Publications by authors named "Dan R Littman"

99Publications

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.

Cell 2020 Aug 1;182(3):641-654.e20. Epub 2020 Jul 1.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Department of Pathology, New York University School of Medicine, New York, NY, USA. Electronic address:

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August 2020

BCR selection and affinity maturation in Peyer's patch germinal centres.

Nature 2020 06 6;582(7812):421-425. Epub 2020 May 6.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.

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June 2020

Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier.

Nature 2020 03 12;579(7800):575-580. Epub 2020 Feb 12.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.

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March 2020

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.

Cell Rep 2020 01;30(3):914-931.e9

Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Imagine Institute, INSERM UMR 1163, ATIP-Avenir Team, Université de Paris, 24 Boulevard du Montparnasse, 75015 Paris, France; The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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January 2020

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.

Cell 2020 01 19;180(1):79-91.e16. Epub 2019 Dec 19.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York, NY 10016, USA. Electronic address:

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January 2020

A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection.

Cell Host Microbe 2019 11;26(5):691-701.e5

Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Inserm, U604, 75015 Paris, France; INRA, Unité sous-contrat 2020, 75015 Paris, France. Electronic address:

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November 2019

Distinct Polysaccharide Utilization Profiles of Human Intestinal Prevotella copri Isolates.

Cell Host Microbe 2019 11;26(5):680-690.e5

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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November 2019

Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.

Immunity 2019 07 2;51(1):185-197.e6. Epub 2019 Jul 2.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Divisions of Immunobiology and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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July 2019

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain silencing in cytotoxic T cells.

Genes Dev 2019 06 11;33(11-12):669-683. Epub 2019 Apr 11.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

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June 2019

Author Correction: c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.

Nature 2019 02;566(7744):E7

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, 10016, USA.

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February 2019

Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development.

Nat Commun 2018 09 5;9(1):3594. Epub 2018 Sep 5.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, 10016, USA.

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September 2018

Critical Role for the Microbiota in CXCR1 Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.

Immunity 2018 07 3;49(1):151-163.e5. Epub 2018 Jul 3.

Alkek Center for Metagenomics and Microbiome Research and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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July 2018

Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.

Cell Host Microbe 2018 03;23(3):366-381.e9

Center for Infectious Disease Research, Seattle, WA 98109, USA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.

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March 2018

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.

Nature 2018 02 7;554(7692):373-377. Epub 2018 Feb 7.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

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February 2018

New traffic light on Th17 Avenue.

Cell Res 2018 Feb 8;28(2):139-140. Epub 2017 Dec 8.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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February 2018

Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs.

Cell Host Microbe 2017 11;22(5):697-704.e4

Department of Immunobiology, University of Arizona, Tucson, AZ 85719, USA; Arizona Arthritis Center, College of Medicine, University of Arizona, Tucson, AZ 85719, USA. Electronic address:

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November 2017

From the Thymus to the Mucosa: A Three-Decade Journey.

Authors:
Dan R Littman

J Immunol 2017 10;199(7):2183-2187

The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016; and The Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016

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October 2017

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.

Nature 2017 09 13;549(7673):528-532. Epub 2017 Sep 13.

Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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September 2017

Reversing behavioural abnormalities in mice exposed to maternal inflammation.

Nature 2017 09 13;549(7673):482-487. Epub 2017 Sep 13.

McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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September 2017

Quantitative Measurements of HIV-1 and Dextran Capture by Human Monocyte-derived Dendritic Cells (MDDCs).

Bio Protoc 2016 Nov;6(22)

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA.

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November 2016

Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? If So, Is There Potential for Efficacious Microbiota-Based Vaccines?

Authors:
Dan R Littman

Cold Spring Harb Perspect Biol 2018 02 1;10(2). Epub 2018 Feb 1.

Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016.

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February 2018

Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.

Front Immunol 2017 22;8:291. Epub 2017 Mar 22.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY, USA.

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March 2017

Short- and long-term effects of oral vancomycin on the human intestinal microbiota.

J Antimicrob Chemother 2017 01 5;72(1):128-136. Epub 2016 Oct 5.

Departamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain

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January 2017

The microbiota in adaptive immune homeostasis and disease.

Nature 2016 07;535(7610):75-84

The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.

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July 2016

Tcf1 and Lef1 pack their own HDAC.

Nat Immunol 2016 05;17(6):615-6

The Kimmel Center for Biology and Medicine of the Skirball Institute and the Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA.

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May 2016

Regulation of RORγt in Inflammatory Lymphoid Cell Differentiation.

Cold Spring Harb Symp Quant Biol 2015 11;80:257-63. Epub 2016 Mar 11.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016 Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016.

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January 2018

How Thymocytes Achieve Their Fate.

Authors:
Dan R Littman

J Immunol 2016 Mar;196(5):1983-4

The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016; and Howard Hughes Medical Institute, Chevy Chase, MD 20815

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March 2016

Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells.

Cell 2016 Feb 28;164(4):695-709. Epub 2016 Jan 28.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute. Electronic address:

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February 2016

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.

Science 2016 Feb 28;351(6276):933-9. Epub 2016 Jan 28.

Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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February 2016

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.

Cell 2015 Oct 24;163(2):381-93. Epub 2015 Sep 24.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; The Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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October 2015

Releasing the Brakes on Cancer Immunotherapy.

Authors:
Dan R Littman

Cell 2015 Sep;162(6):1186-90

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; The Howard Hughes Medical Institute. Electronic address:

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September 2015

Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases.

Arthritis Rheumatol 2016 Jan;68(1):35-45

New York University School of Medicine and New York University Hospital for Joint Diseases, New York, New York.

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January 2016

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.

Cancer Cell 2015 Jun;27(6):755-68

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA; Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address:

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June 2015

Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages.

Nat Immunol 2015 Jul 1;16(7):746-54. Epub 2015 Jun 1.

1] The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, USA. [2] Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA.

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July 2015

The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity.

Curr Opin Rheumatol 2015 Jul;27(4):381-7

Department of Medicine, Jill Roberts Institute for IBD Research, Weill Cornell Medical College, New York, New York, USA.

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July 2015

Sparse and compositionally robust inference of microbial ecological networks.

PLoS Comput Biol 2015 May 7;11(5):e1004226. Epub 2015 May 7.

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America; Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America; Simons Center for Data Analysis, Simons Foundation, New York, New York, United States of America.

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May 2015

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

J Exp Med 2015 May 27;212(5):607-17. Epub 2015 Apr 27.

Gladstone Institute of Virology and Immunology, Gladstone Institute of Neurological Disease, School of Medecine, Department of Neurology, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158 Gladstone Institute of Virology and Immunology, Gladstone Institute of Neurological Disease, School of Medecine, Department of Neurology, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158

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May 2015

Identification of natural RORγ ligands that regulate the development of lymphoid cells.

Cell Metab 2015 Feb;21(2):286-298

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.

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February 2015

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

J Exp Med 2014 Jul 14;211(8):1571-83. Epub 2014 Jul 14.

The Kimmel Center for Biology and Medicine of the Skirball Institute and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016The Kimmel Center for Biology and Medicine of the Skirball Institute and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016

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July 2014

Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity.

Cold Spring Harb Symp Quant Biol 2013 9;78:193-201. Epub 2014 Jun 9.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016 Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016

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March 2015

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.

Nature 2014 Jun 13;510(7503):152-6. Epub 2014 Apr 13.

1] The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA [2] Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA.

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June 2014

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Cell 2013 Dec;155(7):1596-609

Molecular Neurobiology Program, The Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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December 2013

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.

Elife 2013 Nov 5;2:e01202. Epub 2013 Nov 5.

Department of Medicine, New York University School of Medicine and Hospital for Joint Diseases, New York, United States.

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November 2013

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

ACS Med Chem Lett 2013 Jan;4(1):79-84

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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January 2013

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.

Science 2013 Jun 9;340(6139):1456-9. Epub 2013 May 9.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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June 2013

Harnessing CD4⁺ T cell responses in HIV vaccine development.

Nat Med 2013 Feb 6;19(2):143-9. Epub 2013 Feb 6.

US Military HIV Research Program, Henry M. Jackson Foundation, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

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February 2013

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.

Nature 2013 Feb 13;494(7435):116-20. Epub 2013 Jan 13.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

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February 2013

Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.

Eur J Immunol 2012 Sep;42(9):2232-7

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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September 2012

Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt.

J Immunol 2012 Aug 9;189(4):1765-72. Epub 2012 Jul 9.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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August 2012

Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.

Nat Neurosci 2012 Jun 17;15(7):962-9. Epub 2012 Jun 17.

Department of Molecular Embryology, Max Planck Institute of Immunology, Freiburg, Germany.

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June 2012

Interactions between the microbiota and the immune system.

Science 2012 Jun 6;336(6086):1268-73. Epub 2012 Jun 6.

The Howard Hughes Medical Institute and Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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June 2012

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.

Arthritis Rheum 2012 Oct;64(10):3083-94

Division of Rheumatology, New York University and New York University Hospital for Joint Diseases, New York, New York 10003, USA.

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October 2012

Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy.

J Leukoc Biol 2012 Sep 27;92(3):413-9. Epub 2012 Mar 27.

Department of Microbiology and Immunology, Indiana University School of Medicine, South Bend, IN, USA.

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September 2012

Dynamic microRNA gene transcription and processing during T cell development.

J Immunol 2012 Apr 29;188(7):3257-67. Epub 2012 Feb 29.

Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

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April 2012

A rare intestinal infection with systemic effects.

Gastroenterol Hepatol (N Y) 2012 Jan;8(1):60-3

Department of Digestive and Liver Diseases, Columbia University Medical Center, New York, New York, USA.

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January 2012

Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.

Immunity 2012 Feb 2;36(2):276-87. Epub 2012 Feb 2.

Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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February 2012

The microbiome in infectious disease and inflammation.

Annu Rev Immunol 2012 6;30:759-95. Epub 2012 Jan 6.

Department of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

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July 2012

Role of the commensal microbiota in normal and pathogenic host immune responses.

Cell Host Microbe 2011 Oct;10(4):311-23

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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October 2011

Hiding in plain sight: how HIV evades innate immune responses.

Cell 2011 Oct;147(2):271-4

Institut Curie-INSERM U, Paris, France.

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October 2011

The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.

Curr Top Microbiol Immunol 2012 ;356:165-88

Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.

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April 2012

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment.

Cell Host Microbe 2011 Sep;10(3):260-72

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, USA.

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September 2011

Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.

Proc Natl Acad Sci U S A 2011 Sep 22;108(36):14873-8. Epub 2011 Aug 22.

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

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September 2011

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.

Nature 2011 Apr 27;472(7344):486-90. Epub 2011 Mar 27.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

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April 2011

RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.

Immunity 2011 Mar;34(3):303-14

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

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March 2011

Modulation of immune homeostasis by commensal bacteria.

Curr Opin Microbiol 2011 Feb 5;14(1):106-14. Epub 2011 Jan 5.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

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February 2011

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.

Gastroenterology 2011 Mar 11;140(3):957-65. Epub 2010 Dec 11.

Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.

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March 2011

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.

Nature 2010 Sep;467(7312):214-7

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

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September 2010

Canonical and alternate functions of the microRNA biogenesis machinery.

Genes Dev 2010 Sep 16;24(17):1951-60. Epub 2010 Aug 16.

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.

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September 2010

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

Nature 2010 Apr;464(7293):1371-5

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

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April 2010

Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.

Genes Dev 2010 Apr;24(7):659-69

The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

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April 2010

Th17 and regulatory T cells in mediating and restraining inflammation.

Cell 2010 Mar;140(6):845-58

Howard Hughes Medical Institute, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, 10016, USA.

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March 2010