Dan L Longo

Dan L Longo

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Dan L Longo

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Personalized Medicine for Primary Treatment of Serous Ovarian Cancer.

Authors:
Dan L Longo

N Engl J Med 2019 12;381(25):2471-2474

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http://dx.doi.org/10.1056/NEJMe1914488DOI Listing
December 2019

Detecting Breast Cancer in Women with Dense Breasts.

Authors:
Dan L Longo

N Engl J Med 2019 11;381(22):2169-2170

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http://dx.doi.org/10.1056/NEJMe1912943DOI Listing
November 2019

Talking about Toxicity - "What We've Got Here Is a Failure to Communicate".

N Engl J Med 2019 Oct;381(15):1406-1408

From Massachusetts General Hospital, Boston (C.A.S.).

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http://dx.doi.org/10.1056/NEJMp1908310DOI Listing
October 2019

The Precision of Evidence Needed to Practice "Precision Medicine".

N Engl J Med 2019 06 3;380(25):2472-2474. Epub 2019 Jun 3.

From the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (D.J.H.).

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http://dx.doi.org/10.1056/NEJMe1906088DOI Listing
June 2019

The Surprisingly Positive Association Between Obesity and Cancer Immunotherapy Efficacy.

JAMA 2019 Apr;321(13):1247-1248

Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2019.0463DOI Listing
April 2019

Progress in BRCA-Mutated Ovarian Cancer.

N Engl J Med 2018 12;379(26):2567-2568

From the Departments of Hematology-Oncology and Medicine, Harvard Medical School (D.R.S.).

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http://dx.doi.org/10.1056/NEJMe1812644DOI Listing
December 2018

Macrophage Checkpoint Blockade in Cancer - Back to the Future.

N Engl J Med 2018 11;379(18):1777-1779

From the Humanitas Clinical and Research Center and Humanitas University, Milan (A.M.); and the William Harvey Research Institute, Queen Mary University of London, London (A.M.).

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http://www.nejm.org/doi/10.1056/NEJMe1811699
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http://dx.doi.org/10.1056/NEJMe1811699DOI Listing
November 2018

Recent progress in systemic treatment for lung cancer.

Curr Opin Pulm Med 2018 07;24(4):355-366

Harvard Medical School, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MCP.0000000000000493DOI Listing
July 2018

Exploiting Viruses to Treat Diseases.

N Engl J Med 2018 07 26;379(2):194-196. Epub 2018 Jun 26.

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http://dx.doi.org/10.1056/NEJMe1807181DOI Listing
July 2018

Progress in the Treatment of Hodgkin's Lymphoma.

N Engl J Med 2018 Jan 10;378(4):392-394. Epub 2017 Dec 10.

From the Yale Cancer Center, New Haven, CT (V.T.D.).

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http://dx.doi.org/10.1056/NEJMe1715141DOI Listing
January 2018

A Milestone for CAR T Cells.

N Engl J Med 2017 12 10;377(26):2593-2596. Epub 2017 Dec 10.

From the Earle A. Chiles Research Institute and the Providence Portland Medical Center, Portland, OR (E.T., W.J.U.).

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http://dx.doi.org/10.1056/NEJMe1714680DOI Listing
December 2017

Which Anti-CD20 Antibody Is Better in Follicular Lymphoma?

N Engl J Med 2017 10;377(14):1389-1390

From the University of Nebraska, Omaha (J.O.A.).

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http://dx.doi.org/10.1056/NEJMe1706154DOI Listing
October 2017

Imatinib Changed Everything.

Authors:
Dan L Longo

N Engl J Med 2017 03;376(10):982-983

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http://www.nejm.org/doi/10.1056/NEJMe1700833
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http://dx.doi.org/10.1056/NEJMe1700833DOI Listing
March 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
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http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

Novel genetic loci associated with hippocampal volume.

Authors:
Derrek P Hibar Hieab H H Adams Neda Jahanshad Ganesh Chauhan Jason L Stein Edith Hofer Miguel E Renteria Joshua C Bis Alejandro Arias-Vasquez M Kamran Ikram Sylvane Desrivières Meike W Vernooij Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Ashley H Beecham Alexa Beiser Manon Bernard Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Qiang Chen Christopher R K Ching Vincent Chouraki Gabriel Cuellar-Partida Fabrice Crivello Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Oliver Grimm Michael E Griswold Tulio Guadalupe Boris A Gutman Johanna Hass Unn K Haukvik David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Kjetil N Jørgensen Nazanin Karbalai Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre F Marquand Mar Matarin Karen A Mather Manuel Mattheisen David R McKay Yuri Milaneschi Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Paul Nyquist Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Lukas Pirpamer Benno Pütz Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Stefan Ropele Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Arvin Saremi Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Stella Trompet Dhananjay Vaidya Jeroen Van der Grond Sven J Van der Lee Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Katharina Wittfeld Girma Woldehawariat Christiane Wolf Thomas Wolfers Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Anton J M De Craen Eco J C De Geus Philip L De Jager Greig I De Zubicaray Ian J Deary Stéphanie Debette Charles DeCarli Norman Delanty Chantal Depondt Anita DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Christian Enzinger Susanne Erk Thomas Espeseth Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Myriam Fornage Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Asta K Håberg Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Matthew Huentelman Hilleke E Hulshoff Pol Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Francis J McMahon Katie L McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Helena Schmidt Peter R Schofield Sigurdur Sigursson Andrew Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Magda Tsolaki Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad van der Lugt Nic J A van der Wee Neeltje E M Van Haren Dennis van 't Ent Marie-Jose Van Tol Badri N Vardarajan Bruno Vellas Dick J Veltman Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright Ronald H Zielke Alan B Zonderman Nicholas G Martin Cornelia M Van Duijn Margaret J Wright W T Longstreth Gunter Schumann Hans J Grabe Barbara Franke Lenore J Launer Sarah E Medland Sudha Seshadri Paul M Thompson M Arfan Ikram

Nat Commun 2017 01 18;8:13624. Epub 2017 Jan 18.

Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253632PMC
January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Authors:
Hieab H H Adams Derrek P Hibar Vincent Chouraki Jason L Stein Paul A Nyquist Miguel E Rentería Stella Trompet Alejandro Arias-Vasquez Sudha Seshadri Sylvane Desrivières Ashley H Beecham Neda Jahanshad Katharina Wittfeld Sven J Van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Alexa Beiser Manon Bernard Joshua C Bis Laura M E Blanken Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Corina U Greven Oliver Grimm Michael E Griswold Tulio Guadalupe Johanna Hass Unn K Haukvik Saima Hilal Edith Hofer David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Jiemin Liao David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre Marquand Mar Matarin Karen A Mather Manuel Mattheisen Bernard Mazoyer David R McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza-Schreiber Ryan L Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B Rajan Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Russell Thomson Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Dhananjay Vaidya Jeroen Van der Grond Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Girma Woldehawariat Christiane Wolf Thomas Wolfers Bing Xu Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Neelum T Aggarwal Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Christopher Chen Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Eco J C De Geus Philip L De Jager Greig I de Zubicaray Norman Delanty Chantal Depondt Anita L DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Susanne Erk Thomas Espeseth Denis A Evans Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Hans J Grabe Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Hilleke E Hulshoff Pol Masashi Ikeda M Kamran Ikram Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo W T Longstreth Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Katie L McMahon Francis J McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Peter R Schofield Sigurdur Sigurdsson Andy Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Velandai Srikanth Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Henning Tiemeier Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad Van der Lugt Nic J A Van der Wee Cornelia M Van Duijn Neeltje E M Van Haren Dennis Van T Ent Marie-Jose Van Tol Badri N Vardarajan Dick J Veltman Meike W Vernooij Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright H Ronald Zielke Alan B Zonderman Ian J Deary Charles DeCarli Helena Schmidt Nicholas G Martin Anton J M De Craen Margaret J Wright Lenore J Launer Gunter Schumann Myriam Fornage Barbara Franke Stéphanie Debette Sarah E Medland M Arfan Ikram Paul M Thompson

Nat Neurosci 2016 12 3;19(12):1569-1582. Epub 2016 Oct 3.

Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227112PMC
December 2016

PARP Inhibitors in Ovarian Cancer Treatment.

N Engl J Med 2016 12;375(22):2197-2198

From the Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York (D.R.S.).

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http://dx.doi.org/10.1056/NEJMe1612843DOI Listing
December 2016

Is watch and wait still acceptable for patients with low-grade follicular lymphoma?

Blood 2016 06 18;127(23):2804-8. Epub 2016 Mar 18.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/blood-2015-11-632745DOI Listing
June 2016

More on Data Sharing.

N Engl J Med 2016 05;374(19):1896-7

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http://dx.doi.org/10.1056/NEJMc1602586DOI Listing
May 2016

Real Personalized Medicine.

J Natl Compr Canc Netw 2016 Feb;14(2):233-6

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http://dx.doi.org/10.6004/jnccn.2016.0024DOI Listing
February 2016

Drug-Induced Megaloblastic Anemia.

N Engl J Med 2016 02;374(7):696-7

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http://www.nejm.org/doi/10.1056/NEJMc1515180
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http://dx.doi.org/10.1056/NEJMc1515180DOI Listing
February 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

Eur J Immunol 2016 Jan 19;46(1):212-22. Epub 2015 Nov 19.

Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/eji.201445422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858723PMC
January 2016

Data Sharing.

N Engl J Med 2016 Jan;374(3):276-7

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http://dx.doi.org/10.1056/NEJMe1516564DOI Listing
January 2016

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity.

Cancer Res 2015 Dec 22;75(24):5260-72. Epub 2015 Oct 22.

Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland. Basic Sciences Program, Leidos Biomedical Research, Inc., Frederick, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681610PMC
December 2015

Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells.

J Immunol 2015 Dec 13;195(12):5780-6. Epub 2015 Nov 13.

Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD; and

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http://www.jimmunol.org/content/195/12/5780.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1501023
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http://dx.doi.org/10.4049/jimmunol.1501023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670797PMC
December 2015

Second Cancers after Treatment for Hodgkin's Lymphoma--Continuing Cause for Concern.

N Engl J Med 2015 Dec;373(26):2572-3

From the University of Manchester and the Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (J.R.).

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http://dx.doi.org/10.1056/NEJMe1511947DOI Listing
December 2015

Combined-Modality Therapy for Early-Stage Diffuse Large B-Cell Lymphoma: Knowing When to Quit.

Authors:
Dan L Longo

J Clin Oncol 2015 Nov 17;33(32):3684-5. Epub 2015 Aug 17.

Harvard Medical School, Brigham and Women's Hospital, Boston, MA

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http://dx.doi.org/10.1200/JCO.2015.63.0285DOI Listing
November 2015

Improving Prospects for Targeting RAS.

J Clin Oncol 2015 Nov 14;33(31):3650-9. Epub 2015 Sep 14.

Harshabad Singh and Bruce A. Chabner, Massachusetts General Hospital Cancer Center; Harshabad Singh, Dana-Farber Cancer Institute; and Dan L. Longo, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2015.62.1052DOI Listing
November 2015

Cautious Optimism for Offspring of Women with Cancer during Pregnancy.

N Engl J Med 2015 Nov 28;373(19):1875-6. Epub 2015 Sep 28.

From the Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston (M.F.G.).

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http://dx.doi.org/10.1056/NEJMe1512188DOI Listing
November 2015

Drug-Induced Megaloblastic Anemia.

N Engl J Med 2015 Oct;373(17):1649-58

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http://dx.doi.org/10.1056/NEJMra1508861DOI Listing
October 2015

Monoclonal Antibodies in Multiple Myeloma Come of Age.

N Engl J Med 2015 Sep 26;373(13):1264-6. Epub 2015 Aug 26.

From the Massachusetts General Hospital Cancer Center and Harvard Medical School - both in Boston (N.R.).

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http://www.nejm.org/doi/10.1056/NEJMe1509419
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http://dx.doi.org/10.1056/NEJMe1509419DOI Listing
September 2015

Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.

Immunity 2015 Aug 28;43(2):240-50. Epub 2015 Jul 28.

Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA; Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770886PMC
August 2015

Precision medicine--personalized, problematic, and promising.

N Engl J Med 2015 Jun 27;372(23):2229-34. Epub 2015 May 27.

From the University of Pennsylvania Perelman School of Medicine, Philadelphia (J.L.J.).

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http://dx.doi.org/10.1056/NEJMsb1503104DOI Listing
June 2015

Common genetic variants influence human subcortical brain structures.

Authors:
Derrek P Hibar Jason L Stein Miguel E Renteria Alejandro Arias-Vasquez Sylvane Desrivières Neda Jahanshad Roberto Toro Katharina Wittfeld Lucija Abramovic Micael Andersson Benjamin S Aribisala Nicola J Armstrong Manon Bernard Marc M Bohlken Marco P Boks Janita Bralten Andrew A Brown M Mallar Chakravarty Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk den Braber Sudheer Giddaluru Aaron L Goldman Oliver Grimm Tulio Guadalupe Johanna Hass Girma Woldehawariat Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Loes M Olde Loohuis Michelle Luciano Christine Macare Karen A Mather Manuel Mattheisen Yuri Milaneschi Kwangsik Nho Martina Papmeyer Adaikalavan Ramasamy Shannon L Risacher Roberto Roiz-Santiañez Emma J Rose Alireza Salami Philipp G Sämann Lianne Schmaal Andrew J Schork Jean Shin Lachlan T Strike Alexander Teumer Marjolein M J van Donkelaar Kristel R van Eijk Raymond K Walters Lars T Westlye Christopher D Whelan Anderson M Winkler Marcel P Zwiers Saud Alhusaini Lavinia Athanasiu Stefan Ehrlich Marina M H Hakobjan Cecilie B Hartberg Unn K Haukvik Angelien J G A M Heister David Hoehn Dalia Kasperaviciute David C M Liewald Lorna M Lopez Remco R R Makkinje Mar Matarin Marlies A M Naber D Reese McKay Margaret Needham Allison C Nugent Benno Pütz Natalie A Royle Li Shen Emma Sprooten Daniah Trabzuni Saskia S L van der Marel Kimm J E van Hulzen Esther Walton Christiane Wolf Laura Almasy David Ames Sampath Arepalli Amelia A Assareh Mark E Bastin Henry Brodaty Kazima B Bulayeva Melanie A Carless Sven Cichon Aiden Corvin Joanne E Curran Michael Czisch Greig I de Zubicaray Allissa Dillman Ravi Duggirala Thomas D Dyer Susanne Erk Iryna O Fedko Luigi Ferrucci Tatiana M Foroud Peter T Fox Masaki Fukunaga J Raphael Gibbs Harald H H Göring Robert C Green Sebastian Guelfi Narelle K Hansell Catharina A Hartman Katrin Hegenscheid Andreas Heinz Dena G Hernandez Dirk J Heslenfeld Pieter J Hoekstra Florian Holsboer Georg Homuth Jouke-Jan Hottenga Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Ryota Kanai Maria Keil Jack W Kent Peter Kochunov John B Kwok Stephen M Lawrie Xinmin Liu Dan L Longo Katie L McMahon Eva Meisenzahl Ingrid Melle Sebastian Mohnke Grant W Montgomery Jeanette C Mostert Thomas W Mühleisen Michael A Nalls Thomas E Nichols Lars G Nilsson Markus M Nöthen Kazutaka Ohi Rene L Olvera Rocio Perez-Iglesias G Bruce Pike Steven G Potkin Ivar Reinvang Simone Reppermund Marcella Rietschel Nina Romanczuk-Seiferth Glenn D Rosen Dan Rujescu Knut Schnell Peter R Schofield Colin Smith Vidar M Steen Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Maria C Valdés Hernández Dennis van 't Ent Marcel van der Brug Nic J A van der Wee Marie-Jose van Tol Dick J Veltman Thomas H Wassink Eric Westman Ronald H Zielke Alan B Zonderman David G Ashbrook Reinmar Hager Lu Lu Francis J McMahon Derek W Morris Robert W Williams Han G Brunner Randy L Buckner Jan K Buitelaar Wiepke Cahn Vince D Calhoun Gianpiero L Cavalleri Benedicto Crespo-Facorro Anders M Dale Gareth E Davies Norman Delanty Chantal Depondt Srdjan Djurovic Wayne C Drevets Thomas Espeseth Randy L Gollub Beng-Choon Ho Wolfgang Hoffmann Norbert Hosten René S Kahn Stephanie Le Hellard Andreas Meyer-Lindenberg Bertram Müller-Myhsok Matthias Nauck Lars Nyberg Massimo Pandolfo Brenda W J H Penninx Joshua L Roffman Sanjay M Sisodiya Jordan W Smoller Hans van Bokhoven Neeltje E M van Haren Henry Völzke Henrik Walter Michael W Weiner Wei Wen Tonya White Ingrid Agartz Ole A Andreassen John Blangero Dorret I Boomsma Rachel M Brouwer Dara M Cannon Mark R Cookson Eco J C de Geus Ian J Deary Gary Donohoe Guillén Fernández Simon E Fisher Clyde Francks David C Glahn Hans J Grabe Oliver Gruber John Hardy Ryota Hashimoto Hilleke E Hulshoff Pol Erik G Jönsson Iwona Kloszewska Simon Lovestone Venkata S Mattay Patrizia Mecocci Colm McDonald Andrew M McIntosh Roel A Ophoff Tomas Paus Zdenka Pausova Mina Ryten Perminder S Sachdev Andrew J Saykin Andy Simmons Andrew Singleton Hilkka Soininen Joanna M Wardlaw Michael E Weale Daniel R Weinberger Hieab H H Adams Lenore J Launer Stephan Seiler Reinhold Schmidt Ganesh Chauhan Claudia L Satizabal James T Becker Lisa Yanek Sven J van der Lee Maritza Ebling Bruce Fischl W T Longstreth Douglas Greve Helena Schmidt Paul Nyquist Louis N Vinke Cornelia M van Duijn Luting Xue Bernard Mazoyer Joshua C Bis Vilmundur Gudnason Sudha Seshadri M Arfan Ikram Nicholas G Martin Margaret J Wright Gunter Schumann Barbara Franke Paul M Thompson Sarah E Medland

Nature 2015 Apr 21;520(7546):224-9. Epub 2015 Jan 21.

QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.

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April 2015

Controversies in the treatment of early-stage Hodgkin's lymphoma.

N Engl J Med 2015 Apr;372(17):1667-9

From the Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha (J.O.A.).

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April 2015

Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane-Induced Death by AS101 via Inhibition of the VLA-4-IL10-Survivin Axis.

Mol Cancer Res 2015 Mar 28;13(3):411-22. Epub 2014 Oct 28.

C.A.I.R. Institute, The Safdiè AIDS and Immunology Research Center, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

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March 2015

Release the hounds! Activating the T-cell response to cancer.

N Engl J Med 2015 Jan 6;372(4):374-5. Epub 2014 Dec 6.

From the Section of Medical Oncology, Yale University School of Medicine, New Haven, CT (M.S.).

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January 2015

Cancer-drug discovery--let's get ready for the next period.

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Dan L Longo

N Engl J Med 2014 Dec;371(23):2227-8

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December 2014

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.

J Exp Med 2014 Nov 3;211(12):2373-83. Epub 2014 Nov 3.

Department of Dermatology, Department of Pathology and Laboratory Medicine, Department of Radiation Oncology, and Department of Dermatology and Internal Medicine, University of California, Davis, Sacramento, CA 95817

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November 2014

Chromatin properties of regulatory DNA probed by manipulation of transcription factors.

J Comput Biol 2014 Aug 11;21(8):569-77. Epub 2014 Jun 11.

1 National Institute on Aging, National Institutes of Health , Baltimore, Maryland.

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August 2014

PALB2 mutations and breast-cancer risk.

N Engl J Med 2014 Aug;371(6):566-8

From the Health Disparities Research Section, Laboratory of Epidemiology and Populations Sciences, National Institute on Aging, National Institutes of Health, Baltimore (M.K.E.).

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August 2014

Redox modulation of adjacent thiols in VLA-4 by AS101 converts myeloid leukemia cells from a drug-resistant to drug-sensitive state.

Cancer Res 2014 Jun 3;74(11):3092-103. Epub 2014 Apr 3.

Authors' Affiliations: C.A.I.R. Institute, The Safdiè AIDS and Immunology Research Center, The Mina & Everard Goodman Faculty of Life Sciences; Chemistry Department, Bar-Ilan University, Ramat-Gan; Department of Hematology, Kaplan Medical Center, Rehovot, Israel; and Laboratory of Molecular Biology and Immunology, Biomedical Research Center, National Institute on Aging, Baltimore, Maryland

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June 2014

Pharmacodynamic biomarkers: falling short of the mark?

Clin Cancer Res 2014 May;20(10):2587-94

Authors' Affiliations: Department of Medicine, Massachusetts General Hospital Cancer Center; and Department of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts.

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May 2014

Multiple myeloma in the very old: an IASIA conference report.

J Natl Cancer Inst 2014 Apr 3;106(5). Epub 2014 Apr 3.

Affiliations of authors: Division of Hematologic Malignancies and Cellular Therapy, Duke Cancer Institute, Durham, NC (SAT, HJC); Cancer Center of Western Wisconsin, New Richmond, WI (GRS); Institute for Advanced Studies in Aging and Geriatric Medicine, Falls Church, VA (GRS, WBE, IQF, BK, JWY); Division of Hematology and Oncology, University of Maryland, Baltimore, MD (AB); Division of Hematology, Mayo Clinic, Rochester, MN (AD); Division of Geriatric Medicine, University of Illinois College of Medicine, Chicago, IL (DJ); Division of Hematology, Harvard Medical School, Cambridge, MA (DLL); Bristol-Meyers Squibb, Plainsboro, NJ (AN); Myeloma Unit, University of Torino, Torino, Italy (AP); Center on Aging and Health, Johns Hopkins University, Baltimore, MD (JW); Department of Social and Preventive Medicine, Roswell Park Cancer Institute, University of Buffalo, Roswell Park Cancer Institute, Buffalo, NY (JWY).

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April 2014

Covert operations: cancer's many subversive tactics in overcoming host defenses.

Authors:
Dan L Longo

Trans Am Clin Climatol Assoc 2013 ;124:163-73

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March 2014

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation.

FASEB J 2014 Jan 30;28(1):382-94. Epub 2013 Sep 30.

2Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. P.G.,

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January 2014

Reply to P. Borchmann et al.

Authors:
Dan L Longo

J Clin Oncol 2013 Aug 8;31(24):3046. Epub 2013 Jul 8.

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August 2013

Personality traits and leptin.

Psychosom Med 2013 Jun 22;75(5):505-9. Epub 2013 May 22.

Florida State University College of Medicine, 1115 W. Call Street, Tallahassee, FL 32306, USA.

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June 2013

Murine natural killer cell licensing and regulation by T regulatory cells in viral responses.

Proc Natl Acad Sci U S A 2013 Apr 15;110(18):7401-6. Epub 2013 Apr 15.

Department of Dermatology, University of California at Davis, Sacramento, CA 95817, USA.

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April 2013

An interview with Dan L. Longo, Section Editor of the Malignant hematological diseases section.

Authors:
Dan L Longo

BMC Hematol 2013 Apr 10;13(1). Epub 2013 Apr 10.

Hematology Division, Department of Medicine, Brigham and Women's Hospital, 10 Shattuck St, Boston, MA, 02115, USA.

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April 2013

Treatment of advanced Hodgkin lymphoma: the more things change, the more they stay the same.

Authors:
Dan L Longo

J Clin Oncol 2013 Feb 26;31(6):660-2. Epub 2012 Nov 26.

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February 2013

Relationship between mean corpuscular volume and cognitive performance in older adults.

J Am Geriatr Soc 2013 Jan 10;61(1):84-9. Epub 2013 Jan 10.

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224, USA.

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January 2013

Talking with patients about dying.

N Engl J Med 2013 01;368(5):481

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January 2013

Talking with patients about dying.

N Engl J Med 2012 Oct;367(17):1651-2

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October 2012

Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging.

J Gerontol A Biol Sci Med Sci 2012 Sep 2;67(9):963-9. Epub 2012 May 2.

Department of Neurology, Johns Hopkins University School of Medicine, Meyer 6-113, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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September 2012

Transforming growth factor β1 (TGF-β1) suppresses growth of B-cell lymphoma cells by p14(ARF)-dependent regulation of mutant p53.

J Biol Chem 2012 Jun 23;287(27):23184-95. Epub 2012 May 23.

Lymphocyte Cell Biology Unit, Laboratory of Molecular Biology and Immunology, Intramural Research Program, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA.

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June 2012

Tumor heterogeneity and personalized medicine.

Authors:
Dan L Longo

N Engl J Med 2012 Mar;366(10):956-7

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March 2012

Involvement of mTOR in CXCL12 mediated T cell signaling and migration.

PLoS One 2011 12;6(9):e24667. Epub 2011 Sep 12.

Lymphocyte Cell Biology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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February 2012

Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.

Blood 2012 Feb 19;119(6):1590-8. Epub 2011 Dec 19.

Department of Dermatology, School of Medicine, University of California-Davis, 2921 Stockton Blvd., Sacramento, CA 95817, USA.

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February 2012

Cancer immunotherapy: are we there yet?

Semin Cancer Biol 2012 Feb 8;22(1):1-2. Epub 2012 Jan 8.

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February 2012

Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses.

Semin Cancer Biol 2012 Feb 12;22(1):50-9. Epub 2012 Jan 12.

Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, United States.

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February 2012

Follicular lymphoma: to treat or not to treat is no longer the question.

J Natl Cancer Inst 2012 Jan 21;104(1):3-5. Epub 2011 Dec 21.

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January 2012

Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats.

Pharmacol Biochem Behav 2011 Nov 22;100(1):205-11. Epub 2011 Aug 22.

Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA.

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November 2011

Redirecting T cells.

N Engl J Med 2011 Aug 10;365(8):754-7. Epub 2011 Aug 10.

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August 2011

Multiple loci are associated with white blood cell phenotypes.

PLoS Genet 2011 Jun 30;7(6):e1002113. Epub 2011 Jun 30.

Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.

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June 2011

Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18.

PLoS One 2011 May 10;6(5):e18553. Epub 2011 May 10.

Lymphocyte Cell Biology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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May 2011

Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production.

J Inflamm (Lond) 2011 Mar 7;8. Epub 2011 Mar 7.

Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, (251 Bayview Boulevard), Baltimore, MD, (21224), USA.

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March 2011

Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis.

Magn Reson Med 2011 Feb 30;65(2):377-84. Epub 2010 Nov 30.

Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.

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February 2011

Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor.

J Biol Chem 2011 Jan 11;286(2):1093-102. Epub 2010 Nov 11.

Laboratory of Immunology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA.

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January 2011

Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.

Mol Cancer Res 2011 Jan 3;9(1):78-89. Epub 2010 Dec 3.

Lymphocyte Cell Biology Section, Laboratory of Immunology, Biomedical Research Center, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076720PMC
January 2011

Transcriptional regulation of BRCA1 expression by a metabolic switch.

Nat Struct Mol Biol 2010 Dec 21;17(12):1406-13. Epub 2010 Nov 21.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460552PMC
December 2010

New therapies for castration-resistant prostate cancer.

Authors:
Dan L Longo

N Engl J Med 2010 Jul;363(5):479-81

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July 2010