Daniel B Graham

Daniel B Graham

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Daniel B Graham

Daniel B Graham

Publications by authors named "Daniel B Graham"

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Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.

Immunity 2019 Oct;51(4):696-708.e9

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193037
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http://dx.doi.org/10.1016/j.immuni.2019.09.004DOI Listing
October 2019

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships.

Cell 2019 Aug;178(5):1041-1056

Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778965PMC
August 2019

induces intestinal adaptive immune responses during homeostasis.

Science 2019 06;364(6446):1179-1184

Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1126/science.aaw7479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645389PMC
June 2019

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.

Cell Host Microbe 2019 05;25(5):668-680.e7

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193020
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http://dx.doi.org/10.1016/j.chom.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544385PMC
May 2019

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.

Gastroenterology 2019 02 2;156(3):812-815.e22. Epub 2018 Nov 2.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759855PMC
February 2019

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

Cell 2018 11 1;175(5):1307-1320.e22. Epub 2018 Nov 1.

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome informatics and Therapeutics, MIT, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183131
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http://dx.doi.org/10.1016/j.cell.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239889PMC
November 2018

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Cell Rep 2018 07;24(4):838-850

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156773PMC
July 2018

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Cell Rep 2016 12;17(11):2955-2965

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661940PMC
December 2016

Resources for the design of CRISPR gene editing experiments.

Genome Biol 2015 Nov 27;16:260. Epub 2015 Nov 27.

Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

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http://genomebiology.com/2015/16/1/260
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http://dx.doi.org/10.1186/s13059-015-0823-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661947PMC
November 2015

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

PLoS One 2014 2;9(6):e98606. Epub 2014 Jun 2.

Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041763PMC
January 2015

CRISPR-Cas9 knockin mice for genome editing and cancer modeling.

Cell 2014 Oct 25;159(2):440-55. Epub 2014 Sep 25.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265475PMC
October 2014

From genetics of inflammatory bowel disease towards mechanistic insights.

Trends Immunol 2013 Aug 30;34(8):371-8. Epub 2013 Apr 30.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.it.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735683PMC
August 2013

Polarity gene discs large homolog 1 regulates the generation of memory T cells.

Eur J Immunol 2013 May 9;43(5):1185-94. Epub 2013 Apr 9.

Divison of Immunobiology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/eji.201142362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894631PMC
May 2013

Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.

J Immunol 2013 Mar 18;190(6):2485-9. Epub 2013 Feb 18.

Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.1203208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649847PMC
March 2013

ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo.

PLoS One 2009 27;4(2):e4652. Epub 2009 Feb 27.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004652PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645696PMC
April 2009

DLGH1 is a negative regulator of T-lymphocyte proliferation.

Mol Cell Biol 2007 Nov 27;27(21):7574-81. Epub 2007 Aug 27.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/MCB.00439-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169038PMC
November 2007

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

J Exp Med 2007 Nov 5;204(12):2889-97. Epub 2007 Nov 5.

Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1084/jem.20071283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118522PMC
November 2007

Vav proteins control MyD88-dependent oxidative burst.

Blood 2007 Apr 7;109(8):3360-8. Epub 2006 Dec 7.

Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-07-03
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http://dx.doi.org/10.1182/blood-2006-07-033662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852252PMC
April 2007

CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.

J Immunol 2006 Nov;177(9):6098-107

Department of Immunology, Mayo Clinic College of Medicine,301 Guggenheim Building, Rochester, MN 55905, USA.

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http://www.jimmunol.org/content/177/9/6098.full.pdf
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http://dx.doi.org/10.4049/jimmunol.177.9.6098DOI Listing
November 2006

Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.

J Immunol 2006 Aug;177(4):2349-55

Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.177.4.2349DOI Listing
August 2006

Increased thymic output in HIV-negative patients after antiretroviral therapy.

AIDS 2005 Sep;19(14):1467-72

Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1097/01.aids.0000182520.69159.8aDOI Listing
September 2005