Publications by authors named "Dan Yang"

1,032 Publications

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An inferior-superior colliculus circuit controls auditory cue-directed visual spatial attention.

Authors:
Fei Hu Yang Dan

Neuron 2021 Oct 14. Epub 2021 Oct 14.

Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

Selective attention modulates neuronal activity in multiple brain regions, but the origins of attention signals remain unclear. We show that, during a visual task requiring spatial attention directed by an auditory cue, an inferior-superior colliculus circuit provides the key attention signal. In mice performing a task based on a visual stimulus in the cued hemifield while ignoring a conflicting stimulus on the uncued side, the visual cortex (V1) and superior colliculus (SC) showed strong attentional modulation, with a shorter latency in the SC. The nucleus of the brachium of the inferior colliculus (nBIC), which provides auditory inputs to the SC, was activated not only at auditory cue onset but also during the delay period before the visual stimulus. The delay activity, but not cue onset activity, was crucial for task performance and attentional modulation in the SC and V1. These results establish a new behavioral paradigm for studying visual attention in mice and identify a midbrain signal controlling auditory cue-directed spatial attention.
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http://dx.doi.org/10.1016/j.neuron.2021.10.004DOI Listing
October 2021

A High-Wet-Strength Biofilm for Readable and Highly Sensitive Humidity Sensors.

Nano Lett 2021 Oct 26. Epub 2021 Oct 26.

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, China.

Low-cost and flexible biofilm humidity sensors with good wet strength are crucial for humidity detection. However, it remains a great challenge to integrate good reversibility, rapid humidity response, and robust humid mechanical strength in one sensor. In this respect, we report a facile method to prepare a sustainable biofilm (named MC film) from sisal cellulose microcrystals (MSF--COOH) and citric acid (CA). After cross-linking with CA, the MC film exhibits excellent wet strength and rapid humidity response. More importantly, MC film can be used over a wide temperature range with excellent durability and reversibility for humidity detection. A highly sensitive humidity sensor fabricated from the MC film exhibits high reversibility and excellent water resistance and can be applied in humidity and personalized breath health monitoring. Our work fills the gap between biomaterial design and high-performance sensing devices.
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http://dx.doi.org/10.1021/acs.nanolett.1c02452DOI Listing
October 2021

Synthesis of calcium-aluminum-layered double hydroxide and a polypyrrole decorated product for efficient removal of high concentrations of aqueous hexavalent chromium.

J Colloid Interface Sci 2021 Oct 6;607(Pt 2):1963-1972. Epub 2021 Oct 6.

School of Water Conservancy and Environment, University of Jinan, Jinan 250022, PR China. Electronic address:

To efficiently remove high concentrations of hexavalent chromium (Cr(VI)), calcium-aluminum-layered double hydroxide (CaAl-LDH, denoted as CAL), and polypyrrole-modified CAL (CAL-PPy) were prepared by hydrothermal and in situ polymerization methods, respectively. The chemical structure, morphology, and elemental results indicated that the chain-like polypyrrole was decorated with hexagonal CAL. The specific surface area of CAL-PPy increased from 8.746 m/g to 24.24 m/g. The adsorption performances of CAL and CAL-PPy for aqueous Cr(VI) were investigated using batch equilibrium experiments. The decontamination process of aqueous Cr(VI) (100 mg/L) reached the equilibrium state within 50 min, and the kinetic data met the pseudo-second-order kinetic equation. The Langmuir model described the isothermal data properly, and the obtained theoretical adsorption capacity of CAL for Cr(VI) at 318 K was 34.06 mg/g, while that of CAL-PPy was 66.14 mg/g. The removal mechanisms involved electrostatic attraction, surface complexation, anion exchange, and reduction to low-toxicity Cr(III). Therefore, CAL and CAL-PPy have underlying applications in treating real wastewater containing Cr(VI).
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http://dx.doi.org/10.1016/j.jcis.2021.10.014DOI Listing
October 2021

All-Dielectric Huygens' Metasurface for Wavefront Manipulation in the Visible Region.

Materials (Basel) 2021 Oct 11;14(20). Epub 2021 Oct 11.

Guangxi Key Laboratory of Wireless Broadband Communication and Signal Processing, School of Information and Communication, Guilin University of Electronic Technology, Guilin 541004, China.

All-dielectric Huygens' metasurfaces have been widely used in wavefront manipulation through multipole interactions. Huygens' metasurfaces utilize the superposition between an electric dipole and a magnetic dipole resonance to realize transmission enhancement and an accumulated 2π phase change. Benefiting from this unique property, we design and numerically investigate an all-dielectric Huygens' metasurface exhibiting high-efficiency anomalous refraction. To suppress the substrate effect, the metasurface structure is submerged in a dielectric plate. We strategically placed two elements in four short periods to form a unit cell and adjusted the spacing between the two elements to effectively inhibit the interaction between elements. At the operating wavelength of 692 nm, the obtained anomalous transmission efficiency is over 90.7% with a diffraction angle of 30.84°. The performance of the proposed structure is far superior to most of the existing phase-gradient metasurface structures in the visible region, which paves the way for designing efficient beam deflection devices.
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http://dx.doi.org/10.3390/ma14205967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537766PMC
October 2021

A Bibliometric and Visual Analysis of Global Community Resilience Research.

Int J Environ Res Public Health 2021 Oct 15;18(20). Epub 2021 Oct 15.

School of Civil Engineering, Dalian University of Technology, Dalian 116024, China.

Resilience is an important issue in urban development, and community resilience (CR) is the most typical representative in building urban resilience, which has become the forefront of international resilience research. This paper presents a bibliometric and visual analysis of community resilience research collected from the WoS Core Collection database over the past two decades. H-index, citation frequency, centrality and starting year were adopted to analyze the research objects by bibliometric tools including CiteSpace, VOSviewer, and Gephi. The national and institutional characteristics of macro-geographical distribution and the characteristics of disciplines, journals, authors, and author cooperation of micro-knowledge network distribution were revealed. Finally, the potential research directions of community resilience in the future were discussed. The results show that there are three stages in community resilience research. Seven intellectual bases constitute the research background for community resilience, including social capital mechanism, the evolution of resilience knowledge, earthquake resistance and disaster mitigation, substance abuse, resilient development in rural communities, resilience-building in the least-developed countries, and emergency preparedness. Our analysis shows that the hottest community resilience research topics are the concept of resilience, climate resilience, the social capital mechanism, macro-environment and disaster-reduction policies, and an evaluation index system for community resilience.
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http://dx.doi.org/10.3390/ijerph182010857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535544PMC
October 2021

Syringa microphylla Diels: A comprehensive review of its phytochemical, pharmacological, pharmacokinetic, and toxicological characteristics and an investigation into its potential health benefits.

Phytomedicine 2021 Oct 12;93:153770. Epub 2021 Oct 12.

Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai 519030, PR China.

Background: Syringa microphylla Diels is a plant in the family Syringa Linn. For hundreds of years, its flowers and leaves have been used as a folk medicine for the treatment of cough, inflammation, colds, sore throat, acute hepatitis, chronic hepatitis, early liver cirrhosis, fatty liver, and oesophageal cancer.

Purpose: For the first time, we have comprehensively reviewed information on Syringa microphylla Diels that is not included in the Pharmacopoeia, clarified the pharmacological mechanisms of Syringa microphylla Diels and its active ingredients from a molecular biology perspective, compiled in vivo and in vitro animal experimental data and clinical data, and summarized the toxicology and pharmacokinetics of Syringa microphylla Diels. The progress in toxicology research is expected to provide a theoretical basis for the development of new drugs from Syringa microphylla Diels, a natural source of compounds that are potentially beneficial to human health.

Methods: The PubMed, Google Scholar, China National Knowledge Infrastructure, Web of Science, SciFinder Scholar and Thomson Reuters databases were utilized to conduct a comprehensive search of published literature as of July 2021 to find original literature related to Syringa microphylla Diels and its active ingredients.

Results: To date, 72 compounds have been isolated and identified from Syringa microphylla Diels, and oleuropein, verbascoside, isoacteoside, echinacoside, forsythoside B, and eleutheroside B are the main active components. These compounds have antioxidant, antibacterial, anti-inflammatory, and neuroprotective effects, and their safety and effectiveness have been demonstrated in long-term traditional applications. Molecular pharmacology experiments have indicated that the active ingredients of Syringa microphylla Diels exert their pharmacological effects in various ways, primarily by reducing oxidative stress damage via Nrf2/ARE pathway regulation, regulating inflammatory factors and inducing apoptosis through the MAPK and NF-κB pathways.

Conclusion: This comprehensive review of Syringa microphylla Diels provides new insights into the correlations among molecular mechanisms, the importance of toxicology and pharmacokinetics, and potential ways to address the limitations of current research. As Syringa microphylla Diels is a natural low-toxicity botanical medicine, it is worthy of development and utilization and is an excellent choice for treating various diseases.
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http://dx.doi.org/10.1016/j.phymed.2021.153770DOI Listing
October 2021

Dynamic Effects of the Third Generation Bisphosphonate of Risedronate on Rat Osteoporotic Fractures for Clinical Usage Guidance.

Orthop Surg 2021 Oct 21. Epub 2021 Oct 21.

Department of Orthopaedics, Children's Hospital of Shanghai, Shanghai, China.

Objective: To better understand the risks of bisphosphonates in order to develop guidance for appropriate clinical usage, to compared femoral fracture healing at different time points and to explore the effects of Residronate on fracture healing.

Methods: Osteoporosis model was achieved by ovariectomy surgery, followed by surgical incision of left femoral shaft 4 weeks after ovariectomy surgery. Three days after fracture surgery, risedronateor saline was fed by intragastric administration. X ray examination was used to check the callus formation, Bone Mineral Density (BMD), Bone Mineral Content (BMC), biomechanical, imaging and micromorphological of bone tissue as well as the trabecular bone parameters were all examined. The femoral pathology tissue of each rat was used to analyze trabecular bone parameters, including trabecular bone volume/tissue volume (Tb. BV/TV), bone surface to tissue volume ratio (BS/TV), trabecular bone mineral density (Tb. BMD), trabecular bone number (Tb. N), trabecular bone thickness (Tb. Th) and small bone Trabecular bone space (Tb. Sp).

Results: Via X-ray and pathologically, risedronate treatment promoted the callus forming at the fracture site during the following 6 weeks after osteoporotic fracture by X-ray (P < 0.01), increased the local bone mineral density (P < 0.01), and accelerated the fracture healing during the first 3 weeks (P <0.01), but delayed facture healing in the later 3 weeks (P < 0.01). Risedronate increased the bone continuity of fracture at 7th week, but this phenomenon was not found at the 10th week (P < 0.01). Delayed fracture healing occurred locally at the fracture site. At 7th week, Risedronate may promote cartilage cells proliferating at fracture site, increase the dense of bone trabeculae and the connection of bone trabeculae, thicken the bone cortex showing better fracture healing than OPF-Saline groups (P < 0.01). However, these parameter did not continue during the 7th and 10th weeks. Comparing the first and the later 3 weeks, the rats in group Osteoporotic Fracture-Risedronate (OPF-RD) accelerated the local fracture healing in the first 3 weeks but not in the last 3 weeks, which is consistent for the BMD and BMC among each group (P < 0.05). Through evaluation of bone mineral density and bone mineral content, risedronate dramatically increased the BMD at the fracture site and resulted in reduction of BMC by risedronate at the fracture site (P < 0.05) among each group still exist, indicating dramatic (P < 0.05). Through load testing, Risedronate increased the structural strength and mechanical indexes of the new callus (P < 0.01).

Conclusion: Risedronate can improve the structural strength and mechanical index of newborn callus. Longer than 7 weeks usage of third generation bisphosphonate of risedronate does not contribute to osteoporotic fracture.
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http://dx.doi.org/10.1111/os.13158DOI Listing
October 2021

Nanoprotein Interaction Atlas Reveals the Transport Pathway of Gold Nanoparticles across Epithelium and Its Association with Wnt/β-Catenin Signaling.

ACS Nano 2021 Oct 21. Epub 2021 Oct 21.

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.

A tremendous number of proteins participate in the delivery and transport process of nanomedicines. Nanoprotein interactions not only mediate drug delivery but also determine drug safety. In the field of biomedical sciences, the epithelial barrier is a huge challenge for gastrointestinal, intratracheal, intranasal, vaginal, and intrauterine delivery of nanomedicines. However, the molecular mechanisms by which nanomedicines cross tissue or cell barriers are not well understood. Here, we explored the nanoprotein interactions during the transcytosis of nanoparticles across the epithelial barrier by focusing on the transport pathway and mechanisms. Due to the limitations of traditional methods in resolving nanoprotein interactions, we developed a backward analysis strategy. By simultaneously analyzing the protein corona on the particle surface and the cellular response after transcytosis, we integrated the information on both directly and indirectly interacting proteins, establishing a holistic nanoprotein interaction atlas. It revealed the dominant role of the EV/ER/Golgi/SV pathway in the transcytosis of nanoparticles. More importantly, based on the established atlas, we discovered the association of Wnt/β-catenin signaling with nanoparticle transportation. The endocytosis for entering cells and exocytosis/transcytosis for leaving cells were differently regulated by the Wnt pathway. Notably, this regulatory effect was dependent on the particle size. Bigger nanoparticles departed from cells through the exocytosis pathway faster because of the specific bridging effect on the Wnt-Frizzled interaction and the feedback loop construction based on the exosomes. This mechanism gives an interpretation at the molecular level to the transcytosis dilemma of larger nanoparticles. Moreover, the size-dependent Wnt/β-catenin signaling pathway provides a promising regulatory and screening platform for the transportation of different nanomedicines through the epithelial barrier.
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http://dx.doi.org/10.1021/acsnano.1c06452DOI Listing
October 2021

All-Dielectric Phase-Gradient Metasurface Performing High-Efficiency Anomalous Transmission in the Near-Infrared Region.

Nanoscale Res Lett 2021 Oct 20;16(1):158. Epub 2021 Oct 20.

Guangxi Key Laboratory of Wireless Broadband Communication and Signal Processing, School of Information and Communication, Guilin University of Electronic Technology, Guilin, 541004, China.

We propose and numerically demonstrate a phase-gradient metasurface with high anomalous transmission efficiency and a large anomalous refraction angle that consists of discontinuous regular hexagonal nanorods supported by a silica substrate. The metasurface achieves high anomalous transmission efficiency and a full 2[Formula: see text] phase shift for the wavelength range of 1400-1600 nm. At a central wavelength of approximately 1529 nm, the total transmission efficiency reaches 96.5%, and the desired anomalous transmission efficiency reaches 96.2%, with an anomalous refraction angle as large as 30.64. With the adjustment of the period and the number of nanorods per periodic interval, the anomalous transmission efficiency exceeds 69.6% for a large anomalous refraction angle of 68.58. The superior performance of the proposed design may pave the way for its application in optical wavefront control devices.
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http://dx.doi.org/10.1186/s11671-021-03616-wDOI Listing
October 2021

2D Piezoelectric Bi MoO Nanoribbons for GSH-Enhanced Sonodynamic Therapy.

Adv Mater 2021 Oct 16:e2106838. Epub 2021 Oct 16.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals of developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi MoO -poly(ethylene glycol) nanoribbons (BMO NRs) are designed as piezoelectric sonosensitizers for glutathione (GSH)-enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, and the GSH-activated BMO NRs (GBMO) exhibit an oxygen-deficient structure, which can promote the separation of electron-hole pairs, thereby enhancing the efficiency of ROS production in SDT. The ultrathin GBMO NRs are piezoelectric, in which ultrasonic waves introduce mechanical strain to the nanoribbons, resulting in piezoelectric polarization and band tilting, thus accelerating toxic ROS production. The as-synthesized BMO NRs enable excellent computed tomography imaging of tumors and significant tumor suppression in vitro and in vivo. A piezoelectric Bi MoO sonosensitizer-mediated two-step enhancement SDT process, which is activated by endogenous GSH and amplified by exogenous ultrasound, is proposed. This process not only provides new options for improving SDT but also broadens the application of 2D piezoelectric materials as sonosensitizers in SDT.
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http://dx.doi.org/10.1002/adma.202106838DOI Listing
October 2021

EFL/ESL Students' Perceptions of Distributive, Procedural, and Interactional Justice: The Impact of Positive Teacher-Student Relation.

Authors:
Dan Yang

Front Psychol 2021 28;12:755234. Epub 2021 Sep 28.

Foreign Language School, Yancheng Teachers University, Yancheng, China.

The correlation between teacher-student interpersonal relationships and students' perception of different dimensions of justice using in the learning context has been found absolutely important since it can provide a nice learning environment for students in which they can comfortably learn a new language. Even though several studies have been carried out regarding the above-mentioned points, a review paper that focuses on the importance between these two variables by which students' learning is influenced seems of great interest. In this study, the author has strived hard to highlight the interplay between the aforementioned variables. First of all, Justice and its dimensions including distributive, procedural, and interactional justice are described in the learning context. Then the effect of the positive relationship between teachers and students is accentuated. Following it, different types of characteristics that are crucially noticeable considering teacher-student interpersonal relationship including "teachers care," "teacher clarity," "teacher confirmation," "teacher credibility," "teacher immediacy," "teacher stroke," "teacher-student rapport" are discussed. The term "positive psychology" accompanied by its factors is defined then. What is discussed then is classroom justice as a teacher-student interpersonal factor. Finally, it is concluded with implications and suggestions for future studies.
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http://dx.doi.org/10.3389/fpsyg.2021.755234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506034PMC
September 2021

Association of Daytime Napping with chronic diseases among Tibetan people in China: a cross-sectional study.

BMC Public Health 2021 Oct 8;21(1):1810. Epub 2021 Oct 8.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, China.

Background: Obesity, diabetes, and hypertension, as three of the most prevalent chronic diseases, remain a daunting health challenge. However, to our knowledge, no study has made a thorough examination of the association between the three chronic diseases and daytime napping, a widely accepted behavior in many countries. This is especially necessary among Tibetan populations, whose lifestyles and health outcomes may be unique, yet patterns of chronic diseases and napping are under-examined. Thus, we sought to explore the aforementioned association in the Tibetan population of China.

Methods: A total of 2902 participants aged 45-79 in 2019 were included. Multivariate logistic regressions were conducted in 2020. The sex disparity was examined through interaction and stratified analyses.

Results: Hypertension (40.7%) was more prevalent than obesity (20.2%) and diabetes (21.6%). Comparing to non-nappers, those who napped were more likely to have any conditions (OR = 1.30, 95% CI = 1.04-1.62 for 1-59 min/day group and OR = 1.40, 95% CI = 1.10-1.80 for ≥60 min/day group). Participants who had 1-59 min/day of napping were more likely to develop obesity (OR = 1.37, 95% CI = 1.07-1.75), and ≥ 60 min/day of napping was associated with diabetes (OR = 1.33, 95% CI = 1.01-1.74). The interactions between napping and sex were not statistically significant in the models.

Conclusions: The study revealed napping was unfavorably associated with obesity, diabetes, and any conditions in Tibetan people living on the Tibetan Plateau. Future interventions regarding the three chronic diseases may pay more attention to napping.

Trial Registration: Not applicable.
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http://dx.doi.org/10.1186/s12889-021-11871-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501682PMC
October 2021

Effects of carbazochrome sodium sulfonate combined with tranexamic acid on hemostasis and inflammation during perioperative period of total hip arthroplasty: A randomized controlled trial.

Orthop Traumatol Surg Res 2021 Sep 30:103092. Epub 2021 Sep 30.

Department of Orthopaedics, West China Hospital, Sichuan University, 37# Wainan Guoxue Road, 610041 Chengdu, People's Republic of China. Electronic address:

Background: The hemostatic effect of tranexamic acid (TXA) combined with carbazochrome sodium sulfonate (CSS) in total hip arthroplasty (THA) has not been determined. Therefore we performed a randomized study aiming to evaluate the effects of CSS combined with TXA on perioperative blood loss and inflammatory response of THA.

Hypothesis: CSS combined with TXA can effectively reduce perioperative blood loss and immune response compared to TXA.

Material And Methods: This randomized placebo-controlled trial assigned 150 patients undergoing unilateral primary total hip arthroplasty who underwent direct anterior approach surgery to 3 groups: group A received TXA plus topical CSS; group B received TXA only; and group C received placebo. The main outcome was total blood loss. Secondary outcomes included reduction in hemoglobin concentration, coagulation parameters, inflammatory marker levels, perioperative visual analog scale (VAS) pain score, transfusion rates, postoperative hospital stay, and incidence of thromboembolic events.

Results: Total blood loss in group A (668.84±230.95ml) was lower than in group B (940.96±359.22ml) and C (1166.52±342.85ml, p<0.05). We also found that compared with group B, postoperative hip pain, biomarker level of inflammation, visual analogue score (VAS) pain score in group A were significantly improved. The transfusion rate and unit of group A were significantly lower than group C (8 patients; 17.5 units), but there was no statistical difference between group A (no transfusion) and group B (2 patients; 4 units). No differences were observed in thromboembolic and other outcomes among the groups.

Discussion: The combined application of topic CSS and TXA is more effective than TXA alone following THA in regard of reducing total blood loss. In addition, CSS combined with TXA is better than TXA alone in terms of improving postoperative hip pain and reducing the level of inflammatory factors.

Level Of Evidence: I; randomized controlled study.
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http://dx.doi.org/10.1016/j.otsr.2021.103092DOI Listing
September 2021

Insight into the effect of fatty acid composition on the texture of French fries.

J Sci Food Agric 2021 Oct 1. Epub 2021 Oct 1.

National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China.

Background: Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear. In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.

Results: The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil. The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil. However, the peaks of starch-lipid complexes were hardly observed during frying. Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil. Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.

Conclusion: Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries. This indicated that the texture of fries can be manipulated by altering the fatty acid composition of the oil. © 2021 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.11550DOI Listing
October 2021

Plasmonic [email protected] Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy.

J Am Chem Soc 2021 Oct 28;143(39):16113-16127. Epub 2021 Sep 28.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nanoparticles (NPs) onto the surfaces of CuS nanosheets ([email protected] NSs) as a highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging and enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher photothermal conversion efficiency via the local electromagnetic enhancement as well as a greater radiation dose deposition in the form of glutathione depletion and reactive oxygen species generation. As a result, the depth of tissue penetration is improved, and hypoxia of the tumor microenvironment is alleviated. With synergistic enhancement in the efficacy of photothermal ablation and radiotherapy, the tumor can be eliminated without later recurrence. It is believed that these multifunctional heterostructures will play a vital role in future oncotherapy with the enhanced synergistic effects of radiotherapy and photothermal ablation under the guided imaging of a potential dual-modality system.
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http://dx.doi.org/10.1021/jacs.1c06652DOI Listing
October 2021

Platelet Function Tests Predicting the Efficacy and Safety of Aspirin Secondary Prevention.

Neurol Res 2021 Sep 28:1-8. Epub 2021 Sep 28.

Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.

Objective: To precisely prevent stroke, we evaluated three platelet function tests and their associations with clinical outcomes in ischemic stroke patients.

Methods: On-treatment platelet reactivity of acute minor stroke patients taking aspirin plus clopidogrel was tested by light transmittance aggregometry (LTA), thromboelastography (TEG) and platelet function analyzer (PFA). Mann-Whitney U tests and receiver operating characteristic (ROC) curve analysis were used to assess their associations with recurrent events and clinical outcome prediction.

Results: 127 acute minor stroke patients were stringently selected and followed for 13 months. Eight patients (6.3%) self-reported the recurrence and 13 (10.2%) patients self-reported bleeding. Recurrent patients displayed significantly higher on-treatment platelet reactivity when measured with LTA ( = 0.030) and PFA ( < 0.001). Further ROC analysis demonstrated that LTA and PFA had modest-to-fair ability to predict stroke recurrence (LTA: area under the curve [AUC], 0.765; 95% CI, 0.584-0.945, PFA: AUC, 0.832; 95% CI, 0.658-1.000). However, TEG (measured by the platelet inhibition rate) could not detect the difference between recurrent patients and non-recurrent patients ( = 0.515) and predict recurrent events (AUC, 0.569; 95% CI, 0.368-0.770). None of the tests were associated with bleeding except for PFA ( < 0.001), with AUC of PFA reaching 0.772 (0.726-0.818).

Conclusions: Of the three tests assessed, the predictive accuracies of PFA and LTA were satisfying for aspirin secondary prevention, while TEG's performance was poor. Only PFA could provide accurate prognostic information for bleeding.
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http://dx.doi.org/10.1080/01616412.2021.1981103DOI Listing
September 2021

A Deep Neural Network Method for Arterial Blood Flow Profile Reconstruction.

Entropy (Basel) 2021 Aug 27;23(9). Epub 2021 Aug 27.

School of Information Science & Engineering, Northeastern University, Shenyang 110819, China.

Arterial stenosis will reduce the blood flow to various organs or tissues, causing cardiovascular diseases. Although there are mature diagnostic techniques in clinical practice, they are not suitable for early cardiovascular disease prediction and monitoring due to their high cost and complex operation. In this paper, we studied the electromagnetic effect of arterial blood flow and proposed a method based on the deep neural network for arterial blood flow profile reconstruction. The potential difference and weight matrix are used as inputs to the method, and its output is an estimate of the internal blood flow velocity distribution for arterial blood flow profile reconstruction. Firstly, the weight matrix is input into the convolutional auto-encode (CAE) network to extract its features. Then, the weight matrix features and potential difference are combined to obtain the features of the blood velocity distribution. Finally, the velocity features are reconstructed into blood flow velocity distribution by a convolution neural network (CNN). All data sets are obtained from a model of the carotid artery with different rates of stenosis in a uniform magnetic field by COMSOL. The results show that the average root mean square error of the reconstruction results obtained by the proposed method is 0.0333, and the average correlation coefficient is 0.9721, which is better than the corresponding indicators of the Tikhonov, back propagation (BP) and CNN methods. The simulation results show that the proposed method can achieve high accuracy in blood flow profile reconstruction and is of great significance for the early diagnosis of arterial stenosis and other vessel diseases.
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http://dx.doi.org/10.3390/e23091114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467034PMC
August 2021

The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.

Mol Ther Nucleic Acids 2021 Dec 29;26:388-400. Epub 2021 Jul 29.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.

RNA-binding proteins (RBPs) are a set of proteins involved in many steps of post-transcriptional regulation to maintain cellular homeostasis. Ovarian cancer (OC) is the most deadly gynecological cancer, but the roles of RBPs in OC are not fully understood. Here, we reported that the RBP QKI5 was significantly negatively correlated with aggressive tumor stage and worse prognosis in serous OC patients. QKI5 could suppress the growth and metastasis of OC cells both and . Transcriptome analysis showed that QKI5 negatively regulated the expression of the transcriptional coactivator TAZ and its downstream targets (e.g., CTGF and CYR61). Mechanistically, QKI5 bound to TAZ mRNA and recruited EDC4, thus decreasing the stability of TAZ mRNA. Functionally, TAZ was involved in the QKI5-mediated tumor suppression of OC cells, and QKI5 expression was inversely correlated with TAZ, CTGF, and CYR61 expression in OC patients. Together, our study indicates that QKI5 plays a tumor-suppressive role and negatively regulates TAZ expression in OC.
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http://dx.doi.org/10.1016/j.omtn.2021.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426461PMC
December 2021

Identifying Needs and Barriers to Diabetes Dietary Education in Chinese People with Type 2 Diabetes and Their Family Members in Guangzhou: A Qualitative Study.

Diabetes Metab Syndr Obes 2021 15;14:4005-4014. Epub 2021 Sep 15.

School of Nursing, Sun Yat-sen University, Guangzhou, People's Republic of China.

Purpose: The purpose of this exploratory qualitative study was to identify the needs and barriers to diabetes dietary education issues in a Chinese context among people with type 2 diabetes and also their family members.

Patients And Methods: Nineteen patients with type 2 diabetes and 15 family members were randomly selected from a larger study in Guangzhou. Descriptive phenomenological qualitative inquiry guided this study.

Results: Both patients and their family members claimed a variety of needs regarding diabetes dietary information and that it should be patient-centered. In addition, both groups identified the effectiveness and helpfulness of diabetes diet-related health education, but family members reported a lack of professional education. Patients reported that the barriers to diabetes diet-related health education were: 1) patients' different faculties of memory and acceptance, 2) educators' methods of explaining the information, 3) lack of advertising and intensity of publicity both inside and outside of the hospital. Family members identified that diabetes diet-related health education assisted them with taking care of patients with diabetes and it was also beneficial for themselves to gain more dietary knowledge and develop healthy dietary habits.

Conclusion: It is necessary to make some adjustment to traditional diabetes dietary education. It may be a good strategy to investigate the needs and faculties of memory and acceptance of people with diabetes before starting a diabetes education program. Hospitals should intensify their publicity of diabetes education and make it more attractive to patients with diabetes and their family members. Educators should add information specifically for family members while conducting diabetes education. Tertiary hospitals could provide standardized training regarding diabetes-related health education to community family physicians; in this way, diabetes education could gradually be transferred to them and both groups of clinicians could share in the education.
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http://dx.doi.org/10.2147/DMSO.S327988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450603PMC
September 2021

Characteristics of macrophages from myelodysplastic syndrome microenvironment.

Exp Cell Res 2021 Nov 20;408(1):112837. Epub 2021 Sep 20.

Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. Electronic address:

Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic neoplasms. The progression of malignancy is closely associated with immune regulation. Macrophages are indispensable tissue components and have been proposed to play a role in the pathophysiology of hematopoietic malignancies. However, the specific role of macrophages in the development of MDS remains unclear. Here, we investigated the characteristics and phenotypic evolution of macrophages from patients with MDS. Macrophages from patients with MDS expressed CD68, CD86 and CD163. Furthermore, MDS macrophages exhibited more M2-related characteristics. Moreover, a number of phenotype-associated genes in MDS macrophages exhibited diverse responses to iron overload or iron chelation upon stimulation by ferric chloride or deferoxamine (DFO, an iron chelator). Ferric chloride polarized MDS macrophages to exhibit more M1-related characteristics, a phenomenon that could be partially reversed by DFO. Therefore, this study reveals the characteristics and phenotypic evolution of MDS macrophages and broadens the knowledge of macrophage plasticity in hematopoietic malignancies.
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http://dx.doi.org/10.1016/j.yexcr.2021.112837DOI Listing
November 2021

Spermidine resets circadian clock phase in NIH3T3 cells.

Biomed Res 2021 ;42(5):221-227

Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University.

Irregular light-dark cycles desynchronize the circadian clock via hormonal and neuronal pathways and increase the risk of various diseases. This study demonstrated that a single pulse of spermidine-a polyamine-strongly induced circadian phase advances in the presence or absence of dexamethasone (a synthetic glucocorticoid) in NIH3T3 cells transfected with the Bmal1 promotor-driven luciferase reporter gene. The spermidine-induced phase advances were 2-3 fold greater than were the dexamethasone-induced shifts. The phase resetting effect of spermidine occurred in a dose- and time-dependent manner and was not blocked by RU486, an antagonist of glucocorticoid receptors. Spermidine treatment modulated the expression of clock genes within 60 min, which was sooner than changes in the expression of autophagy-related genes. These findings suggested that spermidine is a potent modulator of the circadian phase, acting through glucocorticoid receptor-independent pathways, and may be useful for treating diseases related to circadian desynchrony.
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http://dx.doi.org/10.2220/biomedres.42.221DOI Listing
January 2021

Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma.

Acta Biomater 2021 Sep 13. Epub 2021 Sep 13.

College of Pharmacy, Jinan University, Guangzhou 510632, China.

Cutaneous melanoma is one of the most common malignant skin cancer with high lethality. Chemotherapy and photothermal therapy are important and extensively studied treatment modalities for melanoma. However, these therapies still face some challenges, which severely restrict their further applications, such as unsatisfactory efficacy of monotherapy, nonspecific uptake and release during drug delivery, and unexpected adverse effects from system administration. Recently, the strategies of collaboration, functional modification, stimuli-responsive design, and topical administration all show great prospect for solving above problems. In this research, a multifunctional nanoparticle-integrated dissolving microneedle drug delivery system was constructed, in which the nanoparticles were prepared based on the framework with the incorporation of photothermal agent (CuS) into Zeolitic imidazolate framework-8 and functionalized by hyaluronic acid. This system can co-load multi-modal drugs, improve specific uptake and distribution of targeted tumor, deliver drug locally, and release drug intelligently and spatiotemporally, thereby promising a low-dose administration with high efficiency. The high inhibiting tumor performance and excellent systematic safety were verified both in vitro and in vivo. Together, this smart design overcame the drawbacks of monotherapy and conventional system administration. We believe the nanoparticle-integrated dissolving microneedles will be in prospect of clinical application for more superficial tumors with further delicate optimization. STATEMENT OF SIGNIFICANCE: Melanoma is one of the most common skin cancers with high lethality. Extensively studied chemotherapy and photothermal therapy still face some challenges, such as the limited therapeutic efficacy and the severe system adverse effects. In order to overcome these drawbacks, the multifunctional nanoparticle-integrated dissolving microneedles (DMNs) were designed. Especially, the nanoparticles could co-load multi-modal drugs, improve specific uptake, and release drug intelligently and spatiotemporally. The microneedles could increase the drug accumulation in tumor, thus achieving excellent therapeutic efficacy and reducing side effects. This system paved the way to a less invasive, more focused and efficient therapeutic strategy for melanoma therapy.
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http://dx.doi.org/10.1016/j.actbio.2021.09.009DOI Listing
September 2021

Effect of regular and irregular stimulation cycles of dexamethasone on circadian clock in NIH3T3 cells.

Chronobiol Int 2021 Sep 15:1-9. Epub 2021 Sep 15.

Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

Animal studies have shown that irregular light-dark cycles cause circadian desynchronization, while few studies have addressed the effect of regular/irregular stimulation cycles of signaling hormones on the cellular clock . Here, we examined how cellular clocks respond to regular and irregular stimulation cycles of dexamethasone, using NIH3T3 cells transfected with the promoter-driven luciferase () reporter gene. Cyclic stimulation with dexamethasone at different time intervals (18-28 h, 3 times regularly) revealed that bioluminescence rhythms can be entrained to 22 and 24 h cycles during the stimulation period, but not to other cycles. The rhythm entrained for 24 h cycles persisted for at least one day after the last stimulation. Irregular dexamethasone treatment (16, 24, and 16 h, sequentially; short-term jet lag protocol) resulted in an overall upregulation and phase shifts of the temporal expression of several clock genes and cell cycle genes, including and . Regular dexamethasone stimulation three times with 24 h cycles also caused upregulation of and expression, but not and expression. In conclusion, our study identified the entrainable range of the circadian clock in NIH3T3 cells to the dexamethasone stimulation cycle and demonstrated that irregular dexamethasone treatment could disturb the expression of cell cycle genes.
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http://dx.doi.org/10.1080/07420528.2021.1977654DOI Listing
September 2021

Self-Healing and Elastic Triboelectric Nanogenerators for Muscle Motion Monitoring and Photothermal Treatment.

ACS Nano 2021 09 15;15(9):14653-14661. Epub 2021 Sep 15.

School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0245, United States.

Owing to wearing and unpredictable damage, the working lifetime of triboelectric nanogenerators (TENGs) is largely limited. In this work, we prepared a single-electrode multifunctional TENG (MF-TENG) that exhibits fast self-healing, human health monitoring capability, and photothermal properties. The device consists of a thin self-healing poly(vinyl alcohol)-based hydrogel sandwiched between two self-healing silicone elastomer films. The MF-TENG exhibits a short-circuit current, short-circuit transfer charge, and open-circuit voltage of 7.98 μA, 78.34 nC, and 38.57 V, respectively. Furthermore, owing to the repairable networks of the dynamic imine bonds in the charged layer and the borate ester bonds in the electrodes, the prepared device could recover its original state after mechanical damage within 10 min at room temperature. The MF-TENG can be attached to different human joints for self-powered monitoring of personal health information. Additionally, the MF-TENG under near-infrared laser irradiation can provide a photothermal therapy for assisting the recovery of human joints motion. It is envisaged that the proposed MF-TENG can be applied to the fields of wearable electronics and health-monitoring devices.
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http://dx.doi.org/10.1021/acsnano.1c04384DOI Listing
September 2021

How to Choose an Interfacial Modifier for Organic Photovoltaics Using Simple Surface Energy Considerations.

ACS Appl Mater Interfaces 2021 Sep 14;13(38):46134-46141. Epub 2021 Sep 14.

Lehrstuhl für Funktionelle Materialien, Physik-Department, Technische Universität München, James-Franck-Street 1, 85748 Garching, Germany.

Organic photovoltaics are typically composed of at least four different materials, including the donor and acceptor components of the bulk heterojunction, the interfacial layers at each electrode, the electrodes themselves, and solution additives that may persist in the final sandwich structure. The interplay of surface energies between these different layers is profoundly complex, as the deposition and annealing of one layer on top of another may be influenced by the surface energy of these interfaces. While the energy levels of one layer with respect to adjacent layers are important to facilitate charge separation and collection at the electrodes, the relative surface energies of the interfaces in contact with the multicomponent bulk heterojunction can be beneficial or disadvantageous, or be neutral, with respect to the performance of the OPV device. Because the bulk heterojunction is a mixture of donor and acceptor polymers and/or small molecules, the accumulation of one of the components on the underlying electrode interface can be driven by surface energy considerations. A donor- or acceptor-rich interface may affect charge carrier flow to the electrode, thus affecting the overall efficiency. Here, ITO/PEDOT:PSS electrodes in forward organic photovoltaic devices are treated with five different thin interfacial layers to change the relative surface energy of this electrode with respect to the adjacent bulk heterojunction. Contact angle measurements with four probe liquids enable calculation of the surface energies, and the results are compared with the performance of forward-biased organic photovoltaic devices. Time-of-flight secondary ion mass spectrometry results substantiate the predictions of gradients in the bulk heterojunction layers, and grazing-incidence wide-angle X-ray scattering measurements show the impact on the polymer crystallites. Thus, a simple algorithm based on surface energy considerations may inform which interfacial layer for a given bulk heterojunction in an organic photovoltaic device can be the most appropriate.
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http://dx.doi.org/10.1021/acsami.1c12790DOI Listing
September 2021

Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics.

J Zhejiang Univ Sci B 2021 Sept 15;22(9):733-745

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Abdominal aortic aneurysm (AAA) and atherosclerosis (AS) have considerable similarities in clinical risk factors and molecular pathogenesis. The aim of our study was to investigate the differences between AAA and AS from the perspective of metabolomics, and to explore the potential mechanisms of differential metabolites via integration analysis with transcriptomics. Plasma samples from 32 AAA and 32 AS patients were applied to characterize the metabolite profiles using untargeted liquid chromatography-mass spectrometry (LC-MS). A total of 18 remarkably different metabolites were identified, and a combination of seven metabolites could potentially serve as a biomarker to distinguish AAA and AS, with an area under the curve (AUC) of 0.93. Subsequently, we analyzed both the metabolomics and transcriptomics data and found that seven metabolites, especially 2'-deoxy-D-ribose (2dDR), were significantly correlated with differentially expressed genes. In conclusion, our study presents a comprehensive landscape of plasma metabolites in AAA and AS patients, and provides a research direction for pathogenetic mechanisms in atherosclerotic AAA.
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http://dx.doi.org/10.1631/jzus.B2000713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435341PMC
September 2021

Adnexal masses: Diagnostic performance of contrast-enhanced ultrasound using the simple rules from the International Ovarian Tumor Analysis group.

Int J Gynaecol Obstet 2021 Sep 12. Epub 2021 Sep 12.

Ultrasound Medical Center, Lanzhou University Second Hospital, Lanzhou, China.

Objective: To evaluate the role of the Simple Rules (SR) from the International Ovarian Tumor Analysis group in contrast-enhanced ultrasound (CEUS) of for the differential diagnosis of benign and malignant adnexal tumors.

Methods: A total of 180 patients with suspected malignant adnexal masses admitted to Lanzhou University Second Hospital were included, all of whom received conventional ultrasound (US) and CEUS examination before surgery. All masses were assessed using SR in US and SR in CEUS. To compare the diagnostic performance, the sensitivity, specificity, negative and positive predictive values, Youden index, and area under the curves values of SR in US and SR in CEUS were obtained.

Results: Sensitivity, negative predictive values, Youden index, and area under the curves were better for SR in CEUS than SR in US. The specificity and negative predictive value of SR in CEUS were lower than that of SR in US. Compared with SR in US, SR in CEUS significantly reduced the number of uncertain masses (21, 36.7% vs. 66, 11.7%).

Conclusion: We concluded that SR in CEUS performed well in the diagnosis of malignant adnexal masses. SR in CEUS is a supplement to SR in US.
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http://dx.doi.org/10.1002/ijgo.13926DOI Listing
September 2021

Absence of serological or molecular evidence of infection in farmed swine in the Hong Kong Special Administrative Region.

One Health 2021 Dec 30;13:100321. Epub 2021 Aug 30.

Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong, China.

Leptospirosis is an important zoonotic disease with several maintenance host species including swine. A cross sectional survey was undertaken between January to October 2020 to investigate the prevalence of leptospirosis in farmed swine in the Hong Kong Special Administrative Region (HKSAR) of China. Serum samples were collected from swine on seven farms (15 swine per farm; ten multiparous sows and five twelve-week-old weaners), while kidney samples were collected from 64 swine submitted for routine post-mortem (26 farms; average 2.4 swine per farm, range 1-6). Microscopic agglutination tests (MAT) to a panel of 24 antigens did not reveal any evidence of seroconversion at a titre of 1:100. Polymerase chain reaction (PCR) testing of the kidney samples for DNA did not detect any evidence of infection. Bayesian methods were used to compute the probability that the leptospirosis prevalence in farmed swine in the HKSAR was <3%, given none of the 105 swine sampled were positive on the MAT. The results of this study demonstrate no serological or molecular evidence of leptospirosis in farmed swine in the HKSAR. Subsequent statistical analysis supports the conclusion that the prevalence of leptospirosis in farmed swine in the HKSAR is negligible at present.
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http://dx.doi.org/10.1016/j.onehlt.2021.100321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411228PMC
December 2021

Erratum: "Distinct chemical fixation of CO enabled by exotic gold nanoclusters" [J. Chem. Phys. 155, 054305 (2021)].

J Chem Phys 2021 Sep;155(9):099901

School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

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http://dx.doi.org/10.1063/5.0066159DOI Listing
September 2021

Contrast-Enhanced Ultrasound Findings of Hepatocellular Carcinoma With Neuroendocrine Carcinoma: A Case Report.

Front Med (Lausanne) 2021 16;8:602346. Epub 2021 Aug 16.

Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, China.

Hepatocellular carcinoma (HCC) with the concurrent occurrence of primary hepatic neuroendocrine carcinoma (NEC) of the liver is extremely rare. Preoperative diagnosis of HCC combined with NEC is very difficult. Here, we presented a case report of HCC combined with NEC. A 33-year-old male was admitted to our hospital due to focal liver lesion. To further the diagnosis, he received laboratory tests, conventional ultrasound, contrast-enhanced ultrasound (CEUS), and magnetic resonance imaging (MRI). Grayscale ultrasound showed a hypoechoic nodule with peripheral hypoechoic halo and central small patches of anechoic area in the hepatic segment VI, and the liver background was cirrhosis. In the CEUS, the solid component of the nodule was rapidly homogeneous hyper-enhancement in the arterial phase. Then, the enhancement of the nodule was washed out slowly and gradually; the nodule presented heterogeneously mild enhancement in the portal phase, and slight hypo-enhancement was showed in the late phase. The hypo-enhanced area was mainly located in the surrounding space. Meanwhile, there was a small piece of non-enhanced area within the lesion center in the whole three-phase imaging. MRI showed a lobular contoured mass in segment VI. The patient underwent middle liver resection, splenectomy, and cholecystectomy. The pathological diagnosis was a HCC with NEC. At the time of the preparation of this manuscript, the patient has been alive without recurrence or distant metastases for 6 months since the surgery. We mainly focus on the ultrasound imaging characteristics, especially its enhancement manifestations on CEUS. In this report, since this article is a case report, which is based on the clinical information of the patient and does not involve the patient's privacy, informed consent is not necessary. In addition, the patient agreed to publish the case. To the best of our knowledge, this report is the first to describe the CEUS patterns of the HCC combined with NEC. Herein, we report a case that provides novel insights that will improve clinicians' awareness of the clinical and ultrasound manifestations of this mixed tumor, resulting in improved diagnosis, treatment, and outcomes.
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http://dx.doi.org/10.3389/fmed.2021.602346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415301PMC
August 2021
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