Publications by authors named "Daniel C Douek"

100Publications

Convergent Evolution in Breadth of Two V6-1-Encoded Influenza Antibody Clonotypes from a Single Donor.

Cell Host Microbe 2020 09 2;28(3):434-444.e4. Epub 2020 Jul 2.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, San Diego, CA 92037, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

A Global lmmunological Observatory to meet a time of pandemics.

Elife 2020 06 8;9. Epub 2020 Jun 8.

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.

View Article and Find Full Text PDF
June 2020

'Rinse and Replace': Boosting T Cell Turnover To Reduce HIV-1 Reservoirs.

Trends Immunol 2020 06 12;41(6):466-480. Epub 2020 May 12.

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

View Article and Find Full Text PDF
June 2020

What policy makers need to know about COVID-19 protective immunity.

Lancet 2020 05 27;395(10236):1527-1529. Epub 2020 Apr 27.

Department of Infectious Diseases, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK; Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK.

View Article and Find Full Text PDF
May 2020

Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.

Cell Host Microbe 2019 12 21;26(6):748-763.e20. Epub 2019 Nov 21.

Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address:

View Article and Find Full Text PDF
December 2019

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues.

J Clin Invest 2020 02;130(2):789-798

Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.

View Article and Find Full Text PDF
February 2020

The peripheral differentiation of human natural killer T cells.

Immunol Cell Biol 2019 07 8;97(6):586-596. Epub 2019 Apr 8.

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

View Article and Find Full Text PDF
July 2019

Manipulating the Interferon Signaling Pathway: Implications for HIV Infection.

Virol Sin 2019 Apr 14;34(2):192-196. Epub 2019 Feb 14.

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 20892, USA.

View Article and Find Full Text PDF
April 2019

Conflicting evidence for HIV enrichment in CD32 CD4 T cells.

Nature 2018 09 19;561(7723):E9-E16. Epub 2018 Sep 19.

Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
September 2018

T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient.

Cancer Immunol Immunother 2018 Nov 22;67(11):1767-1776. Epub 2018 Aug 22.

Department of Microbiology and Immunology, Emory Vaccine Center, Winship Cancer Institute, Emory University School of Medicine, 1510 Clifton Road, Rm G209, Atlanta, GA, 30322, USA.

View Article and Find Full Text PDF
November 2018

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design.

Front Immunol 2018 14;9:1876. Epub 2018 Aug 14.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.

View Article and Find Full Text PDF
September 2019

HIV Infection: Advances Toward a Cure.

Authors:
Daniel C Douek

Top Antivir Med 2018 Apr;25(4):121-125

Vaccine Research Center of the National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
April 2018

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state.

Nucleic Acids Res 2017 Sep;45(16):e148

Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.

View Article and Find Full Text PDF
September 2017

Stochastic principles governing alternative splicing of RNA.

PLoS Comput Biol 2017 Sep 14;13(9):e1005761. Epub 2017 Sep 14.

Genome Analysis Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

View Article and Find Full Text PDF
September 2017

Perspectives on Human Immunodeficiency Virus (HIV) Cure: HIV Persistence in Tissue.

J Infect Dis 2017 03;215(suppl_3):S128-S133

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

View Article and Find Full Text PDF
March 2017

Intrathecal T-cell clonal expansions in patients with multiple sclerosis.

Ann Clin Transl Neurol 2016 06 20;3(6):422-33. Epub 2016 Apr 20.

Division of Brain Sciences Faculty of Medicine Imperial College London London United Kingdom.

View Article and Find Full Text PDF
June 2016

Interferons and HIV Infection: The Good, the Bad, and the Ugly.

Pathog Immun 2016 ;1(1):107-116

Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

View Article and Find Full Text PDF
January 2016

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.

PLoS Pathog 2016 Apr 19;12(4):e1005580. Epub 2016 Apr 19.

Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

View Article and Find Full Text PDF
April 2016

Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection.

AIDS Res Ther 2016 11;13:19. Epub 2016 Apr 11.

Clinic of Infectious, Diseases Department of Health Sciences, San Paolo Hospital, University of Milan, Via di Rudini' 8, 20142 Milan, Italy.

View Article and Find Full Text PDF
September 2016

System-wide Analysis of the T Cell Response.

Cell Rep 2016 Mar 10;14(11):2733-44. Epub 2016 Mar 10.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article and Find Full Text PDF
March 2016

Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.

Immunol Cell Biol 2016 07 10;94(6):583-92. Epub 2016 Feb 10.

Sorbonne Universités, UPMC Univ Paris 06, DHU FAST, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.

View Article and Find Full Text PDF
July 2016

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.

Sci Transl Med 2015 Apr;7(285):285ra63

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. Program for Cell Enhancement and Technologies for Immunotherapy, The Sheikh Zayed Institute for Pediatric Surgical Innovation, the Center for Cancer and Immunology Research, and the Division of Blood and Marrow Transplantation, Children's National Health System and The George Washington University, Washington, DC 20052, USA. Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

View Article and Find Full Text PDF
April 2015

Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation.

PLoS Pathog 2014 Dec 11;10(12):e1004543. Epub 2014 Dec 11.

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America; SEARCH, Bangkok, Thailand; The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.

View Article and Find Full Text PDF
December 2014

Quantification of HTLV-1 clonality and TCR diversity.

PLoS Comput Biol 2014 Jun 19;10(6):e1003646. Epub 2014 Jun 19.

Section of Immunology, Wright-Fleming Institute, Imperial College School of Medicine, London, United Kingdom.

View Article and Find Full Text PDF
June 2014

Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.

J Allergy Clin Immunol 2014 Jun 3;133(6):1667-75. Epub 2014 May 3.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md. Electronic address:

View Article and Find Full Text PDF
June 2014

Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.

J Virol 2014 Jun 2;88(12):6778-92. Epub 2014 Apr 2.

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Division of Comparative Pathology, Tulane National Primate Research Center (TNPRC), Covington, Louisiana, USA Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

View Article and Find Full Text PDF
June 2014

Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.

J Allergy Clin Immunol 2014 Apr 7;133(4):1109-15. Epub 2014 Jan 7.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address:

View Article and Find Full Text PDF
April 2014

Immune activation, HIV persistence, and the cure.

Authors:
Daniel C Douek

Top Antivir Med 2013 Sep-Oct;21(4):128-32

National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF
August 2014

Systemic effects of inflammation on health during chronic HIV infection.

Immunity 2013 Oct;39(4):633-45

University of California, San Francisco, San Francisco, CA 94114, USA. Electronic address:

View Article and Find Full Text PDF
October 2013

Two demyelinating diseases in the brain of a single patient, PML and MS: how to minimize 'one' while treating the 'other'.

Expert Rev Clin Immunol 2013 Oct;9(10):887-90

Laboratory of Molecular Medicine and Neuroscience, NINDS, National Institutes of Health Bethesda, MD 20892, USA.

View Article and Find Full Text PDF
October 2013

Immune activation and HIV persistence: implications for curative approaches to HIV infection.

Immunol Rev 2013 Jul;254(1):326-42

Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA.

View Article and Find Full Text PDF
July 2013

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy.

AIDS 2013 Sep;27(14):2207-17

aUniversity of California Davis Medical School bVeterans Administration Northern California Healthcare System, Sacramento cUniversity of California - Davis dCenter for Comparative Medicine, Davis, California eVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland fBaylor College of Medicine and Texas Children's Hospital, Houston, Texas gCARES Clinic, Sacramento, California hMayo Clinic, Rochester, Minnesota, USA.

View Article and Find Full Text PDF
September 2013

Microbial translocation in HIV infection: causes, consequences and treatment opportunities.

Nat Rev Microbiol 2012 Sep 13;10(9):655-66. Epub 2012 Aug 13.

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article and Find Full Text PDF
September 2012

Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes.

J Immunol 2012 Sep 23;189(5):2404-13. Epub 2012 Jul 23.

State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.

View Article and Find Full Text PDF
September 2012