Damian C Crowther

Damian C Crowther

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Damian C Crowther

Damian C Crowther

Publications by authors named "Damian C Crowther"

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Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting.

Adv Drug Deliv Rev 2019 Feb 22;140:129-135. Epub 2018 Sep 22.

Microphysiological Systems Center of Excellence, Drug Safety & Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X183024
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http://dx.doi.org/10.1016/j.addr.2018.09.009DOI Listing
February 2019

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a model of Alzheimer's disease.

J Biol Chem 2018 08 10;293(34):13090-13099. Epub 2018 Jun 10.

From the School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom,

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http://dx.doi.org/10.1074/jbc.RA118.003319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109938PMC
August 2018

Central and peripheral circadian clocks and their role in Alzheimer's disease.

Dis Model Mech 2017 10;10(10):1187-1199

Neuroscience, Innovative Medicines and Early Development, AstraZeneca, Granta Park, Cambridge, CB21 6GH, UK

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http://dx.doi.org/10.1242/dmm.030627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665458PMC
October 2017

CCT complex restricts neuropathogenic protein aggregation via autophagy.

Nat Commun 2016 12 8;7:13821. Epub 2016 Dec 8.

Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/ncomms13821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155164PMC
December 2016

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Epileptic Disord 2016 Sep;18(S2):103-110

Department of Genetics, University of Cambridge, UK, MedImmune Limited, Cambridge, United Kingdom.

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http://dx.doi.org/10.1684/epd.2016.0847DOI Listing
September 2016

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.

Sci Rep 2016 Sep 23;6:33759. Epub 2016 Sep 23.

University of Cambridge, Department of Genetics, Downing Site, Cambridge, CB2 3EH, United Kingdom.

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http://dx.doi.org/10.1038/srep33759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034315PMC
September 2016

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems.

Free Radic Biol Med 2016 07 14;96:57-66. Epub 2016 Apr 14.

INSERM UMR 1141 and Université Paris 7, Faculté de Médecine Denis Diderot, Hôpital Robert Debré, 48, Boulevard Sérurier, 75019 Paris, France.

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.006DOI Listing
July 2016

Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity.

Neurobiol Aging 2016 May 11;41:39-52. Epub 2016 Feb 11.

Department of Genetics, University of Cambridge, Cambridge, UK; Neuroscience IMED, MedImmune Limited, Granta Park, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869574PMC
May 2016

Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease.

Methods Mol Biol 2016 ;1303:227-39

Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.

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http://dx.doi.org/10.1007/978-1-4939-2627-5_13DOI Listing
April 2016

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

PLoS One 2014 31;9(7):e102985. Epub 2014 Jul 31.

Department of Genetics, University of Cambridge, Cambridge, United Kingdom; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102985PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117641PMC
October 2015

The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ.

Hum Mol Genet 2015 Jul 7;24(14):3929-38. Epub 2015 May 7.

Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, MedImmune Limited, Aaron Klug Building, Granta Park, Cambridge CB21 6GH, UK

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http://dx.doi.org/10.1093/hmg/ddv130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476443PMC
July 2015

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model.

Dis Model Mech 2015 Jul 23;8(7):657-67. Epub 2015 Apr 23.

Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK MedImmune Limited, Aaron Klug Building, Granta Park, Cambridge CB21 6GH, UK

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.019042
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http://dx.doi.org/10.1242/dmm.019042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486857PMC
July 2015

Insights into amyloid disease from fly models.

Essays Biochem 2014 ;56:69-83

University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, U.K.

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http://dx.doi.org/10.1042/bse0560069DOI Listing
May 2015

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.

Dis Model Mech 2014 Apr 26;7(4):445-58. Epub 2014 Feb 26.

Department of Genetics, Downing Site, Cambridge, CB2 3EH, UK.

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http://dx.doi.org/10.1242/dmm.014134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974455PMC
April 2014

Retro-inversal of intracellular selected β-amyloid-interacting peptides: implications for a novel Alzheimer's disease treatment.

Biochemistry 2014 Apr 21;53(13):2101-11. Epub 2014 Mar 21.

School of Biological Sciences, University of Essex , Wivenhoe Park, Colchester CO4 3SQ, U.K.

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http://dx.doi.org/10.1021/bi5001257DOI Listing
April 2014

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.

Biochim Biophys Acta 2013 Dec 2;1832(12):2115-26. Epub 2013 Aug 2.

Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

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http://dx.doi.org/10.1016/j.bbadis.2013.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898073PMC
December 2013

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

Hum Mol Genet 2013 Nov 28;22(22):4616-26. Epub 2013 Jun 28.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/hmg/ddt310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889810PMC
November 2013

p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.

J Biol Chem 2013 Mar 22;288(11):7606-17. Epub 2013 Jan 22.

Department of Medicine and Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M112.424655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597802PMC
March 2013

Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development.

J Cell Sci 2013 Mar 15;126(Pt 6):1406-15. Epub 2013 Feb 15.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.117614
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http://dx.doi.org/10.1242/jcs.117614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644141PMC
March 2013

Endoplasmic reticulum dysfunction in neurological disease.

Lancet Neurol 2013 Jan;12(1):105-18

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S1474-4422(12)70238-7DOI Listing
January 2013

Functional genomics in Drosophila models of human disease.

Brief Funct Genomics 2012 Sep 22;11(5):405-15. Epub 2012 Aug 22.

Department of Genetics, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1093/bfgp/els038DOI Listing
September 2012

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.

Biochem J 2012 Jun;444(3):487-95

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, U.K.

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http://dx.doi.org/10.1042/BJ20112141DOI Listing
June 2012

Prion-induced toxicity in PrP transgenic Drosophila.

Exp Mol Pathol 2012 Apr 31;92(2):194-201. Epub 2012 Jan 31.

University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES, UK.

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http://dx.doi.org/10.1016/j.yexmp.2012.01.005DOI Listing
April 2012

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.

J Biol Chem 2011 Dec 13;286(48):41647-55. Epub 2011 Oct 13.

Molecular Neurobiology Unit, Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.

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http://dx.doi.org/10.1074/jbc.M111.274548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308874PMC
December 2011

Unravelling the twists and turns of the serpinopathies.

FEBS J 2011 Oct 20;278(20):3859-67. Epub 2011 Jun 20.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08201.xDOI Listing
October 2011

Modeling serpin conformational diseases in Drosophila melanogaster.

Methods Enzymol 2011 ;499:227-58

Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-386471-0.00012-2DOI Listing
October 2011

Using a Drosophila model of Alzheimer's disease.

SEB Exp Biol Ser 2008 ;60:57-77

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, UK.

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July 2011

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease.

J Neurosci Methods 2011 Apr 18;197(1):186-9. Epub 2011 Feb 18.

Department of Genetics, University of Cambridge, UK; Department of Chemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1016/j.jneumeth.2011.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712187PMC
April 2011

Characterisation of serpin polymers in vitro and in vivo.

Methods 2011 Mar 27;53(3):255-66. Epub 2010 Nov 27.

Dept. of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.ymeth.2010.11.008DOI Listing
March 2011

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.

J Biol Chem 2011 Feb 8;286(6):4248-56. Epub 2010 Dec 8.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 0XY, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.158980
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http://dx.doi.org/10.1074/jbc.M110.158980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039358PMC
February 2011

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.

J Cell Sci 2010 Sep 3;123(Pt 17):2892-900. Epub 2010 Aug 3.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1242/jcs.070078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923568PMC
September 2010

Alzheimer's disease: insights from Drosophila melanogaster models.

Trends Biochem Sci 2010 Apr 25;35(4):228-35. Epub 2009 Dec 25.

MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX13QX.

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http://dx.doi.org/10.1016/j.tibs.2009.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856915PMC
April 2010

Methods and models in neurodegenerative and systemic protein aggregation diseases.

Front Biosci (Landmark Ed) 2010 Jan 1;15:373-96. Epub 2010 Jan 1.

Molecular Biotechnology/IFM, Linkoping University, SE-581 83, Linkoping, Sweden.

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January 2010

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.

J Biol Chem 2009 Aug 23;284(34):22793-802. Epub 2009 Jun 23.

Department of Medicine, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.027102
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http://dx.doi.org/10.1074/jbc.M109.027102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755687PMC
August 2009

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

Hum Mol Genet 2008 Jun 11;17(11):1527-39. Epub 2008 Feb 11.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/hmg/ddn041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387220PMC
June 2008

Protein misfolding and disease: from the test tube to the organism.

Curr Opin Chem Biol 2008 Feb 18;12(1):25-31. Epub 2008 Mar 18.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://dx.doi.org/10.1016/j.cbpa.2008.02.011DOI Listing
February 2008

A Drosophila model of Alzheimer's disease.

Methods Enzymol 2006 ;412:234-55

Department of Medicine, University of Cambridge, CIMR Wellcome Trust, Cambridge, United Kingdom CB2 2XY.

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http://dx.doi.org/10.1016/S0076-6879(06)12015-7DOI Listing
November 2006

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.

J Biol Chem 2006 Sep 17;281(39):29268-77. Epub 2006 Jul 17.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M600690200DOI Listing
September 2006

Therapeutic targets from a Drosophila model of Alzheimer's disease.

Curr Opin Pharmacol 2004 Oct;4(5):513-6

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1016/j.coph.2004.07.001DOI Listing
October 2004

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.

Front Biosci 2004 Sep 1;9:2873-91. Epub 2004 Sep 1.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom.

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http://dx.doi.org/10.2741/1444DOI Listing
September 2004

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.

Eur J Biochem 2004 Aug;271(16):3360-7

Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, UK.

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http://dx.doi.org/10.1111/j.1432-1033.2004.04270.xDOI Listing
August 2004

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.

Eur J Hum Genet 2004 Mar;12(3):167-72

1Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5201127DOI Listing
March 2004

Nucleation of alpha 1-antichymotrypsin polymerization.

Biochemistry 2003 Mar;42(8):2355-63

Neurology Unit, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, United Kingdom.

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http://dx.doi.org/10.1021/bi0259305DOI Listing
March 2003

Familial conformational diseases and dementias.

Hum Mutat 2002 Jul;20(1):1-14

University of Cambridge Neurology Unit, Cambridge Institute for Medical Research, Cambridge, UK.

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http://dx.doi.org/10.1002/humu.10100DOI Listing
July 2002

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.

J Biol Chem 2002 May 5;277(19):17367-73. Epub 2002 Mar 5.

Respiratory Medicine Unit and Neurology Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M200680200DOI Listing
May 2002