Publications by authors named "Dalia Barsyte-Lovejoy"

71Publications

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.

J Med Chem 2020 05 14;63(10):5477-5487. Epub 2020 May 14.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286362PMC
May 2020

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.

Elife 2020 Apr 16;9. Epub 2020 Apr 16.

Institut de Recherche en Immunologie et Cancérologie (IRIC), Département de biologie moléculaire, Faculté de Médecine, Université de Montréal, Montréal, Canada.

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http://dx.doi.org/10.7554/eLife.47333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192583PMC
April 2020

SETD7 at the heart of chromatin factor interplay.

Stem Cell Investig 2019 1;6:20. Epub 2019 Aug 1.

Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.21037/sci.2019.06.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737390PMC
August 2019

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer Cell 2019 08;36(2):194-209.e9

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194031PMC
August 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).

J Med Chem 2019 10 24;62(20):8996-9007. Epub 2019 Jul 24.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00522DOI Listing
October 2019

Targeting protein methylation: from chemical tools to precision medicines.

Cell Mol Life Sci 2019 Aug 18;76(15):2967-2985. Epub 2019 May 18.

Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1007/s00018-019-03147-9DOI Listing
August 2019

Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion.

Front Endocrinol (Lausanne) 2019 1;10:22. Epub 2019 Feb 1.

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fendo.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367273PMC
February 2019

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

Exp Hematol 2019 01 22;69:27-36. Epub 2018 Oct 22.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X183086
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http://dx.doi.org/10.1016/j.exphem.2018.10.006DOI Listing
January 2019

Targeting human SET1/MLL family of proteins.

Protein Sci 2017 04 6;26(4):662-676. Epub 2017 Mar 6.

Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7.

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http://dx.doi.org/10.1002/pro.3129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368065PMC
April 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.

J Proteome Res 2016 06 10;15(6):2052-9. Epub 2016 May 10.

Structural Genomics Consortium, University of Toronto , 101 College Street, MaRS Centre, South Tower, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1021/acs.jproteome.6b00220DOI Listing
June 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer Cell 2015 Dec 25;28(6):715-729. Epub 2015 Nov 25.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00382-7.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500382
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http://dx.doi.org/10.1016/j.ccell.2015.10.005DOI Listing
December 2015

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

ACS Chem Biol 2016 Mar 8;11(3):772-781. Epub 2015 Dec 8.

Departments of Structural and Chemical Biology, Oncological Sciences, and Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acschembio.5b00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798913PMC
March 2016

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.

Nature 2015 Sep 2;525(7568):206-11. Epub 2015 Sep 2.

Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature15251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568559PMC
September 2015

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

ACS Med Chem Lett 2015 Apr 2;6(4):408-12. Epub 2015 Mar 2.

Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada ; The Department of Pharmacology and Toxicology, University of Toronto , Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1021/ml500467hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394339PMC
April 2015

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

ChemMedChem 2014 Mar 17;9(3):549-53. Epub 2014 Jan 17.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/cmdc.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005005PMC
March 2014

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

J Med Chem 2013 Nov 31;56(21):8931-42. Epub 2013 Oct 31.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, ‡National Institute of Mental Health Psychoactive Drug Screening Program, §Department of Pharmacology, School of Medicine, and ∥Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/jm401480rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880643PMC
November 2013

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

ACS Chem Biol 2013 24;8(6):1324-34. Epub 2013 Apr 24.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, §Department of Biochemistry and Biophysics, School of Medicine, ∥Department of Pharmacology, School of Medicine, ⊥National Institute of Mental Health Psychoactive Drug Screening Program, and ¶Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/cb400133jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773059PMC
August 2014

Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction.

Prog Biophys Mol Biol 2013 Dec 14;113(3):375-86. Epub 2013 Mar 14.

Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON M5S 3G5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2013.02.002DOI Listing
December 2013

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.

Nat Chem Biol 2013 Mar 6;9(3):184-91. Epub 2013 Jan 6.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.1157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577944PMC
March 2013

C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.

Mol Cell Neurosci 2013 Jan 28;52:38-50. Epub 2012 Sep 28.

Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada M5S 3G5.

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http://dx.doi.org/10.1016/j.mcn.2012.09.006DOI Listing
January 2013

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.

Nat Struct Mol Biol 2012 Nov 30;19(11):1155-60. Epub 2012 Sep 30.

Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://www.nature.com/articles/nsmb.2391
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http://dx.doi.org/10.1038/nsmb.2391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492551PMC
November 2012

Histone recognition and large-scale structural analysis of the human bromodomain family.

Cell 2012 Mar;149(1):214-31

Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.1016/j.cell.2012.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326523PMC
March 2012

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

J Med Chem 2011 Sep 5;54(17):6139-50. Epub 2011 Aug 5.

Center for Integrative Chemical Biology and Drug Discovery, Division of Medicinal Chemistry and Natural Products, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/jm200903zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171737PMC
September 2011

Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family.

Gen Comp Endocrinol 2010 Jan 29;165(2):330-6. Epub 2009 Jul 29.

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.ygcen.2009.07.013DOI Listing
January 2010

CUL7 is a novel antiapoptotic oncogene.

Cancer Res 2007 Oct;67(20):9616-22

Division of Cancer Genomics, Ontario Cancer Institute and Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0644DOI Listing
October 2007

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.

Proc Natl Acad Sci U S A 2007 Jul 28;104(28):11754-9. Epub 2007 Jun 28.

Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1073/pnas.0703040104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913903PMC
July 2007

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis.

Cancer Res 2006 May;66(10):5330-7

Division of Cancer Genomics and Proteomics, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0037DOI Listing
May 2006

Cancer therapeutics: targeting the dark side of Myc.

Eur J Cancer 2005 Nov 20;41(16):2485-501. Epub 2005 Oct 20.

Ontario Cancer Institute/Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ont., Canada M5G 2M9.

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http://dx.doi.org/10.1016/j.ejca.2005.08.017DOI Listing
November 2005

Promoter-binding and repression of PDGFRB by c-Myc are separable activities.

Nucleic Acids Res 2004 29;32(11):3462-8. Epub 2004 Jun 29.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1093/nar/gkh669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC443544PMC
July 2004

ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif.

Biochem J 2004 Aug;381(Pt 3):693-9

School of Biological Sciences, University of Manchester, Michael Smith building, Oxford Road, Manchester, M13 9PT, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20031940
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http://dx.doi.org/10.1042/BJ20031940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133878PMC
August 2004

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism.

Oncogene 2004 Apr;23(19):3481-6

Division of Cellular and Molecular Biology, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2M9.

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http://www.nature.com/articles/1207487
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http://dx.doi.org/10.1038/sj.onc.1207487DOI Listing
April 2004

Specificity determinants in MAPK signaling to transcription factors.

J Biol Chem 2002 Mar 10;277(12):9896-903. Epub 2002 Jan 10.

School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M108145200DOI Listing
March 2002