Publications by authors named "Damien J Keating"

81Publications

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Cell Host Microbe 2020 Dec 16. Epub 2020 Dec 16.

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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December 2020

The Suitability of Glioblastoma Cell Lines as Models for Primary Glioblastoma Cell Metabolism.

Cancers (Basel) 2020 Dec 11;12(12). Epub 2020 Dec 11.

Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5042, Australia.

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December 2020

Circulating cathepsin S improves glycemic control in mice.

J Endocrinol 2020 Dec 1. Epub 2020 Dec 1.

M Watt, Department of Physiology, The University of Melbourne, Melbourne, 3010, Australia.

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December 2020

Amperometry in Single Cells and Tissue.

Authors:
Damien J Keating

Methods Mol Biol 2021 ;2233:223-231

Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.

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January 2021

The ever-changing roles of serotonin.

Int J Biochem Cell Biol 2020 08 29;125:105776. Epub 2020 May 29.

Flinders Health and Medical Research Institute, Flinders University, Adelaide, 5042, Australia. Electronic address:

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August 2020

Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine.

Neurogastroenterol Motil 2020 08 7;32(8):e13869. Epub 2020 May 7.

Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

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August 2020

Islets and pancreatic ductal adenocarcinoma - An opportunity for translational research from the 'Bench to the Bedside'.

Pancreatology 2020 Apr 5;20(3):385-390. Epub 2020 Feb 5.

College of Medicine and Public Health, Flinders University, South Australia, Australia.

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April 2020

Mechanisms controlling hormone secretion in human gut and its relevance to metabolism.

J Endocrinol 2019 11 29;244(1):R1-R15. Epub 2019 Nov 29.

D Keating, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

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November 2019

The gut microbiome regulates host glucose homeostasis via peripheral serotonin.

Proc Natl Acad Sci U S A 2019 10 16;116(40):19802-19804. Epub 2019 Sep 16.

Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia;

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October 2019

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release.

Front Physiol 2019 16;10:428. Epub 2019 Apr 16.

Molecular and Cellular Physiology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

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April 2019

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.

Endocr Rev 2019 08;40(4):1092-1107

Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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August 2019

Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism.

Neurotox Res 2019 May 22;35(4):883-897. Epub 2019 Feb 22.

Flinders Proteomics Facility, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, Australia.

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May 2019

Metformin Triggers PYY Secretion in Human Gut Mucosa.

J Clin Endocrinol Metab 2019 07;104(7):2668-2674

College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.

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July 2019

The Regulation of Peripheral Metabolism by Gut-Derived Hormones.

Front Endocrinol (Lausanne) 2018 4;9:754. Epub 2019 Jan 4.

College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

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January 2019

Gut Mechanisms Linking Intestinal Sweet Sensing to Glycemic Control.

Front Endocrinol (Lausanne) 2018 4;9:741. Epub 2018 Dec 4.

Faculty of Health and Medical Sciences & Centre of Research Excellence in Translating Nutritional Science to Good Health, Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.

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December 2018

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

Pharmacol Res 2019 02 21;140:50-55. Epub 2018 Jun 21.

College of Medicine and Public Health and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia. Electronic address:

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February 2019

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle.

J Neurosci 2018 06 28;38(24):5507-5522. Epub 2018 May 28.

Cyber Sensing and Shaping, Cyber and Electronic Warfare Division, Defence, Science and Technology Group, Edinburgh, South Australia 5111, Australia.

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June 2018

ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells.

BMC Res Notes 2018 May 9;11(1):285. Epub 2018 May 9.

Flinders University College of Medicine and Public Health, Flinders Medical Centre Room 4E-431, Flinders Drive, Bedford Park, SA, 5042, Australia.

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May 2018

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes.

Oncotarget 2017 Oct 16;8(53):90693-90705. Epub 2017 Sep 16.

ABSL-3 Laboratory at the Center for Animal Experiment and Institute of Animal Model for Human Disease, Wuhan University School of Medicine, Wuhan, P. R. China.

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October 2017

The neuronal and endocrine roles of RCAN1 in health and disease.

Clin Exp Pharmacol Physiol 2018 04 29;45(4):377-383. Epub 2017 Nov 29.

College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.

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April 2018

Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

Curr Diab Rep 2017 Oct 28;17(12):128. Epub 2017 Oct 28.

Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

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October 2017

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon.

Am J Physiol Gastrointest Liver Physiol 2018 01 21;314(1):G53-G64. Epub 2017 Sep 21.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University , Adelaide South Australia.

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January 2018

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

J Neurochem 2018 02 27;144(3):302-317. Epub 2017 Sep 27.

School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia.

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February 2018

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine.

Diabetes 2017 08 6;66(8):2144-2149. Epub 2017 Apr 6.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia

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August 2017

The Diverse Metabolic Roles of Peripheral Serotonin.

Endocrinology 2017 05;158(5):1049-1063

Discipline of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide 5042, Australia.

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May 2017

Regional differences in nutrient-induced secretion of gut serotonin.

Physiol Rep 2017 Mar;5(6)

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia

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March 2017

Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.

Cell Signal 2017 07 1;35:176-187. Epub 2017 Mar 1.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia; South Australian Health and medical Research Institute, Adelaide, SA, Australia. Electronic address:

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July 2017

Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine.

BMC Evol Biol 2016 10 13;16(1):214. Epub 2016 Oct 13.

Centre for Neuroscience and Department of Human Physiology, Flinders University, Adelaide, South Australia, Australia.

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October 2016

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

Adv Exp Med Biol 2016 ;891:113-22

Department of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, SA, Australia.

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June 2017

Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.

J Neurochem 2016 09 18;138(5):710-21. Epub 2016 Jul 18.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia.

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September 2016

The 18th International Symposia on Chromaffin Cell Biology.

J Neurochem 2016 06;137(6):847-8

Discipline of Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, Australia.

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June 2016

Exocytosis in non-neuronal cells.

J Neurochem 2016 06 2;137(6):849-59. Epub 2016 May 2.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.

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June 2016

Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules.

Stem Cells Int 2016 16;2016:4304916. Epub 2015 Dec 16.

School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, SA 5000, Australia; Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, P.O. Box 2100, Adelaide, SA 5001, Australia.

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January 2016

Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability.

Nutr Metab (Lond) 2015 15;12:55. Epub 2015 Dec 15.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Sturt Rd, Adelaide, SA 5042 Australia ; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, 5001 Australia.

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December 2015

Fusion Pore Size Limits 5-HT Release From Single Enterochromaffin Cell Vesicles.

J Cell Physiol 2016 Jul 10;231(7):1593-600. Epub 2015 Dec 10.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia.

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July 2016

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating.

J Physiol 2015 Aug;593(15):3235

Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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August 2015

CrossTalk opposing view: 5-HT is not necessary for peristalsis.

J Physiol 2015 Aug;593(15):3229-31

Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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August 2015

Gut Serotonin Is a Regulator of Obesity and Metabolism.

Gastroenterology 2015 Jul 27;149(1):253-5. Epub 2015 May 27.

South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia; Centre for Neuroscience and Department of Human Physiology, Flinders University, Adelaide, Australia.

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July 2015

Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking.

Nat Commun 2015 Feb 24;6:6297. Epub 2015 Feb 24.

The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.

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February 2015

Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder.

Hum Mol Genet 2015 Apr 11;24(7):2000-10. Epub 2014 Dec 11.

Women's and Children's Health Research Institute, North Adelaide and Discipline of Medicine, School of Paediatrics and Reproductive Health, Robinson Research Institute and, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide, SA, Australia,

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April 2015

RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.

Oxid Med Cell Longev 2014 9;2014:520316. Epub 2014 Jun 9.

Molecular and Cellular Neuroscience Group, Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA 5042, Australia.

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February 2015

Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.

J Physiol 2014 Apr 23;592(7):1505-18. Epub 2013 Dec 23.

Department of Human Physiology, School of Medicine, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.

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April 2014

The β-cell/EC axis: how do islet cells talk to each other?

Diabetes 2014 Jan;63(1):3-11

Department of Human Physiology, Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia.

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January 2014

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.

J Physiol 2013 Dec 7;591(23):5959-75. Epub 2013 Oct 7.

D. Keating: Department of Human Physiology and Centre for Neuroscience, Flinders University, Sturt Road, Adelaide, 5001, Australia.

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December 2013

RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity.

J Neurochem 2013 Feb;124(3):290-9

Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia.

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February 2013

Aging differentially affects multiple aspects of vesicle fusion kinetics.

PLoS One 2011 18;6(11):e27820. Epub 2011 Nov 18.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia.

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April 2012

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

Am J Physiol Gastrointest Liver Physiol 2011 Sep 23;301(3):G519-27. Epub 2011 Jun 23.

Discipline of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia.

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September 2011

ClC-3--a granular anion transporter involved in insulin secretion?

Cell Metab 2010 Oct;12(4):307-308

ZBAF, Institut für Physiologie, Universität Witten/Herdecke, 58453 Witten, Germany.

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October 2010

Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes.

Gastroenterology 2010 Feb 24;138(2):659-70 670.e1-2. Epub 2009 Sep 24.

Department of Human Physiology, Flinders University, School of Medicine, South Australia, Australia.

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February 2010

The contribution of voltage-gated Ca2+ currents to K+ channel activation during ovine adrenal chromaffin cell development.

Int J Dev Neurosci 2009 Jun 13;27(4):357-63. Epub 2009 Mar 13.

School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, Australia.

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June 2009

NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development.

J Neurosci 2009 Mar;29(11):3419-30

Max Delbrück Centrum für Molekulare Medizin (MDC) and Leibniz Institut für Molekulare Pharmakologie (FMP), D-13125 Berlin, Germany.

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March 2009

Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue.

J Neurosci 2008 Oct;28(42):10587-98

Zentrum für Molekulare Neurobiologie (ZMNH), Universität Hamburg, D-20246 Hamburg, Germany.

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October 2008

Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.

Hum Mol Genet 2008 Nov 2;17(21):3281-90. Epub 2008 Aug 2.

Departments of Biochemistry and Molecular Biology and Anatomy and Developmental Biology, Monash University, Building 13C, Wellington Rd, Clayton 3168, Victoria, Australia.

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November 2008

Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells.

J Endocrinol 2008 Feb;196(2):377-84

Department of Physiology, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China.

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February 2008

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.

Hum Mol Genet 2008 Apr 7;17(7):1020-30. Epub 2008 Jan 7.

Molecular and Cellular Neuroscience Group, Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia.

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April 2008

Mitochondrial dysfunction, oxidative stress, regulation of exocytosis and their relevance to neurodegenerative diseases.

Authors:
Damien J Keating

J Neurochem 2008 Jan 25;104(2):298-305. Epub 2007 Oct 25.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, Australia.

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January 2008

Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2.

Am J Physiol Endocrinol Metab 2007 Jun 27;292(6):E1863-70. Epub 2007 Feb 27.

Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia.

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June 2007

Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1.

Ageing Res Rev 2006 Nov 26;5(4):388-401. Epub 2006 Jan 26.

Prince Henry's Institute of Medical Research, Clayton, Vic., Australia.

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November 2006

Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways.

Endocrine 2005 Nov;28(2):217-24

Department of Physiology, Fourth Military Medical University, Shannxi, China.

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November 2005

Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids.

Endocrinology 2006 Feb 27;147(2):674-82. Epub 2005 Oct 27.

Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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February 2006

Oxygen-sensing pathway for SK channels in the ovine adrenal medulla.

Clin Exp Pharmacol Physiol 2005 Oct;32(10):882-7

School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

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October 2005

Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors.

Endocrinology 2005 Nov 4;146(11):4975-84. Epub 2005 Aug 4.

Prince Henry's Institute of Medical Research, Monash University, Melbourne, Australia.

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November 2005

Activin A stimulates catecholamine secretion from rat adrenal chromaffin cells: a new physiological mechanism.

J Endocrinol 2005 Aug;186(2):R1-5

Prince Henry's Institute of Medical Research, Clayton, Australia.

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August 2005