Dan Staerk

Dan Staerk

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Potential of Sorbus berry extracts for management of type 2 diabetes: Metabolomics investigation of H NMR spectra, α-amylase and α-glucosidase inhibitory activities, and in vivo anti-hyperglycaemic activity of S. norvegica.

J Ethnopharmacol 2019 Oct 5;242:112061. Epub 2019 Jul 5.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.112061DOI Listing
October 2019

2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity.

Phytochemistry 2019 Oct 5;166:112054. Epub 2019 Jul 5.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2019.112054DOI Listing
October 2019

High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.

Br J Anaesth 2019 Aug 18;123(2):e204-e214. Epub 2019 Jan 18.

Multidisciplinary Pain Center, Department of Neuroanaesthesiology, Neuroscience Center, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark; Department of Clinical Sciences, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/j.bja.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676012PMC
August 2019

Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles.

Talanta 2019 Aug 12;200:279-287. Epub 2019 Mar 12.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2019.03.047DOI Listing
August 2019

Immobilized α-amylase magnetic beads for ligand fishing: Proof of concept and identification of α-amylase inhibitors in Ginkgo biloba.

Phytochemistry 2019 Aug 16;164:94-101. Epub 2019 May 16.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2019.04.016DOI Listing
August 2019

Unraveling the complexity of complex mixtures by combining high-resolution pharmacological, analytical and spectroscopic techniques: antidiabetic constituents in Chinese medicinal plants.

Faraday Discuss 2019 Aug;218(0):202-218

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1039/c8fd00223aDOI Listing
August 2019

F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by F NMR.

J Biomol NMR 2019 Apr 18;73(3-4):167-182. Epub 2019 Mar 18.

Section for Biotechnology, Department of Chemistry and Bioscience, Aalborg University, Frederik Bajers Vej 7H, 9220, Aalborg, Denmark.

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http://dx.doi.org/10.1007/s10858-019-00239-3DOI Listing
April 2019

Identification of α-Glucosidase Inhibitors in Machilus litseifolia by Combined Use of High-Resolution α-Glucosidase Inhibition Profiling and HPLC-PDA-HRMS-SPE-NMR.

J Nat Prod 2019 02 22;82(2):249-258. Epub 2019 Jan 22.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences , University of Copenhagen , Universitetsparken 2 , DK-2100 Copenhagen , Denmark.

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http://dx.doi.org/10.1021/acs.jnatprod.8b00609DOI Listing
February 2019

Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin.

Food Chem 2019 Jan 21;270:481-486. Epub 2018 Jul 21.

Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen DK-1958, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S03088146183128
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http://dx.doi.org/10.1016/j.foodchem.2018.07.142DOI Listing
January 2019

Simultaneous quantification of high-dose naloxone and naloxone-3-β-d-glucuronide in human plasma by UHPLC-MS/MS.

Bioanalysis 2019 Jan 21. Epub 2019 Jan 21.

Department of Drug Design & Pharmacology, Faculty of Health & Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.4155/bio-2018-0134DOI Listing
January 2019

Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures.

FEMS Yeast Res 2018 12;18(8)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1093/femsyr/foy094DOI Listing
December 2018

Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans.

Sci Rep 2018 08 27;8(1):12853. Epub 2018 Aug 27.

Section for Synthetic Biology, Department of Biotechnology and Biomedicine, The Technical University of Denmark, Kongens Lyngby, Denmark.

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http://dx.doi.org/10.1038/s41598-018-30816-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110711PMC
August 2018

High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from .

Molecules 2018 Jul 17;23(7). Epub 2018 Jul 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.3390/molecules23071755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100288PMC
July 2018

Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude root bark of Morus alba L.

J Chromatogr A 2018 Jun 21;1556:55-63. Epub 2018 Apr 21.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Science, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2018.04.041DOI Listing
June 2018

On the biosynthetic origin of carminic acid.

Insect Biochem Mol Biol 2018 05 16;96:51-61. Epub 2018 Mar 16.

Department of Bioengineering and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221 and 223, 2800 Kongens Lyngby, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ibmb.2018.03.002DOI Listing
May 2018

Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity.

Biochem J 2018 05 24;475(10):1773-1788. Epub 2018 May 24.

Center for Biopharmaceuticals and Biobarriers in Drug Delivery, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1042/BCJ20180155DOI Listing
May 2018

Recreational drug use at a major music festival: trend analysis of anonymised pooled urine.

Clin Toxicol (Phila) 2018 04 17;56(4):245-255. Epub 2017 Aug 17.

b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences , University of Copenhagen , Denmark.

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http://dx.doi.org/10.1080/15563650.2017.1360496DOI Listing
April 2018

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus.

Plant J 2018 03 14;93(5):943-958. Epub 2018 Feb 14.

Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871, Frederiksberg C, Denmark.

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http://dx.doi.org/10.1111/tpj.13822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838521PMC
March 2018

Athenolide A, a New Steroidal Lactone from the Leaves of Athenaea martiana (Solanaceae) Determined by Means of HPLC-HR-MS-SPE-NMR Analysis.

Chem Biodivers 2018 Jan 25;15(1). Epub 2017 Dec 25.

Department of Drug Design and Pharmacology, Faculty of Healthy and Medicinal Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, DK-2100, Denmark.

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http://dx.doi.org/10.1002/cbdv.201700455DOI Listing
January 2018

Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability.

Biochim Biophys Acta Biomembr 2017 Dec 15;1859(12):2483-2494. Epub 2017 Sep 15.

Section for Biologics, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.09.015DOI Listing
December 2017

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa.

Nat Commun 2017 12 7;8(1):1987. Epub 2017 Dec 7.

Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.

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http://dx.doi.org/10.1038/s41467-017-02031-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719414PMC
December 2017

Investigation of antidiabetic potential of Phyllanthus niruri L. using assays for α-glucosidase, muscle glucose transport, liver glucose production, and adipogenesis.

Biochem Biophys Res Commun 2017 11 18;493(1):869-874. Epub 2017 Sep 18.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bbrc.2017.09.080DOI Listing
November 2017

Synthesis of C-Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies-Based Biosynthetic Pathway.

Chembiochem 2017 10 21;18(19):1893-1897. Epub 2017 Aug 21.

Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg, Denmark.

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http://dx.doi.org/10.1002/cbic.201700331DOI Listing
October 2017

High-Resolution Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Vietnamese Plants.

Molecules 2017 Jul 20;22(7). Epub 2017 Jul 20.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.3390/molecules22071228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152321PMC
July 2017

Isolation and structure elucidation of cyclopeptide alkaloids from Ziziphus nummularia and Ziziphus spina-christi by HPLC-DAD-MS and HPLC-PDA-(HRMS)-SPE-NMR.

Phytochemistry 2017 Jun 8;138:163-169. Epub 2017 Mar 8.

Natural Products & Food Research and Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.phytochem.2017.02.029DOI Listing
June 2017

Potential of Polygonum cuspidatum Root as an Antidiabetic Food: Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-HRMS and NMR for Identification of Antidiabetic Constituents.

J Agric Food Chem 2017 Jun 24;65(22):4421-4427. Epub 2017 May 24.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/acs.jafc.7b01353DOI Listing
June 2017

Characterization of Antileishmanial Compounds from L. Leaves Using Semi-High Resolution Antileishmanial Profiling Combined with HPLC-HRMS-SPE-NMR.

Front Pharmacol 2017 31;8:337. Epub 2017 May 31.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of CopenhagenCopenhagen, Denmark.

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http://dx.doi.org/10.3389/fphar.2017.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449460PMC
May 2017

Dual high-resolution inhibition profiling and HPLC-HRMS-SPE-NMR analysis for identification of α-glucosidase and radical scavenging inhibitors in Solanum americanum Mill.

Fitoterapia 2017 Apr 13;118:42-48. Epub 2017 Feb 13.

Department of Drug Design and Pharmacology, Faculty of Healthy and Medicinal Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2017.02.002DOI Listing
April 2017

Advancing HPLC-PDA-HRMS-SPE-NMR Analysis of Coumarins in Coleonema album by Use of Orthogonal Reversed-Phase C and Pentafluorophenyl Separations.

J Nat Prod 2017 04 1;80(4):1020-1027. Epub 2017 Mar 1.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/acs.jnatprod.6b01020DOI Listing
April 2017

Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity.

Fitoterapia 2017 Apr 16;118:126-131. Epub 2017 Mar 16.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.fitote.2017.03.003DOI Listing
April 2017

Facilitated Visual Interpretation of Scores in Principal Component Analysis by Bioactivity-Labeling of 1H-NMR Spectra-Metabolomics Investigation and Identification of a New α-Glucosidase Inhibitor in Radix Astragali.

Molecules 2017 Mar 6;22(3). Epub 2017 Mar 6.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.3390/molecules22030411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155417PMC
March 2017

Hemolymph metabolites and osmolality are tightly linked to cold tolerance of Drosophila species: a comparative study.

J Exp Biol 2016 08 15;219(Pt 16):2504-13. Epub 2016 Jun 15.

Zoophysiology, Department of Bioscience, Aarhus University, C.F. Møllers Allé 3, Building 1131, Aarhus DK-8000, Denmark

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http://dx.doi.org/10.1242/jeb.140152DOI Listing
August 2016

Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Proc Natl Acad Sci U S A 2016 08 9;113(34):E5082-9. Epub 2016 Aug 9.

Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen, DK-1871 Frederiksberg C, Denmark; Center for Synthetic Biology "bioSYNergy," DK-1871 Frederiksberg C, Denmark;

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http://dx.doi.org/10.1073/pnas.1607504113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003294PMC
August 2016

Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR.

Food Chem 2016 Jul 2;203:16-22. Epub 2016 Feb 2.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2016.02.001DOI Listing
July 2016

Screening for potential α-glucosidase and α-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes.

J Ethnopharmacol 2016 Jun 31;186:189-195. Epub 2016 Mar 31.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03788741163017
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http://dx.doi.org/10.1016/j.jep.2016.03.060DOI Listing
June 2016

High-Resolution α-Glucosidase Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Antidiabetic Compounds in Eremanthus crotonoides (Asteraceae).

Molecules 2016 Jun 16;21(6). Epub 2016 Jun 16.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.

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http://dx.doi.org/10.3390/molecules21060782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273868PMC
June 2016

Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.

J Nat Prod 2016 Apr 9;79(4):1063-72. Epub 2016 Mar 9.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/acs.jnatprod.5b01128DOI Listing
April 2016

High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite.

Phytochemistry 2015 Nov 18;119:62-9. Epub 2015 Sep 18.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2015.09.005DOI Listing
November 2015

Magnetic Ligand Fishing as a Targeting Tool for HPLC-HRMS-SPE-NMR: α-Glucosidase Inhibitory Ligands and Alkylresorcinol Glycosides from Eugenia catharinae.

J Nat Prod 2015 Nov 23;78(11):2657-65. Epub 2015 Oct 23.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036580PMC
November 2015

Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv.

Fitoterapia 2015 Sep 20;105:102-6. Epub 2015 Jun 20.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X153002
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2015.06.013DOI Listing
September 2015

High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: α-Glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrtaceae).

Phytochemistry 2015 Aug 30;116:246-252. Epub 2015 Apr 30.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2015.04.004DOI Listing
August 2015

Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites.

J Ethnopharmacol 2015 May 11;165:1-8. Epub 2015 Feb 11.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2015.02.014DOI Listing
May 2015

Combined use of high-resolution α-glucosidase inhibition profiling and high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy for investigation of antidiabetic principles in crude plant extracts.

J Agric Food Chem 2015 Mar 17;63(8):2257-63. Epub 2015 Feb 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jf506297kDOI Listing
March 2015

Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata.

J Nat Prod 2015 Feb 13;78(2):294-300. Epub 2015 Feb 13.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np5009416DOI Listing
February 2015

Secondary metabolite comparison of the species within the Heterobasidion annosum s.l. complex.

Phytochemistry 2014 Dec 23;108:243-51. Epub 2014 Sep 23.

Department of Chemistry and Biotechnology, Uppsala BioCenter, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-75007 Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2014.08.028DOI Listing
December 2014

Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa.

J Ethnopharmacol 2014 Nov 23;157:171-80. Epub 2014 Sep 23.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2014.09.027DOI Listing
November 2014

High-resolution α-amylase assay combined with high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy for expedited identification of α-amylase inhibitors: proof of concept and α-amylase inhibitor in cinnamon.

J Agric Food Chem 2014 Nov 17;62(47):11465-71. Epub 2014 Nov 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jf5047283DOI Listing
November 2014

Assessment of constituents in Allium by multivariate data analysis, high-resolution α-glucosidase inhibition assay and HPLC-SPE-NMR.

Food Chem 2014 Oct 21;161:192-8. Epub 2014 Mar 21.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2014.03.062DOI Listing
October 2014

High-resolution bacterial growth inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antibacterial constituents in Chinese plants used to treat snakebites.

J Ethnopharmacol 2014 Sep 17;155(2):1276-83. Epub 2014 Jul 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2014.07.019DOI Listing
September 2014

High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of fungal plasma membrane H(+)-ATPase inhibitors from plants.

J Agric Food Chem 2014 Jun 6;62(24):5595-602. Epub 2014 Jun 6.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jf501605zDOI Listing
June 2014

Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.

ACS Med Chem Lett 2014 Apr 31;5(4):293-7. Epub 2014 Jan 31.

Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ml4002503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027773PMC
April 2014

Coupling HPLC-SPE-NMR with a microplate-based high-resolution antioxidant assay for efficient analysis of antioxidants in food--validation and proof-of-concept study with caper buds.

Food Chem 2013 Dec 4;141(4):4010-8. Epub 2013 Jul 4.

Department of Basic Sciences and Environment, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark.

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http://dx.doi.org/10.1016/j.foodchem.2013.06.115DOI Listing
December 2013

High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of potential health-promoting constituents in sea aster and searocket--new Nordic food ingredients.

J Agric Food Chem 2013 Sep 30;61(36):8616-23. Epub 2013 Aug 30.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jf402949yDOI Listing
September 2013

Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC-SPE-NMR for advanced bioactivity profiling of plant extracts.

Phytochem Anal 2013 Feb 17;24(2):141-7. Epub 2012 Sep 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1002/pca.2393DOI Listing
February 2013

Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives.

PLoS One 2012 14;7(9):e45405. Epub 2012 Sep 14.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045405PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443238PMC
February 2013

Development of a bioassay-coupled HPLC-SPE-ttNMR platform for identification of α-glucosidase inhibitors in apple peel (Malus ×domestica Borkh.).

Food Chem 2012 Dec 26;135(3):1692-9. Epub 2012 May 26.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.foodchem.2012.05.075DOI Listing
December 2012

Comprehensive analysis of commercial willow bark extracts by new technology platform: combined use of metabolomics, high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy and high-resolution radical scavenging assay.

J Chromatogr A 2012 Nov 10;1262:130-7. Epub 2012 Sep 10.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.chroma.2012.09.013DOI Listing
November 2012

[Physiological effects of rare earth elements and their application in traditional Chinese medicine].

Zhongguo Zhong Yao Za Zhi 2012 Aug;37(15):2238-41

Shandong Analysis and Test Center, Ji'nan 250014, China.

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August 2012

Effect of residual water and microwave heating on the half-life of the reagents and reactive intermediates in peptide synthesis.

Chemistry 2012 Jul 13;18(29):9024-31. Epub 2012 Jun 13.

IGM, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark.

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http://dx.doi.org/10.1002/chem.201200711DOI Listing
July 2012

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum.

Environ Microbiol 2012 May 18;14(5):1159-70. Epub 2012 Jan 18.

Department of Animal Science, Faculty of Science and Technology, Aarhus University, Blichers Allé 20, Tjele, Denmark.

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http://dx.doi.org/10.1111/j.1462-2920.2011.02696.xDOI Listing
May 2012

Efficient and versatile COMU-mediated solid-phase submonomer synthesis of arylopeptoids (oligomeric N-substituted aminomethyl benzamides).

Org Biomol Chem 2011 Oct 12;9(19):6832-43. Epub 2011 Aug 12.

Department of Basic Sciences and Environment, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.

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http://xlink.rsc.org/?DOI=c1ob05729d
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http://dx.doi.org/10.1039/c1ob05729dDOI Listing
October 2011

Production of unusual dispiro metabolites in Pestalotiopsis virgatula endophyte cultures: HPLC-SPE-NMR, electronic circular dichroism, and time-dependent density-functional computation study.

J Nat Prod 2011 Oct 26;74(10):2206-15. Epub 2011 Sep 26.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np2005665DOI Listing
October 2011

Two novel classes of enzymes are required for the biosynthesis of aurofusarin in Fusarium graminearum.

J Biol Chem 2011 Mar 4;286(12):10419-28. Epub 2011 Feb 4.

Department of Agriculture and Ecology, Faculty of Life Sciences, University of Copenhagen, DK-1870 Frederiksberg, Denmark.

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http://dx.doi.org/10.1074/jbc.M110.179853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060495PMC
March 2011

New resistance-correlated saponins from the insect-resistant crucifer Barbarea vulgaris.

J Agric Food Chem 2010 May;58(9):5509-14

Department of Basic Sciences and Environment, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark.

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http://dx.doi.org/10.1021/jf903988fDOI Listing
May 2010

Butenolides from plant-derived smoke: natural plant-growth regulators with antagonistic actions on seed germination.

J Nat Prod 2010 Feb;73(2):267-9

Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.

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http://pubs.acs.org/doi/abs/10.1021/np900630w
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http://dx.doi.org/10.1021/np900630wDOI Listing
February 2010

HPLC-SPE-NMR identification of a novel metabolite containing the benzo[c]oxepin skeleton from the endophytic fungus Pestalotiopsis virgatula culture.

Planta Med 2009 Aug 16;75(10):1104-6. Epub 2009 Jul 16.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1055/s-0029-1185951DOI Listing
August 2009

Accelerated dereplication of crude extracts using HPLC-PDA-MS-SPE-NMR: quinolinone alkaloids of Haplophyllum acutifolium.

Phytochemistry 2009 May 18;70(8):1055-61. Epub 2009 Jun 18.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.phytochem.2009.05.004DOI Listing
May 2009

Identification of reaction products between drug substances and excipients by HPLC-SPE-NMR: ester and amide formation between citric acid and 5-aminosalicylic acid.

J Pharm Biomed Anal 2009 Apr 27;49(3):839-42. Epub 2008 Dec 27.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jpba.2008.12.028DOI Listing
April 2009

New bisbenzylisoquinoline alkaloid from Laureliopsis philippiana.

Fitoterapia 2009 Mar 27;80(2):112-4. Epub 2008 Nov 27.

Department of Basic Sciences and Environment, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.

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http://dx.doi.org/10.1016/j.fitote.2008.11.002DOI Listing
March 2009

Antimalarial sesquiterpene lactones from Distephanus angulifolius.

Phytochemistry 2009 Mar 18;70(5):601-7. Epub 2009 Mar 18.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.phytochem.2009.02.005DOI Listing
March 2009

Application of rotated PCA models to facilitate interpretation of metabolite profiles: commercial preparations of St. John's Wort.

Planta Med 2009 Feb 18;75(3):271-9. Epub 2008 Dec 18.

Department of Food Science, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1055/s-0028-1112194DOI Listing
February 2009

Piperidine and tetrahydropyridine alkaloids from Lobelia siphilitica and Hippobroma longiflora.

J Nat Prod 2009 Feb;72(2):312-5

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np800743wDOI Listing
February 2009

Microwave-assisted ring-opening of activated aziridines with resin-bound amines.

J Org Chem 2008 May 1;73(9):3566-9. Epub 2008 Apr 1.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jo702612uDOI Listing
May 2008

Combining PARAFAC analysis of HPLC-PDA profiles and structural characterization using HPLC-PDA-SPE-NMR-MS experiments: commercial preparations of St. John's Wort.

Anal Chem 2008 Mar 9;80(6):1978-87. Epub 2008 Feb 9.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac702064pDOI Listing
March 2008

Targeted natural product isolation guided by HPLC-SPE-NMR: constituents of Hubertia species.

J Nat Prod 2007 Sep 7;70(9):1472-7. Epub 2007 Sep 7.

Department of Medicinal Chemistry, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np0702741DOI Listing
September 2007

Identification of natural products using HPLC-SPE combined with CapNMR.

Anal Chem 2007 Jan;79(2):727-35

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac0616963DOI Listing
January 2007

Structural analysis of complex saponins of Balanites aegyptiaca by 800 MHz 1H NMR spectroscopy.

Magn Reson Chem 2006 Oct;44(10):923-8

Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1002/mrc.1879DOI Listing
October 2006

Identification of major and minor constituents of Harpagophytum procumbens (Devil's claw) using HPLC-SPE-NMR and HPLC-ESIMS/APCIMS.

J Nat Prod 2006 Sep;69(9):1280-8

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np0601612DOI Listing
September 2006

Dovyalicin-type spermidine alkaloids from Dovyalis species.

J Nat Prod 2006 Sep;69(9):1300-4

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np060204eDOI Listing
September 2006

Multivariate analysis of integrated and full-resolution 1H-NMR spectral data from complex pharmaceutical preparations: St. John's wort.

Planta Med 2006 May;72(6):556-63

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.

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http://dx.doi.org/10.1055/s-2006-931567DOI Listing
May 2006

Discovering new natural products directly from crude extracts by HPLC-SPE-NMR: chinane diterpenes in Harpagophytum procumbens.

J Nat Prod 2006 Apr;69(4):527-30

Department of Medicinal Chemistry and Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np050504gDOI Listing
April 2006

Rapid extract dereplication using HPLC-SPE-NMR: analysis of isoflavonoids from Smirnowia iranica.

J Nat Prod 2005 Oct;68(10):1500-9

Department of Medicinal Chemistry and Department of Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np0502037DOI Listing
October 2005

HPLC-SPE-NMR hyphenation in natural products research: optimization of analysis of Croton membranaceus extract.

Magn Reson Chem 2005 Sep;43(9):771-5

Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Copenhagen.

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http://dx.doi.org/10.1002/mrc.1613DOI Listing
September 2005

Hyphenation of solid-phase extraction with liquid chromatography and nuclear magnetic resonance: application of HPLC-DAD-SPE-NMR to identification of constituents of Kanahia laniflora.

Anal Chem 2005 Jun;77(11):3547-53

Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac050212kDOI Listing
June 2005

Naravelia zeylanica [corrected] occurrence of primary benzamides in flowering plants.

Nat Prod Res 2005 Apr;19(3):291-4

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1080/14786410410001714641DOI Listing
April 2005

N4-alkyloxycarbonyl derivatives of cytosine: physicochemical characterisation, and cytosine regeneration rates and release from alginic acid gels.

Eur J Pharm Sci 2004 Dec;23(4-5):337-45

Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ejps.2004.08.007DOI Listing
December 2004

Isolation of a library of aromadendranes from Landolphia dulcis and its characterization using the VolSurf approach.

J Nat Prod 2004 May;67(5):799-805

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/np0340450DOI Listing
May 2004