Dan Theodorescu

Dan Theodorescu

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Dan Theodorescu

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The Role of Transcription Factor YY1 in the Biology of Cancer.

Crit Rev Oncog 2017 ;22(1-2):13-21

Department of Pharmacology, University of Colorado, Denver, Colorado; Department of Surgery (Urology), University of Colorado, Denver, Colorado; University of Colorado Comprehensive Cancer Center, Denver, Colorado.

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http://dx.doi.org/10.1615/CritRevOncog.2017021071DOI Listing
April 2019

Metastatic cells are preferentially vulnerable to lysosomal inhibition.

Proc Natl Acad Sci U S A 2018 09 20;115(36):E8479-E8488. Epub 2018 Aug 20.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.

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http://dx.doi.org/10.1073/pnas.1706526115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130375PMC
September 2018

A Gene Expression Signature Predicts Bladder Cancer Cell Line Sensitivity to EGFR Inhibition.

Bladder Cancer 2018 Jul 30;4(3):269-282. Epub 2018 Jul 30.

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.3233/BLC-170161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087449PMC
July 2018

Two methods of prediction signatures.

Nat Rev Urol 2018 Jun;15(6):340-342

Department of Pharmacology, University of Colorado, Denver, CO, USA.

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http://dx.doi.org/10.1038/s41585-018-0004-2DOI Listing
June 2018

Systematic Review: Characteristics and Preclinical Uses of Bladder Cancer Cell Lines.

Bladder Cancer 2018 Apr 26;4(2):169-183. Epub 2018 Apr 26.

Department of Surgery (Urology), University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.3233/BLC-180167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929350PMC
April 2018

Precision medicine for urothelial bladder cancer: update on tumour genomics and immunotherapy.

Nat Rev Urol 2018 02 14;15(2):92-111. Epub 2017 Nov 14.

Department of Surgery (Urology), University of Colorado, 12631 E. 17th Avenue, Aurora, Colorado, 80045, USA.

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http://dx.doi.org/10.1038/nrurol.2017.179DOI Listing
February 2018

Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer.

Mol Cancer Res 2018 01 2;16(1):69-77. Epub 2017 Oct 2.

Department of Surgery (Urology), University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0260DOI Listing
January 2018

RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.

Pharmacol Rev 2018 01;70(1):1-11

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China (C.Y.); Departments of Surgery (Urology) and Pharmacology, University of Colorado, Aurora, Colorado (D.T.); and University of Colorado Comprehensive Cancer Center, Aurora, Colorado (D.T.)

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http://dx.doi.org/10.1124/pr.117.014415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712631PMC
January 2018

Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis.

Cancer Res 2017 09 3;77(18):4858-4867. Epub 2017 Jul 3.

Departments of Surgery and Pharmacology, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600841PMC
September 2017

Pharmacogenomic considerations in the treatment of muscle-invasive bladder cancer.

Pharmacogenomics 2017 Aug 26;18(12):1167-1178. Epub 2017 Jul 26.

University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.2217/pgs-2017-0055DOI Listing
August 2017

New Sister Journal .

Bladder Cancer 2017 Jul 27;3(3):143. Epub 2017 Jul 27.

University of Colorado Cancer Center, Aurora, Colorado, USA. E-mail:

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/BLC-179021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545903PMC
July 2017

Synthesis of novel Ral inhibitors: An in vitro and in vivo study.

Bioorg Med Chem Lett 2016 12 12;26(23):5815-5818. Epub 2016 Oct 12.

Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301652PMC
December 2016

CD44: A metastasis driver and therapeutic target.

Oncoscience 2016 30;3(11-12):320-321. Epub 2016 Dec 30.

Department of Surgery, University of Colorado, Denver, Aurora, CO 80045; Department of Pharmacology, University of Colorado, Denver, Aurora, CO 80045; University of Colorado Comprehensive Cancer Center, Aurora, CO 80045.

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http://dx.doi.org/10.18632/oncoscience.335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235920PMC
December 2016

High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing.

J Mol Med (Berl) 2016 09 31;94(9):1015-24. Epub 2016 Mar 31.

Department of Chemistry, University of California, 307 Lewis Hall, Berkeley, CA, 94720, USA.

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http://dx.doi.org/10.1007/s00109-016-1407-2DOI Listing
September 2016

GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis.

Cancer Res 2016 09 16;76(17):5175-85. Epub 2016 Jun 16.

Department of Pharmacology, University of Colorado, Denver, Colorado. Department of Surgery (Urology), University of Colorado, Denver, Colorado. University of Colorado Comprehensive Cancer Center, Denver, Colorado.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010501PMC
September 2016

An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression.

Cancer Cell 2016 09 1;30(3):432-443. Epub 2016 Sep 1.

Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, CT 06520, USA; Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(16)30385-3.pd
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http://www.cell.com/cms/attachment/2065889170/2066482205/mmc
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http://dx.doi.org/10.1016/j.ccell.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154333PMC
September 2016

Development and Validation of Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a Multi-center Study.

Clin Cancer Res 2016 Aug 29;22(16):4077-86. Epub 2016 Mar 29.

Laboratory of Biology, Department of Basic Medical Sciences, University of Athens School of Medicine, Athens, Greece. Laboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2715DOI Listing
August 2016

Drugging the Ral GTPase.

Small GTPases 2015 ;6(3):157-9

a Departments of Surgery (Urology) and Pharmacology ; University of Colorado ; Aurora , CO USA.

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http://dx.doi.org/10.1080/21541248.2015.1018403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601353PMC
June 2016

Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis.

Clin Cancer Res 2016 Mar 21;22(5):1274-83. Epub 2015 Oct 21.

Department of Surgery (Urology), University of Colorado, Denver, Colorado. Department of Pharmacology, University of Colorado, Denver, Colorado. University of Colorado Comprehensive Cancer Center, Denver, Colorado.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775343PMC
March 2016

New and promising strategies in the management of bladder cancer.

Am Soc Clin Oncol Educ Book 2015 :105-12

From the Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute at the National Institutes of Health, Bethesda, MD; US Oncology Research, Houston, TX and Comprehensive Cancer Centers of Nevada, Las Vegas, NV; University of Colorado Cancer Center, Denver, CO.

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http://meetinglibrary.asco.org/content/115000105-156
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http://dx.doi.org/10.14694/EdBook_AM.2015.35.105DOI Listing
February 2016

Pharmacogenomics: Biomarker-Directed Therapy for Bladder Cancer.

Urol Clin North Am 2016 Feb 31;43(1):77-86. Epub 2015 Oct 31.

University of Colorado Cancer Center, Aurora, CO, USA; Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ucl.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663013PMC
February 2016

Altered expression of transmembrane mucins, MUC1 and MUC4, in bladder cancer: pathological implications in diagnosis.

PLoS One 2014 26;9(3):e92742. Epub 2014 Mar 26.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America; Buffett Cancer Center, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966814PMC
December 2015

One step closer to targeting RAS.

Cell Cycle 2015 ;14(3):287-8

a Departments of Surgery (Urology) and Pharmacology ; University of Colorado ; Aurora , CO USA.

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http://dx.doi.org/10.1080/15384101.2015.1006534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614980PMC
December 2015

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.

Genes Dev 2015 Nov 29;29(21):2219-24. Epub 2015 Oct 29.

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA; Howard Hughes Medical Institute, University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA; University of Colorado Comprehensive Cancer Center, Aurora, Colorado 80045, USA;

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http://dx.doi.org/10.1101/gad.269498.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647555PMC
November 2015

Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.

Mol Cancer Res 2015 Sep 15;13(9):1306-15. Epub 2015 Jun 15.

Departments of Surgery (Urology) and Pharmacology, University of Colorado, Aurora, Colorado. University of Colorado Comprehensive Cancer Center, Aurora, Colorado.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573363PMC
September 2015

A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica.

Sci Rep 2015 Sep 8;5:13613. Epub 2015 Sep 8.

Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia USA.

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http://dx.doi.org/10.1038/srep13613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561901PMC
September 2015

Targeting glycogen metabolism in bladder cancer.

Nat Rev Urol 2015 Jul 26;12(7):383-91. Epub 2015 May 26.

University of Colorado Comprehensive Cancer Center, MS F-434, 13001 East 17th Place, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrurol.2015.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678000PMC
July 2015

The Prognostic Value of Cell Cycle Gene Expression Signatures in Muscle Invasive, High-Grade Bladder Cancer.

Bladder Cancer 2015 Apr 30;1(1):45-63. Epub 2015 Apr 30.

Department of Surgery, University of Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.3233/BLC-150012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218186PMC
April 2015

RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.

Mol Cancer Res 2015 Mar 16;13(3):483-92. Epub 2014 Dec 16.

Department of Surgery and Pharmacology University of Colorado, Aurora, Colorado. University of Colorado Comprehensive Cancer Center, Aurora, Colorado.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369172PMC
March 2015

The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.

Acta Pharmacol Sin 2015 Mar 5;36(3):291-7. Epub 2015 Jan 5.

1] Department of Surgery, University of Colorado, Aurora, CO 80045, USA [2] Department of Pharmacology, University of Colorado, Aurora, CO 80045, USA [3] University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/aps.2014.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349922PMC
March 2015

The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations.

Nucleic Acids Res 2014 24;42(17):e133. Epub 2014 Jul 24.

Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA Department of Pharmacology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA

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http://dx.doi.org/10.1093/nar/gku631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176155PMC
February 2015

A rho GDP dissociation inhibitor produced by apoptotic T-cells inhibits growth of Mycobacterium tuberculosis.

PLoS Pathog 2015 Feb 6;11(2):e1004617. Epub 2015 Feb 6.

Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Center, Tyler, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450061PMC
February 2015

Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.

Science 2015 Feb 5;347(6225):1006-10. Epub 2015 Feb 5.

Howard Hughes Medical Institute, University of Colorado BioFrontiers Institute, Boulder, CO 80309, USA. Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/science.1260200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640672PMC
February 2015

Robust prognostic gene expression signatures in bladder cancer and lung adenocarcinoma depend on cell cycle related genes.

PLoS One 2014 22;9(1):e85249. Epub 2014 Jan 22.

Department of Surgery, University of Colorado, Aurora, Colorado, United States of America ; Department of Pharmacology, University of Colorado, Aurora, Colorado, United States of America ; University of Colorado Comprehensive Cancer Center, Aurora, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085249PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898982PMC
December 2014

Decade in review-bladder cancer: international progress: from cytology to genomics.

Nat Rev Urol 2014 11 2;11(11):609-10. Epub 2014 Sep 2.

University of Colorado Comprehensive Cancer Center, MS F-434, 13001 East 17th Place, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrurol.2014.236DOI Listing
November 2014

Discovery and characterization of small molecules that target the GTPase Ral.

Nature 2014 Nov 14;515(7527):443-7. Epub 2014 Sep 14.

1] Department of Surgery, University of Colorado, Aurora, Colorado 80045, USA [2] Department of Pharmacology, University of Colorado, Aurora, Colorado 80045, USA [3] University of Colorado Comprehensive Cancer Center, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/nature13713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351747PMC
November 2014

Looking forward, looking back-10 years in urology.

Nat Rev Urol 2014 11 28;11(11):649-55. Epub 2014 Oct 28.

University of Colorado Comprehensive Cancer Center, MS F-434, 13001 East 17th Place, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrurol.2014.263DOI Listing
November 2014

Bladder cancer: bladder preservation--learning what we don't know.

Nat Rev Urol 2014 Jun 20;11(6):310-2. Epub 2014 May 20.

University of Colorado Comprehensive Cancer Center, 13001 East 17th Place, MS #F-434, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrurol.2014.102DOI Listing
June 2014

A cell of origin gene signature indicates human bladder cancer has distinct cellular progenitors.

Stem Cells 2014 Apr;32(4):974-82

Mathematics and Computer Science Department, Eastern Connecticut State University, Willimantic, Connecticut, USA.

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http://dx.doi.org/10.1002/stem.1625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960367PMC
April 2014

Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease.

J Natl Cancer Inst 2014 Apr 3;106(5). Epub 2014 Apr 3.

Affiliations of authors: Department of Surgery (SGui, CP, YR, CRL, JED, GD, CO, DT) and Department of Pharmacology (SGui, CP, YR, CRL, JED, GD, CO, DT), University of Colorado, Denver, CO; Sigma-Aldrich Research Biotech, Saint Louis, MO (AS, SK, HH); Department of Pathology, Cleveland Clinic, Cleveland, OH (SGup, DH); Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA (MH); Department of Medicine, University of California at San Francisco, San Francisco, CA (MH); Center for Regulatory and Environmental Analytical Metabolomics, Department of Chemistry, University of Louisville, Louisville, KY (PL); Graduate Center of Toxicology, Biopharm Complex, University of Kentucky, Lexington, KY (ANL, TW-MF); University of Colorado Comprehensive Cancer Center, Denver, CO (DT). Present affiliations: Department of Biomedical Informatics, Windber Research Institute, Windber, PA (YR); Mathematics and Computer Science Department, Eastern Connecticut State University, Willimantic, CT (GD).

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http://dx.doi.org/10.1093/jnci/dju062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580555PMC
April 2014

Telomerase in bladder cancer: back to a better future?

Eur Urol 2014 Feb 28;65(2):370-1. Epub 2013 Oct 28.

University of Colorado Comprehensive Cancer Center, Aurora, CO, USA; Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, Boulder, CO, USA.

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http://dx.doi.org/10.1016/j.eururo.2013.10.019DOI Listing
February 2014

Words of wisdom. Re: Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma.

Eur Urol 2014 Feb;65(2):501

University of Colorado Comprehensive Cancer Center, Aurora, CO, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838130119
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http://dx.doi.org/10.1016/j.eururo.2013.10.054DOI Listing
February 2014

Pharmacogenomics in bladder cancer.

Urol Oncol 2014 Jan;32(1):16-22

Department of Surgery, University of Colorado, Aurora, CO; University of Colorado Comprehensive Cancer Center, Aurora, CO. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2013.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904434PMC
January 2014

Frequent truncating mutations of STAG2 in bladder cancer.

Nat Genet 2013 Dec 13;45(12):1428-30. Epub 2013 Oct 13.

1] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA. [2] Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ng.2800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875130PMC
December 2013

Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression.

J Thorac Oncol 2013 Dec;8(12):1492-501

Departments of *Surgery, †Pharmacology, ‖Biostatistics and Informatics, #Pathology, and ‡Division of Medical Oncology, University of Colorado, Aurora, Colorado; ¶University of Colorado Comprehensive Cancer Center, Aurora, Colorado; and §Department of Medicine, National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.1097/JTO.0000000000000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934792PMC
December 2013

Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization.

Clin Cancer Res 2013 Jun 10;19(11):2850-60. Epub 2013 Apr 10.

Department of Surgery (Urology), University of Colorado, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695228PMC
June 2013

Loss of SPARC in bladder cancer enhances carcinogenesis and progression.

J Clin Invest 2013 Feb 16;123(2):751-66. Epub 2013 Jan 16.

Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1172/JCI64782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561835PMC
February 2013

Clinical opportunities and challenges in targeting tumour dormancy.

Nat Rev Clin Oncol 2013 Jan 27;10(1):41-51. Epub 2012 Nov 27.

Department of Surgery and Pharmacology, University of Colorado Comprehensive Cancer Center, Building 500, 13001 East 17th Place, Aurora, CO 80045, USA.

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http://www.nature.com/articles/nrclinonc.2012.207
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http://dx.doi.org/10.1038/nrclinonc.2012.207DOI Listing
January 2013

The faces and friends of RhoGDI2.

Cancer Metastasis Rev 2012 Dec;31(3-4):519-28

Center for Cell Signaling and Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1007/s10555-012-9376-6DOI Listing
December 2012

CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated.

Proc Natl Acad Sci U S A 2012 Dec 25;109(51):E3588-96. Epub 2012 Sep 25.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1073/pnas.1113960109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529071PMC
December 2012

Permissive role of endothelin receptors in tumor metastasis.

Life Sci 2012 Oct 17;91(13-14):522-7. Epub 2012 Apr 17.

Department of Urology, University of Virginia, USA.

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http://dx.doi.org/10.1016/j.lfs.2012.03.040DOI Listing
October 2012

Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve?

Life Sci 2012 Oct 6;91(13-14):528-39. Epub 2012 Aug 6.

Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.lfs.2012.07.034DOI Listing
October 2012

RhoGDI2 suppresses bladder cancer metastasis via reduction of inflammation in the tumor microenvironment.

Oncoimmunology 2012 Oct;1(7):1175-1177

Department of Urology; University of Virginia; Charlottesville, VA USA.

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http://dx.doi.org/10.4161/onci.20594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494636PMC
October 2012

Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.

Cancer Res 2012 Jul 14;72(14):3480-91. Epub 2012 May 14.

Department of Urology, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842017PMC
July 2012

Perspectives on personalized cancer care.

Urol Oncol 2012 Mar-Apr;30(2):121-5

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373832PMC
June 2012

RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.

J Clin Invest 2012 Apr 12;122(4):1503-18. Epub 2012 Mar 12.

Department of Urology, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1172/JCI61392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314474PMC
April 2012

Adenosine A2B receptor blockade slows growth of bladder and breast tumors.

J Immunol 2012 Jan 23;188(1):198-205. Epub 2011 Nov 23.

Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1101845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819109PMC
January 2012

In vitro transcriptomic prediction of hepatotoxicity for early drug discovery.

J Theor Biol 2011 Dec 27;290:27-36. Epub 2011 Aug 27.

Department of Biophysics, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.jtbi.2011.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386613PMC
December 2011

Bladder cancer in 2011: the dawn of personalized medicine.

Nat Rev Urol 2011 Dec 20;9(2):65-6. Epub 2011 Dec 20.

University of Colorado Comprehensive Cancer Center, 1665 Aurora Court, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrurol.2011.220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020619PMC
December 2011

Biomarkers for prognosis and treatment selection in advanced bladder cancer patients.

Curr Opin Urol 2011 Sep;21(5):420-7

Department of Surgery, University of Colorado, Aurora, Colorado, USA.

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http://dx.doi.org/10.1097/MOU.0b013e32834956d6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257805PMC
September 2011

A 20 gene model for predicting nodal involvement in bladder cancer patients with muscle invasive tumors.

PLoS Curr 2011 Aug 11;3:RRN1248. Epub 2011 Aug 11.

Department of Surgery, University of Colorado, Aurora, Colorado, USA; Department of Pathology, University of Colorado, Aurora, Colorado, USA; University of Colorado Cancer Center and The Public Library of Science (PLoS) is a non-profit open-access publisher, committed to making scientific and medical research literature a freely accessible public resource.

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http://dx.doi.org/10.1371/currents.RRN1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157080PMC
August 2011

RREB1 transcription factor splice variants in urologic cancer.

Am J Pathol 2011 Jul;179(1):477-86

Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123806PMC
July 2011

Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells.

Prostate 2011 Jun 4;71(8):791-800. Epub 2010 Nov 4.

Department of Pharmacology-Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/pros.21295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043153PMC
June 2011

Genetic testing for metastasis: potential for improved cancer treatment.

Future Oncol 2011 Jun;7(6):697-701

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http://dx.doi.org/10.2217/fon.11.48DOI Listing
June 2011

Words of wisdom. Re: mortality results from the Göteborg randomised population-based prostate-cancer screening trial.

Eur Urol 2010 Dec;58(6):938-9

University of Colorado Cancer Center, University of Colorado Denver, Denver, CO, USA.

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http://dx.doi.org/10.1016/j.eururo.2010.09.017DOI Listing
December 2010