Daniel Brewer

Daniel Brewer

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Daniel Brewer

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A Four-Group Urine Risk Classifier for Predicting Outcome in Prostate Cancer Patients.

Authors:
Shea P Connell Marcel Hanna Frank McCarthy Rachel Hurst Martyn Webb Helen Curley Helen Walker Rob Mills Richard Y Ball Martin G Sanda Kathryn L Pellegrini Dattatraya Patil Antoinette S Perry Jack Schalken Hardev Pandha Hayley Whitaker Nening Dennis Christine Stuttle Ian G Mills Ingrid Guldvik Chris Parker Daniel S Brewer Colin S Cooper Jeremy Clark

BJU Int 2019 May 20. Epub 2019 May 20.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK.

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http://dx.doi.org/10.1111/bju.14811DOI Listing
May 2019

Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.

Authors:
Heba Alshaker Qi Wang Daniel Brewer Dmitri Pchejetski

Front Pharmacol 2019 27;10:303. Epub 2019 Mar 27.

School of Medicine, University of East Anglia, Norwich, United Kingdom.

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http://dx.doi.org/10.3389/fphar.2019.00303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445839PMC
March 2019

epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer.

Authors:
Eve O'Reilly Alexandra V Tuzova Anna L Walsh Niamh M Russell Odharnaith O'Brien Sarah Kelly Odharna Ni Dhomhnallain Liam DeBarra Connie M Dale Rick Brugman Gavin Clarke Olivia Schmidt Shane O'Meachair Dattatraya Patil Kathryn L Pellegrini Neil Fleshner Julia Garcia Fang Zhao Stephen Finn Robert Mills Marcelino Y Hanna Rachel Hurst Elizabeth McEvoy William M Gallagher Rustom P Manecksha Colin S Cooper Daniel S Brewer Bharati Bapat Martin G Sanda Jeremy Clark Antoinette S Perry

JCO Precis Oncol 2019 14;2019. Epub 2019 Jan 14.

University College Dublin.

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http://dx.doi.org/10.1200/PO.18.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383793PMC
January 2019

DESNT: A Poor Prognosis Category of Human Prostate Cancer.

Authors:
Bogdan-Alexandru Luca Daniel S Brewer Dylan R Edwards Sandra Edwards Hayley C Whitaker Sue Merson Nening Dennis Rosalin A Cooper Steven Hazell Anne Y Warren Rosalind Eeles Andy G Lynch Helen Ross-Adams Alastair D Lamb David E Neal Krishna Sethia Robert D Mills Richard Y Ball Helen Curley Jeremy Clark Vincent Moulton Colin S Cooper

Eur Urol Focus 2018 12 6;4(6):842-850. Epub 2017 Mar 6.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669460PMC
December 2018

A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prostate cancer.

Authors:
Fang Zhao Ekaterina Olkhov-Mitsel Shivani Kamdar Renu Jeyapala Julia Garcia Rachel Hurst Marcelino Yazbek Hanna Robert Mills Alexandra V Tuzova Eve O'Reilly Sarah Kelly Colin Cooper Daniel Brewer Antoinette S Perry Jeremy Clark Neil Fleshner Bharati Bapat

Clin Epigenetics 2018 11 23;10(1):147. Epub 2018 Nov 23.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0575-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260648PMC
November 2018

Von Hippel-Lindau with early onset of hemangioblastoma and multiple drop-metastases like spinal lesions: A case report.

Authors:
Thinh H Nguyen Teresia Pham Thea Strickland Daniel Brewer Muhittin Belirgen Mohamad M Al-Rahawan

Medicine (Baltimore) 2018 Sep;97(39):e12477

School of Medicine, Texas Tech University Health Science Center, Lubbock, TX.

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http://Insights.ovid.com/crossref?an=00005792-201809280-0005
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http://dx.doi.org/10.1097/MD.0000000000012477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181531PMC
September 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Authors:
David C Wedge Gunes Gundem Thomas Mitchell Dan J Woodcock Inigo Martincorena Mohammed Ghori Jorge Zamora Adam Butler Hayley Whitaker Zsofia Kote-Jarai Ludmil B Alexandrov Peter Van Loo Charlie E Massie Stefan Dentro Anne Y Warren Clare Verrill Dan M Berney Nening Dennis Sue Merson Steve Hawkins William Howat Yong-Jie Lu Adam Lambert Jonathan Kay Barbara Kremeyer Katalin Karaszi Hayley Luxton Niedzica Camacho Luke Marsden Sandra Edwards Lucy Matthews Valeria Bo Daniel Leongamornlert Stuart McLaren Anthony Ng Yongwei Yu Hongwei Zhang Tokhir Dadaev Sarah Thomas Douglas F Easton Mahbubl Ahmed Elizabeth Bancroft Cyril Fisher Naomi Livni David Nicol Simon Tavaré Pelvender Gill Christopher Greenman Vincent Khoo Nicholas Van As Pardeep Kumar Christopher Ogden Declan Cahill Alan Thompson Erik Mayer Edward Rowe Tim Dudderidge Vincent Gnanapragasam Nimish C Shah Keiran Raine David Jones Andrew Menzies Lucy Stebbings Jon Teague Steven Hazell Cathy Corbishley Johann de Bono Gerhardt Attard William Isaacs Tapio Visakorpi Michael Fraser Paul C Boutros Robert G Bristow Paul Workman Chris Sander Freddie C Hamdy Andrew Futreal Ultan McDermott Bissan Al-Lazikani Andrew G Lynch G Steven Bova Christopher S Foster Daniel S Brewer David E Neal Colin S Cooper Rosalind A Eeles

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.

Authors:
Niedzica Camacho Peter Van Loo Sandra Edwards Jonathan D Kay Lucy Matthews Kerstin Haase Jeremy Clark Nening Dennis Sarah Thomas Barbara Kremeyer Jorge Zamora Adam P Butler Gunes Gundem Sue Merson Hayley Luxton Steve Hawkins Mohammed Ghori Luke Marsden Adam Lambert Katalin Karaszi Gill Pelvender Charlie E Massie Zsofia Kote-Jarai Keiran Raine David Jones William J Howat Steven Hazell Naomi Livni Cyril Fisher Christopher Ogden Pardeep Kumar Alan Thompson David Nicol Erik Mayer Tim Dudderidge Yongwei Yu Hongwei Zhang Nimish C Shah Vincent J Gnanapragasam William Isaacs Tapio Visakorpi Freddie Hamdy Dan Berney Clare Verrill Anne Y Warren David C Wedge Andrew G Lynch Christopher S Foster Yong Jie Lu G Steven Bova Hayley C Whitaker Ultan McDermott David E Neal Rosalind Eeles Colin S Cooper Daniel S Brewer

PLoS Genet 2017 Sep 25;13(9):e1007001. Epub 2017 Sep 25.

Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628936PMC
September 2017

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients.

Authors:
Colin S Cooper Jeremy Clark Daniel S Brewer Dylan R Edwards

Eur Urol 2016 Feb 9;69(2):229-30. Epub 2015 Oct 9.

School of Biological Sciences, University of East Anglia, Norwich, UK.

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http://dx.doi.org/10.1016/j.eururo.2015.09.038DOI Listing
February 2016

For many patients who use large amounts of health care services, the need is intense yet temporary.

Authors:
Tracy L Johnson Deborah J Rinehart Josh Durfee Daniel Brewer Holly Batal Joshua Blum Carlos I Oronce Paul Melinkovich Patricia Gabow

Health Aff (Millwood) 2015 Aug;34(8):1312-9

Patricia Gabow is a professor of medicine at the University of Colorado School of Medicine and, now retired, was CEO at Denver Health.

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http://content.healthaffairs.org/content/34/8/1312.full.pdf
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http://content.healthaffairs.org/content/34/8/1312.full.pdf+
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https://chsr.med.uky.edu/sites/default/files/What%20We%20Are
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http://content.healthaffairs.org/cgi/doi/10.1377/hlthaff.201
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http://dx.doi.org/10.1377/hlthaff.2014.1186DOI Listing
August 2015

Augmenting Predictive Modeling Tools with Clinical Insights for Care Coordination Program Design and Implementation.

Authors:
Tracy L Johnson Daniel Brewer Raymond Estacio Tara Vlasimsky Michael J Durfee Kathy R Thompson Rachel M Everhart Deborath J Rinehart Holly Batal

EGEMS (Wash DC) 2015 30;3(1):1181. Epub 2015 Jul 30.

Denver Health.

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http://dx.doi.org/10.13063/2327-9214.1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537083PMC
August 2015

Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Authors:
Colin S Cooper Rosalind Eeles David C Wedge Peter Van Loo Gunes Gundem Ludmil B Alexandrov Barbara Kremeyer Adam Butler Andrew G Lynch Niedzica Camacho Charlie E Massie Jonathan Kay Hayley J Luxton Sandra Edwards Zsofia Kote-Jarai Nening Dennis Sue Merson Daniel Leongamornlert Jorge Zamora Cathy Corbishley Sarah Thomas Serena Nik-Zainal Manasa Ramakrishna Sarah O'Meara Lucy Matthews Jeremy Clark Rachel Hurst Richard Mithen Robert G Bristow Paul C Boutros Michael Fraser Susanna Cooke Keiran Raine David Jones Andrew Menzies Lucy Stebbings Jon Hinton Jon Teague Stuart McLaren Laura Mudie Claire Hardy Elizabeth Anderson Olivia Joseph Victoria Goody Ben Robinson Mark Maddison Stephen Gamble Christopher Greenman Dan Berney Steven Hazell Naomi Livni Cyril Fisher Christopher Ogden Pardeep Kumar Alan Thompson Christopher Woodhouse David Nicol Erik Mayer Tim Dudderidge Nimish C Shah Vincent Gnanapragasam Thierry Voet Peter Campbell Andrew Futreal Douglas Easton Anne Y Warren Christopher S Foster Michael R Stratton Hayley C Whitaker Ultan McDermott Daniel S Brewer David E Neal

Nat Genet 2015 Jun;47(6):689

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http://www.nature.com/articles/ng0615-689b
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http://dx.doi.org/10.1038/ng0615-689bDOI Listing
June 2015

HES5 silencing is an early and recurrent change in prostate tumourigenesis.

Authors:
Charles E Massie Inmaculada Spiteri Helen Ross-Adams Hayley Luxton Jonathan Kay Hayley C Whitaker Mark J Dunning Alastair D Lamb Antonio Ramos-Montoya Daniel S Brewer Colin S Cooper Rosalind Eeles Anne Y Warren Simon Tavaré David E Neal Andy G Lynch

Endocr Relat Cancer 2015 Apr 5;22(2):131-44. Epub 2015 Jan 5.

Cancer Research UK Cambridge InstituteUniversity of Cambridge, Cambridge, CB2 0RE, UKDivision of Genetics and EpidemiologyThe Institute of Cancer Research, Sutton, UKDepartment of Biological Sciences and School of MedicineUniversity of East Anglia, Norwich, UKRoyal Marsden NHS Foundation TrustLondon and Sutton, UKDepartments of PathologyUrologySurgical OncologyAddenbrooke's Hospital, Hills Road, Cambridge, UK

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http://dx.doi.org/10.1530/ERC-14-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335379PMC
April 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Authors:
Colin S Cooper Rosalind Eeles David C Wedge Peter Van Loo Gunes Gundem Ludmil B Alexandrov Barbara Kremeyer Adam Butler Andrew G Lynch Niedzica Camacho Charlie E Massie Jonathan Kay Hayley J Luxton Sandra Edwards ZSofia Kote-Jarai Nening Dennis Sue Merson Daniel Leongamornlert Jorge Zamora Cathy Corbishley Sarah Thomas Serena Nik-Zainal Sarah O'Meara Lucy Matthews Jeremy Clark Rachel Hurst Richard Mithen Robert G Bristow Paul C Boutros Michael Fraser Susanna Cooke Keiran Raine David Jones Andrew Menzies Lucy Stebbings Jon Hinton Jon Teague Stuart McLaren Laura Mudie Claire Hardy Elizabeth Anderson Olivia Joseph Victoria Goody Ben Robinson Mark Maddison Stephen Gamble Christopher Greenman Dan Berney Steven Hazell Naomi Livni Cyril Fisher Christopher Ogden Pardeep Kumar Alan Thompson Christopher Woodhouse David Nicol Erik Mayer Tim Dudderidge Nimish C Shah Vincent Gnanapragasam Thierry Voet Peter Campbell Andrew Futreal Douglas Easton Anne Y Warren Christopher S Foster Michael R Stratton Hayley C Whitaker Ultan McDermott Daniel S Brewer David E Neal

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

The evolutionary history of lethal metastatic prostate cancer.

Authors:
Gunes Gundem Peter Van Loo Barbara Kremeyer Ludmil B Alexandrov Jose M C Tubio Elli Papaemmanuil Daniel S Brewer Heini M L Kallio Gunilla Högnäs Matti Annala Kati Kivinummi Victoria Goody Calli Latimer Sarah O'Meara Kevin J Dawson William Isaacs Michael R Emmert-Buck Matti Nykter Christopher Foster Zsofia Kote-Jarai Douglas Easton Hayley C Whitaker David E Neal Colin S Cooper Rosalind A Eeles Tapio Visakorpi Peter J Campbell Ultan McDermott David C Wedge G Steven Bova

Nature 2015 Apr 1;520(7547):353-357. Epub 2015 Apr 1.

Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1038/nature14347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413032PMC
April 2015

A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue.

Authors:
Ping Wu Brian A Walker Annemiek Broyl Martin Kaiser David C Johnson Rowan Kuiper Mark van Duin Walter M Gregory Faith E Davies Daniel Brewer Dirk Hose Pieter Sonneveld Gareth J Morgan

Leuk Lymphoma 2015 Mar 19;56(3):594-601. Epub 2014 Aug 19.

Section of Haemato-Oncology.

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http://dx.doi.org/10.3109/10428194.2014.911863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444991PMC
March 2015

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next-generation DNA sequencing.

Authors:
David Manson-Bahr Richard Ball Gunes Gundem Krishna Sethia Robert Mills Mark Rochester Victoria Goody Elizabeth Anderson Sarah O'Meara Marcus Flather Matthew Keeling Marcelino Yazbek-Hanna Rachel Hurst Helen Curley Jeremy Clark Daniel S Brewer Ultan McDermott Colin Cooper

J Clin Pathol 2015 Mar 13;68(3):212-7. Epub 2015 Jan 13.

Norwich Medical School and School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.

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http://dx.doi.org/10.1136/jclinpath-2014-202754DOI Listing
March 2015

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.

Authors:
Young Seok Ju Ludmil B Alexandrov Moritz Gerstung Inigo Martincorena Serena Nik-Zainal Manasa Ramakrishna Helen R Davies Elli Papaemmanuil Gunes Gundem Adam Shlien Niccolo Bolli Sam Behjati Patrick S Tarpey Jyoti Nangalia Charles E Massie Adam P Butler Jon W Teague George S Vassiliou Anthony R Green Ming-Qing Du Ashwin Unnikrishnan John E Pimanda Bin Tean Teh Nikhil Munshi Mel Greaves Paresh Vyas Adel K El-Naggar Tom Santarius V Peter Collins Richard Grundy Jack A Taylor D Neil Hayes David Malkin Christopher S Foster Anne Y Warren Hayley C Whitaker Daniel Brewer Rosalind Eeles Colin Cooper David Neal Tapio Visakorpi William B Isaacs G Steven Bova Adrienne M Flanagan P Andrew Futreal Andy G Lynch Patrick F Chinnery Ultan McDermott Michael R Stratton Peter J Campbell

Elife 2014 Oct 1;3. Epub 2014 Oct 1.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.

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http://dx.doi.org/10.7554/eLife.02935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371858PMC
October 2014

Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.

Authors:
Jie Zuo Daniel S Brewer Volker M Arlt Colin S Cooper David H Phillips

BMC Genomics 2014 Oct 8;15:880. Epub 2014 Oct 8.

Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment & Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://dx.doi.org/10.1186/1471-2164-15-880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209037PMC
October 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Authors:
Jose M C Tubio Yilong Li Young Seok Ju Inigo Martincorena Susanna L Cooke Marta Tojo Gunes Gundem Christodoulos P Pipinikas Jorge Zamora Keiran Raine Andrew Menzies Pablo Roman-Garcia Anthony Fullam Moritz Gerstung Adam Shlien Patrick S Tarpey Elli Papaemmanuil Stian Knappskog Peter Van Loo Manasa Ramakrishna Helen R Davies John Marshall David C Wedge Jon W Teague Adam P Butler Serena Nik-Zainal Ludmil Alexandrov Sam Behjati Lucy R Yates Niccolo Bolli Laura Mudie Claire Hardy Sancha Martin Stuart McLaren Sarah O'Meara Elizabeth Anderson Mark Maddison Stephen Gamble Christopher Foster Anne Y Warren Hayley Whitaker Daniel Brewer Rosalind Eeles Colin Cooper David Neal Andy G Lynch Tapio Visakorpi William B Isaacs Laura Van't Veer Carlos Caldas Christine Desmedt Christos Sotiriou Sam Aparicio John A Foekens Jórunn Erla Eyfjörd Sunil R Lakhani Gilles Thomas Ola Myklebost Paul N Span Anne-Lise Børresen-Dale Andrea L Richardson Marc Van de Vijver Anne Vincent-Salomon Gert G Van den Eynden Adrienne M Flanagan P Andrew Futreal Sam M Janes G Steven Bova Michael R Stratton Ultan McDermott Peter J Campbell

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Poly(amidoamine) dendrimer nanocarriers and their aerosol formulations for siRNA delivery to the lung epithelium.

Authors:
Denise S Conti Daniel Brewer Jordan Grashik Sumant Avasarala Sandro R P da Rocha

Mol Pharm 2014 Jun 8;11(6):1808-22. Epub 2014 May 8.

Department of Chemical Engineering and Materials Science, College of Engineering, Wayne State University , 5050 Anthony Wayne Drive, Detroit, Michigan 48202, United States.

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http://pubs.acs.org/doi/10.1021/mp4006358
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http://dx.doi.org/10.1021/mp4006358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051247PMC
June 2014

Novel progesterone receptors: neural localization and possible functions.

Authors:
Sandra L Petersen Karlie A Intlekofer Paula J Moura-Conlon Daniel N Brewer Javier Del Pino Sans Justin A Lopez

Front Neurosci 2013 Sep 19;7:164. Epub 2013 Sep 19.

Molecular and Cellular Neuroendocrinology, Department of Veterinary and Animal Sciences, University of Massachusetts Amherst Amherst, MA, USA.

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http://dx.doi.org/10.3389/fnins.2013.00164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776953PMC
September 2013

Improved risk stratification in myeloma using a microRNA-based classifier.

Authors:
Ping Wu Luca Agnelli Brian A Walker Katia Todoerti Marta Lionetti David C Johnson Martin Kaiser Fabio Mirabella Christopher Wardell Walter M Gregory Faith E Davies Daniel Brewer Antonino Neri Gareth J Morgan

Br J Haematol 2013 Aug 30;162(3):348-59. Epub 2013 May 30.

Section of Haemato-Oncology, Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1111/bjh.12394DOI Listing
August 2013

Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study.

Authors:
David Olmos Daniel Brewer Jeremy Clark Daniel C Danila Chris Parker Gerhardt Attard Martin Fleisher Alison Hm Reid Elena Castro Shahneen K Sandhu Lorraine Barwell Nikhil Babu Oommen Suzanne Carreira Charles G Drake Robert Jones Colin S Cooper Howard I Scher Johann S de Bono

Lancet Oncol 2012 Nov 9;13(11):1114-24. Epub 2012 Oct 9.

Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.1016/S1470-2045(12)70372-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878433PMC
November 2012

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer.

Authors:
Alison H M Reid Gerhardt Attard Daniel Brewer Susana Miranda Ruth Riisnaes Jeremy Clark Lucy Hylands Sue Merson Roy Vergis Charles Jameson Søren Høyer Karina Dalsgaard Sørenson Michael Borre Chris Jones Johann S de Bono Colin S Cooper

Mod Pathol 2012 Jun 30;25(6):902-10. Epub 2012 Mar 30.

The Institute of Cancer Research, Sutton, Surrey, UK.

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http://www.nature.com/articles/modpathol2011207
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http://dx.doi.org/10.1038/modpathol.2011.207DOI Listing
June 2012

Propellant-based inhalers for the non-invasive delivery of genes via oral inhalation.

Authors:
Denise S Conti Balaji Bharatwaj Daniel Brewer Sandro R P da Rocha

J Control Release 2012 Feb 1;157(3):406-17. Epub 2011 Oct 1.

Department of Chemical Engineering and Materials Science, College of Engineering, Wayne State University, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1016/j.jconrel.2011.09.089DOI Listing
February 2012

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1.

Authors:
Francesca Morgera Margaret R Sallah Michelle L Dubuke Pallavi Gandhi Daniel N Brewer Chavela M Carr Mary Munson

Mol Biol Cell 2012 Jan 23;23(2):337-46. Epub 2011 Nov 23.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1091/mbc.E11-08-0670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258177PMC
January 2012

siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer.

Authors:
Alix Bee Daniel Brewer Carol Beesley Andrew Dodson Shiva Forootan Timothy Dickinson Patricia Gerard Brian Lane Sheng Yao Colin S Cooper Mustafa B A Djamgoz Christine M Gosden Youqiang Ke Christopher S Foster

PLoS One 2011 22;6(7):e22672. Epub 2011 Jul 22.

Section of Cellular Pathology and Molecular Genetics, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022672PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142177PMC
December 2011

A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment.

Authors:
Ping Wu Brian A Walker Daniel Brewer Walter M Gregory John Ashcroft Fiona M Ross Graham H Jackson Anthony J Child Faith E Davies Gareth J Morgan

Clin Cancer Res 2011 Oct 19;17(19):6347-55. Epub 2011 Aug 19.

Section of Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-0994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866998PMC
October 2011

A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma.

Authors:
Natsuko Suwaki Elsa Vanhecke Katelyn M Atkins Manuela Graf Katherine Swabey Paul Huang Peter Schraml Holger Moch Amy Mulick Cassidy Daniel Brewer Bissan Al-Lazikani Paul Workman Johann De-Bono Stan B Kaye James Larkin Martin E Gore Charles L Sawyers Peter Nelson Tomasz M Beer Hao Geng Lina Gao David Z Qian Joshi J Alumkal Gary Thomas George V Thomas

Sci Transl Med 2011 Jun;3(85):85ra47

Section of Cell and Molecular Biology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1126/scitranslmed.3002004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303496PMC
June 2011

Lateralization of the central circadian pacemaker output: a test of neural control of peripheral oscillator phase.

Authors:
Carrie E Mahoney Daniel Brewer Mary K Costello Judy McKinley Brewer Eric L Bittman

Am J Physiol Regul Integr Comp Physiol 2010 Sep 30;299(3):R751-61. Epub 2010 Jun 30.

Program in Neuroscience and Behavior and Department of Biology, University of Massachusetts, Amherst, Massachusetts, USA.

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http://dx.doi.org/10.1152/ajpregu.00746.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944421PMC
September 2010

Dissection of a complex transcriptional response using genome-wide transcriptional modelling.

Authors:
Martino Barenco Daniel Brewer Efterpi Papouli Daniela Tomescu Robin Callard Jaroslav Stark Michael Hubank

Mol Syst Biol 2009 17;5:327. Epub 2009 Nov 17.

Department of Molecular Heamatology and Cancer Biology, UCL Institute of Child Health, London, UK.

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http://dx.doi.org/10.1038/msb.2009.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795478PMC
May 2010

PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.

Authors:
Sheng Yao Alix Bee Daniel Brewer Andrew Dodson Carol Beesley Youqiang Ke Laurence Ambroisine Gabrielle Fisher Heinrich Møller Tim Dickinson Patricia Gerard Lu-Yu Lian Janet Risk Brian Lane Paul Smith Victor Reuter Daniel Berney Christine Gosden Peter Scardino Jack Cuzick Mustafa B A Djamgoz Colin Cooper Christopher S Foster

Genes Cancer 2010 May;1(5):444-64

Division of Cellular Pathology and Molecular Genetics, University of Liverpool, UK.

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http://dx.doi.org/10.1177/1947601910376079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092210PMC
May 2010

The structure of the Myo4p globular tail and its function in ASH1 mRNA localization.

Authors:
Alexander Heuck Ingrid Fetka Daniel N Brewer Daniela Hüls Mary Munson Ralf-Peter Jansen Dierk Niessing

J Cell Biol 2010 May;189(3):497-510

Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1083/jcb.201002076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867299PMC
May 2010

A census of amplified and overexpressed human cancer genes.

Authors:
Thomas Santarius Janet Shipley Daniel Brewer Michael R Stratton Colin S Cooper

Nat Rev Cancer 2010 01;10(1):59-64

The Wellcome Trust Sanger Centre, Wellcome Trust Genome Campus Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nrc2771DOI Listing
January 2010

Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer.

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Sameer Jhavar Daniel Brewer Sandra Edwards Zsofia Kote-Jarai Gerhardt Attard Jeremy Clark Penny Flohr Timothy Christmas Alan Thompson Matthew Parker Christopher Shepherd Ulf-Hakan Stenman Tania Marchbank Raymond J Playford Christopher Woodhouse Christopher Ogden Cyril Fisher Gyula Kovacs Cathy Corbishley Charles Jameson Andy Norman Johann De-Bono Anders Bjartell Rosalind Eeles Colin S Cooper

BJU Int 2009 May 25;103(9):1256-69. Epub 2008 Nov 25.

Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, Surrey, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2008.08200.xDOI Listing
May 2009

Interlaboratory and interplatform comparison of microarray gene expression analysis of HepG2 cells exposed to benzo(a)pyrene.

Authors:
Sarah L Hockley Karen Mathijs Yvonne C M Staal Daniel Brewer Ian Giddings Joost H M van Delft David H Phillips

OMICS 2009 Apr;13(2):115-25

Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1089/omi.2008.0060DOI Listing
April 2009

Expression profiling of CD133+ and CD133- epithelial cells from human prostate.

Authors:
Christopher J Shepherd Siân Rizzo Ioanna Ledaki Melissa Davies Daniel Brewer Gerhardt Attard Johann de Bono David L Hudson

Prostate 2008 Jun;68(9):1007-24

Prostate Stem Cell Laboratory, Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1002/pros.20765DOI Listing
June 2008

Fitting ordinary differential equations to short time course data.

Authors:
Daniel Brewer Martino Barenco Robin Callard Michael Hubank Jaroslav Stark

Philos Trans A Math Phys Eng Sci 2008 Feb;366(1865):519-44

Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1098/rsta.2007.2108DOI Listing
February 2008

Detection of TMPRSS2-ERG translocations in human prostate cancer by expression profiling using GeneChip Human Exon 1.0 ST arrays.

Authors:
Sameer Jhavar Alison Reid Jeremy Clark Zsofia Kote-Jarai Timothy Christmas Alan Thompson Christopher Woodhouse Christopher Ogden Cyril Fisher Cathy Corbishley Johann De-Bono Rosalind Eeles Daniel Brewer Colin Cooper

J Mol Diagn 2008 Jan 28;10(1):50-7. Epub 2007 Dec 28.

Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.2353/jmoldx.2008.070085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175543PMC
January 2008

AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.

Authors:
Sarah L Hockley Volker M Arlt Daniel Brewer Robert Te Poele Paul Workman Ian Giddings David H Phillips

Chem Res Toxicol 2007 Dec 19;20(12):1797-810. Epub 2007 Oct 19.

Section of Molecular Carcinogenesis, The Institute of Cancer Research, Surrey, UK.

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http://dx.doi.org/10.1021/tx700252nDOI Listing
December 2007

Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2.

Authors:
Sarah L Hockley Volker M Arlt Daniel Brewer Ian Giddings David H Phillips

BMC Genomics 2006 Oct 16;7:260. Epub 2006 Oct 16.

Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621085PMC
October 2006

Ranked prediction of p53 targets using hidden variable dynamic modeling.

Authors:
Martino Barenco Daniela Tomescu Daniel Brewer Robin Callard Jaroslav Stark Michael Hubank

Genome Biol 2006 31;7(3):R25. Epub 2006 Mar 31.

Institute of Child Health, University College London, Guilford Street, London WC1N 1EH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557743PMC
July 2006

The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles.

Authors:
Mylavarapu V S Sivaram Melonnie L M Furgason Daniel N Brewer Mary Munson

Nat Struct Mol Biol 2006 Jun 14;13(6):555-6. Epub 2006 May 14.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1038/nsmb1096DOI Listing
June 2006

Correction of scaling mismatches in oligonucleotide microarray data.

Authors:
Martino Barenco Jaroslav Stark Daniel Brewer Daniela Tomescu Robin Callard Michael Hubank

BMC Bioinformatics 2006 May 9;7:251. Epub 2006 May 9.

Institute of Child Health, University College London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1508160PMC
May 2006

Nutrition in chronic disease management in the elderly.

Authors:
Jane V White Daniel E Brewer M David Stockton Donald S Keeble Amy J Keenum Edwin S Rogers Elizabeth S Lennon

Nutr Clin Pract 2003 Feb;18(1):3-11

Department of Family Medicine, Graduate School of Medicine, University of Tennessee-Knoxville, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

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February 2003