Dan M Roden

Dan M Roden

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Dan M Roden

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Understanding the use of observational and randomized data in cardiovascular medicine.

Eur Heart J 2020 Jul;41(27):2571-2578

Radcliffe Department of Medicine, Division of Cardiovascular Medicine, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1093/eurheartj/ehaa020DOI Listing
July 2020

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome.

Authors:
Najim Lahrouchi Rafik Tadros Lia Crotti Yuka Mizusawa Pieter G Postema Leander Beekman Roddy Walsh Kanae Hasegawa Julien Barc Marko Ernsting Kari L Turkowski Andrea Mazzanti Britt M Beckmann Keiko Shimamoto Ulla-Britt Diamant Yanushi D Wijeyeratne Yu Kucho Tomas Robyns Taisuke Ishikawa Elena Arbelo Michael Christiansen Annika Winbo Reza Jabbari Steven A Lubitz Johannes Steinfurt Boris Rudic Bart Loeys M Ben Shoemaker Peter E Weeke Ryan Pfeiffer Brianna Davies Antoine Andorin Nynke Hofman Federica Dagradi Matteo Pedrazzini David J Tester J Martijn Bos Georgia Sarquella-Brugada Óscar Campuzano Pyotr G Platonov Birgit Stallmeyer Sven Zumhagen Eline A Nannenberg Jan H Veldink Leonard H van den Berg Ammar Al-Chalabi Christopher E Shaw Pamela J Shaw Karen E Morrison Peter M Andersen Martina Müller-Nurasyid Daniele Cusi Cristina Barlassina Pilar Galan Mark Lathrop Markus Munter Thomas Werge Marta Ribasés Tin Aung Chiea C Khor Mineo Ozaki Peter Lichtner Thomas Meitinger J Peter van Tintelen Yvonne Hoedemaekers Isabelle Denjoy Antoine Leenhardt Carlo Napolitano Wataru Shimizu Jean-Jacques Schott Jean-Baptiste Gourraud Takeru Makiyama Seiko Ohno Hideki Itoh Andrew D Krahn Charles Antzelevitch Dan M Roden Johan Saenen Martin Borggrefe Katja E Odening Patrick T Ellinor Jacob Tfelt-Hansen Jonathan R Skinner Maarten P van den Berg Morten Salling Olesen Josep Brugada Ramón Brugada Naomasa Makita Jeroen Breckpot Masao Yoshinaga Elijah R Behr Annika Rydberg Takeshi Aiba Stefan Kääb Silvia G Priori Pascale Guicheney Hanno L Tan Christopher Newton-Cheh Michael J Ackerman Peter J Schwartz Eric Schulze-Bahr Vincent Probst Minoru Horie Arthur A Wilde Michael W T Tanck Connie R Bezzina

Circulation 2020 Jul 20;142(4):324-338. Epub 2020 May 20.

Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, The Netherlands (N.L., R.T., Y.M., P.G.P., L.B., R.W., N.H., H.L.T., A.A.W., C.R.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.045956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382531PMC
July 2020

Cardiovascular Toxicities Associated With Hydroxychloroquine and Azithromycin: An Analysis of the World Health Organization Pharmacovigilance Database.

Circulation 2020 Jul 22;142(3):303-305. Epub 2020 May 22.

Sorbonne Université, Institut national de la santé et de la recherche médicale (INSERM), Assistance Publique - Hopitaux de Paris, Clinical Investigation Center, Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France (L.S.N., C.F., C.F.-B., J.-E.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.048238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365677PMC
July 2020

High-Throughput Reclassification of SCN5A Variants.

Am J Hum Genet 2020 Jul 12;107(1):111-123. Epub 2020 Jun 12.

Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332654PMC
July 2020

Atrial Fibrillation Is a Complex Trait: Very Complex.

Circ Res 2020 Jul 2;127(2):244-246. Epub 2020 Jul 2.

Medicine (Cardiovascular Medicine and Clinical Pharmacology) (D.M.R.), Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCRESAHA.120.317112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337979PMC
July 2020

Considerations for Drug Interactions on QTc in Exploratory COVID-19 Treatment.

Circulation 2020 06 8;141(24):e906-e907. Epub 2020 Apr 8.

Electrophysiology and Arrhythmia Services, Cooper University Hospital, Camden, NJ (A.M.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.047521DOI Listing
June 2020

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel K11.1.

Heart Rhythm 2020 Jun 6. Epub 2020 Jun 6.

Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2020.05.041DOI Listing
June 2020

A Bayesian method to estimate variant-induced disease penetrance.

PLoS Genet 2020 06 22;16(6):e1008862. Epub 2020 Jun 22.

Department of Biostatistics Vanderbilt University, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347235PMC
June 2020

How Will Genetics Inform the Clinical Care of Atrial Fibrillation?

Circ Res 2020 Jun 18;127(1):111-127. Epub 2020 Jun 18.

Department of Medicine, Stanford Center for Inherited Cardiovascular Diseases, Stanford University, Palo Alto, CA (M.V.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.120.316365DOI Listing
June 2020

Genetic susceptibility for COVID-19-associated sudden cardiac death in African Americans.

Heart Rhythm 2020 May 5. Epub 2020 May 5.

Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2020.04.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198426PMC
May 2020

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Authors:
Ioanna Ntalla Lu-Chen Weng James H Cartwright Amelia Weber Hall Gardar Sveinbjornsson Nathan R Tucker Seung Hoan Choi Mark D Chaffin Carolina Roselli Michael R Barnes Borbala Mifsud Helen R Warren Caroline Hayward Jonathan Marten James J Cranley Maria Pina Concas Paolo Gasparini Thibaud Boutin Ivana Kolcic Ozren Polasek Igor Rudan Nathalia M Araujo Maria Fernanda Lima-Costa Antonio Luiz P Ribeiro Renan P Souza Eduardo Tarazona-Santos Vilmantas Giedraitis Erik Ingelsson Anubha Mahajan Andrew P Morris Fabiola Del Greco M Luisa Foco Martin Gögele Andrew A Hicks James P Cook Lars Lind Cecilia M Lindgren Johan Sundström Christopher P Nelson Muhammad B Riaz Nilesh J Samani Gianfranco Sinagra Sheila Ulivi Mika Kähönen Pashupati P Mishra Nina Mononen Kjell Nikus Mark J Caulfield Anna Dominiczak Sandosh Padmanabhan May E Montasser Jeff R O'Connell Kathleen Ryan Alan R Shuldiner Stefanie Aeschbacher David Conen Lorenz Risch Sébastien Thériault Nina Hutri-Kähönen Terho Lehtimäki Leo-Pekka Lyytikäinen Olli T Raitakari Catriona L K Barnes Harry Campbell Peter K Joshi James F Wilson Aaron Isaacs Jan A Kors Cornelia M van Duijn Paul L Huang Vilmundur Gudnason Tamara B Harris Lenore J Launer Albert V Smith Erwin P Bottinger Ruth J F Loos Girish N Nadkarni Michael H Preuss Adolfo Correa Hao Mei James Wilson Thomas Meitinger Martina Müller-Nurasyid Annette Peters Melanie Waldenberger Massimo Mangino Timothy D Spector Michiel Rienstra Yordi J van de Vegte Pim van der Harst Niek Verweij Stefan Kääb Katharina Schramm Moritz F Sinner Konstantin Strauch Michael J Cutler Diane Fatkin Barry London Morten Olesen Dan M Roden M Benjamin Shoemaker J Gustav Smith Mary L Biggs Joshua C Bis Jennifer A Brody Bruce M Psaty Kenneth Rice Nona Sotoodehnia Alessandro De Grandi Christian Fuchsberger Cristian Pattaro Peter P Pramstaller Ian Ford J Wouter Jukema Peter W Macfarlane Stella Trompet Marcus Dörr Stephan B Felix Uwe Völker Stefan Weiss Aki S Havulinna Antti Jula Katri Sääksjärvi Veikko Salomaa Xiuqing Guo Susan R Heckbert Henry J Lin Jerome I Rotter Kent D Taylor Jie Yao Renée de Mutsert Arie C Maan Dennis O Mook-Kanamori Raymond Noordam Francesco Cucca Jun Ding Edward G Lakatta Yong Qian Kirill V Tarasov Daniel Levy Honghuang Lin Christopher H Newton-Cheh Kathryn L Lunetta Alison D Murray David J Porteous Blair H Smith Bruno H Stricker André Uitterlinden Marten E van den Berg Jeffrey Haessler Rebecca D Jackson Charles Kooperberg Ulrike Peters Alexander P Reiner Eric A Whitsel Alvaro Alonso Dan E Arking Eric Boerwinkle Georg B Ehret Elsayed Z Soliman Christy L Avery Stephanie M Gogarten Kathleen F Kerr Cathy C Laurie Amanda A Seyerle Adrienne Stilp Solmaz Assa M Abdullah Said M Yldau van der Ende Pier D Lambiase Michele Orini Julia Ramirez Stefan Van Duijvenboden David O Arnar Daniel F Gudbjartsson Hilma Holm Patrick Sulem Gudmar Thorleifsson Rosa B Thorolfsdottir Unnur Thorsteinsdottir Emelia J Benjamin Andrew Tinker Kari Stefansson Patrick T Ellinor Yalda Jamshidi Steven A Lubitz Patricia B Munroe

Nat Commun 2020 05 21;11(1):2542. Epub 2020 May 21.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/s41467-020-15706-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242331PMC
May 2020

Deep Mutational Scan of an Voltage Sensor.

Circ Genom Precis Med 2020 Feb 12;13(1):e002786. Epub 2020 Jan 12.

Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics (A.M.G., B.M.K., T.Y., Y.W., T.S., J.-E.S., D.M.R.), Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCGEN.119.002786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031040PMC
February 2020

An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.

Circulation 2020 02 16;141(6):429-439. Epub 2020 Jan 16.

Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (M.B., J.R.G., M.J.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.043114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035205PMC
February 2020

Response by Salem et al to Letter Regarding Article, "Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes".

Circulation 2020 02 3;141(5):e63-e64. Epub 2020 Feb 3.

Department of Medicine and Pharmacology, Cardio-Oncology Program (J.-E.S., J.J.M., D.M.R.), Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.045215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041671PMC
February 2020

CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease.

Int J Cardiol 2020 01 19;298:107-113. Epub 2019 Jul 19.

The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2019.07.058DOI Listing
January 2020

Heart failure and atrial tachyarrhythmia on abiraterone: A pharmacovigilance study.

Arch Cardiovasc Dis 2020 Jan 2;113(1):9-21. Epub 2019 Nov 2.

Department of pharmacology, Sorbonne université, Inserm CIC Paris-Est, ICAN, UNICO-GRECO, Sorbonne Cardio-Oncology program, regional pharmacovigilance centre, Pitié-Salpêtrière hospital, AP-HP, 75013 Paris, France; Cardio-oncology program, department of medicine and pharmacology, Vanderbilt university medical center, 37232 Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.acvd.2019.09.006DOI Listing
January 2020

John A. Oates: A Founding Father of Clinical Pharmacology.

Authors:
Dan M Roden

Clin Pharmacol Ther 2019 12 16;106(6):1155-1157. Epub 2019 Sep 16.

Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1614DOI Listing
December 2019

Genomic Medicine Year in Review: 2019.

Am J Hum Genet 2019 12 5;105(6):1072-1075. Epub 2019 Dec 5.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ajhg.2019.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202138PMC
December 2019

SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.

Heart Rhythm 2019 11 21;16(11):1676-1685. Epub 2019 May 21.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825529PMC
November 2019

Cardiovascular Toxicities Associated With Ibrutinib.

J Am Coll Cardiol 2019 10;74(13):1667-1678

Departments of Medicine and Pharmacology, Cardio-Oncology program, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.07.056DOI Listing
October 2019

Clopidogrel Pharmacogenetics - Why the Wait?

Authors:
Dan M Roden

N Engl J Med 2019 10;381(17):1677-1678

From the Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville.

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http://dx.doi.org/10.1056/NEJMe1911496DOI Listing
October 2019

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

Authors:
Amand F Schmidt Michael V Holmes David Preiss Daniel I Swerdlow Spiros Denaxas Ghazaleh Fatemifar Rupert Faraway Chris Finan Dennis Valentine Zammy Fairhurst-Hunter Fernando Pires Hartwig Bernardo Lessa Horta Elina Hypponen Christine Power Max Moldovan Erik van Iperen Kees Hovingh Ilja Demuth Kristina Norman Elisabeth Steinhagen-Thiessen Juri Demuth Lars Bertram Christina M Lill Stefan Coassin Johann Willeit Stefan Kiechl Karin Willeit Dan Mason John Wright Richard Morris Goya Wanamethee Peter Whincup Yoav Ben-Shlomo Stela McLachlan Jackie F Price Mika Kivimaki Catherine Welch Adelaida Sanchez-Galvez Pedro Marques-Vidal Andrew Nicolaides Andrie G Panayiotou N Charlotte Onland-Moret Yvonne T van der Schouw Giuseppe Matullo Giovanni Fiorito Simonetta Guarrera Carlotta Sacerdote Nicholas J Wareham Claudia Langenberg Robert A Scott Jian'an Luan Martin Bobak Sofia Malyutina Andrzej Pająk Ruzena Kubinova Abdonas Tamosiunas Hynek Pikhart Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Tine Jess Jackie Cooper Steve E Humphries Murray Brilliant Terrie Kitchner Hakon Hakonarson David S Carrell Catherine A McCarty Kirchner H Lester Eric B Larson David R Crosslin Mariza de Andrade Dan M Roden Joshua C Denny Cara Carty Stephen Hancock John Attia Elizabeth Holliday Rodney Scott Peter Schofield Martin O'Donnell Salim Yusuf Michael Chong Guillaume Pare Pim van der Harst M Abdullah Said Ruben N Eppinga Niek Verweij Harold Snieder Tim Christen D O Mook-Kanamori Stefan Gustafsson Lars Lind Erik Ingelsson Raha Pazoki Oscar Franco Albert Hofman Andre Uitterlinden Abbas Dehghan Alexander Teumer Sebastian Baumeister Marcus Dörr Markus M Lerch Uwe Völker Henry Völzke Joey Ward Jill P Pell Tom Meade Ingrid E Christophersen Anke H Maitland-van der Zee Ekaterina V Baranova Robin Young Ian Ford Archie Campbell Sandosh Padmanabhan Michiel L Bots Diederick E Grobbee Philippe Froguel Dorothée Thuillier Ronan Roussel Amélie Bonnefond Bertrand Cariou Melissa Smart Yanchun Bao Meena Kumari Anubha Mahajan Jemma C Hopewell Sudha Seshadri Caroline Dale Rui Providencia E Costa Paul M Ridker Daniel I Chasman Alex P Reiner Marylyn D Ritchie Leslie A Lange Alex J Cornish Sara E Dobbins Kari Hemminki Ben Kinnersley Marc Sanson Karim Labreche Matthias Simon Melissa Bondy Philip Law Helen Speedy James Allan Ni Li Molly Went Niels Weinhold Gareth Morgan Pieter Sonneveld Björn Nilsson Hartmut Goldschmidt Amit Sud Andreas Engert Markus Hansson Harry Hemingway Folkert W Asselbergs Riyaz S Patel Brendan J Keating Naveed Sattar Richard Houlston Juan P Casas Aroon D Hingorani

BMC Cardiovasc Disord 2019 10 29;19(1):240. Epub 2019 Oct 29.

Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.

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http://dx.doi.org/10.1186/s12872-019-1187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820948PMC
October 2019

Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.

Clin Pharmacol Ther 2019 09 23;106(3):623-631. Epub 2019 May 23.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941886PMC
September 2019

Pharmacogenomics.

Lancet 2019 08 5;394(10197):521-532. Epub 2019 Aug 5.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)31276-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707519PMC
August 2019

Genomic medicine for undiagnosed diseases.

Lancet 2019 Aug 5;394(10197):533-540. Epub 2019 Aug 5.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)31274-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709871PMC
August 2019

Building evidence and measuring clinical outcomes for genomic medicine.

Lancet 2019 Aug 5;394(10198):604-610. Epub 2019 Aug 5.

Genomic Medicine Institute, Geisinger, Danville, PA, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)31278-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730663PMC
August 2019

A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping.

MDM Policy Pract 2019 Jul-Dec;4(2):2381468319864337. Epub 2019 Aug 17.

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1177/2381468319864337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699004PMC
August 2019

Multiple mechanisms underlie increased cardiac late sodium current.

Heart Rhythm 2019 07 21;16(7):1091-1097. Epub 2019 Jan 21.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271193003
Publisher Site
http://dx.doi.org/10.1016/j.hrthm.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655535PMC
July 2019

Adverse Events Associated with Risperidone Use in Pediatric Patients: A Retrospective Biobank Study.

Drugs Real World Outcomes 2019 Jun;6(2):59-71

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://link.springer.com/10.1007/s40801-019-0151-7
Publisher Site
http://dx.doi.org/10.1007/s40801-019-0151-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520321PMC
June 2019

Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.

J Am Coll Cardiol 2019 05;73(17):2195-2205

Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, Tennessee; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.jacc.2019.01.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501811PMC
May 2019

CYP2D6 genotype and adverse events to risperidone in children and adolescents.

Pediatr Res 2019 04 19;85(5):602-606. Epub 2019 Jan 19.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41390-019-0305-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435416PMC
April 2019

A current understanding of drug-induced QT prolongation and its implications for anticancer therapy.

Authors:
Dan M Roden

Cardiovasc Res 2019 04;115(5):895-903

Department of Medicine, Vanderbilt University Medical Center, 2215B Garland Avenue, Room 1285B, Nashville, TN, USA.

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http://dx.doi.org/10.1093/cvr/cvz013DOI Listing
April 2019

My Cousin Also Has Atrial Fibrillation: Family Relationships in a Genomic Era.

JACC Clin Electrophysiol 2019 04;5(4):501-503

Vanderbilt Genetics Institute and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.jacep.2019.03.002DOI Listing
April 2019

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2019 03 5;7(3):227-238. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391516PMC
March 2019

GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.

Am J Hum Genet 2019 03 28;104(3):503-519. Epub 2019 Feb 28.

Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Data Science Institute, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407495PMC
March 2019

Protein structure aids predicting functional perturbation of missense variants in and .

Comput Struct Biotechnol J 2019 1;17:206-214. Epub 2019 Feb 1.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.csbj.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383132PMC
February 2019

Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors.

Heart 2018 11 2;104(22):1859-1863. Epub 2018 May 2.

AP-HP, Pitié-Salpêtrière Hospital Department of Pharmacology CIC-1421 Pharmacovigilance Unit INSERM UMR ICAN 1166 Sorbonne Université UPMC, Univ Paris 06, Institute of CArdiometabolism and Nutrition (ICAN), Paris, France.

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2017-312934
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http://dx.doi.org/10.1136/heartjnl-2017-312934DOI Listing
November 2018

Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms.

Pharmacol Ther 2018 09 24;189:89-103. Epub 2018 Apr 24.

Vanderbilt University Medical Center, Cardio-oncology Program, Department of Medicine, Nashville, Tennessee, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA; Sorbonne Université, INSERM CIC Paris-Est, AP-HP, ICAN, Pitié-Salpêtrière Hospital, Department of Pharmacology, F-75013 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258183007
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http://dx.doi.org/10.1016/j.pharmthera.2018.04.009DOI Listing
September 2018

Growing Pains in Cardiovascular Genetics.

Authors:
Dan M Roden

Circulation 2018 09;138(12):1206-1209

Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206881PMC
September 2018

Arrhythmia genetics: Not dark and lite, but 50 shades of gray.

Heart Rhythm 2018 08 27;15(8):1231-1232. Epub 2018 Apr 27.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271183039
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http://dx.doi.org/10.1016/j.hrthm.2018.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590670PMC
August 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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http://dx.doi.org/10.1038/s41467-018-04766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178PMC
July 2018

Exploiting ion channel structure to assess rare variant pathogenicity.

Heart Rhythm 2018 06 9;15(6):890-894. Epub 2018 Jan 9.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984725PMC
June 2018

Inhibition of the -Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic.

J Pharmacol Exp Ther 2018 06 21;365(3):460-466. Epub 2018 Mar 21.

Departments of Medicine (T.Y., D.F.M, J.M., D.M.R.), Pharmacology (T.Y., D.M.R.), and Biomedical Informatics (D.M.R.), Vanderbilt University School of Medicine, Nashville, Tennessee

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http://dx.doi.org/10.1124/jpet.117.246157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931436PMC
June 2018

Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years.

Am J Cardiol 2018 06 13;121(12):1552-1557. Epub 2018 Mar 13.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.amjcard.2018.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975107PMC
June 2018

Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 06 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0133-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136836PMC
June 2018

Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome.

Clin Pharmacol Ther 2018 05 13;103(5):787-794. Epub 2018 Mar 13.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134843PMC
May 2018

Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications.

Pharmacol Res 2018 04 12;130:44-51. Epub 2018 Feb 12.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, United States; Department of Medicine, Vanderbilt University Medical Center, United States. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965292PMC
April 2018

Evaluation of a Novel System to Enhance Clinicians' Recognition of Preadmission Adverse Drug Reactions.

Appl Clin Inform 2018 04 9;9(2):313-325. Epub 2018 May 9.

Department of Biomedical Informatics, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, Tennessee, United States.

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http://dx.doi.org/10.1055/s-0038-1646963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943080PMC
April 2018

Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records.

Clin Transl Sci 2018 03 17;11(2):112-122. Epub 2017 Nov 17.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1111/cts.12522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866959PMC
March 2018

The Influence of Big (Clinical) Data and Genomics on Precision Medicine and Drug Development.

Clin Pharmacol Ther 2018 03 5;103(3):409-418. Epub 2018 Feb 5.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805632PMC
March 2018

Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.

Circulation 2018 02;137(6):619-630

Departments of Cardiovascular Diseases, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Divisions of Heart Rhythm Services and Pediatric Cardiology, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (M.J.A.)

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383807PMC
February 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.

Sci Rep 2017 09 12;7(1):11303. Epub 2017 Sep 12.

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-017-09396-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595875PMC
September 2017