Dr Damian Yap, MBiochem (Oxon), DIC, PhD (Imperial Coll, Lond) - University of British Columbia - Research Associate

Dr Damian Yap

MBiochem (Oxon), DIC, PhD (Imperial Coll, Lond)

University of British Columbia

Research Associate

Vancouver, BC | Canada

Main Specialties: Molecular Genetic Pathology, Oncology, Other

ORCID logohttps://orcid.org/0000-0002-5370-4592

Dr Damian Yap, MBiochem (Oxon), DIC, PhD (Imperial Coll, Lond) - University of British Columbia - Research Associate

Dr Damian Yap

MBiochem (Oxon), DIC, PhD (Imperial Coll, Lond)

Introduction

Primary Affiliation: University of British Columbia - Vancouver, BC , Canada

Specialties:

Research Interests:

Education

Oct 1997 - Dec 2000
Imperial College London
PhD Clinical Medicine Research
Oct 1993 - Jun 1997
University of Oxford
MBiochem (1:1)
Biochemistry

Experience

Jan 2002 - Dec 2005
University of British Columbia
Research Associate
Pathology and Laboratory Medicine
Jan 2001
University of Cambridge
Research Associate
Molecular Oncology
Oct 1997 - Aug 2000
Imperial College London
Graduate Student
Infectious Diseases

Publications

29Publications

1064Reads

37Profile Views

1705PubMed Central Citations

Clonal genotype and population structure inference from single-cell tumor sequencing.

Nat Methods 2016 07 16;13(7):573-6. Epub 2016 May 16.

Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nmeth.3867DOI Listing
July 2016
41 Reads
14 Citations
32.072 Impact Factor

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.

Neoplasia 2015 Aug;17(8):650-60

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674484PMC
August 2015
5 Reads
5 Citations

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Nature 2015 Feb 26;518(7539):422-6. Epub 2014 Nov 26.

1] Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada [2] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada [3] Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada [4] Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.

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http://dx.doi.org/10.1038/nature13952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864027PMC
February 2015
42 Reads
138 Citations
42.351 Impact Factor

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

Breast Cancer Res 2015 Jan 9;17. Epub 2015 Jan 9.

Department of Pathology and Laboratory Medicine, University of British Columbia, and BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada.

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http://dx.doi.org/10.1186/s13058-014-0510-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322558PMC
January 2015
46 Reads
5 Citations

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Genome Res 2014 Nov 24;24(11):1881-93. Epub 2014 Jul 24.

Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Computer Science, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada;

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http://dx.doi.org/10.1101/gr.180281.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216928PMC
November 2014
36 Reads
51 Citations
14.630 Impact Factor

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

Haematologica 2014 Sep 3;99(9):1456-64. Epub 2014 Jun 3.

Department of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Germany

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http://dx.doi.org/10.3324/haematol.2013.101386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562534PMC
September 2014
130 Reads
4 Citations
5.870 Impact Factor

Solution NMR structure and histone binding of the PHD domain of human MLL5.

PLoS One 2013 9;8(10):e77020. Epub 2013 Oct 9.

Northeast Structural Genomics Consortium and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077020PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793974PMC
June 2014
34 Reads
9 Citations
3.234 Impact Factor

PyClone: statistical inference of clonal population structure in cancer.

Nat Methods 2014 Apr 16;11(4):396-8. Epub 2014 Mar 16.

1] Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada. [2] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nmeth.2883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864026PMC
April 2014
10 Reads
151 Citations
32.072 Impact Factor

Mll5 is required for normal spermatogenesis.

PLoS One 2011 1;6(11):e27127. Epub 2011 Nov 1.

Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027127PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206077PMC
March 2012
30 Reads
14 Citations
3.234 Impact Factor

Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.

Exp Hematol 2011 Aug 27;39(8):866-79.e1. Epub 2011 May 27.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.exphem.2011.05.008DOI Listing
August 2011
11 Reads
5 Citations
2.480 Impact Factor

Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation.

Cell Cycle 2010 Apr 1;9(7):1390-8. Epub 2010 Apr 1.

Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.4161/cc.9.7.11253DOI Listing
April 2010
6 Reads
5 Citations

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

Blood 2009 Feb 14;113(7):1432-43. Epub 2008 Oct 14.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2008-06-162263DOI Listing
February 2009
11 Reads
42 Citations
10.452 Impact Factor

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

Cancer Res 2004 Jul;64(14):4749-54

Ludwig Institute for Cancer Research, St. Mary's Branch, Norfolk Place, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-1305-2DOI Listing
July 2004
4 Reads
16 Citations
9.330 Impact Factor

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.

Mol Cell Biol 2002 Jan;22(1):78-93

Ludwig Institute for Cancer Research, Imperial College School of Medicine, London W2 1PG, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134205PMC
http://dx.doi.org/10.1128/mcb.22.1.78-93.2002DOI Listing
January 2002
4 Reads
18 Citations
4.780 Impact Factor

Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation.

J Biol Chem 2000 Nov;275(47):37296-302

Ludwig Institute for Cancer Research, Imperial College of Science, Technology and Medicine at St. Mary's Campus, Norfolk Place, London, W2 1PG United Kingdom.

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http://dx.doi.org/10.1074/jbc.M004359200DOI Listing
November 2000
4.573 Impact Factor

mdm2: a bridge over the two tumour suppressors, p53 and Rb.

Oncogene 1999 Dec;18(53):7681-9

Ludwig Institute for Cancer Research, Imperial College School of Medicine, St. Mary's campus, Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1038/sj.onc.1202954DOI Listing
December 1999
8.459 Impact Factor

Ligation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells.

Authors:
S An D Yap K A Knox

Cell Immunol 1997 Nov;181(2):139-52

Department of Biochemistry, University of Oxford, UK.

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http://dx.doi.org/10.1006/cimm.1997.1211DOI Listing
November 1997
6 Reads
1.924 Impact Factor