Publications by authors named "Dan Zhao"

1,218 Publications

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Ultrathin Covalent Organic Framework Membranes via a Multi-Interfacial Engineering Strategy for Gas Separation.

Adv Mater 2021 Sep 17:e2104946. Epub 2021 Sep 17.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.

Covalent organic frameworks (COFs) are promising membrane materials due to their high porosity, ordered arrangements, and high stability. However, the relatively large pore size and complicated membrane preparation processes of COFs limit their applications in sieving small gas molecules, even at a lab scale. Herein, a multi-interfacial engineering strategy is proposed, that is, direct layer-by-layer interfacial reaction of two COFs (TpPa-SO H and TpTG ) with different pore sizes to form narrowed apertures at the COF-COF interfaces atop a relatively large-pore COF (COF-LZU1) film. At 423 K, one fabricated 155 nm-thick ultrathin COF membrane displays H permeance as high as 2163 gas permeation units (GPU) and a H /CO selectivity of 26, transcending the 2008 Robeson upper bound. This strategy not only provides high-performance membrane candidates for H separation, but also enlightens the interfacial engineering and pore engineering manipulation for other COFs, porous polymers, and their membranes.
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http://dx.doi.org/10.1002/adma.202104946DOI Listing
September 2021

A Co-Expression Network Reveals the Potential Regulatory Mechanism of lncRNAs in Relapsed Hepatocellular Carcinoma.

Front Oncol 2021 31;11:745166. Epub 2021 Aug 31.

Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Background: The mechanistic basis for relapsed hepatocellular carcinoma (HCC) remains poorly understood. Recent research has highlighted the important roles of long non-coding RNAs (lncRNAs) in HCC. However, there are only a few studies on the association between lncRNAs and HCC relapse.

Methods: Differentially expressed lncRNAs and mRNAs between a primary HCC group and relapsed HCC group were identified using the edge R package to analyze the GSE101432 dataset. The differentially expressed lncRNAs and mRNAs were used to construct a lncRNA-mRNA co-expression network. Weighted gene co-expression network analysis followed by Gene Ontology (GO) enrichment analyses were conducted on the database. Furthermore, correlation and survival analyses were performed using The Cancer Genome Atlas database, and expression in the clinical samples was verified by qRT-PCR. Thereafter, we inputted the genes from the two groups into the HCC TNM stage and tumor grade database from TCGA. Finally, we performed Kaplan-Meier survival analysis on the lncRNAs related to relapsed HCC.

Results: In this study, lncRNAs and mRNAs associated with HCC relapse were identified. Two gene modules were found to be closely linked to this. The GO terms in the yellow and black modules were related to cell proliferation, differentiation, and survival, as well as some transcription-related biological processes. Through qRT-PCR, we found that the expression levels of LINC00941 and LINC00668 in relapsed HCC were higher than those in primary HCC. Further, mRNA levels of , , , , , and were changed in relapsed HCC compared to levels in primary HCC. In addition, we verified that these genes could predict the overall survival and recurrence-free survival of HCC. Moreover, we found that LINC00668 and LINC00941 could affect tumor grade and TNM stages. In total, we identified and validated two lncRNAs (LINC00941 and LINC00668) and six mRNAs (, , , , , ) associated with HCC relapse.

Conclusion: In summary, we identified the key gene modules and central genes associated with relapsed HCC and constructed lncRNA-mRNA networks related to this. These genes are likely to have potential prognostic value for relapsed HCC and might shed new light on novel biomarkers or diagnostic targets for relapsed HCC.
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http://dx.doi.org/10.3389/fonc.2021.745166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438305PMC
August 2021

A deep-learning framework for multi-level peptide-protein interaction prediction.

Nat Commun 2021 Sep 15;12(1):5465. Epub 2021 Sep 15.

Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, 100084, China.

Peptide-protein interactions are involved in various fundamental cellular functions and their identification is crucial for designing efficacious peptide therapeutics. Recently, a number of computational methods have been developed to predict peptide-protein interactions. However, most of the existing prediction approaches heavily depend on high-resolution structure data. Here, we present a deep learning framework for multi-level peptide-protein interaction prediction, called CAMP, including binary peptide-protein interaction prediction and corresponding peptide binding residue identification. Comprehensive evaluation demonstrated that CAMP can successfully capture the binary interactions between peptides and proteins and identify the binding residues along the peptides involved in the interactions. In addition, CAMP outperformed other state-of-the-art methods on binary peptide-protein interaction prediction. CAMP can serve as a useful tool in peptide-protein interaction prediction and identification of important binding residues in the peptides, which can thus facilitate the peptide drug discovery process.
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http://dx.doi.org/10.1038/s41467-021-25772-4DOI Listing
September 2021

Low-temperature degradation of toluene over Ag-MnO-ACF composite catalyst.

Environ Technol 2021 Sep 13:1-25. Epub 2021 Sep 13.

School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China.

Volatile organic compounds (VOCs) have caused a serious threat to the atmosphere and human health. Therefore, it is of great significance to exploit effective catalytic materials for the safe and effective catalytic elimination of VOCs. Herein, Ag-MnO-ACF composite catalysts were constructed via a two-step impregnation strategy and used for catalytic toluene degradation. A remarkable low-temperature catalytic activity (= 50℃), excellent stability, as well as CO selectivity (80%) were achieved over the Ag-MnO-ACF catalyst. A series of characterizations indicated that the unique manganese defects structure of birnessite phase manganese oxide played an essential role for toluene oxidation, which was conducive to generating surface adsorbed oxygen. The higher ratio of Mn/Mn, abundant surface adsorbed oxygen and highly dispersed Ag species were determined to significantly facilitate toluene degradation. The mechanism of efficient degradation of toluene at low temperature was proposed. O and HO molecules were activated via surface hydroxyl and Mn defects on Ag-MnO-ACF to produce sufficient •OH, enhancing the degradation performance of toluene. We provide a new idea for the catalytic oxidation of benzene VOCs at low even room temperatures.
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http://dx.doi.org/10.1080/09593330.2021.1980830DOI Listing
September 2021

Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation.

Evid Based Complement Alternat Med 2021 2;2021:9561613. Epub 2021 Sep 2.

Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing 100029, China.

Background: Cinnamic acid (CA) has been shown to have many beneficial effects including regulating lipid metabolism and reducing obesity. However, its effect on nonalcoholic fatty liver disease (NAFDL) has not been investigated in detail. Thus, we performed this study in order to explore CA's effect on hepatic lipid metabolism and the underlying mechanisms.

Method: Oleic acid (OA) was used to induce lipid accumulation in HepG2 cells. After coincubation with CA, the cells were stained with oil red O and the triglyceride (TG) content was assessed. Key genes in lipogenesis and fatty acid oxidation pathways were tested. Additionally, db/db and wt/wt mice were divided into three groups, with the wt/wt mice representing the normal group and the db/db mice being divided into the NAFLD and CA groups. After 4 weeks of oral treatment, all mice were sacrificed and the blood lipid profile and liver tissues were assessed.

Results: CA treatment reduced the lipid accumulation in HepG2 cells and in db/db mouse livers. ACLY, ACC, FAS, SCD1, PPAR, and CD36 were significantly downregulated, while CPT1A, PGC1, and PPAR were significantly upregulated.

Conclusion: CA's therapeutic effect on NAFLD may be attributed to its ability to lower hepatic lipid accumulation, which is mediated by suppression of hepatic lipogenesis and fatty acid intake, as well as increased fatty acid oxidation.
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http://dx.doi.org/10.1155/2021/9561613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433026PMC
September 2021

C1q/TNF-related protein 9 decreases cardiomyocyte hypoxia/reoxygenation-induced inflammation by inhibiting the TLR4/MyD88/NF-κB signaling pathway.

Exp Ther Med 2021 Oct 8;22(4):1139. Epub 2021 Aug 8.

Department of Critical Care Medicine, Shenzhen Hyzen Hospital, Shenzhen, Guangdong 518000, P.R. China.

C1q/TNF-related protein 9 (CTRP9) acts as an adipokine and has been reported to exert numerous biological functions, such as anti-inflammatory and anti-oxidative stress effects, in ischemic heart disease. In the present study, the role of CTRP9 in neonatal rat cardiomyocytes (NRCMs) following hypoxia/reoxygenation (H/R) and the underlying mechanism was investigated. Adenoviral vectors containing CTRP9 or green fluorescent protein were transfected into NRCMs. A H/R model was constructed 2 days after transfection by 2 h incubation under hypoxia followed by 4 h of reoxygenation. Lactate dehydrogenase (LDH), creatine kinase (CK) and CK-myocardial band (CK-MB) levels were detected by a biochemical analyzer using biochemical kits. In addition, cell viability was detected using trypan blue staining to determine the extent of cell injury. Inflammatory cytokines TNF-α, IL-6 and IL-10 were measured by ELISA. Western blotting and reverse transcription-quantitative PCR were used to evaluate the expression levels of CTRP9, toll-like receptor 4 (TLR4), myeloid differentiation primary response (MyD88) and NF-κB. The DNA binding activity of NF-κB was also detected using an electrophoretic mobility shift assay. The results indicated that transfection with adenoviral vectors containing CTRP9 could markedly enhance CTRP9 expression. CTRP9 overexpression increased cell viability and decreased the release of LDH, CK and CK-MB. In addition, CTRP9 overexpression reduced TNF-α and IL-6 levels whilst increasing IL-10 levels, but decreased the expression of TLR4, MyD88 and NF-κB. Furthermore, the DNA binding activity of NF-κB under H/R was also decreased by CTRP9 overexpression. In conclusion, the results of the present study suggested that CTRP9 could protect cardiomyocytes from H/R injury, which was at least partially due to the inhibition of the TLR4/MyD88/NF-κB signaling pathway to reduce the release of inflammatory cytokines.
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http://dx.doi.org/10.3892/etm.2021.10573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393267PMC
October 2021

Visual detection of binary, ternary, and quaternary protein interactions in fission yeast by Pil1 co-tethering assay.

J Cell Sci 2021 Sep 9. Epub 2021 Sep 9.

National Institute of Biological Sciences, 102206 Beijing, China.

Protein-protein interactions are vital for executing nearly all cellular processes. To facilitate the detection of protein-protein interactions in living cells of the fission yeast Schizosaccharomyces pombe, here we present an efficient and convenient method termed the Pil1 co-tethering assay. In its basic form, we tether a bait protein to mCherry-tagged Pil1, which forms cortical filamentary structures, and examine whether a GFP-tagged prey protein colocalizes with the bait. We demonstrate that this assay is capable of detecting pairwise protein-protein interactions of cytosolic proteins and nuclear proteins. Furthermore, we show that this assay can be used for detecting not only binary protein-protein interactions, but also ternary and quaternary protein-protein interactions. Using this assay, we systematically characterized the protein-protein interactions in the Atg1 complex and in the phosphatidylinositol 3-kinase (PtdIns3K) complexes and found that Atg38 is incorporated into the PtdIns3K complex I via an Atg38-Vps34 interaction. Our data show that this assay is a useful and versatile tool and should be added to the routine toolbox of fission yeast researchers.
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http://dx.doi.org/10.1242/jcs.258774DOI Listing
September 2021

Robust and Multifunctional Porous Polyetheretherketone Fiber Fabricated via a Microextrusion CO Foaming.

Macromol Rapid Commun 2021 Sep 7:e2100463. Epub 2021 Sep 7.

School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China.

Fabrication of multifunctional porous fibers with excellent mechanical properties has attracted abundant attention in the fields of personal thermal management textiles and smart wearable devices. However, the high cost and harsh preparation environment of the traditional solution-solvent phase separation method for making porous fibers aggravates the problems of resource consumption and environmental pollution. Herein, a microextrusion process that combines environmentally friendly CO physical foaming with fused deposition modeling technology is proposed, via the dual features of high gas uptake and restricted cell growth, to implement the continuous production of porous polyetheretherketone (PEEK) fibers with a production efficiency of 10.5 cm s . The porous PEEK fiber exhibits excellent stretchability (234.8% strain) and good high-temperature thermal insulation property. The open-cell structure on the surface is favorable for the adsorption to achieve superhydrophobicity (154.4°) and high-efficiency photocatalytic degradation of rhodamine B (90.4%). Moreover, the parameterized controllability of the cell structure is beneficial to widening the multifunctional window. In short, the first porous PEEK physical foaming fiber, which opens up a new avenue for the application expansion, especially in the medical field, is realized.
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http://dx.doi.org/10.1002/marc.202100463DOI Listing
September 2021

Dexmedetomidine reduces acute kidney injury after endovascular aortic repair of Stanford type B aortic dissection: A randomized, double-blind, placebo-controlled pilot study.

J Clin Anesth 2021 Sep 3;75:110498. Epub 2021 Sep 3.

Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address:

Study Objective: To determine the effect of dexmedetomidine on acute kidney injury (AKI) following endovascular aortic repair (EVAR) for Stanford type B aortic dissection (TBAD).

Design: Randomized, double-blind, placebo-controlled, pilot study.

Setting: University Hospital.

Patients: 102 TBAD patients undergoing EVAR procedures were enrolled. Patients with dissection involving aortic arch or renal artery were excluded.

Interventions: Patients were randomly assigned, in a 1:1 ratio, to a dexmedetomidine group (intravenous dexmedetomidine 0.4 μg/kg/h immediately after anesthesia induction and 0.1 μg/kg/h after extubation, which was maintained until 24 h) or a normal saline control group.

Measurements: The primary outcome was the incidence of AKI within the first two days after surgery, based on the Acute Kidney Injury Network (AKIN) criteria. The secondary outcomes included serum cystatin C and estimated glomerular filtration rate on postoperative days 1, 2, and 7, and in-hospital need for renal replacement therapy (RRT). Long-term outcomes included RRT and all-cause mortality.

Main Results: Ninety-eight patients completed the study (dexmedetomidine, n = 48; control, n = 50). AKIN stage 1 AKI occurred in 3/48 (6.3%) patients receiving dexmedetomidine, compared with 11/50 (22%) patients receiving normal saline (odds ratio = 0.24, 95% CI: 0.07 to 0.89, P = 0.041). This difference remained significant after adjusting for baseline covariates (adjusted odds ratio = 0.21, 95% CI: 0.05 to 0.84; P = 0.028). Dexmedetomidine led to a lower serum cystatin C on postoperative day 1 (median [IQR] mg/L: 1.31 [1.02-1.72] vs. 1.58 [1.28-1.96]). There were no between-group differences in other secondary or long-term outcomes. During the follow-up (median = 28.4 months), 1 patient in the dexmedetomidine group and 3 patients in the control group required RRT.

Conclusions: Dexmedetomidine reduced the incidence of AKI in TBAD patients after EVAR procedures. The long-term benefits of dexmedetomidine in this patient population warrant further investigation.

Trial Registration: ChiCTR-IPR-15006372.
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http://dx.doi.org/10.1016/j.jclinane.2021.110498DOI Listing
September 2021

Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.

Nat Commun 2021 08 31;12(1):5196. Epub 2021 Aug 31.

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence of bone metastasis (>87%) compared to estrogen-negative patients (<56%). To understand the mechanism of this bone-tropism of ER tumor, and to identify liquid biopsy biomarkers for patients with high risk of bone metastasis, the secreted extracellular vesicles and cytokines from bone-tropic breast cancer cells are examined in this study. Both exosomal miR-19a and Integrin-Binding Sialoprotein (IBSP) are found to be significantly upregulated and secreted from bone-tropic ER breast cancer cells, increasing their levels in the circulation of patients. IBSP is found to attract osteoclast cells and create an osteoclast-enriched environment in the bone, assisting the delivery of exosomal miR-19a to osteoclast to induce osteoclastogenesis. Our findings reveal a mechanism by which ER breast cancer cells create a microenvironment favorable for colonization in the bone. These two secreted factors can also serve as effective biomarkers for ER breast cancer to predict their risks of bone metastasis. Furthermore, our screening of a natural compound library identifies chlorogenic acid as a potent inhibitor for IBSP-receptor binding to suppress bone metastasis of ER tumor, suggesting its preventive use for bone recurrence in ER patients.
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http://dx.doi.org/10.1038/s41467-021-25473-yDOI Listing
August 2021

Gene co-expression analysis identifies modules related to insufficient sleep in humans.

Sleep Med 2021 Aug 13;86:68-74. Epub 2021 Aug 13.

Department of Anus & Intestine Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, Zhejiang 315040, PR China. Electronic address:

Background: Insufficient sleep and circadian rhythm disruption may cause cancer, obesity, cardiovascular disease, and cognitive impairment. The underlying mechanisms need to be elucidated.

Method: Weighted gene co-expression network analysis (WGCNA) was used to identify co-expressed modules. Connectivity Map tool was used to identify candidate drugs based on top connected genes. R ptestg package was utilized to detected module rhythmicity alteration. A hypergeometric test was used to test the enrichment of insomnia SNP signals in modules. Google Scholar was used to validate the modules and hub genes by literature.

Results: We identified a total of 45 co-expressed modules. These modules were stable and preserved. Eight modules were correlated with sleep restriction duration. Module rhythmicity was disrupted in sleep restriction subjects. Hub genes that involve in insufficient sleep also play important roles in sleep disorders. Insomnia GWAS signals were enriched in six modules. Finally, eight drugs associated with sleep disorders were identified.

Conclusion: Systems biology method was used to identify sleep-related modules, hub genes, and candidate drugs. Module rhythmicity was altered in sleep insufficient subjects. Thiamphenicol, lisuride, timolol, and piretanide are novel candidates for sleep disorders.
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http://dx.doi.org/10.1016/j.sleep.2021.08.010DOI Listing
August 2021

Crucial Impact of Residue Chirality on the Gelation Process and Biodegradability of Thermoresponsive Polypeptide Hydrogels.

Biomacromolecules 2021 Sep 17;22(9):3992-4003. Epub 2021 Aug 17.

CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. China.

Thermosensitive polypeptide hydrogels have gained considerable attention in potential biomedical applications, of which the polymer structure may be tuned by residue chirality. In this study, polypeptide-based block copolymers with different chiralities were synthesized by ring-opening polymerization of γ-ethyl-l-glutamate -carboxyanhydride and/or γ-ethyl-d-glutamate -carboxyanhydride using amino-terminated monomethoxy poly(ethylene glycol) as a macroinitiator. All mPEG-polypeptide copolymers underwent sol-gel transition with an increase in temperature. The block copolymers with mixed enantiomeric residues of γ-ethyl-l-glutamate (ELG) and γ-ethyl-d-glutamate (EDG) in the polypeptide blocks exhibited lower critical gelation concentrations and lower critical gelation temperatures compared with those composed of pure ELG or EDG residues. We established that the difference in gelation properties between the copolymers was derived from the distinction of the secondary structures. We further demonstrated the influence of polypeptide chirality on the degradability and biocompatibility of hydrogels . Our findings provide insights into the design of hydrogels having tailored secondary conformation, gelation property, and biodegradability.
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http://dx.doi.org/10.1021/acs.biomac.1c00785DOI Listing
September 2021

Rapid and Specific Imaging of Extracellular Signaling Molecule Adenosine Triphosphate with a Self-Phosphorylating DNAzyme.

J Am Chem Soc 2021 Aug 20. Epub 2021 Aug 20.

Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada.

Adenosine 5'-triphosphate (ATP) is a central extracellular signaling agent involved in various physiological and pathological processes. However, precise measurements of the temporal and spatial components of ATP dynamics are lacking due primarily to the limitations of available methods for ATP detection. Here, we report on the first effort to design a self-phosphorylating DNAzyme (SPDz) sensor for fluorescence imaging of ATP. In response to ATP, SPDz sensors exhibit subsecond response kinetics, extremely high specificity, and micromolar affinities. In particular, we demonstrate cell-surface-anchored SPDz sensors for fluorescence imaging of both stress-induced endogenous ATP release in astrocytes and mechanical stimulation-evoked ATP release at the single-cell level. We also validated their utility for visualizing the rapid dynamic properties of ATP signaling upon electrical stimulation in astrocytes. Thus, SPDz sensors are robust tools for monitoring ATP signaling underlying diverse cellular processes.
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http://dx.doi.org/10.1021/jacs.1c04925DOI Listing
August 2021

Actaticas A-G, Cycloartane Triterpenes From With Their Antiproliferative Activity.

Front Chem 2021 29;9:695456. Epub 2021 Jul 29.

Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Phytochemical studies on the rhizomes of led to the isolation of seven new cycloartane triterpenes, actaticas A-G (). Their structures were determined by NMR, HRESIMS, and chemical analysis. All the isolates were evaluated for their antiproliferative activity against HT-29 and McF-7 cell lines. The results showed that all the compounds displayed cytotoxicity. All compounds showed significant inhibitory effects with IC values of 9.2-26.4 μM.
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http://dx.doi.org/10.3389/fchem.2021.695456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358065PMC
July 2021

Interactive effects of serum ferritin and high sensitivity C-reactive protein on diabetes in hypertensive patients.

J Trace Elem Med Biol 2021 Jul 28;68:126824. Epub 2021 Jul 28.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China. Electronic address:

Background: Hypertensive patients, often characterized by chronic inflammation, are susceptible to diabetes. Evidence suggests that the positive association between serum ferritin (SF) and diabetes was affected by high-sensitivity C-reactive protein (hs-CRP), an inflammation marker. We investigate whether there was an interaction between SF and hs-CRP on diabetes in hypertensive patients.

Methods: We analysed data of 1,735 hypertensive people in this cross-sectional study. Diabetes was diagnosed when fasting blood glucose ≥ 7.0 mmol/L and/or a previous clinical diagnosis of diabetes. Logistic regression models were used to estimate the association of the SF and hs-CRP with diabetes. Multiplicative interaction was evaluated by incorporating a cross-product term for SF and hs-CRP to the logistic regression model. Additive interaction was assessed by calculating the relative excess risk of interaction (RERI) and attributed proportion due to interaction (AP).

Results: In the adjusted analysis, SF (highest vs lowest tertile: odds ratio [OR], 1.61; 95 % confidence interval [CI], 1.20-2.16) was positively associated with diabetes. There was no multiplicative interaction between SF and hs-CRP, but evidence of additive interaction in regard to diabetes (RERI: 0.86; 95 % CI: 0.06-1.67). Compared to the patients with low SF (lower two thirds) and low hs-CRP (≤ 2 mg/L), those with high SF (upper one third) and high hs-CRP (> 2 mg/L) had increased OR for diabetes (adjusted OR: 2.33 [1.65-3.30]), with 37.0 % of the effects attributed to the additive interaction (AP: 0.37; 95 % CI: 0.09-0.65).

Conclusions: Within a cross-sectional study consisting of hypertensive patients, co-exposure to high SF and high hs-CRP was synergistically associated with diabetes. Dietary intervention or pharmacological treatment to lowering SF concentration may help to reduce diabetes morbidity in hypertensive patient with chronic inflammation.
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http://dx.doi.org/10.1016/j.jtemb.2021.126824DOI Listing
July 2021

The level of carbon dioxide is the determinant of successful non-invasive ventilation pressure titration in patients with non-hypercapnic primary central sleep apnea: a case report.

J Clin Sleep Med 2021 Jul 27. Epub 2021 Jul 27.

Respiratory and Critical Care Medicine Department of Tianjin Medical University General Hospital, Tianjin, China.

Primary central sleep apnea (CSA) is classified as non-hypercapnic CSA. High loop gain, lower carbon dioxide (CO) reserves, and other reasons can lead to hypocapnia in patients who develop intermittent hyperventilation during sleep. Therefore, it is necessary to monitor nocturnal CO level for these patients. We report a female patient diagnosed with non-hypercapnic primary CSA who complained of snoring, apnea, and excessive daytime sleepiness. With the monitoring of transcutaneous partial pressure of CO (PtcCO), manual non-invasive ventilation (NIV) pressure titration was performed with continuous positive airway pressure (CPAP), bilevel positive airway pressure in a spontaneous-timed mode (BPAP-ST), and adaptive servo-ventilation (ASV) mode for three nights, respectively. Only ASV mode could stabilize the PtcCO above the apneic threshold (AT, approximately 40 mmHg) with successfully eliminating central apnea events. It is concluded that the level of CO is the determinant of successful NIV pressure titration in patients with non-hypercapnic CSA.
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http://dx.doi.org/10.5664/jcsm.9568DOI Listing
July 2021

The association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio cholesterol ratio and thickened carotid intima-media thickness: A case-control study.

Vascular 2021 Jul 27:17085381211035282. Epub 2021 Jul 27.

Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.

Background: It is indicated that Low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C ratio) has greater predictive value for thickened carotid intima-media thickness (CIMT) comparing with classic lipid parameters. However, there have been few reports about their association in general Chinese population.

Method: We included a total of 1220 CIMT participants and 2440 matched controls, who had ultrasonography of carotid artery during 2009 and 2016. Univariate and multivariate logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for thickened CIMT risk associated with LDL-C/HDL-C ratio.

Result: In the univariate logistic regression model, there was significant association between LDL-C/HDL-C ratio and thickened CIMT (Q4 vs. Q1, OR = 1.94, 95% CI: 1.60-2.36; < 0.05). After adjusting for potential covariates, LDL-C/HDL-C ratio remained significantly associated with thickened CIMT (Q4 vs. Q1, OR = 1.81, 95% CI: 1.41-2.34, < 0.001; ≥3.05 v.s. <3.05, OR = 1.66, 95% CI: 1.37-2.02). In subgroup analyses, the association between LDL-C/HDL-C ratio and thickened CIMT remained significant in the subgroups stratified by sex, impaired fasting glucose (IFG), hypertension, and fatty liver disease but only remained significant in the subgroups of ≥45 years (OR = 2.01, 95% CI: 1.46-2.76; 0.05), BMI ≥24 (kg/m) (OR = 2.22; 95% CI = 1.63-3.03; Ptrend < 0.05) and BMI ≥25 (kg/m) (OR = 2.50, 95% CI: 1.76-3.54; < 0.05), dyslipidemia (OR = 3.28, 95% CI: 1.83-5,85; 0.001), and without periodontitis (OR = 2.08, 95% CI: 1.54-2.81 ; Ptrend < 0.05) comparing Q4 to Q1. Similar results were observed in the subgroup analyses for LDL-C/HDL-C ratio ≥3.05 v.s. <3.05 except for the age stratification.

Conclusion: High LDL-C/HDL-C ratio could significantly increase the risk of thickened CIMT independent of gender, IFG, hypertension, and fatty liver disease in general Chinese population.
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http://dx.doi.org/10.1177/17085381211035282DOI Listing
July 2021

Rapidly Thermoreversible and Biodegradable Polypeptide Hydrogels with Sol-Gel-Sol Transition Dependent on Subtle Manipulation of Side Groups.

Biomacromolecules 2021 Aug 23;22(8):3522-3533. Epub 2021 Jul 23.

CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.

Thermoreversible hydrogels are attractive materials for biomedical applications, but their applications are still limited by nonbiodegradability and/or slow temperature-dependent gel-to-sol transition rates. In this research, we prepared a range of amphiphilic diblock, triblock, and four-armed star block copolymers composed of poly(ethylene glycol) (PEG) and poly(γ-(2-(2-ethoxyethoxy)ethyl)-l-glutamate) (P(EEOLG)) segments, which can form rapidly thermoreversible hydrogels at physiological temperature. Intriguingly, the obtained hydrogels can transform from gel to sol within 10-70 s in response to the temperature decrease from 37 to 0 °C. The thermosensitive sol-gel-sol transitions are markedly faster than previously reported thermoreversible PEG-poly(l-glutamate) derivative hydrogels with subtle differences in the side groups and a widely studied poly(d,l-lactide--glycolide)--PEG--poly(d,l-lactide--glycolide) (PLGA-PEG-PLGA) hydrogel that required a much longer time of 40∼150 min. Further investigation of the relationship between the hydrogel property and polymer structure is performed, and the self-assembly mechanisms of different copolymers are proposed. Cytotoxicity assays and subcutaneous degradation experiments reveal that the PEG/P(EEOLG) block copolymers are biocompatible and biodegradable. The polypeptide hydrogel can therefore be used as a three-dimensional platform for facile cell culture and collection by regulating the temperature.
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http://dx.doi.org/10.1021/acs.biomac.1c00583DOI Listing
August 2021

Association of Sensory Impairment and Health Care Utilization Among Chinese Older Adults With and Without Functional Impairment.

J Am Med Dir Assoc 2021 Jul 14. Epub 2021 Jul 14.

Centre for Health Management and Policy, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, China. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2021.06.024DOI Listing
July 2021

Pulling-Force Spinning Top for Serum Separation Combined with Paper-Based Microfluidic Devices in COVID-19 ELISA Diagnosis.

ACS Sens 2021 07 15;6(7):2709-2719. Epub 2021 Jul 15.

Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.

The spread of Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), resulting in a global pandemic with around four million deaths. Although there are a variety of nucleic acid-based tests for detecting SARS-CoV-2, these methods have a relatively high cost and require expensive supporting equipment. To overcome these limitations and improve the efficiency of SARS-CoV-2 diagnosis, we developed a microfluidic platform that collected serum by a pulling-force spinning top and paper-based microfluidic enzyme-linked immunosorbent assay (ELISA) for quantitative IgA/IgM/IgG measurements in an instrument-free way. We further validated the paper-based microfluidic ELISA analysis of SARS-CoV-2 receptor-binding domain (RBD)-specific IgA/IgM/IgG antibodies from human blood samples as a good measurement with higher sensitivity compared with traditional IgM/IgG detection (99.7% vs 95.6%) for early illness onset patients. In conclusion, we provide an alternative solution for the diagnosis of SARS-CoV-2 in a portable manner by this smart integration of pulling-force spinning top and paper-based microfluidic immunoassay.
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http://dx.doi.org/10.1021/acssensors.1c00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290923PMC
July 2021

Complete and rapid degradation of glyphosate with FeCeO catalyst for peroxymonosulfate activation at room temperature.

Environ Res 2021 Jul 6;201:111618. Epub 2021 Jul 6.

Huadian Aqua Membrane Separation Technology (Tianjin) Co. Ltd., Tianjin, 301700, China.

Glyphosate, a common broad-spectrum herbicide, is a serious environmental pollutant that causes a significant threat to humans. Hence, there is a pressing task to remove glyphosate from the environment. Here, we report an excellent FeCeO catalyst synthesized via the one-step co-precipitation method for activating peroxymonosulfate (PMS) to degrade glyphosate at 25 °C. As a result, glyphosate is completely degraded with a high degradation rate of 400 mg L·h, and the TOC and TN removals are 85.6% and 80.8%, respectively. As proven by systematic characterizations, the Fe-Ce synergistic effect plays a significant role in promoting PMS activation. The main reactive oxygen species for glyphosate oxidation are surface-bound SO· and ·OH, produced by activating PMS by electron transfer between Fe/Fe and Ce/Ce of FeCeO. In light of the products determined, the possible degradation process of glyphosate is also speculated: C-N and C-P bonds of glyphosate molecules are attacked to form aminomethylphosphonic acid (AMPA) and orthophosphate (PO) by surface-bound SO· and ·OH that continuously mineralize and dephosphorylate AMPA to generate small molecules and inorganic ions, such as HO and PO. The results of this work suggest that FeCeO/PMS could provide a potential candidate for efficiently removing organic compounds containing nitrogen or phosphorus from wastewater.
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http://dx.doi.org/10.1016/j.envres.2021.111618DOI Listing
July 2021

A pH-Triggered Self-Unpacking Capsule Containing Zwitterionic Hydrogel-Coated MOF Nanoparticles for Efficient Oral Exendin-4 Delivery.

Adv Mater 2021 Aug 3;33(32):e2102044. Epub 2021 Jul 3.

CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Oral peptide or protein delivery is considered a revolutionary alternative to daily subcutaneous injection; however, major challenges remain in terms of impediments of the gastrointestinal environment and the intestinal epithelium consisting of mucus and the epithelial cell layer, leading to low bioavailability. To protect against gastrointestinal degradation and promote penetration across the intestinal mucosa, a pH-triggered self-unpacking capsule encapsulating zwitterionic hydrogel-coated metal-organic framework (MOF) nanoparticles is engineered. The MOF nanoparticles possess a high exendin-4 loading capacity, and the zwitterionic hydrogel layer imparts unique capability of permeation across the mucus layer and effective internalization by epithelial cells to the nano-vehicles. In addition to the gastro-resistant feature, the pH-responsive capsules are dissociated drastically in the intestinal environment due to the rapid generation of abundant CO bubbles, which triggers a sudden release of the nanoparticles. After oral administration of the capsules containing exendin-4-loaded nanoparticles into a diabetes rat model, markedly enhanced plasma exendin-4 levels are achieved for over 8 h, leading to significantly increased endogenous insulin secretion and a remarkable hypoglycemic effect with a relative pharmacological availability of 17.3%. Owing to the low risk of hypoglycemia, this oral exendin-4 strategy will provide a vast potential for daily and facile diabetes treatment.
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http://dx.doi.org/10.1002/adma.202102044DOI Listing
August 2021

PEDOT-Coated Red Phosphorus Nanosphere Anodes for Pseudocapacitive Potassium-Ion Storage.

Nanomaterials (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Center of Nanomaterials for Renewable Energy, State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710054, China.

Potassium-ion batteries (KIBs) have come up as a potential alternative to lithium-ion batteries due to abundant potassium storage in the crust. Red phosphorus is a promising anode material for KIBs with abundant resources and high theoretical capacity. Nevertheless, large volume expansion, low electronic conductivity, and limited K charging speed in red phosphorus upon cycling have severely hindered the development of red phosphorus-based anodes. To obtain improved conductivity and structural stability, surface engineering of red phosphorus is required. Poly(3,4-ethylenedioxythiophene) (PEDOT)-coated red phosphorus nanospheres ([email protected]) with an average diameter of 60 nm were synthesized via a facile solution-phase approach. PEDOT can relieve the volume change of red phosphorus and promote electron/ion transportation during charge-discharge cycles, which is partially corroborated by our DFT calculations. A specific capacity of 402 mAh g at 0.1 A g after 40 cycles, and a specific capacity of 302 mAh g at 0.5 A g after 275 cycles, were achieved by [email protected] anode with a high pseudocapacitive contribution of 62%. The surface-interface engineering for the organic-inorganic composite of [email protected] provides a novel perspective for broad applications of red phosphorus-based KIBs in fast charging occasions.
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http://dx.doi.org/10.3390/nano11071732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308171PMC
June 2021

An ISFET Microarray Sensor System for Detecting the DNA Base Pairing.

Micromachines (Basel) 2021 Jun 22;12(7). Epub 2021 Jun 22.

State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China.

Deoxyribonucleic acid (DNA) sequencing technology provides important data for the disclosure of genetic information and plays an important role in gene diagnosis and gene therapy. Conventional sequencing devices are expensive and require large and bulky optical structures and additional fluorescent labeling steps. Sequencing equipment based on a semiconductor chip has the advantages of fast sequencing speed, low cost and small size. The detection of DNA base pairing is the most important step in gene sequencing. In this study, a large-scale ion-sensitive field-effect transistor (ISFET) array chip with more than 13 million sensitive units is successfully designed for detecting the DNA base pairing. DNA base pairing is successfully detected by the sensor system, which includes the ISFET microarray chip, microfluidic system, and test platform. The chip achieves a high resolution of at least 0.5 mV, thus enabling the recognition of the change of 0.01 pH value. This complementary metal-oxide semiconductor (CMOS) compatible and cost-efficient sensor array chip, together with other specially designed components, can form a complete DNA sequencing system with potential application in the molecular biology fields.
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http://dx.doi.org/10.3390/mi12070731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305849PMC
June 2021

Evaluation of Euthanasia Methods on Behavioral and Physiological Responses of Newly Hatched Male Layer Chicks.

Animals (Basel) 2021 Jun 17;11(6). Epub 2021 Jun 17.

Department of Poultry Science, Texas A&M AgriLife Research, College Station, TX 77843, USA.

Newly hatched male layer chicks are considered as "by-products" in the egg industry and must be humanely euthanized at the hatchery. Instantaneous mechanical destruction (maceration) is the predominant euthanasia method applied in poultry hatcheries and is approved by the American Veterinary Medical Association (AVMA). However, maceration is not perceived by the public to be a humane means of euthanasia. The effects of alternative euthanasia methods, including carbon dioxide (CO) or nitrogen (N) inhalation, and a commercial negative pressure stunning system on behavioral and physiological responses of day-of-hatch male layer chicks, were evaluated in a field trial. Chick behaviors, including ataxia, loss of posture, convulsions, cessation of vocalization, and cessation of movement, were monitored. Serum hormones were assessed at the end of each of the alternative euthanasia treatments, including a control group allowed to breathe normal atmospheric air. The N method induced unconsciousness and death later than the CO and negative pressure methods, and increased serum corticosterone concentrations of neonatal chicks. Carbon dioxide inhalation increased serotonin concentrations as compared to controls, as well as the N and the negative pressure methods. The behavioral and physical responses observed in this study suggest that both CO inhalation and negative pressure stunning can be employed to humanely euthanize neonatal male layer chicks.
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http://dx.doi.org/10.3390/ani11061802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235231PMC
June 2021

Associations between Adherence to Four A Priori Dietary Indexes and Cardiometabolic Risk Factors among Hyperlipidemic Patients.

Nutrients 2021 Jun 24;13(7). Epub 2021 Jun 24.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518106, China.

Little is known about which currently available a priori dietary indexes provide best guidance for reducing cardiometabolic risk factors (CMRF) among hyperlipidemic patients. This study was designed to compare the associations between four a priori dietary indexes, including Diet Balance Index (DBI-16), Chinese Healthy Eating Index (CHEI), Mediterranean Diet Score (MDS) and Dietary Approaches to Stop Hypertension (DASH) and CMRF among hyperlipidemic patients. A total of 269 participants were enrolled into the cross-sectional study. DBI-16, CHEI, MDS, and DASH scores were calculated using established methods. CMRF was measured using standard methods. DBI-total scores (DBI-TS) were inversely associated with triglyceride concentrations and TC:HDL-C ratio, and positively associated with HDL-C and ApoA1 concentrations (all < 0.05), while the results for DBI-low bound scores (DBI-LBS) were opposite. DBI-high bound scores (DBI-HBS) and DASH scores were positively and inversely associated with glucose concentrations, respectively (both < 0.05). Higher diet quality distance (DQD) was positively associated with higher TC, LDL-C and ApoB concentrations, and TC:HDL-C and LDL-C:HDL-C ratios, and lower HDL-C and ApoA1 concentrations and ApoA1:ApoB ratio (all < 0.05). CHEI scores were inversely associated with triglyceride concentrations ( = 0.036). None of the dietary indexes was associated with blood pressures. DBI-16 provided most comprehensive evaluations of the overall diet quality and balance for optimizing cardiometabolic health among hyperlipidemic individuals.
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http://dx.doi.org/10.3390/nu13072179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308401PMC
June 2021

Differentiation of cystic biliary atresia and choledochal cysts using prenatal ultrasonography.

Ultrasonography 2021 May 10. Epub 2021 May 10.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.

Purpose: This study explored the performance of prenatal ultrasonography in the differential diagnosis of cystic biliary atresia (CBA) and choledochal cyst (CC).

Methods: Fetuses diagnosed with hepatic hilar cyst in the second trimester were included in this study. A series of prenatal ultrasound examinations were performed in the second and third trimesters. The diameter of the gallbladder (GB) and hepatic cyst were measured, as well as the wall thickness of the GB. The GB-cyst connection, visibility of the right hepatic artery (RHA), and other concomitant abnormalities were carefully evaluated. A neonatal transabdominal ultrasound examination was performed within 1 week after birth, and clinical data were followed up to 6 months after birth.

Results: Between January 1, 2016 and January 31, 2020, 53 fetuses diagnosed with hepatic hilar cyst were recruited. Eight were excluded because they were lost to follow-up. Among the 45 cases included in this study, 10 were diagnosed with CBA and 35 with CC after birth. Statistically significant differences were found in GB width, wall thickness, change in GB width, change in cyst length, GB-cyst connection, and RHA visibility between the CBA and CC groups. GB width showed the best diagnostic performance with an area under the curve (AUC) of 0.899. The combination of GB width, GB wall thickness, and GB-cyst connection yielded a comparable AUC of 0.971.

Conclusion: The GB should be carefully evaluated in fetuses with hepatic hilar cyst. Prenatal ultrasound findings could provide suggestive parameters for the differential diagnosis of CBA from CC.
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http://dx.doi.org/10.14366/usg.21028DOI Listing
May 2021

Fertilizer and pesticide reduction in cherry tomato production to achieve multiple environmental benefits in Guangxi, China.

Sci Total Environ 2021 Nov 19;793:148527. Epub 2021 Jun 19.

College of Resources and Environmental Sciences, National Academy of Agriculture Green Development, Key Laboratory of Plant-Soil Interactions, Ministry of Education, China Agricultural University, Beijing 100193, China.

Cherry tomatoes, as a highly profitable vegetable, consume a substantial amount of fertilizer and pesticide compared with other staple crops, which leads to remarkably negative environmental impacts. The optimization of these agricultural inputs to mitigate these environmental burdens and improve cherry tomato yield has drawn little attention. This study used life cycle assessment (LCA) combined with a field investigation to analyze the environmental benefits under optimized fertilizer and pesticide inputs (i.e., reduction of 24.7% nitrogen, 35.6% phosphorus pentoxide, 18.8% potassium oxide, 17.1% organic fertilizer, and 30.9% pesticides) compared to traditional farmer inputs. Results showed that: (1) compared to traditional farmer management, optimized inputs reduced the energy depletion by 24.7%, water depletion by 6.4%, global warming by 28.8%, acidification by 23.7%, aquatic eutrophication by 34.2%, human toxicity by 34.8%, aquatic eco-toxicity by 34.8%, and soil eco-toxicity by 26.7%, respectively; (2) among them, aquatic eco-toxicity and aquatic eutrophication were the major environmental impacts in cherry tomato production and were mainly attributed to chlorothalonil and phosphate fertilizer use, respectively; and (3) optimized inputs decreased the total environmental index and environmental damage cost by 33.8% and 28.1%, respectively, without compromising the yield. These findings provide insight into optimizing fertilizer and pesticide usage to alleviate multiple environmental impacts while maintaining cherry tomato yield and improving economic benefits. Further studies should focus mainly on less harmful pesticide utilization and phosphate use efficiency improvement, which may achieve vegetable production system sustainability in China and also provide a reference value for vegetable production systems in the Global South.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148527DOI Listing
November 2021

Synergistically Assembled Cobalt-Telluride/Graphene Foam with High-Performance Electromagnetic Wave Absorption in Both Gigahertz and Terahertz Band Ranges.

ACS Appl Mater Interfaces 2021 Jul 24;13(26):30967-30979. Epub 2021 Jun 24.

National Institute for Advanced Materials, Tianjin Key Laboratory of Metal and Molecule Based Material Chemistry, Key Laboratory of Functional Polymer Materials, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Materials Science and Engineering, Nankai University, Tianjin 300350, PR China.

Electromagnetic wave (EMW)-absorbing materials have a great impact on civil use and national defense. In this paper, a novel composite, [email protected] (the mass ratio of reduced graphene oxide to CoTe is 1:6, annealed at 300 °C), has been obtained through a facile melt-diffusion method and solvothermal method. The as-prepared samples have shown excellent reflection losses (RL) and effective adsorption bandwidth (EAB) by controlling the loading of CoTe and the annealing temperature. The sample has exhibited a RL of -62.2 dB at 13.04 GHz with the matching thickness of 3.53 mm, and the EAB reaches 8.2 GHz at 2-18 GHz. Moreover, excellent terahertz (THz) absorption property is also obtained at 0.2-2.0 THz. A RL of 54.07 dB is acquired, and the EAB covers 100% of the entire measured bandwidth. Thus, [email protected] can be considered as a promising EMW absorption material in both gigahertz and terahertz band ranges.
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http://dx.doi.org/10.1021/acsami.1c05351DOI Listing
July 2021

Risk Factors of Psychological Responses of Chinese University Students During the COVID-19 Outbreak: Cross-sectional Web-Based Survey Study.

J Med Internet Res 2021 07 21;23(7):e29312. Epub 2021 Jul 21.

Department of Neurosurgery, The Fourth Hospital of China Medical University, Shenyang, China.

Background: COVID-19 is a highly contagious and highly pathogenic disease caused by a novel coronavirus, SARS-CoV-2, and it has become a pandemic. As a vulnerable population, university students are at high risk during the epidemic, as they have high mobility and often overlook the severity of the disease because they receive incomplete information about the epidemic. In addition to the risk of death from infection, the epidemic has placed substantial psychological pressure on the public. In this respect, university students are more prone to psychological problems induced by the epidemic compared to the general population because for most students, university life is their first time outside the structure of the family, and their mental development is still immature. Internal and external expectations and academic stress lead to excessive pressure on students, and unhealthy lifestyles also deteriorate their mental health. The outbreak of COVID-19 was a significant social event, and it could potentially have a great impact on the life and the mental health of university students. Therefore, it is of importance to investigate university students' mental health status during the outbreak of COVID-19.

Objective: The principal objective of this study was to investigate the influencing factors of the psychological responses of Chinese university students during the COVID-19 outbreak.

Methods: This study used data from a survey conducted in China between February 21 and 24, 2020, and the data set contains demographic information and psychological measures including the Self-Rating Anxiety Scale, the Self-Rating Depression Scale, and the compulsive behaviors portion of the Yale-Brown Obsessive-Compulsive Scale. A total of 2284 questionnaires were returned, and 2270 of them were valid and were used for analysis. The Mann-Whitney U test for two independent samples and binary logistic regression models were used for statistical analysis.

Results: Our study surveyed 563 medical students and 1707 nonmedical students. Among them, 251/2270 students (11.06%) had mental health issues. The results showed that contact history of similar infectious disease (odds ratio [OR] 3.363, P=.02), past medical history (OR 3.282, P<.001), and compulsive behaviors (OR 3.525, P<.001) contributed to the risk of mental health issues. Older students (OR 0.928, P=.02), regular daily life during the epidemic outbreak (OR 0.410, P<.001), exercise during the epidemic outbreak (OR 0.456, P<.001), and concern related to COVID-19 (OR 0.638, P=.002) were protective factors for mental health issues.

Conclusions: According to the study results, mental health issues have seriously affected university students, and our results are beneficial for identifying groups of university students who are at risk for possible mental health issues so that universities and families can prevent or intervene in the development of potential mental health issues at the early stage of their development.
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http://dx.doi.org/10.2196/29312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297601PMC
July 2021
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