Daniel B Rainbow

Daniel B Rainbow

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Daniel B Rainbow

Daniel B Rainbow

Publications by authors named "Daniel B Rainbow"

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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases.

Nat Commun 2019 Jul 19;10(1):3216. Epub 2019 Jul 19.

MRC Biostatistics Unit, University of Cambridge, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.

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http://dx.doi.org/10.1038/s41467-019-11271-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642100PMC
July 2019

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

PLoS Genet 2019 Jun 14;15(6):e1008178. Epub 2019 Jun 14.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust/MRC Building, Cambridge Institute for Medical Research, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1008178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568395PMC
June 2019

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus.

Arthritis Res Ther 2018 07 27;20(1):152. Epub 2018 Jul 27.

Department of Medical Genetics, JDRF/Wellcome Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/s13075-018-1649-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062988PMC
July 2018

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.

J Autoimmun 2017 Nov 23;84:75-86. Epub 2017 Jul 23.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust/MRC Building, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Research Campus, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656572PMC
November 2017

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.93739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621870PMC
August 2017

Human IL-6RTIGIT CD4CD127CD25 T cells display potent in vitro suppressive capacity and a distinct Th17 profile.

Clin Immunol 2017 06 9;179:25-39. Epub 2017 Mar 9.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471606PMC
June 2017

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment.

Data Brief 2017 Jun 2;12:676-691. Epub 2017 May 2.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.dib.2017.04.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435581PMC
June 2017

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

Eur J Immunol 2015 Nov 1;45(11):3200-3. Epub 2015 Oct 1.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Research Campus, Cambridge, UK.

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http://dx.doi.org/10.1002/eji.201545646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832369PMC
November 2015

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.

J Immunol 2015 Nov 5;195(10):4841-52. Epub 2015 Oct 5.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1402654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635565PMC
November 2015

Genome-wide transcriptional analyses of islet-specific CD4+ T cells identify Idd9 genes controlling diabetogenic T cell function.

J Immunol 2015 Mar 11;194(6):2654-63. Epub 2015 Feb 11.

Department of Microbiology and Immunology, College of Medicine, Pennsylvania State University, Hershey, PA 17033;

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http://dx.doi.org/10.4049/jimmunol.1401288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374160PMC
March 2015

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.

PLoS One 2014 28;9(2):e89561. Epub 2014 Feb 28.

Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School Renal Division, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089561PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938467PMC
November 2014

Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.

J Immunol 2014 Jul 13;193(2):889-900. Epub 2014 Jun 13.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1303389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082723PMC
July 2014

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity.

Mamm Genome 2013 Oct 11;24(9-10):358-75. Epub 2013 Aug 11.

Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00335-013-9466-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824839PMC
October 2013

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

PLoS Genet 2013 Apr 4;9(4):e1003444. Epub 2013 Apr 4.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1003444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617094PMC
April 2013

Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5.

Diabetes 2012 Jan 21;61(1):166-74. Epub 2011 Nov 21.

Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.2337/db11-0790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237671PMC
January 2012

The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function.

Diabetes 2011 Jul 20;60(7):1955-63. Epub 2011 May 20.

Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.2337/db11-0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121435PMC
July 2011

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.

J Immunol 2011 Jul 25;187(1):325-36. Epub 2011 May 25.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1003523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128927PMC
July 2011

Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.

J Immunol 2010 May 2;184(9):5075-84. Epub 2010 Apr 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge.

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http://dx.doi.org/10.4049/jimmunol.0903734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886967PMC
May 2010

Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells.

Diabetes 2010 Jan 15;59(1):272-81. Epub 2009 Oct 15.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology and Infectious Diseases, Institute for Infection, Immunity and Inflammation, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.2337/db09-0648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797933PMC
January 2010