Daniel Alcolea

Daniel Alcolea

UNVERIFIED PROFILE

Are you Daniel Alcolea?   Register this Author

Register author
Daniel Alcolea

Daniel Alcolea

Publications by authors named "Daniel Alcolea"

Are you Daniel Alcolea?   Register this Author

72Publications

2977Reads

50Profile Views

APP-derived peptides reflect neurodegeneration in frontotemporal dementia.

Authors:
Ignacio Illán-Gala Jordi Pegueroles Victor Montal Daniel Alcolea Eduard Vilaplana Alexandre Bejanin Sergi Borrego-Écija Frederic Sampedro Andrea Subirana María-Belén Sánchez-Saudinós Ricard Rojas-García Hugo Vanderstichele Rafael Blesa Jordi Clarimón Anna Antonell Albert Lladó Raquel Sánchez-Valle Juan Fortea Alberto Lleó

Ann Clin Transl Neurol 2019 Dec 2. Epub 2019 Dec 2.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/acn3.50948DOI Listing
December 2019

Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease.

Authors:
Jose L Cantero Mercedes Atienza Carmen Lage Laszlo Zaborszky Eduard Vilaplana Sara Lopez-Garcia Ana Pozueta Eloy Rodriguez-Rodriguez Rafael Blesa Daniel Alcolea Alberto Lleo Pascual Sanchez-Juan Juan Fortea

Cereb Cortex 2019 Dec 4. Epub 2019 Dec 4.

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, 28031 Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/cercor/bhz224DOI Listing
December 2019

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Authors:
Liu Shi Sarah Westwood Alison L Baird Laura Winchester Valerija Dobricic Fabian Kilpert Shengjun Hong Andre Franke Abdul Hye Nicholas J Ashton Angharad R Morgan Isabelle Bos Stephanie J B Vos Noel J Buckley Mara Ten Kate Philip Scheltens Rik Vandenberghe Silvy Gabel Karen Meersmans Sebastiaan Engelborghs Ellen E De Roeck Kristel Sleegers Giovanni B Frisoni Olivier Blin Jill C Richardson Régis Bordet José L Molinuevo Lorena Rami Anders Wallin Petronella Kettunen Magda Tsolaki Frans Verhey Alberto Lleó Daniel Alcolea Julius Popp Gwendoline Peyratout Pablo Martinez-Lage Mikel Tainta Peter Johannsen Charlotte E Teunissen Yvonne Freund-Levi Lutz Frölich Cristina Legido-Quigley Frederik Barkhof Kaj Blennow Henrik Zetterberg Susan Baker B Paul Morgan Johannes Streffer Pieter Jelle Visser Lars Bertram Simon Lovestone Alejo J Nevado-Holgado

Alzheimers Dement 2019 Nov 5;15(11):1478-1488. Epub 2019 Sep 5.

Department of Psychiatry, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2019.06.4951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880298PMC
November 2019

Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.

Authors:
Mafalda Ramos de Matos Catarina Ferreira Sanna-Kaisa Herukka Hilkka Soininen André Janeiro Isabel Santana Inês Baldeiras Maria Rosário Almeida Alberto Lleó Oriol Dols-Icardo Daniel Alcolea Luisa Benussi Giuliano Binetti Anna Paterlini Roberta Ghidoni Benedetta Nacmias Olga Meulenbroek Linda J C van Waalwijk van Doorn H Bea J Kuiperi Lucrezia Hausner Gunhild Waldemar Anja Hviid Simonsen Magda Tsolaki Olymbia Gkatzima Catarina Resende de Oliveira Marcel M Verbeek Jordi Clarimon Mikko Hiltunen Alexandre de Mendonça Madalena Martins

J Alzheimers Dis 2018 ;66(2):639-652

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-180512DOI Listing
October 2019

The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders.

Authors:
Daniel Alcolea Jordi Clarimón María Carmona-Iragui Ignacio Illán-Gala Estrella Morenas-Rodríguez Isabel Barroeta Roser Ribosa-Nogué Isabel Sala M Belén Sánchez-Saudinós Laura Videla Andrea Subirana Bessy Benejam Sílvia Valldeneu Susana Fernández Teresa Estellés Miren Altuna Miguel Santos-Santos Lídia García-Losada Alexandre Bejanin Jordi Pegueroles Víctor Montal Eduard Vilaplana Olivia Belbin Oriol Dols-Icardo Sònia Sirisi Marta Querol-Vilaseca Laura Cervera-Carles Laia Muñoz Raúl Núñez Soraya Torres M Valle Camacho Ignasi Carrió Sandra Giménez Constance Delaby Ricard Rojas-Garcia Janina Turon-Sans Javier Pagonabarraga Amanda Jiménez Rafael Blesa Juan Fortea Alberto Lleó

Alzheimers Dement (N Y) 2019 14;5:597-609. Epub 2019 Oct 14.

Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.trci.2019.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804606PMC
October 2019

Detection of amyloid beta peptides in body fluids for the diagnosis of alzheimer's disease: Where do we stand?

Authors:
Bhavana Veerabhadrappa Constance Delaby Christophe Hirtz Jérôme Vialaret Daniel Alcolea Alberto Lleó Juan Fortea Mysore Sridhar Santosh Shushil Choubey Sylvain Lehmann

Crit Rev Clin Lab Sci 2019 Oct 29:1-15. Epub 2019 Oct 29.

INSERM U1183, Laboratoire de Biochimie-Protéomique Clinique, CHU de Montpellier, Université de Montpellier, Montpellier, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/10408363.2019.1678011DOI Listing
October 2019

Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse.

Authors:
Daniel Alcolea Jordi Pegueroles Laia Muñoz Valle Camacho Diego López-Mora Alejandro Fernández-León Nathalie Le Bastard Els Huyck Alicia Nadal Verónica Olmedo Frederic Sampedro Victor Montal Eduard Vilaplana Jordi Clarimón Rafael Blesa Juan Fortea Alberto Lleó

Ann Clin Transl Neurol 2019 Sep 28;6(9):1815-1824. Epub 2019 Aug 28.

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/acn3.50873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764494PMC
September 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Authors:
Sven J van der Lee Olivia J Conway Iris Jansen Minerva M Carrasquillo Luca Kleineidam Erik van den Akker Isabel Hernández Kristel R van Eijk Najada Stringa Jason A Chen Anna Zettergren Till F M Andlauer Monica Diez-Fairen Javier Simon-Sanchez Alberto Lleó Henrik Zetterberg Marianne Nygaard Cornelis Blauwendraat Jeanne E Savage Jonas Mengel-From Sonia Moreno-Grau Michael Wagner Juan Fortea Michael J Keogh Kaj Blennow Ingmar Skoog Manuel A Friese Olga Pletnikova Miren Zulaica Carmen Lage Itziar de Rojas Steffi Riedel-Heller Ignacio Illán-Gala Wei Wei Bernard Jeune Adelina Orellana Florian Then Bergh Xue Wang Marc Hulsman Nina Beker Niccolo Tesi Christopher M Morris Begoña Indakoetxea Lyduine E Collij Martin Scherer Estrella Morenas-Rodríguez James W Ironside Bart N M van Berckel Daniel Alcolea Heinz Wiendl Samantha L Strickland Pau Pastor Eloy Rodríguez Rodríguez Bradley F Boeve Ronald C Petersen Tanis J Ferman Jay A van Gerpen Marcel J T Reinders Ryan J Uitti Lluís Tárraga Wolfgang Maier Oriol Dols-Icardo Amit Kawalia Maria Carolina Dalmasso Mercè Boada Uwe K Zettl Natasja M van Schoor Marian Beekman Mariet Allen Eliezer Masliah Adolfo López de Munain Alexander Pantelyat Zbigniew K Wszolek Owen A Ross Dennis W Dickson Neill R Graff-Radford David Knopman Rosa Rademakers Afina W Lemstra Yolande A L Pijnenburg Philip Scheltens Thomas Gasser Patrick F Chinnery Bernhard Hemmer Martijn A Huisman Juan Troncoso Fermin Moreno Ellen A Nohr Thorkild I A Sørensen Peter Heutink Pascual Sánchez-Juan Danielle Posthuma Jordi Clarimón Kaare Christensen Nilüfer Ertekin-Taner Sonja W Scholz Alfredo Ramirez Agustín Ruiz Eline Slagboom Wiesje M van der Flier Henne Holstege

Acta Neuropathol 2019 Aug 27;138(2):237-250. Epub 2019 May 27.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00401-019-02026-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660501PMC
August 2019

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.

Authors:
Pilar Esteve Javier Rueda-Carrasco María Inés Mateo María Jesús Martin-Bermejo Jonathan Draffin Guadalupe Pereyra África Sandonís Inmaculada Crespo Inmaculada Moreno Ester Aso Paula Garcia-Esparcia Estrella Gomez-Tortosa Alberto Rábano Juan Fortea Daniel Alcolea Alberto Lleo Michael T Heneka José M Valpuesta José A Esteban Isidro Ferrer Mercedes Domínguez Paola Bovolenta

Nat Neurosci 2019 08 15;22(8):1258-1268. Epub 2019 Jul 15.

Centro de Biología Molecular 'Severo Ochoa', CSIC-UAM, Universidad Autónoma de Madrid, Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41593-019-0432-1DOI Listing
August 2019

The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.

Authors:
Yuetiva Deming Fabia Filipello Francesca Cignarella Claudia Cantoni Simon Hsu Robert Mikesell Zeran Li Jorge L Del-Aguila Umber Dube Fabiana Geraldo Farias Joseph Bradley John Budde Laura Ibanez Maria Victoria Fernandez Kaj Blennow Henrik Zetterberg Amanda Heslegrave Per M Johansson Johan Svensson Bengt Nellgård Alberto Lleo Daniel Alcolea Jordi Clarimon Lorena Rami José Luis Molinuevo Marc Suárez-Calvet Estrella Morenas-Rodríguez Gernot Kleinberger Michael Ewers Oscar Harari Christian Haass Thomas J Brett Bruno A Benitez Celeste M Karch Laura Piccio Carlos Cruchaga

Sci Transl Med 2019 Aug;11(505)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1126/scitranslmed.aau2291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697053PMC
August 2019

Clinical Subtypes of Dementia with Lewy Bodies Based on the Initial Clinical Presentation.

Authors:
Estrella Morenas-Rodríguez Isabel Sala Andrea Subirana Elba Pascual-Goñi Ma Belén Sánchez-Saudinós Daniel Alcolea Ignacio Illán-Gala María Carmona-Iragui Roser Ribosa-Nogué Valle Camacho Rafael Blesa Juan Fortea Alberto Lleó

J Alzheimers Dis 2018 ;64(2):505-513

Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-180167DOI Listing
July 2019

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study.

Authors:
Alberto Lleó Daniel Alcolea Pablo Martínez-Lage Philip Scheltens Lucilla Parnetti Judes Poirier Anja H Simonsen Marcel M Verbeek Pedro Rosa-Neto Rosalinde E R Slot Mikel Tainta Andrea Izaguirre Babette L R Reijs Lucia Farotti Magda Tsolaki Rik Vandenbergue Yvonne Freund-Levi Frans R J Verhey Jordi Clarimón Juan Fortea Lutz Frolich Isabel Santana José Luis Molinuevo Sylvain Lehmann Pieter J Visser Charlotte E Teunissen Henrik Zetterberg Kaj Blennow

Alzheimers Dement 2019 Jun 6;15(6):742-753. Epub 2019 Apr 6.

Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2019.01.015DOI Listing
June 2019

Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease.

Authors:
Estrella Morenas-Rodríguez Daniel Alcolea Marc Suárez-Calvet Laia Muñoz-Llahuna Eduard Vilaplana Isabel Sala Andrea Subirana Marta Querol-Vilaseca María Carmona-Iragui Ignacio Illán-Gala Roser Ribosa-Nogué Rafael Blesa Christian Haass Juan Fortea Alberto Lleó

Sci Rep 2019 May 24;9(1):7803. Epub 2019 May 24.

Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-019-44173-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534578PMC
May 2019

Cortical microstructure in the behavioural variant of frontotemporal dementia: looking beyond atrophy.

Authors:
Ignacio Illán-Gala Victor Montal Sergi Borrego-Écija Eduard Vilaplana Jordi Pegueroles Daniel Alcolea Belén Sánchez-Saudinós Jordi Clarimón Janina Turón-Sans Nuria Bargalló Sofía González-Ortiz Howard J Rosen Maria Luisa Gorno-Tempini Bruce L Miller Albert Lladó Ricard Rojas-García Rafael Blesa Raquel Sánchez-Valle Alberto Lleó Juan Fortea

Brain 2019 04;142(4):1121-1133

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/brain/awz031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439330PMC
April 2019

Impact of CSF storage volume on the analysis of Alzheimer's disease biomarkers on an automated platform.

Authors:
Constance Delaby Laia Muñoz Soraya Torres Alícia Nadal Nathalie Le Bastard Sylvain Lehmann Alberto Lleó Daniel Alcolea

Clin Chim Acta 2019 Mar 20;490:98-101. Epub 2018 Dec 20.

Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, CIBERNED, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cca.2018.12.021DOI Listing
March 2019

Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid.

Authors:
Alberto Lleó Raúl Núñez-Llaves Daniel Alcolea Cristina Chiva Daniel Balateu-Paños Martí Colom-Cadena Gemma Gomez-Giro Laia Muñoz Marta Querol-Vilaseca Jordi Pegueroles Lorena Rami Albert Lladó José L Molinuevo Mikel Tainta Jordi Clarimón Tara Spires-Jones Rafael Blesa Juan Fortea Pablo Martínez-Lage Raquel Sánchez-Valle Eduard Sabidó Àlex Bayés Olivia Belbin

Mol Cell Proteomics 2019 03 3;18(3):546-560. Epub 2019 Jan 3.

§Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/mcp.RA118.001290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398205PMC
March 2019

Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD.

Authors:
Daniel Alcolea David J Irwin Ignacio Illán-Gala Laia Muñoz Jordi Clarimón Corey T McMillan Juan Fortea Rafael Blesa Edward B Lee John Q Trojanowski Murray Grossman Alberto Lleó

J Neurol Neurosurg Psychiatry 2019 02 8;90(2):180-186. Epub 2018 Oct 8.

Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

View Article

Download full-text PDF

 Source
http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-318993
Publisher Site
http://dx.doi.org/10.1136/jnnp-2018-318993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351153PMC
February 2019

Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.

Authors:
Juan Fortea María Carmona-Iragui Bessy Benejam Susana Fernández Laura Videla Isabel Barroeta Daniel Alcolea Jordi Pegueroles Laia Muñoz Olivia Belbin Mony J de Leon Aleksandra Maleska Maceski Christophe Hirtz Jordi Clarimón Sebastián Videla Constance Delaby Sylvain Lehmann Rafael Blesa Alberto Lleó

Lancet Neurol 2018 10 29;17(10):860-869. Epub 2018 Aug 29.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau-Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S1474-4422(18)30285-0DOI Listing
October 2018

CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum.

Authors:
Ignacio Illán-Gala Daniel Alcolea Victor Montal Oriol Dols-Icardo Laia Muñoz Noemi de Luna Janina Turón-Sans Elena Cortés-Vicente Ma Belén Sánchez-Saudinós Andrea Subirana Isabel Sala Rafael Blesa Jordi Clarimón Juan Fortea Ricard Rojas-García Alberto Lleó

Neurology 2018 10 5;91(17):e1619-e1628. Epub 2018 Oct 5.

From the Sant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau (I.I.-G., D.A., V.M., O.D.-I., L.M., M.B.S.-S., A.S., I.S., R.B., J.C., J.F., A.L.), and Neuromuscular Diseases Unit, Department of Neurology (N.d.L., J.T.-S., E.C.-V., R.R.-G.), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) (I.I.-G., D.A., V.M., O.D.-I., R.B., J.C., J.F., A.L.); and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (N.d.L., J.T.-S., E.C.-V., R.R.-G.), Madrid, Spain.

View Article

Download full-text PDF

 Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000006383DOI Listing
October 2018

Obesity and Alzheimer's disease, does the obesity paradox really exist? A magnetic resonance imaging study.

Authors:
Jordi Pegueroles Amanda Jiménez Eduard Vilaplana Victor Montal María Carmona-Iragui Adriana Pané Daniel Alcolea Laura Videla Anna Casajoana Jordi Clarimón Emilio Ortega Josep Vidal Rafael Blesa Alberto Lleó Juan Fortea

Oncotarget 2018 Oct 5;9(78):34691-34698. Epub 2018 Oct 5.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.26162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205180PMC
October 2018

Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease.

Authors:
Juan R Perea Alberto Lleó Daniel Alcolea Juan Fortea Jesús Ávila Marta Bolós

Front Neurosci 2018 7;12:609. Epub 2018 Sep 7.

Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fnins.2018.00609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137321PMC
September 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

Authors:
Piotr Lewczuk Peter Riederer Sid E O'Bryant Marcel M Verbeek Bruno Dubois Pieter Jelle Visser Kurt A Jellinger Sebastiaan Engelborghs Alfredo Ramirez Lucilla Parnetti Clifford R Jack Charlotte E Teunissen Harald Hampel Alberto Lleó Frank Jessen Lidia Glodzik Mony J de Leon Anne M Fagan José Luis Molinuevo Willemijn J Jansen Bengt Winblad Leslie M Shaw Ulf Andreasson Markus Otto Brit Mollenhauer Jens Wiltfang Martin R Turner Inga Zerr Ron Handels Alexander G Thompson Gunilla Johansson Natalia Ermann John Q Trojanowski Ilker Karaca Holger Wagner Patrick Oeckl Linda van Waalwijk van Doorn Maria Bjerke Dimitrios Kapogiannis H Bea Kuiperij Lucia Farotti Yi Li Brian A Gordon Stéphane Epelbaum Stephanie J B Vos Catharina J M Klijn William E Van Nostrand Carolina Minguillon Matthias Schmitz Carla Gallo Andrea Lopez Mato Florence Thibaut Simone Lista Daniel Alcolea Henrik Zetterberg Kaj Blennow Johannes Kornhuber

World J Biol Psychiatry 2018 06 27;19(4):244-328. Epub 2017 Oct 27.

a Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/15622975.2017.1375556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916324PMC
June 2018

Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease.

Authors:
Jose L Cantero Mercedes Atienza Pascual Sanchez-Juan Eloy Rodriguez-Rodriguez Jose Luis Vazquez-Higuera Ana Pozueta Andrea Gonzalez-Suarez Eduard Vilaplana Jordi Pegueroles Victor Montal Rafael Blesa Daniel Alcolea Alberto Lleo Juan Fortea

Neurobiol Aging 2018 04 20;64:58-67. Epub 2017 Dec 20.

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain; Department of Neurology, Institut d'Investigacions Biomediques Sant Pau-Hospital Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.12.010DOI Listing
April 2018

Challenges associated with biomarker-based classification systems for Alzheimer's disease.

Authors:
Ignacio Illán-Gala Jordi Pegueroles Victor Montal Eduard Vilaplana María Carmona-Iragui Daniel Alcolea Bradford C Dickerson Raquel Sánchez-Valle Mony J de Leon Rafael Blesa Alberto Lleó Juan Fortea

Alzheimers Dement (Amst) 2018 21;10:346-357. Epub 2018 Apr 21.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.dadm.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114028PMC
April 2018

Diagnostic and Prognostic Value of the Combination of Two Measures of Verbal Memory in Mild Cognitive Impairment due to Alzheimer's Disease.

Authors:
Isabel Sala Ignacio Illán-Gala Daniel Alcolea Ma Belén Sánchez-Saudinós Sergio Andrés Salgado Estrella Morenas-Rodríguez Andrea Subirana Laura Videla Jordi Clarimón María Carmona-Iragui Roser Ribosa-Nogué Rafael Blesa Juan Fortea Alberto Lleó

J Alzheimers Dis 2017 ;58(3):909-918

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-170073DOI Listing
March 2018

Cortical microstructural changes along the Alzheimer's disease continuum.

Authors:
Victor Montal Eduard Vilaplana Daniel Alcolea Jordi Pegueroles Ofer Pasternak Sofia González-Ortiz Jordi Clarimón María Carmona-Iragui Ignacio Illán-Gala Estrella Morenas-Rodríguez Roser Ribosa-Nogué Isabel Sala María-Belén Sánchez-Saudinós Maite García-Sebastian Jorge Villanúa Andrea Izagirre Ainara Estanga Mirian Ecay-Torres Ane Iriondo Montserrat Clerigue Mikel Tainta Ana Pozueta Andrea González Eloy Martínez-Heras Sara Llufriu Rafael Blesa Pascual Sanchez-Juan Pablo Martínez-Lage Alberto Lleó Juan Fortea

Alzheimers Dement 2018 03 31;14(3):340-351. Epub 2017 Oct 31.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2017.09.013DOI Listing
March 2018

Kidins220 Correlates with Tau in Alzheimer's Disease Brain and Cerebrospinal Fluid.

Authors:
Andrea Gamir-Morralla Olivia Belbin Juan Fortea Daniel Alcolea Isidro Ferrer Alberto Lleó Teresa Iglesias

J Alzheimers Dis 2017 ;55(4):1327-1333

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-160639DOI Listing
February 2018

Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome.

Authors:
María Carmona-Iragui Telma Santos Sebastián Videla Susana Fernández Bessy Benejam Laura Videla Daniel Alcolea Kaj Blennow Rafael Blesa Alberto Lleó Juan Fortea

J Alzheimers Dis 2017 ;55(4):1489-1496

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-160827DOI Listing
February 2018

A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk.

Authors:
Gemma Tell-Marti Joan Anton Puig-Butille Miriam Potrony Estel Plana Celia Badenas Anna Antonell Raquel Sanchez-Valle José L Molinuevo Alberto Lleó Daniel Alcolea Juan Fortea Rubén Fernández-Santiago Jordi Clarimón Albert Lladó Susana Puig

J Alzheimers Dis 2017 ;56(3):1065-1074

Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-161113DOI Listing
February 2018

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Authors:
Willemijn J Jansen Rik Ossenkoppele Betty M Tijms Anne M Fagan Oskar Hansson William E Klunk Wiesje M van der Flier Victor L Villemagne Giovanni B Frisoni Adam S Fleisher Alberto Lleó Mark A Mintun Anders Wallin Sebastiaan Engelborghs Duk L Na Gäel Chételat José Luis Molinuevo Susan M Landau Niklas Mattsson Johannes Kornhuber Osama Sabri Christopher C Rowe Lucilla Parnetti Julius Popp Tormod Fladby William J Jagust Pauline Aalten Dong Young Lee Rik Vandenberghe Catarina Resende de Oliveira Elisabeth Kapaki Lutz Froelich Adrian Ivanoiu Tomasz Gabryelewicz Marcel M Verbeek Páscual Sanchez-Juan Helmut Hildebrandt Vincent Camus Marzena Zboch David J Brooks Alexander Drzezga Juha O Rinne Andrew Newberg Alexandre de Mendonça Marie Sarazin Gil D Rabinovici Karine Madsen Milica G Kramberger Agneta Nordberg Vincent Mok Barbara Mroczko David A Wolk Philipp T Meyer Magda Tsolaki Philip Scheltens Frans R J Verhey Pieter Jelle Visser Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kaj Blennow Mark A van Buchem Enrica Cavedo Kewei Chen Elena Chipi Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Olymbia Gkatzima Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Peter Johannsen Aleksandra Klimkowicz-Mrowiec Sebastian Köhler Norman Koglin Koen van Laere Mony de Leon Viviana Lisetti Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Arto Nordlund Gerald P Novak George P Paraskevas Gayan Perera Oliver Peters Inez H G B Ramakers Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Henrik Zetterberg

JAMA Psychiatry 2018 01;75(1):84-95

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1001/jamapsychiatry.2017.3391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156PMC
January 2018

Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer's disease.

Authors:
Amanda Jimenez Jordi Pegueroles María Carmona-Iragui Eduard Vilaplana Victor Montal Daniel Alcolea Laura Videla Ignacio Illán-Gala Adriana Pané Anna Casajoana Olivia Belbin Jordi Clarimón Violeta Moizé Josep Vidal Alberto Lleó Juan Fortea Rafael Blesa

Oncotarget 2017 Dec 31;8(62):104706-104716. Epub 2017 Oct 31.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.22218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739594PMC
December 2017

CSF microRNA Profiling in Alzheimer's Disease: a Screening and Validation Study.

Authors:
Adrià Dangla-Valls José Luis Molinuevo Jordi Altirriba Raquel Sánchez-Valle Daniel Alcolea Juan Fortea Lorena Rami Mircea Balasa Cristina Muñoz-García Mario Ezquerra Rubén Fernández-Santiago Alberto Lleó Albert Lladó Anna Antonell

Mol Neurobiol 2017 11 13;54(9):6647-6654. Epub 2016 Oct 13.

Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic i Universitari-, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, Barcelona, 08036, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s12035-016-0106-xDOI Listing
November 2017

Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease.

Authors:
María Carmona-Iragui Mircea Balasa Bessy Benejam Daniel Alcolea Susana Fernández Laura Videla Isabel Sala María Belén Sánchez-Saudinós Estrella Morenas-Rodriguez Roser Ribosa-Nogué Ignacio Illán-Gala Sofía Gonzalez-Ortiz Jordi Clarimón Frederick Schmitt David K Powell Beatriz Bosch Albert Lladó Michael S Rafii Elizabeth Head José Luis Molinuevo Rafael Blesa Sebastián Videla Alberto Lleó Raquel Sánchez-Valle Juan Fortea

Alzheimers Dement 2017 Nov 29;13(11):1251-1260. Epub 2017 Apr 29.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660938PMC
November 2017

Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer's Disease: Potential and Limitations.

Authors:
Marta Cosín-Tomás Anna Antonell Albert Lladó Daniel Alcolea Juan Fortea Mario Ezquerra Albert Lleó Maria José Martí Mercè Pallàs Raquel Sanchez-Valle José Luís Molinuevo Coral Sanfeliu Perla Kaliman

Mol Neurobiol 2017 09 8;54(7):5550-5562. Epub 2016 Sep 8.

Institut d'Investigacions Biomèdiques de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s12035-016-0088-8DOI Listing
September 2017

The pitfalls of biomarker-based classification schemes.

Authors:
Ignacio Illán-Gala Eduard Vilaplana Jordi Pegueroles Victor Montal Daniel Alcolea Rafael Blesa Alberto Lleó Juan Fortea

Alzheimers Dement 2017 09 10;13(9):1072-1074. Epub 2017 Jul 10.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2017.06.002DOI Listing
September 2017

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease.

Authors:
Isabelle Bos Stephanie J Vos Lutz Frölich Johannes Kornhuber Jens Wiltfang Wolfgang Maier Oliver Peters Eckhart Rüther Sebastiaan Engelborghs Ellis Niemantsverdriet Ellen Elisa De Roeck Magda Tsolaki Yvonne Freund-Levi Peter Johannsen Rik Vandenberghe Alberto Lleó Daniel Alcolea Giovanni B Frisoni Samantha Galluzzi Flavio Nobili Silvia Morbelli Alexander Drzezga Mira Didic Bart N van Berckel Eric Salmon Christine Bastin Solene Dauby Isabel Santana Inês Baldeiras Alexandre de Mendonça Dina Silva Anders Wallin Arto Nordlund Preciosa M Coloma Angelika Wientzek Myriam Alexander Gerald P Novak Mark Forrest Gordon Åsa K Wallin Harald Hampel Hilkka Soininen Sanna-Kaisa Herukka Philip Scheltens Frans R Verhey Pieter Jelle Visser

Neurobiol Aging 2017 08 8;56:33-40. Epub 2017 Apr 8.

Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands; Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.03.034DOI Listing
August 2017

CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration.

Authors:
Daniel Alcolea Eduard Vilaplana Marc Suárez-Calvet Ignacio Illán-Gala Rafael Blesa Jordi Clarimón Albert Lladó Raquel Sánchez-Valle José L Molinuevo Guillermo García-Ribas Yaroslau Compta María José Martí Gerard Piñol-Ripoll Guillermo Amer-Ferrer Aina Noguera Ana García-Martín Juan Fortea Alberto Lleó

Neurology 2017 Jul 7;89(2):178-188. Epub 2017 Jun 7.

From the Department of Neurology (D.A., E.V., M.S.-C., I.I.-G., R.B., J.C., J.F., A. Lleó), Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona; Alzheimer's Disease and Other Cognitive Disorders Unit (A. Lladó, R.S.-V., J.L.M.), Department of Neurology, Hospital Clínic, Institut d'Investigació Biomèdica August Pi I Sunyer, Barcelona; Servicio de Neurología (G.G.-R.), Hospital Universitario Ramón y Cajal, Madrid; Parkinson's Disease and Movement Disorders Unit (Y.C., M.J.M.), Neurology Service, Institute of Clinical Neurosciences, Hospital Clínic/IDIBAPS and University of Barcelona; Unitat de Trastorns Cognitius (G.P.-R.), Hospital Santa Maria, Lleida; Unidad de Neurología Cognitiva (G.A.-F., A.N., A.G.-M.), Servicio de Neurología, Hospital Universitari Son Espases, Palma de Mallorca; and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (D.A., E.V., M.S.-C., I.I.-G., R.B., J.C., Y.C., M.J.M., J.F., A. Lleó), Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1212/WNL.0000000000004088DOI Listing
July 2017

Longitudinal brain structural changes in preclinical Alzheimer's disease.

Authors:
Jordi Pegueroles Eduard Vilaplana Victor Montal Frederic Sampedro Daniel Alcolea Maria Carmona-Iragui Jordi Clarimon Rafael Blesa Alberto Lleó Juan Fortea

Alzheimers Dement 2017 May 28;13(5):499-509. Epub 2016 Sep 28.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau- Biomedical Research Institute Sant Pau-Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2016.08.010DOI Listing
May 2017

Cerebrospinal fluid mitochondrial DNA in the Alzheimer's disease continuum.

Authors:
Laura Cervera-Carles Daniel Alcolea Ainara Estanga Mirian Ecay-Torres Andrea Izagirre Montserrat Clerigué Maite García-Sebastián Jorge Villanúa Clàudia Escalas Rafael Blesa Pablo Martínez-Lage Alberto Lleó Juan Fortea Jordi Clarimón

Neurobiol Aging 2017 05 22;53:192.e1-192.e4. Epub 2016 Dec 22.

Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.009DOI Listing
May 2017

Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias.

Authors:
Estrella Morenas-Rodríguez Laura Cervera-Carles Eduard Vilaplana Daniel Alcolea María Carmona-Iragui Oriol Dols-Icardo Roser Ribosa-Nogué Laia Muñoz-Llahuna Isabel Sala M Belén Sánchez-Saudinós Rafael Blesa Jordi Clarimón Juan Fortea Alberto Lleó

J Alzheimers Dis 2016 ;50(2):539-46

Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-150746DOI Listing
November 2016

Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly.

Authors:
Andrew W Varga Margaret E Wohlleber Sandra Giménez Sergio Romero Joan F Alonso Emma L Ducca Korey Kam Clifton Lewis Emily B Tanzi Samuel Tweardy Akifumi Kishi Ankit Parekh Esther Fischer Tyler Gumb Daniel Alcolea Juan Fortea Alberto Lleó Kaj Blennow Henrik Zetterberg Lisa Mosconi Lidia Glodzik Elizabeth Pirraglia Omar E Burschtin Mony J de Leon David M Rapoport Shou-En Lu Indu Ayappa Ricardo S Osorio

Sleep 2016 Nov 1;39(11):2041-2048. Epub 2016 Nov 1.

Center for Brain Health, Department of Psychiatry, NYU Langone Medical Center, New York, NY.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.5665/sleep.6240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070758PMC
November 2016

Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation.

Authors:
María Carmona-Iragui Ana Fernández-Arcos Daniel Alcolea Fabrizio Piazza Estrella Morenas-Rodriguez Sofía Antón-Aguirre Isabel Sala Jordi Clarimon Oriol Dols-Icardo Valle Camacho Frederic Sampedro Josep Munuera Fidel Nuñez-Marin Alberto Lleó Juan Fortea Beatriz Gómez-Ansón Rafael Blesa

J Alzheimers Dis 2016 ;50(1):1-7

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-150614DOI Listing
October 2016

Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion.

Authors:
Marc Suárez-Calvet Valle Camacho Beatriz Gómez-Ansón Sofia Antón Yolanda Vives-Gilabert Oriol Dols-Icardo Jordi Clarimón Daniel Alcolea Rafael Blesa Juan Fortea Alberto Lleó

Alzheimer Dis Assoc Disord 2015 Oct-Dec;29(4):353-6

*Memory Disorders Unit, Department of Neurology, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Departments of †Nuclear Medicine ‡Radiology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau. Universitat Autònoma de Barcelona §Port d'Informació Científica, Institut de Física d'Altes Energies, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/WAD.0000000000000056DOI Listing
September 2016

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.

Authors:
Marc Suárez-Calvet Gernot Kleinberger Miguel Ángel Araque Caballero Matthias Brendel Axel Rominger Daniel Alcolea Juan Fortea Alberto Lleó Rafael Blesa Juan Domingo Gispert Raquel Sánchez-Valle Anna Antonell Lorena Rami José L Molinuevo Frederic Brosseron Andreas Traschütz Michael T Heneka Hanne Struyfs Sebastiaan Engelborghs Kristel Sleegers Christine Van Broeckhoven Henrik Zetterberg Bengt Nellgård Kaj Blennow Alexander Crispin Michael Ewers Christian Haass

EMBO Mol Med 2016 05 2;8(5):466-76. Epub 2016 May 2.

BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/emmm.201506123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120370PMC
May 2016

Copy number variation analysis of the 17q21.31 region and its role in neurodegenerative diseases.

Authors:
Laura Cervera-Carles Javier Pagonabarraga Berta Pascual-Sedano Pau Pastor Antonia Campolongo Juan Fortea Rafael Blesa Daniel Alcolea Estrella Morenas-Rodríguez Isabel Sala Alberto Lleó Jaime Kulisevsky Jordi Clarimón

Am J Med Genet B Neuropsychiatr Genet 2016 Mar 9;171B(2):175-80. Epub 2015 Oct 9.

Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ajmg.b.32390DOI Listing
March 2016

Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study.

Authors:
Flora H Duits Pablo Martinez-Lage Claire Paquet Sebastiaan Engelborghs Alberto Lleó Lucrezia Hausner José L Molinuevo Erik Stomrud Lucia Farotti Inez H G B Ramakers Magda Tsolaki Constance Skarsgård Ragnar Åstrand Anders Wallin Martin Vyhnalek Marie Holmber-Clausen Orestes V Forlenza Laura Ghezzi Martin Ingelsson Erik I Hoff Gerwin Roks Alexandre de Mendonça Janne M Papma Andrea Izagirre Mariko Taga Hanne Struyfs Daniel A Alcolea Lutz Frölich Mircea Balasa Lennart Minthon Jos W R Twisk Staffan Persson Henrik Zetterberg Wiesje M van der Flier Charlotte E Teunissen Philip Scheltens Kaj Blennow

Alzheimers Dement 2016 Feb 11;12(2):154-163. Epub 2015 Sep 11.

Department of Clinical Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2015.08.003DOI Listing
February 2016

Analysis of the CHCHD10 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Spain.

Authors:
Oriol Dols-Icardo Irene Nebot Ana Gorostidi Sara Ortega-Cubero Isabel Hernández Ricard Rojas-García Alberto García-Redondo Monica Povedano Albert Lladó Victoria Álvarez Pascual Sánchez-Juan Julio Pardo Ivonne Jericó Juan Vázquez-Costa Teresa Sevilla Fernando Cardona Begoña Indakoechea Fermín Moreno Roberto Fernández-Torrón Laia Muñoz-Llahuna Sonia Moreno-Grau Maiteé Rosende-Roca Álvaro Vela José Luís Muñoz-Blanco Onofre Combarros Eliecer Coto Daniel Alcolea Juan Fortea Alberto Lleó Raquel Sánchez-Valle Jesús Esteban-Pérez Agustín Ruiz Pau Pastor Adolfo López De Munain Jordi Pérez-Tur Jordi Clarimón

Brain 2015 Dec 7;138(Pt 12):e400. Epub 2015 Jul 7.

1 Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain 2 CIBERNED, Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain.

View Article

Download full-text PDF

 Source
http://digital.csic.es/bitstream/10261/126659/1/2015%20Brain
Web Search
http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
Publisher Site
http://dx.doi.org/10.1093/brain/awv175DOI Listing
December 2015

Effect of REST on brain metabolism in the Alzheimer disease continuum.

Authors:
Oriol Dols-Icardo Eduard Vilaplana Frederic Sampedro Daniel Alcolea Olivia Belbin Valle Camacho Rafael Blesa Alberto Lleó Jordi Clarimón Juan Fortea

Ann Neurol 2015 Oct 25;78(4):661-2. Epub 2015 Aug 25.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ana.24484DOI Listing
October 2015

Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.

Authors:
Niels Kruse Staffan Persson Daniel Alcolea Justyna M C Bahl Ines Baldeiras Elisabetta Capello Davide Chiasserini Luisella Bocchio Chiavetto Andreja Emersic Sebastiaan Engelborghs Erden Eren Tormod Fladby Giovanni Frisoni María-Salud García-Ayllón Sermin Genc Olymbia Gkatzima Niels H H Heegaard André M Janeiro Branislav Kováčech H Bea Kuiperij Maria J Leitão Alberto Lleó Madalena Martins Mafalda Matos Hanne M Mollergard Flavio Nobili Annika Öhrfelt Lucilla Parnetti Catarina Resende de Oliveira Uros Rot Javier Sáez-Valero Hanne Struyfs Julia T Tanassi Peggy Taylor Magda Tsolaki Eugeen Vanmechelen Marcel M Verbeek Norbert Zilka Kaj Blennow Henrik Zetterberg Brit Mollenhauer

Neurobiol Aging 2015 Sep 15;36(9):2587-96. Epub 2015 May 15.

Department of Neuropathology, University Medical Center, Göttingen, Germany; Paracelsus-Elena-Klinik, Kassel, Germany; Department of Neurosurgery, University Medical Center, Göttingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2015.05.003DOI Listing
September 2015

APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls.

Authors:
Frederic Sampedro Eduard Vilaplana Mony J de Leon Daniel Alcolea Jordi Pegueroles Victor Montal María Carmona-Iragui Isabel Sala María-Belén Sánchez-Saudinos Sofía Antón-Aguirre Estrella Morenas-Rodríguez Valle Camacho Carles Falcón Javier Pavía Domènec Ros Jordi Clarimón Rafael Blesa Alberto Lleó Juan Fortea

Oncotarget 2015 Sep;6(29):26663-74

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://www.oncotarget.com/fulltext/5185
Publisher Site
http://dx.doi.org/10.18632/oncotarget.5185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694943PMC
September 2015

Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease.

Authors:
Daniel Alcolea Pablo Martínez-Lage Pascual Sánchez-Juan Javier Olazarán Carmen Antúnez Andrea Izagirre Mirian Ecay-Torres Ainara Estanga Montserrat Clerigué Maria Concepción Guisasola Domingo Sánchez Ruiz Juan Marín Muñoz Miguel Calero Rafael Blesa Jordi Clarimón María Carmona-Iragui Estrella Morenas-Rodríguez Eloy Rodríguez-Rodríguez José Luis Vázquez Higuera Juan Fortea Alberto Lleó

Neurology 2015 Aug 15;85(7):626-33. Epub 2015 Jul 15.

From the Department of Neurology (D.A., R.B., J.C., M.C.-I., E.M.-R., J.F., A.L.), Institut d'Investigacions Biomèdiques Sant Pau, Hospital de Sant Pau, Universitat Autònoma de Barcelona; Fundación CITA-Alzhéimer Fundazioa (P.M.-L., A.I., M.E.-T., A.E., M.C.), San Sebastián; Servicio de Neurología (P.S.-J., E.R.-R., J.L.V.H.), Hospital Universitario Marqués de Valdecilla, Santander; Servicio de Neurología (J.O., D.S.R.) and Unidad de Medicina Experimental (M.C.G.), Hospital General Gregorio Marañón, Madrid; Unidad de Demencias (C.A., J.M.M.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia; Instituto de Salud Carlos III (M.C.), CIBERNED, Madrid; Fundación CIEN (J.O., M.C.), Fundación Reina Sofía, Madrid; and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, CIBERNED (The SIGNAL Study), Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1212/WNL.0000000000001859DOI Listing
August 2015

Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease.

Authors:
Daniel Alcolea Eduard Vilaplana Jordi Pegueroles Victor Montal Pascual Sánchez-Juan Andrea González-Suárez Ana Pozueta Eloy Rodríguez-Rodríguez David Bartrés-Faz Dídac Vidal-Piñeiro Sofía González-Ortiz Santiago Medrano María Carmona-Iragui MaBelén Sánchez-Saudinós Isabel Sala Sofía Anton-Aguirre Frederic Sampedro Estrella Morenas-Rodríguez Jordi Clarimón Rafael Blesa Alberto Lleó Juan Fortea

Neurobiol Aging 2015 Jun 9;36(6):2018-23. Epub 2015 Mar 9.

Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.001DOI Listing
June 2015

Relationship between β-Secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's disease.

Authors:
Daniel Alcolea María Carmona-Iragui Marc Suárez-Calvet M Belén Sánchez-Saudinós Isabel Sala Sofía Antón-Aguirre Rafael Blesa Jordi Clarimón Juan Fortea Alberto Lleó

J Alzheimers Dis 2014 ;42(1):157-67

Memory Unit, Department of Neurology, Inst. Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas, CIBERNED, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-140240DOI Listing
May 2015

Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: an ARIA before the tsunami.

Authors:
Eva Martínez-Lizana María Carmona-Iragui Daniel Alcolea Manuel Gómez-Choco Eduard Vilaplana María B Sánchez-Saudinós Jordi Clarimón Mar Hernández-Guillamon Josep Munuera Ellen Gelpi Beatriz Gómez-Anson Manel de Juan-Delago Raquel Delgado-Mederos Joan Montaner Angel Ois Sergi Amaro Rafael Blesa Joan Martí-Fàbregas Alberto Lleó Juan Fortea

J Cereb Blood Flow Metab 2015 May 4;35(5):710-7. Epub 2015 Mar 4.

1] Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain [2] Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/jcbfm.2015.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420868PMC
May 2015

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Authors:
Willemijn J Jansen Rik Ossenkoppele Dirk L Knol Betty M Tijms Philip Scheltens Frans R J Verhey Pieter Jelle Visser Pauline Aalten Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kristen Bibeau Kaj Blennow David J Brooks Mark A van Buchem Vincent Camus Enrica Cavedo Kewei Chen Gael Chetelat Ann D Cohen Alexander Drzezga Sebastiaan Engelborghs Anne M Fagan Tormod Fladby Adam S Fleisher Wiesje M van der Flier Lisa Ford Stefan Förster Juan Fortea Nadia Foskett Kristian S Frederiksen Yvonne Freund-Levi Giovanni B Frisoni Lutz Froelich Tomasz Gabryelewicz Kiran Dip Gill Olymbia Gkatzima Estrella Gómez-Tortosa Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Helmut Hildebrandt Lianna Ishihara Adrian Ivanoiu William J Jagust Peter Johannsen Ramesh Kandimalla Elisabeth Kapaki Aleksandra Klimkowicz-Mrowiec William E Klunk Sebastian Köhler Norman Koglin Johannes Kornhuber Milica G Kramberger Koen Van Laere Susan M Landau Dong Young Lee Mony de Leon Viviana Lisetti Alberto Lleó Karine Madsen Wolfgang Maier Jan Marcusson Niklas Mattsson Alexandre de Mendonça Olga Meulenbroek Philipp T Meyer Mark A Mintun Vincent Mok José Luis Molinuevo Hanne M Møllergård John C Morris Barbara Mroczko Stefan Van der Mussele Duk L Na Andrew Newberg Agneta Nordberg Arto Nordlund Gerald P Novak George P Paraskevas Lucilla Parnetti Gayan Perera Oliver Peters Julius Popp Sudesh Prabhakar Gil D Rabinovici Inez H G B Ramakers Lorena Rami Catarina Resende de Oliveira Juha O Rinne Karen M Rodrigue Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Christopher C Rowe Eckart Rüther Osama Sabri Páscual Sanchez-Juan Isabel Santana Marie Sarazin Johannes Schröder Christin Schütte Sang W Seo Femke Soetewey Hilkka Soininen Luiza Spiru Hanne Struyfs Charlotte E Teunissen Magda Tsolaki Rik Vandenberghe Marcel M Verbeek Victor L Villemagne Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Anders Wallin Åsa K Wallin Jens Wiltfang David A Wolk Marzena Zboch Henrik Zetterberg

JAMA 2015 May;313(19):1924-38

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden87UCL Institute of Neurology, Queen Square, London, United Kingdom.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1001/jama.2015.4668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486209PMC
May 2015

Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation.

Authors:
Eva Ramos-Fernández Marta Tajes Ernest Palomer Gerard Ill-Raga Mònica Bosch-Morató Biuse Guivernau Irene Román-Dégano Abel Eraso-Pichot Daniel Alcolea Juan Fortea Laura Nuñez Antonio Paez Francesc Alameda Xavier Fernández-Busquets Alberto Lleó Roberto Elosúa Mercé Boada Miguel A Valverde Francisco J Muñoz

J Alzheimers Dis 2014 ;40(3):643-57

Laboratory of Molecular Physiology and Channelopaties, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-130914DOI Listing
December 2014

Feasibility of lumbar puncture in the study of cerebrospinal fluid biomarkers for Alzheimer's disease: a multicenter study in Spain.

Authors:
Daniel Alcolea Pablo Martínez-Lage Andrea Izagirre Montserrat Clerigué María Carmona-Iragui Rosa María Alvarez Juan Fortea Mircea Balasa Estrella Morenas-Rodríguez Albert Lladó Oriol Grau Kaj Blennow Alberto Lleó José L Molinuevo

J Alzheimers Dis 2014 ;39(4):719-26

Department of Neurology, Alzheimer's Disease and other Cognitive Disorders Unit, Hospital Clínic, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-131334DOI Listing
October 2014

Cerebrospinal fluid β-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease.

Authors:
Juan Fortea Eduard Vilaplana Daniel Alcolea María Carmona-Iragui María-Belén Sánchez-Saudinos Isabel Sala Sofía Antón-Aguirre Sofía González Santiago Medrano Jordi Pegueroles Estrella Morenas Jordi Clarimón Rafael Blesa Alberto Lleó

Ann Neurol 2014 Aug 13;76(2):223-30. Epub 2014 Jun 13.

Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - CIBERNED.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ana.24186DOI Listing
August 2014

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Authors:
Gernot Kleinberger Yoshinori Yamanishi Marc Suárez-Calvet Eva Czirr Ebba Lohmann Elise Cuyvers Hanne Struyfs Nadine Pettkus Andrea Wenninger-Weinzierl Fargol Mazaheri Sabina Tahirovic Alberto Lleó Daniel Alcolea Juan Fortea Michael Willem Sven Lammich José L Molinuevo Raquel Sánchez-Valle Anna Antonell Alfredo Ramirez Michael T Heneka Kristel Sleegers Julie van der Zee Jean-Jacques Martin Sebastiaan Engelborghs Asli Demirtas-Tatlidede Henrik Zetterberg Christine Van Broeckhoven Hakan Gurvit Tony Wyss-Coray John Hardy Marco Colonna Christian Haass

Sci Transl Med 2014 Jul;6(243):243ra86

Adolf-Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, 80336 Munich, Germany. Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany. German Center for Neurodegenerative Diseases (DZNE), Munich, 80336 Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1126/scitranslmed.3009093DOI Listing
July 2014

Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation.

Authors:
Marc Suárez-Calvet Oriol Dols-Icardo Albert Lladó Raquel Sánchez-Valle Isabel Hernández Guillermo Amer Sofía Antón-Aguirre Daniel Alcolea Juan Fortea Isidre Ferrer Julie van der Zee Lubina Dillen Christine Van Broeckhoven José Luís Molinuevo Rafael Blesa Jordi Clarimón Alberto Lleó

J Neurol Neurosurg Psychiatry 2014 Jun 4;85(6):684-91. Epub 2013 Dec 4.

Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, , Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://jnnp.bmj.com/content/85/6/684.full.pdf
Web Search
http://jnnp.bmj.com/cgi/doi/10.1136/jnnp-2013-305972
Publisher Site
http://dx.doi.org/10.1136/jnnp-2013-305972DOI Listing
June 2014

Reply: To PMID 23794434.

Authors:
Petar Podlesniy Joana Figueiro-Silva Albert Llado Anna Antonell Raquel Sanchez-Valle Daniel Alcolea Alberto Lleo Jose Luis Molinuevo Nuria Serra Ramon Trullas

Ann Neurol 2014 Mar 7;75(3):460-1. Epub 2014 Mar 7.

Neurobiology Unit, Instituto de Investigaciones Biomedicas de Barcelona, Consejo Superior de Investigaciones Cientificas, CSIC; Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, CIBERNED.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ana.24106DOI Listing
March 2014

Characterization of the repeat expansion size in C9orf72 in amyotrophic lateral sclerosis and frontotemporal dementia.

Authors:
Oriol Dols-Icardo Alberto García-Redondo Ricard Rojas-García Raquel Sánchez-Valle Aina Noguera Estrella Gómez-Tortosa Pau Pastor Isabel Hernández Jesús Esteban-Pérez Marc Suárez-Calvet Sofía Antón-Aguirre Guillermo Amer Sara Ortega-Cubero Rafael Blesa Juan Fortea Daniel Alcolea Aura Capdevila Anna Antonell Albert Lladó José Luís Muñoz-Blanco Jesús S Mora Lucía Galán-Dávila Francisco Javier Rodríguez De Rivera Alberto Lleó Jordi Clarimón

Hum Mol Genet 2014 Feb 20;23(3):749-54. Epub 2013 Sep 20.

Memory Unit and Neuromuscular Diseases Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/hmg/ddt460DOI Listing
February 2014

The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study.

Authors:
Jose L Molinuevo Juan Domingo Gispert Bruno Dubois Michael T Heneka Alberto Lleo Sebastiaan Engelborghs Jesús Pujol Leonardo Cruz de Souza Daniel Alcolea Frank Jessen Marie Sarazin Foudil Lamari Mircea Balasa Anna Antonell Lorena Rami

J Alzheimers Dis 2013 ;36(1):67-77

Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-130203DOI Listing
December 2013

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease.

Authors:
Petar Podlesniy Joana Figueiro-Silva Albert Llado Anna Antonell Raquel Sanchez-Valle Daniel Alcolea Alberto Lleo Jose Luis Molinuevo Nuria Serra Ramon Trullas

Ann Neurol 2013 Nov 4;74(5):655-68. Epub 2013 Sep 4.

Neurobiology Unit, Instituto de Investigaciones Biomedicas de Barcelona, Consejo Superior de Investigaciones Cientificas, CSIC, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ana.23955DOI Listing
November 2013

Comparison of 2 diagnostic criteria for the behavioral variant of frontotemporal dementia.

Authors:
Sónia Costa Marc Suárez-Calvet Sofia Antón Oriol Dols-Icardo Jordi Clarimón Daniel Alcolea Juan Fortea María Carmona Isabel Sala M Belén Sánchez-Saudinós Rafael Blesa Alberto Lleó

Am J Alzheimers Dis Other Demen 2013 Aug 21;28(5):469-76. Epub 2013 May 21.

Department of Neurology, Memory Disorders Unit, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Universitat AutŒnoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1177/1533317513488918DOI Listing
August 2013

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.

Authors:
Marta Pera Daniel Alcolea Raquel Sánchez-Valle Cristina Guardia-Laguarta Martí Colom-Cadena Nahuai Badiola Marc Suárez-Calvet Albert Lladó Alvaro A Barrera-Ocampo Diego Sepulveda-Falla Rafael Blesa José L Molinuevo Jordi Clarimón Isidre Ferrer Ellen Gelpi Alberto Lleó

Acta Neuropathol 2013 Feb 6;125(2):201-13. Epub 2012 Dec 6.

Department of Neurology, Inst. Investigacions Biomediques, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni María Claret, 167, 08025 Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00401-012-1062-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623032PMC
February 2013

Rapidly progressive dementia: experience in a tertiary care medical center.

Authors:
Isabel Sala Marta Marquié María Belén Sánchez-Saudinós Raquel Sánchez-Valle Daniel Alcolea Beatriz Gómez-Ansón Teresa Gómez-Isla Rafael Blesa Alberto Lleó

Alzheimer Dis Assoc Disord 2012 Jul-Sep;26(3):267-71

Department of Neurology, Memory Disorders Unit, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/WAD.0b013e3182368ed4DOI Listing
January 2013

Expansion mutation in C9ORF72 does not influence plasma progranulin levels in frontotemporal dementia.

Authors:
Oriol Dols-Icardo Marc Suárez-Calvet Isabel Hernández Guillermo Amer Sofía Antón-Aguirre Daniel Alcolea Juan Fortea Mercè Boada Lluís Tárraga Rafael Blesa Alberto Lleó Jordi Clarimón

Neurobiol Aging 2012 Aug 11;33(8):1851.e17-9. Epub 2012 Apr 11.

Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2012.03.005DOI Listing
August 2012

The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia.

Authors:
Lluís Samaranch Sebastián Cervantes Ana Barabash Alvaro Alonso José Antonio Cabranes Isabel Lamet Inés Ancín Elena Lorenzo Pablo Martínez-Lage Alberto Marcos Jordi Clarimón Daniel Alcolea Alberto Lleó Rafael Blesa Teresa Gómez-Isla Pau Pastor

J Alzheimers Dis 2010 ;22(4):1065-71

Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-2010-101011DOI Listing
May 2011

Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypes.

Authors:
Núria Setó-Salvia Jordi Clarimón Javier Pagonabarraga Berta Pascual-Sedano Antonia Campolongo Onofre Combarros Jose Ignacio Mateo Daniel Regaña Merce Martínez-Corral Marta Marquié Daniel Alcolea Marc Suárez-Calvet Laura Molina-Porcel Oriol Dols Teresa Gómez-Isla Rafael Blesa Alberto Lleó Jaime Kulisevsky

Arch Neurol 2011 Mar;68(3):359-64

Memory Unit, Neurology Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni M. Claret 167, 08025 Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1001/archneurol.2011.17DOI Listing
March 2011

Remote cerebral hematomas in patients treated with intravenous rt-PA.

Authors:
Eugenia Martínez-Hernández Sergi Martínez-Ramírez Raquel Delgado-Mederos Daniel Alcolea Marta Marquié Rebeca Marín Manuel De Juan Josep Lluis Martí-Vilalta Joan Martí-Fàbregas

J Neurol 2010 Jul 6;257(7):1062-6. Epub 2010 Feb 6.

Department of Neurology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, Barcelona, Spain.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s00415-010-5462-2
Publisher Site
http://dx.doi.org/10.1007/s00415-010-5462-2DOI Listing
July 2010