Dana Crawford

Dana Crawford

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Dana Crawford

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Precision Medicine: Addressing the Challenges of Sharing, Analysis, and Privacy at Scale.

Pac Symp Biocomput 2020 ;25:547-550

University of California, Berkeley, USA.

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January 2020

Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital.

Pac Symp Biocomput 2020 ;25:575-586

Cleveland Institute for Computational Biology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA.

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January 2020

Control (Native) and oxidized (DeMP) mitochondrial RNA are proinflammatory regulators in human.

Free Radic Biol Med 2019 Nov 19;143:62-69. Epub 2019 Jul 19.

Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, 12208, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193083
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.07.019DOI Listing
November 2019

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells.

Food Chem Toxicol 2019 Nov 6;133:110808. Epub 2019 Sep 6.

Department of Biochemistry and Molecular Cell Biology, School of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.

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http://dx.doi.org/10.1016/j.fct.2019.110808DOI Listing
November 2019

Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines.

Public Health Genomics 2019 27;22(1-2):16-24. Epub 2019 Aug 27.

Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA,

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http://dx.doi.org/10.1159/000501974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752968PMC
August 2019

Mind the gap: resources required to receive, process and interpret research-returned whole genome data.

Hum Genet 2019 Jul 3;138(7):691-701. Epub 2019 Jun 3.

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.

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http://dx.doi.org/10.1007/s00439-019-02033-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767905PMC
July 2019

A Social Determinant of Health May Modify Genetic Associations for Blood Pressure: Evidence From a SNP by Education Interaction in an African American Population.

Front Genet 2019 10;10:428. Epub 2019 May 10.

Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, United States.

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http://dx.doi.org/10.3389/fgene.2019.00428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523518PMC
May 2019

Using Electronic Health Records To Generate Phenotypes For Research.

Curr Protoc Hum Genet 2019 01 5;100(1):e80. Epub 2018 Dec 5.

Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.

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http://doi.wiley.com/10.1002/cphg.80
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http://dx.doi.org/10.1002/cphg.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318047PMC
January 2019

Precision Medicine: Improving health through high-resolution analysis of personal data.

Pac Symp Biocomput 2019 ;24:220-223

University of California, Berkeley, USA†Supported by U41 HG007346 and U19 HD077627.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526370PMC
January 2019

Racial Disparities in Lung Cancer Survival: The Contribution of Stage, Treatment, and Ancestry.

J Thorac Oncol 2018 10 6;13(10):1464-1473. Epub 2018 Jun 6.

Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153049PMC
October 2018

Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels.

BMC Med Genomics 2018 Sep 14;11(Suppl 3):66. Epub 2018 Sep 14.

Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1186/s12920-018-0387-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156840PMC
September 2018

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

BMC Med Genomics 2018 Sep 14;11(Suppl 3):70. Epub 2018 Sep 14.

Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Suite 2-527, Cleveland, OH, 44106, USA.

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https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12920-018-0392-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157155PMC
September 2018

PRECISION MEDICINE: FROM DIPLOTYPES TO DISPARITIES TOWARDS IMPROVED HEALTH AND THERAPIES.

Pac Symp Biocomput 2018 ;23:389-399

Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182117PMC
August 2018

Local ancestry transitions modify snp-trait associations.

Pac Symp Biocomput 2018 ;23:424-435

Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN 37235, USA, ²Departments of Biological Sciences, Biomedical Informatics, and Computer Science, Vanderbilt University, Nashville, TN 37235, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728664PMC
August 2018

INTEGRATING COMMUNITY-LEVEL DATA RESOURCES FOR PRECISION MEDICINE RESEARCH.

Pac Symp Biocomput 2018 ;23:618-622

Department of Population and Quantitative Health Sciences, Case Western Reserve University Cleveland, OH, 44106, USA,

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August 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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http://dx.doi.org/10.1038/s41467-018-04766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178PMC
July 2018

Participation of liver stem cells in cholangiocarcinogenesis after aflatoxin B exposure of glutathione S-transferase A3 knockout mice.

Tumour Biol 2018 May;40(5):1010428318777344

1 Wadsworth Center, New York State Department of Health, Albany, NY, USA.

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http://dx.doi.org/10.1177/1010428318777344DOI Listing
May 2018

Germline Genetic Variants and Lung Cancer Survival in African Americans.

Cancer Epidemiol Biomarkers Prev 2017 08 15;26(8):1288-1295. Epub 2017 Jun 15.

Department of Thoracic Surgery, Vanderbilt University Medical School, Nashville, Tennessee.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540773PMC
August 2017

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.

J Natl Cancer Inst 2017 08;109(8)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1093/jnci/djx084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448553PMC
August 2017

Extracting Country-of-Origin from Electronic Health Records for Gene- Environment Studies as Part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study.

AMIA Jt Summits Transl Sci Proc 2017 26;2017:50-57. Epub 2017 Jul 26.

Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543359PMC
July 2017

Reducing Clinical Noise for Body Mass Index Measures Due to Unit and Transcription Errors in the Electronic Health Record.

AMIA Jt Summits Transl Sci Proc 2017 26;2017:102-111. Epub 2017 Jul 26.

Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543370PMC
July 2017

Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci.

Hum Genet 2017 06 8;136(6):771-800. Epub 2017 Apr 8.

Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s00439-017-1787-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485655PMC
June 2017

Oxidized and Original article degraded mitochondrial polynucleotides (DeMPs), especially RNA, are potent immunogenic regulators in primary mouse macrophages.

Free Radic Biol Med 2017 03 4;104:371-379. Epub 2017 Feb 4.

Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.009DOI Listing
March 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

Predicting Incident Coronary Heart Disease Many Markers at a Time.

Circ Cardiovasc Genet 2016 12;9(6):472-473

From the Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001645DOI Listing
December 2016

TESTING POPULATION-SPECIFIC QUANTITATIVE TRAIT ASSOCIATIONS FOR CLINICAL OUTCOME RELEVANCE IN A BIOREPOSITORY LINKED TO ELECTRONIC HEALTH RECORDS: LPA AND MYOCARDIAL INFARCTION IN AFRICAN AMERICANS.

Pac Symp Biocomput 2016 ;21:96-107

Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720978PMC
October 2016

KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.

Pac Symp Biocomput 2016 ;21:285-96

Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Suite 2527, Cleveland, OH 44106, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720994PMC
October 2016

THE CHALLENGES IN USING ELECTRONIC HEALTH RECORDS FOR PHARMACOGENOMICS AND PRECISION MEDICINE RESEARCH.

Pac Symp Biocomput 2016 ;21:369-80

Eastern Virginia Medical School, Norfolk, VA, 23507, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720980PMC
October 2016

Shared Genetic Etiology of Autoimmune Diseases in Patients from a Biorepository Linked to De-identified Electronic Health Records.

Front Genet 2016 20;7:185. Epub 2016 Oct 20.

Department of Epidemiology and Biostatistics, Case Western Reserve UniversityCleveland, OH, USA; Institute for Computational Biology, Case Western Reserve UniversityCleveland, OH, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2016.00
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http://dx.doi.org/10.3389/fgene.2016.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071319PMC
October 2016

eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants.

BMC Med Genomics 2016 08 12;9 Suppl 1:32. Epub 2016 Aug 12.

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa.

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http://dx.doi.org/10.1186/s12920-016-0191-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989894PMC
August 2016

DRUG-DRUG INTERACTION PROFILES OF MEDICATION REGIMENS EXTRACTED FROM A DE-IDENTIFIED ELECTRONIC MEDICAL RECORDS SYSTEM.

AMIA Jt Summits Transl Sci Proc 2016 20;2016:33-40. Epub 2016 Jul 20.

Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, US.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001747PMC
August 2016

Searching in the Dark: Phenotyping Diabetic Retinopathy in a De-Identified Electronic Medical Record Sample of African Americans.

AMIA Jt Summits Transl Sci Proc 2016 20;2016:221-30. Epub 2016 Jul 20.

Case Western Reserve University, Department of Epidemiology and Biostatistics, Cleveland, Ohio; Case Western Reserve University, Institute for Computational Biology, Cleveland, Ohio.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001772PMC
August 2016

Commentary on "Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response" by Ma et al. [Free Radic. Biol. Med. 96 (2016) 347-361].

Authors:
Dana R Crawford

Free Radic Biol Med 2016 07 18;96:465-6. Epub 2016 May 18.

Department of Immunology and Microbial Disease, Albany Medical College, 43 New Scotland Avenue, Albany, NY 12208, United States.

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.05.018DOI Listing
July 2016

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Authors:
Ching-Ti Liu Sridharan Raghavan Nisa Maruthur Edmond Kato Kabagambe Jaeyoung Hong Maggie C Y Ng Marie-France Hivert Yingchang Lu Ping An Amy R Bentley Anne M Drolet Kyle J Gaulton Xiuqing Guo Loren L Armstrong Marguerite R Irvin Man Li Leonard Lipovich Denis V Rybin Kent D Taylor Charles Agyemang Nicholette D Palmer Brian E Cade Wei-Min Chen Marco Dauriz Joseph A C Delaney Todd L Edwards Daniel S Evans Michele K Evans Leslie A Lange Aaron Leong Jingmin Liu Yongmei Liu Uma Nayak Sanjay R Patel Bianca C Porneala Laura J Rasmussen-Torvik Marieke B Snijder Sarah C Stallings Toshiko Tanaka Lisa R Yanek Wei Zhao Diane M Becker Lawrence F Bielak Mary L Biggs Erwin P Bottinger Donald W Bowden Guanjie Chen Adolfo Correa David J Couper Dana C Crawford Mary Cushman John D Eicher Myriam Fornage Nora Franceschini Yi-Ping Fu Mark O Goodarzi Omri Gottesman Kazuo Hara Tamara B Harris Richard A Jensen Andrew D Johnson Min A Jhun Andrew J Karter Margaux F Keller Abel N Kho Jorge R Kizer Ronald M Krauss Carl D Langefeld Xiaohui Li Jingling Liang Simin Liu William L Lowe Thomas H Mosley Kari E North Jennifer A Pacheco Patricia A Peyser Alan L Patrick Kenneth M Rice Elizabeth Selvin Mario Sims Jennifer A Smith Salman M Tajuddin Dhananjay Vaidya Mary P Wren Jie Yao Xiaofeng Zhu Julie T Ziegler Joseph M Zmuda Alan B Zonderman Aeilko H Zwinderman Adebowale Adeyemo Eric Boerwinkle Luigi Ferrucci M Geoffrey Hayes Sharon L R Kardia Iva Miljkovic James S Pankow Charles N Rotimi Michele M Sale Lynne E Wagenknecht Donna K Arnett Yii-Der Ida Chen Michael A Nalls Michael A Province W H Linda Kao David S Siscovick Bruce M Psaty James G Wilson Ruth J F Loos Josée Dupuis Stephen S Rich Jose C Florez Jerome I Rotter Andrew P Morris James B Meigs

Am J Hum Genet 2016 Jul 16;99(1):56-75. Epub 2016 Jun 16.

Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005440PMC
July 2016

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

J Am Heart Assoc 2016 07 14;5(7). Epub 2016 Jul 14.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1161/JAHA.115.002603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015357PMC
July 2016

Extracting Primary Open-Angle Glaucoma from Electronic Medical Records for Genetic Association Studies.

PLoS One 2015 10;10(6):e0127817. Epub 2015 Jun 10.

Department of Epidemiology & Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465698PMC
June 2016

Evidence for extensive pleiotropy among pharmacogenes.

Pharmacogenomics 2016 06 1;17(8):853-66. Epub 2016 Jun 1.

Department of Epidemiology & Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.2217/pgs-2015-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352965PMC
June 2016

Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data.

Front Genet 2016 6;7:76. Epub 2016 May 6.

Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland OH, USA.

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http://dx.doi.org/10.3389/fgene.2016.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858524PMC
May 2016

Measures of exposure impact genetic association studies: an example in vitamin K levels and VKORC1.

Pac Symp Biocomput 2015 :161-70

Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Suite 2527, Cleveland, OH 44106, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299921PMC
April 2016

Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations.

Pac Symp Biocomput 2015 :219-30

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, 1468 Madison Ave., New York, NY 10128, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357227PMC
April 2016

Mitochondrial variation and the risk of age-related macular degeneration across diverse populations.

Pac Symp Biocomput 2015 :243-54

Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, TN 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299880PMC
April 2016

Phenome-Wide Association Studies: Embracing Complexity for Discovery.

Hum Hered 2015 28;79(3-4):111-23. Epub 2015 Jul 28.

Biomedical and Translational Informatics Program, Geisinger Health System, Danville, Pa., USA.

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http://dx.doi.org/10.1159/000381851DOI Listing
April 2016

Leveraging Epidemiologic and Clinical Collections for Genomic Studies of Complex Traits.

Hum Hered 2015 28;79(3-4):137-46. Epub 2015 Jul 28.

Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1159/000381805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528966PMC
April 2016

Unravelling the human genome-phenome relationship using phenome-wide association studies.

Nat Rev Genet 2016 Mar 15;17(3):129-45. Epub 2016 Feb 15.

Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1038/nrg.2015.36DOI Listing
March 2016

The detection and characterization of pleiotropy: discovery, progress, and promise.

Brief Bioinform 2016 Jan 28;17(1):13-22. Epub 2015 Jul 28.

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http://dx.doi.org/10.1093/bib/bbv050DOI Listing
January 2016

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry.

BioData Min 2015 11;8:35. Epub 2015 Nov 11.

Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Suite 2527, Cleveland, OH 44106 USA.

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http://dx.doi.org/10.1186/s13040-015-0068-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642611PMC
November 2015

Accuracy of administratively-assigned ancestry for diverse populations in an electronic medical record-linked biobank.

PLoS One 2014 4;9(6):e99161. Epub 2014 Jun 4.

Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099161PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045967PMC
October 2015

Fish oil improves gene targets of Down syndrome in C57BL and BALB/c mice.

Nutr Res 2015 May 1;35(5):440-8. Epub 2015 Mar 1.

Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA. Electronic address:

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May 2015

The effects of electronic medical record phenotyping details on genetic association studies: HDL-C as a case study.

BioData Min 2015 6;8:15. Epub 2015 May 6.

Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Suite 2527, Cleveland, OH 44106 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428098PMC
May 2015

New genetic loci link adipose and insulin biology to body fat distribution.

Authors:
Dmitry Shungin Thomas W Winkler Damien C Croteau-Chonka Teresa Ferreira Adam E Locke Reedik Mägi Rona J Strawbridge Tune H Pers Krista Fischer Anne E Justice Tsegaselassie Workalemahu Joseph M W Wu Martin L Buchkovich Nancy L Heard-Costa Tamara S Roman Alexander W Drong Ci Song Stefan Gustafsson Felix R Day Tonu Esko Tove Fall Zoltán Kutalik Jian'an Luan Joshua C Randall André Scherag Sailaja Vedantam Andrew R Wood Jin Chen Rudolf Fehrmann Juha Karjalainen Bratati Kahali Ching-Ti Liu Ellen M Schmidt Devin Absher Najaf Amin Denise Anderson Marian Beekman Jennifer L Bragg-Gresham Steven Buyske Ayse Demirkan Georg B Ehret Mary F Feitosa Anuj Goel Anne U Jackson Toby Johnson Marcus E Kleber Kati Kristiansson Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Cameron D Palmer Dorota Pasko Sonali Pechlivanis Marjolein J Peters Inga Prokopenko Alena Stančáková Yun Ju Sung Toshiko Tanaka Alexander Teumer Jana V Van Vliet-Ostaptchouk Loïc Yengo Weihua Zhang Eva Albrecht Johan Ärnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Stefan Böhringer Fabrice Bonnet Yvonne Böttcher Marcel Bruinenberg Delia B Carba Ida H Caspersen Robert Clarke E Warwick Daw Joris Deelen Ewa Deelman Graciela Delgado Alex Sf Doney Niina Eklund Michael R Erdos Karol Estrada Elodie Eury Nele Friedrich Melissa E Garcia Vilmantas Giedraitis Bruna Gigante Alan S Go Alain Golay Harald Grallert Tanja B Grammer Jürgen Gräßler Jagvir Grewal Christopher J Groves Toomas Haller Goran Hallmans Catharina A Hartman Maija Hassinen Caroline Hayward Kauko Heikkilä Karl-Heinz Herzig Quinta Helmer Hans L Hillege Oddgeir Holmen Steven C Hunt Aaron Isaacs Till Ittermann Alan L James Ingegerd Johansson Thorhildur Juliusdottir Ioanna-Panagiota Kalafati Leena Kinnunen Wolfgang Koenig Ishminder K Kooner Wolfgang Kratzer Claudia Lamina Karin Leander Nanette R Lee Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon François Mach Patrik Ke Magnusson Anubha Mahajan Wendy L McArdle Cristina Menni Sigrun Merger Evelin Mihailov Lili Milani Rebecca Mills Alireza Moayyeri Keri L Monda Simon P Mooijaart Thomas W Mühleisen Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Ramaiah Nagaraja Michael A Nalls Narisu Narisu Nicola Glorioso Ilja M Nolte Matthias Olden Nigel W Rayner Frida Renstrom Janina S Ried Neil R Robertson Lynda M Rose Serena Sanna Hubert Scharnagl Salome Scholtens Bengt Sennblad Thomas Seufferlein Colleen M Sitlani Albert Vernon Smith Kathleen Stirrups Heather M Stringham Johan Sundström Morris A Swertz Amy J Swift Ann-Christine Syvänen Bamidele O Tayo Barbara Thorand Gudmar Thorleifsson Andreas Tomaschitz Chiara Troffa Floor Va van Oort Niek Verweij Judith M Vonk Lindsay L Waite Roman Wennauer Tom Wilsgaard Mary K Wojczynski Andrew Wong Qunyuan Zhang Jing Hua Zhao Eoin P Brennan Murim Choi Per Eriksson Lasse Folkersen Anders Franco-Cereceda Ali G Gharavi Åsa K Hedman Marie-France Hivert Jinyan Huang Stavroula Kanoni Fredrik Karpe Sarah Keildson Krzysztof Kiryluk Liming Liang Richard P Lifton Baoshan Ma Amy J McKnight Ruth McPherson Andres Metspalu Josine L Min Miriam F Moffatt Grant W Montgomery Joanne M Murabito George Nicholson Dale R Nyholt Christian Olsson John Rb Perry Eva Reinmaa Rany M Salem Niina Sandholm Eric E Schadt Robert A Scott Lisette Stolk Edgar E Vallejo Harm-Jan Westra Krina T Zondervan Philippe Amouyel Dominique Arveiler Stephan Jl Bakker John Beilby Richard N Bergman John Blangero Morris J Brown Michel Burnier Harry Campbell Aravinda Chakravarti Peter S Chines Simone Claudi-Boehm Francis S Collins Dana C Crawford John Danesh Ulf de Faire Eco Jc de Geus Marcus Dörr Raimund Erbel Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Nita G Forouhi Terrence Forrester Oscar H Franco Ron T Gansevoort Christian Gieger Vilmundur Gudnason Christopher A Haiman Tamara B Harris Andrew T Hattersley Markku Heliövaara Andrew A Hicks Aroon D Hingorani Wolfgang Hoffmann Albert Hofman Georg Homuth Steve E Humphries Elina Hyppönen Thomas Illig Marjo-Riitta Jarvelin Berit Johansen Pekka Jousilahti Antti M Jula Jaakko Kaprio Frank Kee Sirkka M Keinanen-Kiukaanniemi Jaspal S Kooner Charles Kooperberg Peter Kovacs Aldi T Kraja Meena Kumari Kari Kuulasmaa Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Valeriya Lyssenko Satu Männistö André Marette Tara C Matise Colin A McKenzie Barbara McKnight Arthur W Musk Stefan Möhlenkamp Andrew D Morris Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Lyle J Palmer Brenda W Penninx Annette Peters Peter P Pramstaller Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Paul M Ridker Marylyn D Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter Eh Schwarz Alan R Shuldiner Jan A Staessen Valgerdur Steinthorsdottir Ronald P Stolk Konstantin Strauch Anke Tönjes Angelo Tremblay Elena Tremoli Marie-Claude Vohl Uwe Völker Peter Vollenweider James F Wilson Jacqueline C Witteman Linda S Adair Murielle Bochud Bernhard O Boehm Stefan R Bornstein Claude Bouchard Stéphane Cauchi Mark J Caulfield John C Chambers Daniel I Chasman Richard S Cooper George Dedoussis Luigi Ferrucci Philippe Froguel Hans-Jörgen Grabe Anders Hamsten Jennie Hui Kristian Hveem Karl-Heinz Jöckel Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Winfried März Patricia B Munroe Inger Njølstad Ben A Oostra Colin Na Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Chris Power Thomas Quertermous Rainer Rauramaa Fernando Rivadeneira Timo E Saaristo Danish Saleheen Juha Sinisalo P Eline Slagboom Harold Snieder Tim D Spector Kari Stefansson Michael Stumvoll Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Pim van der Harst Giovanni Veronesi Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann Goncalo R Abecasis Themistocles L Assimes Sonja I Berndt Michael Boehnke Ingrid B Borecki Panos Deloukas Lude Franke Timothy M Frayling Leif C Groop David J Hunter Robert C Kaplan Jeffrey R O'Connell Lu Qi David Schlessinger David P Strachan Unnur Thorsteinsdottir Cornelia M van Duijn Cristen J Willer Peter M Visscher Jian Yang Joel N Hirschhorn M Carola Zillikens Mark I McCarthy Elizabeth K Speliotes Kari E North Caroline S Fox Inês Barroso Paul W Franks Erik Ingelsson Iris M Heid Ruth Jf Loos L Adrienne Cupples Andrew P Morris Cecilia M Lindgren Karen L Mohlke

Nature 2015 Feb;518(7538):187-196

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

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February 2015

Genetic studies of body mass index yield new insights for obesity biology.

Authors:
Adam E Locke Bratati Kahali Sonja I Berndt Anne E Justice Tune H Pers Felix R Day Corey Powell Sailaja Vedantam Martin L Buchkovich Jian Yang Damien C Croteau-Chonka Tonu Esko Tove Fall Teresa Ferreira Stefan Gustafsson Zoltán Kutalik Jian'an Luan Reedik Mägi Joshua C Randall Thomas W Winkler Andrew R Wood Tsegaselassie Workalemahu Jessica D Faul Jennifer A Smith Jing Hua Zhao Wei Zhao Jin Chen Rudolf Fehrmann Åsa K Hedman Juha Karjalainen Ellen M Schmidt Devin Absher Najaf Amin Denise Anderson Marian Beekman Jennifer L Bolton Jennifer L Bragg-Gresham Steven Buyske Ayse Demirkan Guohong Deng Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Anuj Goel Jian Gong Anne U Jackson Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Sarah E Medland Michael A Nalls Cameron D Palmer Dorota Pasko Sonali Pechlivanis Marjolein J Peters Inga Prokopenko Dmitry Shungin Alena Stančáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Aaron Isaacs Eva Albrecht Johan Ärnlöv Gillian M Arscott Antony P Attwood Stefania Bandinelli Amy Barrett Isabelita N Bas Claire Bellis Amanda J Bennett Christian Berne Roza Blagieva Matthias Blüher Stefan Böhringer Lori L Bonnycastle Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Ida H Caspersen Yii-Der Ida Chen Robert Clarke E Warwick Daw Anton J M de Craen Graciela Delgado Maria Dimitriou Alex S F Doney Niina Eklund Karol Estrada Elodie Eury Lasse Folkersen Ross M Fraser Melissa E Garcia Frank Geller Vilmantas Giedraitis Bruna Gigante Alan S Go Alain Golay Alison H Goodall Scott D Gordon Mathias Gorski Hans-Jörgen Grabe Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Christopher J Groves Gaëlle Gusto Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Christian Hengstenberg Oddgeir Holmen Jouke-Jan Hottenga Alan L James Janina M Jeff Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Leena Kinnunen Wolfgang Koenig Markku Koskenvuo Wolfgang Kratzer Jaana Laitinen Claudia Lamina Karin Leander Nanette R Lee Peter Lichtner Lars Lind Jaana Lindström Ken Sin Lo Stéphane Lobbens Roberto Lorbeer Yingchang Lu François Mach Patrik K E Magnusson Anubha Mahajan Wendy L McArdle Stela McLachlan Cristina Menni Sigrun Merger Evelin Mihailov Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Ramaiah Nagaraja Markus M Nöthen Ilja M Nolte Stefan Pilz Nigel W Rayner Frida Renstrom Rainer Rettig Janina S Ried Stephan Ripke Neil R Robertson Lynda M Rose Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher William R Scott Thomas Seufferlein Jianxin Shi Albert Vernon Smith Joanna Smolonska Alice V Stanton Valgerdur Steinthorsdottir Kathleen Stirrups Heather M Stringham Johan Sundström Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Bamidele O Tayo Barbara Thorand Gudmar Thorleifsson Jonathan P Tyrer Hae-Won Uh Liesbeth Vandenput Frank C Verhulst Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Helen R Warren Dawn Waterworth Michael N Weedon Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Eoin P Brennan Murim Choi Zari Dastani Alexander W Drong Per Eriksson Anders Franco-Cereceda Jesper R Gådin Ali G Gharavi Michael E Goddard Robert E Handsaker Jinyan Huang Fredrik Karpe Sekar Kathiresan Sarah Keildson Krzysztof Kiryluk Michiaki Kubo Jong-Young Lee Liming Liang Richard P Lifton Baoshan Ma Steven A McCarroll Amy J McKnight Josine L Min Miriam F Moffatt Grant W Montgomery Joanne M Murabito George Nicholson Dale R Nyholt Yukinori Okada John R B Perry Rajkumar Dorajoo Eva Reinmaa Rany M Salem Niina Sandholm Robert A Scott Lisette Stolk Atsushi Takahashi Toshihiro Tanaka Ferdinand M van 't Hooft Anna A E Vinkhuyzen Harm-Jan Westra Wei Zheng Krina T Zondervan Andrew C Heath Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman John Blangero Pascal Bovet Harry Campbell Mark J Caulfield Giancarlo Cesana Aravinda Chakravarti Daniel I Chasman Peter S Chines Francis S Collins Dana C Crawford L Adrienne Cupples Daniele Cusi John Danesh Ulf de Faire Hester M den Ruijter Anna F Dominiczak Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Stephan B Felix Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Oscar H Franco Ron T Gansevoort Pablo V Gejman Christian Gieger Omri Gottesman Vilmundur Gudnason Ulf Gyllensten Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman Georg Homuth G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hyppönen Thomas Illig Kevin B Jacobs Marjo-Riitta Jarvelin Karl-Heinz Jöckel Berit Johansen Pekka Jousilahti J Wouter Jukema Antti M Jula Jaakko Kaprio John J P Kastelein Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Paul Knekt Jaspal S Kooner Charles Kooperberg Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Valeriya Lyssenko Satu Männistö André Marette Tara C Matise Colin A McKenzie Barbara McKnight Frans L Moll Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Pamela A F Madden Gerard Pasterkamp John F Peden Annette Peters Dirkje S Postma Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Paul M Ridker John D Rioux Marylyn D Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Heribert Schunkert Peter E H Schwarz Peter Sever Alan R Shuldiner Juha Sinisalo Ronald P Stolk Konstantin Strauch Anke Tönjes David-Alexandre Trégouët Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Uwe Völker Gérard Waeber Gonneke Willemsen Jacqueline C Witteman M Carola Zillikens Linda S Adair Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Stefan R Bornstein Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten Jennie Hui David J Hunter Kristian Hveem Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Andres Metspalu Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Chris Power Thomas Quertermous Rainer Rauramaa Fernando Rivadeneira Timo E Saaristo Danish Saleheen Naveed Sattar Eric E Schadt David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Unnur Thorsteinsdottir Michael Stumvoll Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Pim van der Harst Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins David R Weir H-Erich Wichmann James F Wilson Pieter Zanen Ingrid B Borecki Panos Deloukas Caroline S Fox Iris M Heid Jeffrey R O'Connell David P Strachan Kari Stefansson Cornelia M van Duijn Gonçalo R Abecasis Lude Franke Timothy M Frayling Mark I McCarthy Peter M Visscher André Scherag Cristen J Willer Michael Boehnke Karen L Mohlke Cecilia M Lindgren Jacques S Beckmann Inês Barroso Kari E North Erik Ingelsson Joel N Hirschhorn Ruth J F Loos Elizabeth K Speliotes

Nature 2015 Feb;518(7538):197-206

Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2015

SecureMA: protecting participant privacy in genetic association meta-analysis.

Bioinformatics 2014 Dec 21;30(23):3334-41. Epub 2014 Aug 21.

Department of Electrical Engineering & Computer Science, Vanderbilt University, Nashville, TN 37232, USA, Department of Computer Science, University of Texas at Dallas, Richardson, TX 75080, USA, Department of Biomedical Informatics, Center for Human Genetics Research, Department of Molecular Physiology and Biophysics and Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA Department of Electrical Engineering & Computer Science, Vanderbilt University, Nashville, TN 37232, USA, Department of Computer Science, University of Texas at Dallas, Richardson, TX 75080, USA, Department of Biomedical Informatics, Center for Human Genetics Research, Department of Molecular Physiology and Biophysics and Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

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December 2014

Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the Epidemiologic Architecture for Genes Linked to Environment Study.

Circ Cardiovasc Genet 2014 Dec 1;7(6):848-53. Epub 2014 Nov 1.

From the Institute for Computational Biology (D.C.C., P.M., J.L.H.), Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH (D.C.C., J.L.H.); Center for Human Genetics Research (L.D., R.G., K.B.-G., J.B., B.M., M.A., N.S.-B.), Department of Molecular Physiology and Biophysics (L.D.), Vanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN (C.S., R.W., P.B., H.H.D.); Hussman Institute for Human Genomics, University of Miami, FL (M.A.P.-V., W.K.S.); and Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore (T.I.P.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305446PMC
December 2014

Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors:
Andrew R Wood Tonu Esko Jian Yang Sailaja Vedantam Tune H Pers Stefan Gustafsson Audrey Y Chu Karol Estrada Jian'an Luan Zoltán Kutalik Najaf Amin Martin L Buchkovich Damien C Croteau-Chonka Felix R Day Yanan Duan Tove Fall Rudolf Fehrmann Teresa Ferreira Anne U Jackson Juha Karjalainen Ken Sin Lo Adam E Locke Reedik Mägi Evelin Mihailov Eleonora Porcu Joshua C Randall André Scherag Anna A E Vinkhuyzen Harm-Jan Westra Thomas W Winkler Tsegaselassie Workalemahu Jing Hua Zhao Devin Absher Eva Albrecht Denise Anderson Jeffrey Baron Marian Beekman Ayse Demirkan Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Ross M Fraser Anuj Goel Jian Gong Anne E Justice Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Julian C Lui Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Michael A Nalls Dale R Nyholt Cameron D Palmer Dorota Pasko Sonali Pechlivanis Inga Prokopenko Janina S Ried Stephan Ripke Dmitry Shungin Alena Stancáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Uzma Afzal Johan Arnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Jennifer L Bolton Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Brendan M Buckley Steven Buyske Ida H Caspersen Peter S Chines Robert Clarke Simone Claudi-Boehm Matthew Cooper E Warwick Daw Pim A De Jong Joris Deelen Graciela Delgado Josh C Denny Rosalie Dhonukshe-Rutten Maria Dimitriou Alex S F Doney Marcus Dörr Niina Eklund Elodie Eury Lasse Folkersen Melissa E Garcia Frank Geller Vilmantas Giedraitis Alan S Go Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Lisette C P G M de Groot Christopher J Groves Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Anke Hannemann Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Gibran Hemani Anjali K Henders Hans L Hillege Mark A Hlatky Wolfgang Hoffmann Per Hoffmann Oddgeir Holmen Jeanine J Houwing-Duistermaat Thomas Illig Aaron Isaacs Alan L James Janina Jeff Berit Johansen Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Juhani Junttila Abel N Kho Leena Kinnunen Norman Klopp Thomas Kocher Wolfgang Kratzer Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon Yingchang Lu Valeriya Lyssenko Patrik K E Magnusson Anubha Mahajan Marc Maillard Wendy L McArdle Colin A McKenzie Stela McLachlan Paul J McLaren Cristina Menni Sigrun Merger Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Narisu Narisu Matthias Nauck Ilja M Nolte Markus M Nöthen Laticia Oozageer Stefan Pilz Nigel W Rayner Frida Renstrom Neil R Robertson Lynda M Rose Ronan Roussel Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher Heribert Schunkert Robert A Scott Joban Sehmi Thomas Seufferlein Jianxin Shi Karri Silventoinen Johannes H Smit Albert Vernon Smith Joanna Smolonska Alice V Stanton Kathleen Stirrups David J Stott Heather M Stringham Johan Sundström Morris A Swertz Ann-Christine Syvänen Bamidele O Tayo Gudmar Thorleifsson Jonathan P Tyrer Suzanne van Dijk Natasja M van Schoor Nathalie van der Velde Diana van Heemst Floor V A van Oort Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Melanie Waldenberger Roman Wennauer Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman Sven Bergmann Reiner Biffar John Blangero Dorret I Boomsma Stefan R Bornstein Pascal Bovet Paolo Brambilla Morris J Brown Harry Campbell Mark J Caulfield Aravinda Chakravarti Rory Collins Francis S Collins Dana C Crawford L Adrienne Cupples John Danesh Ulf de Faire Hester M den Ruijter Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Ron T Gansevoort Pablo V Gejman Christian Gieger Alain Golay Omri Gottesman Vilmundur Gudnason Ulf Gyllensten David W Haas Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew C Heath Christian Hengstenberg Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hypponen Kevin B Jacobs Marjo-Riitta Jarvelin Pekka Jousilahti Antti M Jula Jaakko Kaprio John J P Kastelein Manfred Kayser Frank Kee Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Jaspal S Kooner Charles Kooperberg Seppo Koskinen Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Sara Lupoli Pamela A F Madden Satu Männistö Paolo Manunta André Marette Tara C Matise Barbara McKnight Thomas Meitinger Frans L Moll Grant W Montgomery Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Willem H Ouwehand Gerard Pasterkamp Annette Peters Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Marylyn Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter E H Schwarz Sylvain Sebert Peter Sever Alan R Shuldiner Juha Sinisalo Valgerdur Steinthorsdottir Ronald P Stolk Jean-Claude Tardif Anke Tönjes Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten M Geoffrey Hayes Jennie Hui David J Hunter Kristian Hveem J Wouter Jukema Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Joseph E Powell Chris Power Thomas Quertermous Rainer Rauramaa Eva Reinmaa Paul M Ridker Fernando Rivadeneira Jerome I Rotter Timo E Saaristo Danish Saleheen David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Konstantin Strauch Michael Stumvoll Jaakko Tuomilehto Matti Uusitupa Pim van der Harst Henry Völzke Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann James F Wilson Pieter Zanen Panos Deloukas Iris M Heid Cecilia M Lindgren Karen L Mohlke Elizabeth K Speliotes Unnur Thorsteinsdottir Inês Barroso Caroline S Fox Kari E North David P Strachan Jacques S Beckmann Sonja I Berndt Michael Boehnke Ingrid B Borecki Mark I McCarthy Andres Metspalu Kari Stefansson André G Uitterlinden Cornelia M van Duijn Lude Franke Cristen J Willer Alkes L Price Guillaume Lettre Ruth J F Loos Michael N Weedon Erik Ingelsson Jeffrey R O'Connell Goncalo R Abecasis Daniel I Chasman Michael E Goddard Peter M Visscher Joel N Hirschhorn Timothy M Frayling

Nat Genet 2014 Nov 5;46(11):1173-86. Epub 2014 Oct 5.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

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November 2014

Extraction of echocardiographic data from the electronic medical record is a rapid and efficient method for study of cardiac structure and function.

J Clin Bioinforma 2014 20;4:12. Epub 2014 Sep 20.

Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA ; Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

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October 2014

Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study.

Invest Ophthalmol Vis Sci 2014 Sep 9;55(10):6839-50. Epub 2014 Sep 9.

Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.

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http://dx.doi.org/10.1167/iovs.14-14246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214207PMC
September 2014

Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank.

Pac Symp Biocomput 2014 :200-11

Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 512 Wartik Lab, University Park, PA 16802, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037237PMC
August 2014

Development of a data-mining algorithm to identify ages at reproductive milestones in electronic medical records.

Pac Symp Biocomput 2014 :376-87

Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, TN 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905575PMC
August 2014

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

PLoS Genet 2014 Aug 7;10(8):e1004517. Epub 2014 Aug 7.

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125087PMC
August 2014

Characterization of mitochondrial haplogroups in a large population-based sample from the United States.

Hum Genet 2014 Jul 1;133(7):861-8. Epub 2014 Feb 1.

Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, Tennessee, USA,

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http://dx.doi.org/10.1007/s00439-014-1421-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113317PMC
July 2014

eMERGEing progress in genomics-the first seven years.

Front Genet 2014 17;5:184. Epub 2014 Jun 17.

Department of Biochemistry and Molecular Biology, Pennsylvania State University University Park, PA, USA ; Center for Systems Genomics, Pennsylvania State University University Park, PA, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2014.00
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http://dx.doi.org/10.3389/fgene.2014.00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060012PMC
July 2014

Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia.

J Natl Cancer Inst 2014 Apr 28;106(4):dju061. Epub 2014 Mar 28.

Affiliations of authors: Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (SLP, FRS, CAH); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (MDF, JMK, AY, YL, UP, CC, CK); Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, UK (MT); Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI (CPC, LRW, LL); Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH (YH, CIA); Department of Epidemiology (S-AL, AB, KEN, GH) and Carolina Center for Genome Sciences (KEN), University of North Carolina, Chapel Hill, NC; Molecular Physiology and Biophysics (LD, DCC), Center for Human Genetics Research (LD, RG, HD, DCC, WSB), Vanderbilt Epidemiology Center (JHF), and Biomedical Informatics (WSB), Vanderbilt University, Nashville, TN; Division of Genomic Medicine, National Human Genome Research Institute (LH), and Division of Cancer Epidemiology and Genetics, National Cancer Institute (DA, NC, MTL), National Institutes of Health, Bethesda, MD; Department of Statistics and Biostatistics, Rutgers University, Piscataway, NJ (SB); Information Sciences Institute, University of Southern California, Marina del Rey, CA (ED); Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan (MLC); M.D. Anderson Cancer Center, Houston, TX (WC, MP); Harvard University School of Public Health, Boston, MA (DCC); Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK (JKF); Department of Genetic Epidemiology, University Medical Centre Göttingen, Göttingen, Germany (HB); DKFZ-German Cancer Research Center and Translatio

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http://dx.doi.org/10.1093/jnci/dju061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982896PMC
April 2014

Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery.

Am Heart J 2014 Jan 17;167(1):101-108.e1. Epub 2013 Oct 17.

Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN; Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2013.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868008PMC
January 2014

Detecting and Characterizing Pleiotropy: New Methods for Uncovering the Connection Between the Complexity of Genomic Architecture and Multiple phenotypes.

Pac Symp Biocomput 2014 Jan:183-187

Department of Biochemistry and Molecular Biology, Pennsylvania State University, Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1142/9789814583220_0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108263PMC
January 2014