Publications by authors named "Dan Milea"

100Publications

Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs.

N Engl J Med 2020 04 14;382(18):1687-1695. Epub 2020 Apr 14.

From the Singapore National Eye Center (D.M., D.T., S.S., C.-Y.C., T.Y.W.), Singapore Eye Research Institute (D.M., R.P.N., D.T., C.V., S.S., C.-Y.C., T.Y.W.), Duke-NUS Medical School (D.M., R.P.N., D.T., S.S., C.-Y.C., T.Y.W.), Institute of High Performance Computing, Agency for Science, Technology, and Research (J.Z., X.X., Y.L.), and Yong Loo Lin School of Medicine, National University of Singapore (S.S., T.Y.W.) - all in Singapore; Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran (M.A.F.); the Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, and the Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal (P.F.); the Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (K.V.); the Eye Center, Medical Center, University of Freiburg, Freiburg (W.A.L.), and the Department of Ophthalmology, Ruprecht Karl University of Heidelberg, Mannheim (J.B.J.) - both in Germany; IRCCS Istituto delle Scienze Neurologiche di Bologna, Unità Operativa Complessa Clinica Neurologica, and Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy (C.L.M.); the Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong (C.Y.C.), and Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou (H.Y.) - both in China; the Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark (S.H.); the Department of Ophthalmology, University Hospital of Grenoble-Alpes, and Grenoble-Alpes University, HP2 Laboratory, INSERM Unité 1042, Grenoble (C.C.), Service d'Ophtalmologie, Unité Rétine-Uvéites-Neuro-Ophtalmologie, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux (M.-B.R.), the Department of Ophthalmology, Lille Catholic Hospital, Lille Catholic University, and INSERM Unité 1171, Lille (T.T.H.C.), the Department of Ophthalmology, University Hospital Angers, Angers (P.G.), and Rothschild Foundation Hospital, Paris (C.C.-V.) - all in France; the Department of Clinical Neurosciences, Geneva University Hospital, Geneva (N.S.); the Department of Neurology, SUNY Upstate Medical University, Syracuse, NY (L.J.M.); the American Eye Center, Mandaluyong City, Philippines (R.K.); Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, University College London, London (P.Y.-W.-M.), and Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, and Cambridge Centre for Brain Repair and Medical Research Council Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge (P.Y.-W.-M.) - all in the United Kingdom; the Save Sight Institute, Faculty of Health and Medicine, University of Sydney, Sydney (C.L.F.); the Department of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN (J.J.C.); the Department of Neuro-ophthalmology, Sankara Nethralaya, Medical Research Foundation, Chennai, India (S.A.); the Departments of Ophthalmology, Neurology, and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore (N.R.M.); and the Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta (N.J.N., V.B.).

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http://dx.doi.org/10.1056/NEJMoa1917130DOI Listing
April 2020

Artificial intelligence for detection of optic disc abnormalities.

Curr Opin Neurol 2020 02;33(1):106-110

Singapore Eye Research Institute.

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http://dx.doi.org/10.1097/WCO.0000000000000773DOI Listing
February 2020

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Authors:
Michael A Hauser R Rand Allingham Tin Aung Carly J Van Der Heide Kent D Taylor Jerome I Rotter Shih-Hsiu J Wang Pieter W M Bonnemaijer Susan E Williams Sadiq M Abdullahi Khaled K Abu-Amero Michael G Anderson Stephen Akafo Mahmoud B Alhassan Ifeoma Asimadu Radha Ayyagari Saydou Bakayoko Prisca Biangoup Nyamsi Donald W Bowden William C Bromley Donald L Budenz Trevor R Carmichael Pratap Challa Yii-Der Ida Chen Chimdi M Chuka-Okosa Jessica N Cooke Bailey Vital Paulino Costa Dianne A Cruz Harvey DuBiner John F Ervin Robert M Feldman Miles Flamme-Wiese Douglas E Gaasterland Sarah J Garnai Christopher A Girkin Nouhoum Guirou Xiuqing Guo Jonathan L Haines Christopher J Hammond Leon Herndon Thomas J Hoffmann Christine M Hulette Abba Hydara Robert P Igo Eric Jorgenson Joyce Kabwe Ngoy Janvier Kilangalanga Nkiru Kizor-Akaraiwe Rachel W Kuchtey Hasnaa Lamari Zheng Li Jeffrey M Liebmann Yutao Liu Ruth J F Loos Monica B Melo Sayoko E Moroi Joseph M Msosa Robert F Mullins Girish Nadkarni Abdoulaye Napo Maggie C Y Ng Hugo Freire Nunes Ebenezer Obeng-Nyarkoh Anthony Okeke Suhanya Okeke Olusegun Olaniyi Olusola Olawoye Mariana Borges Oliveira Louise R Pasquale Rodolfo A Perez-Grossmann Margaret A Pericak-Vance Xue Qin Michele Ramsay Serge Resnikoff Julia E Richards Rui Barroso Schimiti Kar Seng Sim William E Sponsel Paulo Vinicius Svidnicki Alberta A H J Thiadens Nkechinyere J Uche Cornelia M van Duijn José Paulo Cabral de Vasconcellos Janey L Wiggs Linda M Zangwill Neil Risch Dan Milea Adeyinka Ashaye Caroline C W Klaver Robert N Weinreb Allison E Ashley Koch John H Fingert Chiea Chuen Khor

JAMA 2019 11;322(17):1682-1691

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1001/jama.2019.16161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865235PMC
November 2019

Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects.

J Glaucoma 2019 08;28(8):691-696

Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering.

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http://dx.doi.org/10.1097/IJG.0000000000001270DOI Listing
August 2019

Light-Induced Pupillary Responses in Alzheimer's Disease.

Front Neurol 2019 12;10:360. Epub 2019 Apr 12.

Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore.

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http://dx.doi.org/10.3389/fneur.2019.00360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473037PMC
April 2019

Embedded deep learning in ophthalmology: making ophthalmic imaging smarter.

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841419827172. Epub 2019 Mar 19.

Visual Neurosciences Group, Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1177/2515841419827172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425531PMC
March 2019

U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults.

Nutrients 2019 Mar 19;11(3). Epub 2019 Mar 19.

Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, #06-13, SNEC Bldg, Singapore 168751, Singapore.

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http://dx.doi.org/10.3390/nu11030660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470536PMC
March 2019

Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases.

Front Neurol 2019 12;10:76. Epub 2019 Feb 12.

Programme in Neuroscience and Behavioural Disorders, Centre for Cognitive Neuroscience, Duke-NUS Medical School, Singapore, Singapore.

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http://dx.doi.org/10.3389/fneur.2019.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379484PMC
February 2019

Metabolomic Profiling of Aqueous Humor in Glaucoma Points to Taurine and Spermine Deficiency: Findings from the Eye-D Study.

J Proteome Res 2019 03 11;18(3):1307-1315. Epub 2019 Feb 11.

Unité Mixte de Recherche MITOVASC, équipe Mitolab, Centre National de la Recherche Scientifique 6015, Institut National de la Santé et de la Recherche Médicale U1083 , Université d'Angers , Angers 49035 , France.

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http://dx.doi.org/10.1021/acs.jproteome.8b00915DOI Listing
March 2019

Future clinical applicability of optical coherence tomography angiography.

Clin Exp Optom 2019 05 11;102(3):260-269. Epub 2018 Dec 11.

Ocular Imaging Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1111/cxo.12854DOI Listing
May 2019

More than meets the eye: Varicella zoster virus-related orbital apex syndrome.

Indian J Ophthalmol 2018 Nov;66(11):1647-1649

Department of Internal Medicine, Singapore General Hospital; Department of Ophthalmology, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.4103/ijo.IJO_592_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213683PMC
November 2018

Transient bilateral optic disc oedema in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).

Can J Ophthalmol 2018 10 3;53(5):e208-e211. Epub 2018 Feb 3.

Centre for Eye Research Australia, Melbourne, Australia; Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.jcjo.2017.11.010DOI Listing
October 2018

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.

Invest Ophthalmol Vis Sci 2018 09;59(11):4355-4361

Equipe Mitolab, Institut Mitovasc, Centre National de la Recherche Scientifique 6015, Institut National de la Santé et de la Recherche Médicale (INSERM) U1083, Université d'Angers, Angers, France.

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http://dx.doi.org/10.1167/iovs.18-24938DOI Listing
September 2018

Retinal Neuronal Loss in Visually Asymptomatic Patients With Myoclonic Epilepsy With Ragged-Red Fibers.

J Neuroophthalmol 2019 Mar;39(1):18-22

Department of Visual Neurosciences (RPN, DM), Singapore Eye Research Institute, The Academia, Singapore; Ophthalmology and Visual Sciences Program (RPN, DM), Duke-NUS Medical School, Singapore; Departments of Ophthalmology, Biochemistry and Genetics (PR, AC, VP, PA-B and DM), Angers University Hospital, Angers, France; Department of Neuro-Ophthalmology (DM), Singapore National Eye Centre, Singapore; and Department of Surgery (Ophthalmology) (HM), Melbourne Medical School, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1097/WNO.0000000000000690DOI Listing
March 2019

Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-Stage Primary Open-Angle Glaucoma.

Ophthalmology 2018 09 21;125(9):1362-1371. Epub 2018 Mar 21.

Singapore Eye Research Institute, Singapore; Ophthalmology and Visual Sciences Program, Duke-NUS Medical School, Singapore; Singapore National Eye Center, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2018.02.024DOI Listing
September 2018

A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders.

Invest Ophthalmol Vis Sci 2018 01;59(1):185-195

Equipe Mitolab, Institut MITOVASC, Centre National de la Recherche Scientifique 6015, Institut National de la Santé et de la Recherche Médicale U1083, Université d'Angers, Angers, France.

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http://dx.doi.org/10.1167/iovs.17-23027DOI Listing
January 2018

Low conversion rate of ocular to generalized myasthenia gravis in Singapore.

Muscle Nerve 2018 05 2;57(5):756-760. Epub 2017 Nov 2.

Singapore National Eye Centre, Singapore Eye Research Institute and Duke-NUS, Singapore.

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http://dx.doi.org/10.1002/mus.25983DOI Listing
May 2018

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Authors:
Tin Aung Mineo Ozaki Mei Chin Lee Ursula Schlötzer-Schrehardt Gudmar Thorleifsson Takanori Mizoguchi Robert P Igo Aravind Haripriya Susan E Williams Yury S Astakhov Andrew C Orr Kathryn P Burdon Satoko Nakano Kazuhiko Mori Khaled Abu-Amero Michael Hauser Zheng Li Gopalakrishnan Prakadeeswari Jessica N Cooke Bailey Alina Popa Cherecheanu Jae H Kang Sarah Nelson Ken Hayashi Shin-Ichi Manabe Shigeyasu Kazama Tomasz Zarnowski Kenji Inoue Murat Irkec Miguel Coca-Prados Kazuhisa Sugiyama Irma Järvelä Patricio Schlottmann S Fabian Lerner Hasnaa Lamari Yildirim Nilgün Mukharram Bikbov Ki Ho Park Soon Cheol Cha Kenji Yamashiro Juan C Zenteno Jost B Jonas Rajesh S Kumar Shamira A Perera Anita S Y Chan Nino Kobakhidze Ronnie George Lingam Vijaya Tan Do Deepak P Edward Lourdes de Juan Marcos Mohammad Pakravan Sasan Moghimi Ryuichi Ideta Daniella Bach-Holm Per Kappelgaard Barbara Wirostko Samuel Thomas Daniel Gaston Karen Bedard Wenda L Greer Zhenglin Yang Xueyi Chen Lulin Huang Jinghong Sang Hongyan Jia Liyun Jia Chunyan Qiao Hui Zhang Xuyang Liu Bowen Zhao Ya-Xing Wang Liang Xu Stéphanie Leruez Pascal Reynier George Chichua Sergo Tabagari Steffen Uebe Matthias Zenkel Daniel Berner Georg Mossböck Nicole Weisschuh Ursula Hoja Ulrich-Christoph Welge-Luessen Christian Mardin Panayiota Founti Anthi Chatzikyriakidou Theofanis Pappas Eleftherios Anastasopoulos Alexandros Lambropoulos Arkasubhra Ghosh Rohit Shetty Natalia Porporato Vijayan Saravanan Rengaraj Venkatesh Chandrashekaran Shivkumar Narendran Kalpana Sripriya Sarangapani Mozhgan R Kanavi Afsaneh Naderi Beni Shahin Yazdani Alireza Lashay Homa Naderifar Nassim Khatibi Antonio Fea Carlo Lavia Laura Dallorto Teresa Rolle Paolo Frezzotti Daniela Paoli Erika Salvi Paolo Manunta Yosai Mori Kazunori Miyata Tomomi Higashide Etsuo Chihara Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Makoto Aihara Masaru Inatani Masahiro Miyake Norimoto Gotoh Fumihiko Matsuda Nagahisa Yoshimura Yoko Ikeda Morio Ueno Chie Sotozono Jin Wook Jeoung Min Sagong Kyu Hyung Park Jeeyun Ahn Marisa Cruz-Aguilar Sidi M Ezzouhairi Abderrahman Rafei Yaan Fun Chong Xiao Yu Ng Shuang Ru Goh Yueming Chen Victor H K Yong Muhammad Imran Khan Olusola O Olawoye Adeyinka O Ashaye Idakwo Ugbede Adeola Onakoya Nkiru Kizor-Akaraiwe Chaiwat Teekhasaenee Yanin Suwan Wasu Supakontanasan Suhanya Okeke Nkechi J Uche Ifeoma Asimadu Humaira Ayub Farah Akhtar Ewa Kosior-Jarecka Urszula Lukasik Ignacio Lischinsky Vania Castro Rodolfo Perez Grossmann Gordana Sunaric Megevand Sylvain Roy Edward Dervan Eoin Silke Aparna Rao Priti Sahay Pablo Fornero Osvaldo Cuello Delia Sivori Tamara Zompa Richard A Mills Emmanuelle Souzeau Paul Mitchell Jie Jin Wang Alex W Hewitt Michael Coote Jonathan G Crowston Sergei Y Astakhov Eugeny L Akopov Anton Emelyanov Vera Vysochinskaya Gyulli Kazakbaeva Rinat Fayzrakhmanov Saleh A Al-Obeidan Ohoud Owaidhah Leyla Ali Aljasim Balram Chowbay Jia Nee Foo Raphael Q Soh Kar Seng Sim Zhicheng Xie Augustine W O Cheong Shi Qi Mok Hui Meng Soo Xiao Yin Chen Su Qin Peh Khai Koon Heng Rahat Husain Su-Ling Ho Axel M Hillmer Ching-Yu Cheng Francisco A Escudero-Domínguez Rogelio González-Sarmiento Frederico Martinon-Torres Antonio Salas Kessara Pathanapitoon Linda Hansapinyo Boonsong Wanichwecharugruang Naris Kitnarong Anavaj Sakuntabhai Hip X Nguyn Giang T T Nguyn Trình V Nguyn Werner Zenz Alexander Binder Daniela S Klobassa Martin L Hibberd Sonia Davila Stefan Herms Markus M Nöthen Susanne Moebus Robyn M Rautenbach Ari Ziskind Trevor R Carmichael Michele Ramsay Lydia Álvarez Montserrat García Héctor González-Iglesias Pedro P Rodríguez-Calvo Luis Fernández-Vega Cueto Çilingir Oguz Nevbahar Tamcelik Eray Atalay Bilge Batu Dilek Aktas Burcu Kasım M Roy Wilson Anne L Coleman Yutao Liu Pratap Challa Leon Herndon Rachel W Kuchtey John Kuchtey Karen Curtin Craig J Chaya Alan Crandall Linda M Zangwill Tien Yin Wong Masakazu Nakano Shigeru Kinoshita Anneke I den Hollander Eija Vesti John H Fingert Richard K Lee Arthur J Sit Bradford J Shingleton Ningli Wang Daniele Cusi Raheel Qamar Peter Kraft Margaret A Pericak-Vance Soumya Raychaudhuri Steffen Heegaard Tero Kivelä André Reis Friedrich E Kruse Robert N Weinreb Louis R Pasquale Jonathan L Haines Unnur Thorsteinsdottir Fridbert Jonasson R Rand Allingham Dan Milea Robert Ritch Toshiaki Kubota Kei Tashiro Eranga N Vithana Shazia Micheal Fotis Topouzis Jamie E Craig Michael Dubina Periasamy Sundaresan Kari Stefansson Janey L Wiggs Francesca Pasutto Chiea Chuen Khor

Nat Genet 2017 07 29;49(7):993-1004. Epub 2017 May 29.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1038/ng.3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685441PMC
July 2017

Reply to Kawada: Diagnostic tests for myasthenia gravis with ocular involvement.

J Neurol Sci 2017 08 23;379:338. Epub 2017 May 23.

Duke-NUS Graduate Medical School, Singapore; Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1016/j.jns.2017.05.047DOI Listing
August 2017

Effect of acute intraocular pressure elevation on the minimum rim width in normal, ocular hypertensive and glaucoma eyes.

Br J Ophthalmol 2018 01 10;102(1):131-135. Epub 2017 May 10.

Singapore National Eye Center, Singapore Eye Research Institute, Singapore, Singapore.

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http://dx.doi.org/10.1136/bjophthalmol-2017-310232DOI Listing
January 2018

Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma.

Invest Ophthalmol Vis Sci 2017 Apr;58(4):2430-2437

Singapore Eye Research Institute, Singapore 2The Ophthalmology and Visual Sciences Academic Clinical Program, Duke-National University of Singapore Medical School, Singapore 3Singapore National Eye Centre, Singapore 4Department of Ophthalmology, Angers University Hospital, Angers, France 11Ophthalmology Department, Glostrup University Hospital, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1167/iovs.16-21002DOI Listing
April 2017

A reappraisal of diagnostic tests for myasthenia gravis in a large Asian cohort.

J Neurol Sci 2017 May 14;376:153-158. Epub 2017 Mar 14.

Duke-NUS Graduate Medical School, Singapore; Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1016/j.jns.2017.03.016DOI Listing
May 2017

Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements.

Invest Ophthalmol Vis Sci 2017 04;58(4):2044-2053

Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 2Singapore Eye Research Institute, Singapore National Eye Center, Singapore.

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http://dx.doi.org/10.1167/iovs.16-21319DOI Listing
April 2017

Pupillary responses to short-wavelength light are preserved in aging.

Sci Rep 2017 03 7;7:43832. Epub 2017 Mar 7.

Center for Cognitive Neuroscience, Duke-NUS Medical School, 169857, Singapore.

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http://dx.doi.org/10.1038/srep43832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339857PMC
March 2017

An anomaly detection approach for the identification of DME patients using spectral domain optical coherence tomography images.

Comput Methods Programs Biomed 2017 Feb 4;139:109-117. Epub 2016 Nov 4.

LE2I, UMR6306, CNRS, Arts et Métiers, Université de Bourgogne-Franche Comté, F-21000 Dijon, France; Center for Intelligent Signal and Imaging Research (CISIR), EEE Department, Universiti Teknologi Petronas, 32610 Seri Iskandar, Perak, Malaysia.

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http://dx.doi.org/10.1016/j.cmpb.2016.11.001DOI Listing
February 2017

Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice.

Invest Ophthalmol Vis Sci 2017 02;58(2):812-820

Pôle de Recherche et d'Enseignement en Médecine Mitochondriale (PREMMi), Institut MITOVASC, Université d'Angers, Angers, France 2Département de Biochimie et Génétique, Centre Hospitalier Universitaire, Angers, France.

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http://dx.doi.org/10.1167/iovs.16-21116DOI Listing
February 2017

Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy.

Br J Ophthalmol 2017 08 5;101(8):1045-1051. Epub 2017 Jan 5.

Singapore National Eye Center, Singapore, Singapore.

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http://dx.doi.org/10.1136/bjophthalmol-2016-309245DOI Listing
August 2017

In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5825-5833

Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 2Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.16-20560DOI Listing
October 2016

Cerebral neural correlates of differential melanopic photic stimulation in humans.

Neuroimage 2017 02 27;146:763-769. Epub 2016 Sep 27.

Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2016.09.061DOI Listing
February 2017

Seeing the sound after visual loss: functional MRI in acquired auditory-visual synesthesia.

Exp Brain Res 2017 02 19;235(2):415-420. Epub 2016 Oct 19.

Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1007/s00221-016-4802-6DOI Listing
February 2017

Author Response: Peripapillary Suprachoroidal Cavitation, Parapapillary Gamma Zone and Optic Disc Rotation Due to the Biomechanics of the Optic Nerve Dura Mater.

Invest Ophthalmol Vis Sci 2016 08;57(10):4374-5

Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore; 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore;

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http://dx.doi.org/10.1167/iovs.16-20118DOI Listing
August 2016

Classification of SD-OCT Volumes Using Local Binary Patterns: Experimental Validation for DME Detection.

J Ophthalmol 2016 31;2016:3298606. Epub 2016 Jul 31.

LE2I UMR6306, CNRS, Arts et Métiers, Université Bourgogne Franche-Comté, 12 rue de la Fonderie, 71200 Le Creusot, France.

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http://dx.doi.org/10.1155/2016/3298606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983398PMC
August 2016

Optical coherence tomography angiography in dural carotid-cavernous sinus fistula.

BMC Ophthalmol 2016 Jul 7;16:93. Epub 2016 Jul 7.

Singapore National Eye Center, Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore.

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http://dx.doi.org/10.1186/s12886-016-0278-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936270PMC
July 2016

Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements.

Invest Ophthalmol Vis Sci 2016 05;57(6):2452-62

Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.15-18986DOI Listing
May 2016

Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis.

Maturitas 2016 Jun 2;88:101-12. Epub 2016 Apr 2.

Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, Angers, France; Singapore Eye Research Institute, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore; Duke-NUS, Neuroscience and Behavioural Disorders, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.maturitas.2016.04.002DOI Listing
June 2016

Factors influencing the pupillary light reflex in healthy individuals.

Graefes Arch Clin Exp Ophthalmol 2016 Jul 12;254(7):1353-9. Epub 2016 Mar 12.

Singapore Eye Research Institute, 11, Third Hospital Avenue #5-00, SNEC Building, Singapore, 168751, Singapore.

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http://dx.doi.org/10.1007/s00417-016-3311-4DOI Listing
July 2016

Genotype-phenotype heterogeneity of ganglion cell and inner plexiform layer deficit in autosomal-dominant optic atrophy.

Acta Ophthalmol 2015 Dec 19;93(8):762-6. Epub 2015 Sep 19.

Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark.

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http://dx.doi.org/10.1111/aos.12835DOI Listing
December 2015

Flavonoids and glaucoma: revisiting therapies from the past.

Authors:
Dan Milea Tin Aung

Graefes Arch Clin Exp Ophthalmol 2015 Nov 7;253(11):1839-40. Epub 2015 Sep 7.

Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore.

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http://dx.doi.org/10.1007/s00417-015-3167-zDOI Listing
November 2015

OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology.

Neurobiol Dis 2016 Jun 23;90:20-6. Epub 2015 Aug 23.

Centre Hospitalier Universitaire, Département de Biochimie et Génétique, Angers, France; UMR CNRS 6214-INSERM 1083, Université d'Angers, Angers, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.08.015DOI Listing
June 2016

Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity.

Ophthalmology 2015 Sep;122(9):1777-85

Program in Neuroscience and Behavioral Disorders, Duke-National University of Singapore Graduate Medical School, Singapore, Republic of Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2015.06.002DOI Listing
September 2015

Age-Related Vitamin D Deficiency Is Associated with Reduced Macular Ganglion Cell Complex: A Cross-Sectional High-Definition Optical Coherence Tomography Study.

PLoS One 2015 19;10(6):e0130879. Epub 2015 Jun 19.

Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic of Angers; UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130879PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474669PMC
May 2016

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma.

Maturitas 2015 Aug 30;81(4):470-4. Epub 2015 May 30.

Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic of Angers, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.maturitas.2015.05.008DOI Listing
August 2015

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Authors:
Zheng Li R Rand Allingham Masakazu Nakano Liyun Jia Yuhong Chen Yoko Ikeda Baskaran Mani Li-Jia Chen Changwon Kee David F Garway-Heath Sarangapani Sripriya Nobuo Fuse Khaled K Abu-Amero Chukai Huang Prasanthi Namburi Kathryn Burdon Shamira A Perera Puya Gharahkhani Ying Lin Morio Ueno Mineo Ozaki Takanori Mizoguchi Subbiah Ramasamy Krishnadas Essam A Osman Mei Chin Lee Anita S Y Chan Liza-Sharmini A Tajudin Tan Do Aurelien Goncalves Pascal Reynier Hong Zhang Rupert Bourne David Goh David Broadway Rahat Husain Anil K Negi Daniel H Su Ching-Lin Ho Augusto Azuara Blanco Christopher K S Leung Tina T Wong Azhany Yakub Yutao Liu Monisha E Nongpiur Jong Chul Han Do Nhu Hon Balekudaru Shantha Bowen Zhao Jinghong Sang NiHong Zhang Ryuichi Sato Kengo Yoshii Songhomita Panda-Jonas Allison E Ashley Koch Leon W Herndon Sayoko E Moroi Pratap Challa Jia Nee Foo Jin-Xin Bei Yi-Xin Zeng Cameron P Simmons Tran Nguyen Bich Chau Philomenadin Ferdinamarie Sharmila Merwyn Chew Blanche Lim Pansy O S Tam Elaine Chua Xiao Yu Ng Victor H K Yong Yaan Fun Chong Wee Yang Meah Saravanan Vijayan Sohn Seongsoo Wang Xu Yik Ying Teo Jessica N Cooke Bailey Jae H Kang Jonathan L Haines Ching Yu Cheng Seang-Mei Saw E-Shyong Tai Julia E Richards Robert Ritch Douglas E Gaasterland Louis R Pasquale Jianjun Liu Jost B Jonas Dan Milea Ronnie George Saleh A Al-Obeidan Kazuhiko Mori Stuart Macgregor Alex W Hewitt Christopher A Girkin Mingzhi Zhang Periasamy Sundaresan Lingam Vijaya David A Mackey Tien Yin Wong Jamie E Craig Xinghuai Sun Shigeru Kinoshita Janey L Wiggs Chiea-Chuen Khor Zhenglin Yang Chi Pui Pang Ningli Wang Michael A Hauser Kei Tashiro Tin Aung Eranga N Vithana

Hum Mol Genet 2015 Jul 10;24(13):3880-92. Epub 2015 Apr 10.

Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore,

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http://dx.doi.org/10.1093/hmg/ddv128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459396PMC
July 2015

Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.

Hum Mutat 2015 Jan 1;36(1):20-5. Epub 2014 Dec 1.

CNRS 6214/INSERM 1083, Angers University, Angers, France; Department of Biochemistry and Genetics, University Hospital, Angers, France.

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http://doi.wiley.com/10.1002/humu.22703
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http://dx.doi.org/10.1002/humu.22703DOI Listing
January 2015

Vitamin D and macular thickness in the elderly: an optical coherence tomography study.

Invest Ophthalmol Vis Sci 2014 Jul 15;55(8):5298-303. Epub 2014 Jul 15.

Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, University Memory Clinic of Angers, UPRES EA 4638, University of Angers, UNAM, Angers, France Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1167/iovs.14-13918DOI Listing
July 2014

Progressive outer retinal necrosis and immunosuppressive therapy in myasthenia gravis.

Case Rep Ophthalmol 2014 Jan 22;5(1):132-7. Epub 2014 Apr 22.

Service d'Ophtalmologie, Centre Hospitalier Universitaire d'Angers, Université d'Angers, LUNAM, Angers, France ; Singapore National Eye Centre, Singapore Eye Research Institute and Duke-NUS, Singapore, Singapore.

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http://dx.doi.org/10.1159/000362662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036147PMC
January 2014

Blue light-filtering intraocular lenses and post-operative mood: a pilot clinical study.

Int Ophthalmol 2015 Apr 23;35(2):249-56. Epub 2014 Apr 23.

Department of Neuroscience, Division of Ophthalmology, Angers University Hospital, 4 rue Larrey, 49933, Angers cedex 9, France,

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http://dx.doi.org/10.1007/s10792-014-9944-6DOI Listing
April 2015

Author reply: To PMID 24120325.

Ophthalmology 2014 Jun 26;121(6):e30-1. Epub 2014 Feb 26.

Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; National Eye Clinic, Kennedy Center, Glostrup, Denmark.

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http://dx.doi.org/10.1016/j.ophtha.2013.12.040DOI Listing
June 2014

Monochromatic Pupillometry in Unilateral Glaucoma Discloses no Adaptive Changes Subserved by the ipRGCs.

Front Neurol 2014 5;5:15. Epub 2014 Feb 5.

Research Laboratory, Department of Ophthalmology, Glostrup Hospital, University of Copenhagen , Glostrup , Denmark.

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http://dx.doi.org/10.3389/fneur.2014.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914022PMC
February 2014

Optic nerve and visual pathways primary glioblastoma treated with radiotherapy and temozolomide chemotherapy.

Eur J Ophthalmol 2014 Jul-Aug;24(4):637-40. Epub 2013 Dec 13.

Department of Ophthalmology, Angers University Hospital, Angers - France.

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http://dx.doi.org/10.5301/ejo.5000416DOI Listing
October 2014

New insights into the visual prognosis of pseudoxanthoma elasticum.

Br J Ophthalmol 2014 Jan 11;98(1):142-3. Epub 2013 Oct 11.

Department of Ophthalmology, LUNAM University, Angers Hospital, , Angers, France.

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http://dx.doi.org/10.1136/bjophthalmol-2013-303235DOI Listing
January 2014

Imaging of the macula indicates early completion of structural deficit in autosomal-dominant optic atrophy.

Ophthalmology 2013 Dec 10;120(12):2672-2677. Epub 2013 Oct 10.

Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; National Eye Clinic, Kennedy Center, Glostrup, Denmark.

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http://dx.doi.org/10.1016/j.ophtha.2013.08.008DOI Listing
December 2013

Delayed diagnosis of oculopharyngeal muscular dystrophy in Denmark: from initial ptosis to genetic testing.

Acta Ophthalmol 2014 May 15;92(3):e247-9. Epub 2013 Jul 15.

Department of Ophthalmology, Glostrup University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/aos.12243DOI Listing
May 2014

Maculopathy and spinocerebellar ataxia type 1: a new association?

J Neuroophthalmol 2013 Sep;33(3):225-31

Department of Ophthalmology, Nantes University Hospital, Nantes, France.

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http://dx.doi.org/10.1097/WNO.0b013e31828d4addDOI Listing
September 2013

Dominant optic atrophy.

Orphanet J Rare Dis 2012 Jul 9;7:46. Epub 2012 Jul 9.

Institut des Neurosciences de Montpellier, U1051 de l'INSERM, Université de Montpellier I et II, BP 74103, F-34091 Montpellier cedex 05, France.

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http://dx.doi.org/10.1186/1750-1172-7-46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526509PMC
July 2012

Impaired saccadic eye movement in primary open-angle glaucoma.

J Glaucoma 2014 Jan;23(1):23-32

*Ophthalmology Department, Fondation Ophtalmologique Adolphe de Rothschild †Ophthalmology Department, Hôpital Bichat-Claude Bernard ‡CRICM, Cogimage, Université Pierre et Marie Curie, UMR 7225, CNRS, INSERM, Paris §Ophthalmology Department, Angers University Hospital, Angers, France ∥Glostrup University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/IJG.0b013e31825c10dcDOI Listing
January 2014

Diagnostic value of optical coherence tomography for intracranial pressure in idiopathic intracranial hypertension.

Graefes Arch Clin Exp Ophthalmol 2013 Feb 18;251(2):567-74. Epub 2012 May 18.

Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 69, 2600, Glostrup, Denmark.

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http://dx.doi.org/10.1007/s00417-012-2039-zDOI Listing
February 2013

Visual loss related to macular subretinal fluid and cystoid macular edema in HIV-related optic neuropathy.

Int Ophthalmol 2012 Aug 13;32(4):405-8. Epub 2012 May 13.

Department of Ophthalmology, Angers University Hospital, CHU Angers, 4 rue Larrey, 49933 Angers Cedex 9, France.

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http://dx.doi.org/10.1007/s10792-012-9575-8DOI Listing
August 2012

Dietary vitamin D and AMD.

Ophthalmology 2012 May;119(5):1090-1; author reply 1091

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http://dx.doi.org/10.1016/j.ophtha.2012.02.005DOI Listing
May 2012

OCT for optic disc evaluation in idiopathic intracranial hypertension.

Graefes Arch Clin Exp Ophthalmol 2011 May 15;249(5):723-30. Epub 2010 Oct 15.

Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.

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http://dx.doi.org/10.1007/s00417-010-1527-2DOI Listing
May 2011

Disease activity in idiopathic intracranial hypertension: a 3-month follow-up study.

J Neurol 2011 Feb 19;258(2):277-83. Epub 2010 Sep 19.

Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600, Glostrup, Denmark.

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http://dx.doi.org/10.1007/s00415-010-5750-xDOI Listing
February 2011

Cerebral migration of intraocular silicone oil: an MRI study.

Acta Ophthalmol 2011 Sep 31;89(6):522-5. Epub 2010 Aug 31.

Department of Ophthalmology, Glostrup University Hospital, Copenhagen, Denmark.

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http://doi.wiley.com/10.1111/j.1755-3768.2009.01793.x
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http://dx.doi.org/10.1111/j.1755-3768.2009.01793.xDOI Listing
September 2011

Never too old to harbour a young man's disease?

Br J Ophthalmol 2011 Jun;95(6):887, 896-7

Ophthalmology Department, University Hospital, Angers, France.

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http://dx.doi.org/10.1136/bjo.2009.161539DOI Listing
June 2011

Genetically determined optic neuropathies.

Curr Opin Neurol 2010 Feb;23(1):24-8

Department of Ophthalmology, Angers University Hospital, Angers, France.

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http://dx.doi.org/10.1097/WCO.0b013e3283347b27DOI Listing
February 2010

Axonal loss occurs early in dominant optic atrophy.

Acta Ophthalmol 2010 May 19;88(3):342-6. Epub 2009 Mar 19.

Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1755-3768.2008.01469.xDOI Listing
May 2010

[Loss of sight and hearing and cognitive dysfunction - Susac's syndrome?].

Ugeskr Laeger 2009 Feb;171(8):618-20

Glostrup Hospital, DK-2600 Glostrup.

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February 2009

Arachnoid cyst causing an optic neuropathy in neurofibromatosis 1.

Acta Ophthalmol 2010 Jun 6;88(4):497-9. Epub 2009 Feb 6.

Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1755-3768.2008.01431.xDOI Listing
June 2010

[Rapidly progressing visual loss in idiopathic intracranial hypertension].

Ugeskr Laeger 2009 Jan;171(5):316-7

Dansk Hovedpinecenter, Glostrup Hospital, DK-2600 Glostrup.

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January 2009