competition and cancer metastasis to bone.

J Clin Invest 2011 Apr 23;121(4):1253-5. Epub 2011 Mar 23.

Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1172/JCI57229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069798PMC
April 2011

CXCR2 is the Tpo of the iceberg.

Blood 2011 Apr;117(16):4166-7

Washington University School of Medicine, USA.

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http://dx.doi.org/10.1182/blood-2011-02-332577DOI Listing
April 2011

Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.

Blood 2011 Mar 1;117(13):3539-47. Epub 2011 Feb 1.

Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2010-10-311704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072877PMC
March 2011

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.

J Exp Med 2011 Feb 31;208(2):251-60. Epub 2011 Jan 31.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20101700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039862PMC
February 2011

Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes.

J Leukoc Biol 2010 Jul 30;88(1):123-31. Epub 2010 Mar 30.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://doi.wiley.com/10.1189/jlb.0709499
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http://dx.doi.org/10.1189/jlb.0709499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892524PMC
July 2010

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow.

J Clin Invest 2010 Jul;120(7):2423-31

Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI41649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898597PMC
July 2010

Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia.

Br J Haematol 2009 Nov 22;147(4):535-42. Epub 2009 Sep 22.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07888.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783282PMC
November 2009

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.

Blood 2009 Aug 13;114(7):1331-9. Epub 2009 Jan 13.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2008-10-184754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727413PMC
August 2009

Dicer and outcomes in patients with acute myeloid leukemia (AML).

Leuk Res 2009 Aug 10;33(8):e127. Epub 2009 Mar 10.

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http://dx.doi.org/10.1016/j.leukres.2009.02.003DOI Listing
August 2009

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.

J Clin Invest 2009 Jun 18;119(6):1714-26. Epub 2009 May 18.

Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University Medical School, St. Louis, Missouri 63110, USA.

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http://www.jci.org/articles/view/38248
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http://dx.doi.org/10.1172/JCI38248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689138PMC
June 2009

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions.

Blood 2009 May 5;113(19):4711-9. Epub 2009 Mar 5.

Department of Medicine, Divisions of Oncology, Washington University School of Medicine, St Louis, MO, USA.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2008-09
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http://dx.doi.org/10.1182/blood-2008-09-177287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680371PMC
May 2009

The many causes of severe congenital neutropenia.

N Engl J Med 2009 Jan;360(1):3-5

University of Washington School of Medicine, Seattle, USA.

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http://dx.doi.org/10.1056/NEJMp0806821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162527PMC
January 2009

Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation.

J Bone Miner Res 2008 Nov;23(11):1765-74

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA..

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http://dx.doi.org/10.1359/jbmr.080612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685485PMC
November 2008

Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion.

J Leukoc Biol 2008 Sep 11;84(3):760-8. Epub 2008 Jun 11.

Division of Oncology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 63110, USA.

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http://doi.wiley.com/10.1189/jlb.1107756
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http://dx.doi.org/10.1189/jlb.1107756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516891PMC
September 2008

Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML.

PLoS One 2008 Jun 18;3(6):e2452. Epub 2008 Jun 18.

Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002452PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409964PMC
June 2008

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

J Clin Invest 2008 Mar;118(3):946-55

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI32704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248325PMC
March 2008

Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia.

Br J Haematol 2008 Jan 20;140(2):210-3. Epub 2007 Nov 20.

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06897.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143022PMC
January 2008

Severe congenital neutropenia and the unfolded protein response.

Curr Opin Hematol 2008 Jan;15(1):1-7

Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3282f13cd2DOI Listing
January 2008

Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential.

Blood 2007 Oct 17;110(7):2414-22. Epub 2007 Jul 17.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-03-00
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988923PMC
October 2007

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.

Blood 2007 Apr 21;109(8):3235-43. Epub 2006 Dec 21.

Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-01-01
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http://dx.doi.org/10.1182/blood-2005-01-015081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852251PMC
April 2007

Regulation of neutrophil homeostasis.

Curr Opin Hematol 2007 Jan;14(1):3-8

Division of Oncology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.

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January 2007