Dale W Laird

Dale W Laird

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Dale W Laird

Publications by authors named "Dale W Laird"

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Dynamic regulation of connexins in stem cell pluripotency.

Stem Cells 2020 Jan 24;38(1):52-66. Epub 2019 Oct 24.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/stem.3092DOI Listing
January 2020

Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line.

Cells 2020 Jan 3;9(1). Epub 2020 Jan 3.

Equipe 4CS, Laboratoire Signalisation et Transports Ioniques Membranaires (STIM), CNRS ERL 7003, Pôle Biologie Santé, University of Poitiers, 86073 Poitiers, France.

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http://dx.doi.org/10.3390/cells9010117DOI Listing
January 2020

Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.

Biomolecules 2019 09 11;9(9). Epub 2019 Sep 11.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.3390/biom9090474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770901PMC
September 2019

Destination and consequences of Panx1 and mutant expression in polarized MDCK cells.

Exp Cell Res 2019 Aug 16;381(2):235-247. Epub 2019 May 16.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A-5C1, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, N6A-5C1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.05.016DOI Listing
August 2019

The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss.

J Cell Sci 2019 01 16;132(2). Epub 2019 Jan 16.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada

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http://dx.doi.org/10.1242/jcs.224097DOI Listing
January 2019

Therapeutic strategies targeting connexins.

Nat Rev Drug Discov 2018 12 12;17(12):905-921. Epub 2018 Oct 12.

Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1038/nrd.2018.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461534PMC
December 2018

Connexins and Disease.

Cold Spring Harb Perspect Biol 2018 09 4;10(9). Epub 2018 Sep 4.

Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11790.

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http://dx.doi.org/10.1101/cshperspect.a029348DOI Listing
September 2018

Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss.

J Cell Sci 2018 05 4;131(9). Epub 2018 May 4.

University of Western Ontario, Department of Anatomy and Cell Biology, London, Ontario, Canada, N6A 5C1

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http://dx.doi.org/10.1242/jcs.214635DOI Listing
May 2018

An update on minding the gap in cancer.

Biochim Biophys Acta Biomembr 2018 Jan 24;1860(1):237-243. Epub 2017 Jun 24.

Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.06.015DOI Listing
January 2018

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Pharmacol Rev 2017 10;69(4):396-478

Physiology Group, Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (L.L.); Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington (P.D.L.); Institute for Pharmacology, University of Leipzig, Leipzig, Germany (S.D.); Department of Pathology and Immunology, Department of Medical Specialization-Cardiology, University of Geneva, Geneva, Switzerland (B.R.K.); Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary (P.F.); Pharmahungary Group, Szeged, Hungary (P.F.); Department of Pediatrics, University of Chicago, Chicago, Illinois (E.C.B.); Department of Anatomy and Cell Biology, University of Western Ontario, Dental Science Building, London, Ontario, Canada (D.W.L.); Cellular and Physiological Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada (C.C.N.); Department of Ophthalmology and The New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand (C.R.G.); and Physiologisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany (R.S.).

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http://dx.doi.org/10.1124/pr.115.012062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612248PMC
October 2017

Critical Role of Cx40 in Reduced Endothelial Electrical Coupling by Lipopolysaccharide and Hypoxia-Reoxygenation.

J Vasc Res 2015 19;52(6):396-403. Epub 2016 May 19.

Lawson Health Research Institute, Critical Illness Research, London, Ont., Canada.

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http://dx.doi.org/10.1159/000445772DOI Listing
September 2017

SnapShot: Connexins and Disease.

Cell 2017 Sep;170(6):1260-1260.e1

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.cell.2017.08.034DOI Listing
September 2017

Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential.

J Bone Miner Res 2017 Jun 5;32(6):1368-1385. Epub 2017 Apr 5.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario. London, ON, Canada.

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http://doi.wiley.com/10.1002/jbmr.3098
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http://dx.doi.org/10.1002/jbmr.3098DOI Listing
June 2017

Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss.

J Biol Chem 2017 06 20;292(23):9721-9732. Epub 2017 Apr 20.

Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada

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http://dx.doi.org/10.1074/jbc.M116.770917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465495PMC
June 2017

Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

Cell Death Dis 2017 06 1;8(6):e2845. Epub 2017 Jun 1.

Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1038/cddis.2017.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520893PMC
June 2017

Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis.

PLoS One 2016 21;11(4):e0154162. Epub 2016 Apr 21.

Department of Physiology and Pharmacology, University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 5C1, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154162PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839729PMC
April 2017

Aberrant Cx43 Expression and Mislocalization in Metastatic Human Melanomas.

J Cancer 2017 9;8(7):1123-1128. Epub 2017 Apr 9.

Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.7150/jca.18569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463425PMC
April 2017

Next-Generation Connexin and Pannexin Cell Biology.

Trends Cell Biol 2016 12 21;26(12):944-955. Epub 2016 Jun 21.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.06.003DOI Listing
December 2016

Connexin Hemichannels: Methods for Dye Uptake and Leakage.

J Membr Biol 2016 12 1;249(6):713-741. Epub 2016 Sep 1.

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/s00232-016-9925-yDOI Listing
December 2016

Differential effects of pannexins on noise-induced hearing loss.

Biochem J 2016 12 26;473(24):4665-4680. Epub 2016 Oct 26.

Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1042/BCJ20160668DOI Listing
December 2016

Gap junctions and cancer: communicating for 50 years.

Nat Rev Cancer 2016 12 21;16(12):775-788. Epub 2016 Oct 21.

Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1038/nrc.2016.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279857PMC
December 2016

Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia.

Mol Biol Cell 2016 07 25;27(14):2172-85. Epub 2016 May 25.

Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada

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http://dx.doi.org/10.1091/mbc.E16-01-0062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945137PMC
July 2016

A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction.

J Biol Chem 2016 Jun 15;291(24):12432-43. Epub 2016 Apr 15.

From the Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada,

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http://dx.doi.org/10.1074/jbc.M116.717934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933456PMC
June 2016

Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora.

J Anat 2016 May 7;228(5):746-56. Epub 2016 Jan 7.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1111/joa.12437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831336PMC
May 2016

Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone.

BMC Cell Biol 2016 May 24;17 Suppl 1:19. Epub 2016 May 24.

INSERM U1026, Tissue Bioengineering, Université Bordeaux, Bordeaux, F-33076, France.

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http://dx.doi.org/10.1186/s12860-016-0088-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896274PMC
May 2016

Connexins in skeletal muscle development and disease.

Semin Cell Dev Biol 2016 Feb 10;50:67-73. Epub 2015 Dec 10.

Department Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5C1. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.12.001DOI Listing
February 2016

Gerald M. Kidder - bridging the gap in cell and developmental biology.

Semin Cell Dev Biol 2016 Feb;50:1-3

Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1016/j.semcdb.2016.02.017DOI Listing
February 2016

Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients.

Biochem J 2015 Nov 8;472(1):55-69. Epub 2015 Sep 8.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, N6A-5C1

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http://dx.doi.org/10.1042/BJ20150652DOI Listing
November 2015

Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions.

J Cell Sci 2015 Nov 10;128(21):3947-60. Epub 2015 Sep 10.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A-5C1 Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A-5C1

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http://jcs.biologists.org/content/joces/128/21/3947.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.174698
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http://dx.doi.org/10.1242/jcs.174698DOI Listing
November 2015

Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

Oncotarget 2015 Nov;6(35):37185-99

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.5953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741923PMC
November 2015

Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function.

PLoS One 2014 2;9(7):e101546. Epub 2014 Jul 2.

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101546PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079510PMC
October 2015

Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.

J Mol Med (Berl) 2015 Aug 4;93(8):845-56. Epub 2015 Jul 4.

Departments of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1007/s00109-015-1311-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703322PMC
August 2015

Mechanisms linking connexin mutations to human diseases.

Cell Tissue Res 2015 Jun 16;360(3):701-21. Epub 2014 Nov 16.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A-5C1, Canada.

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http://dx.doi.org/10.1007/s00441-014-2024-4DOI Listing
June 2015

Insights into the role of connexins in mammary gland morphogenesis and function.

Reproduction 2015 Jun 19;149(6):R279-90. Epub 2015 Mar 19.

Departments of Physiology and PharmacologyAnatomy and Cell BiologyUniversity of Western Ontario, London, Ontario, Canada N6A 5C1 Departments of Physiology and PharmacologyAnatomy and Cell BiologyUniversity of Western Ontario, London, Ontario, Canada N6A 5C1

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http://dx.doi.org/10.1530/REP-14-0661DOI Listing
June 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

CELLULAR SMALL TALK.

Sci Am 2015 May;312(5):70-7

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http://dx.doi.org/10.1038/scientificamerican0515-70DOI Listing
May 2015

Diverse post-translational modifications of the pannexin family of channel-forming proteins.

Channels (Austin) 2014 13;8(2):124-30. Epub 2014 Jan 13.

Department of Anatomy and Cell Biology; University of Western Ontario; London, ON Canada.

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http://dx.doi.org/10.4161/chan.27422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048301PMC
January 2015

Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation.

Int J Biochem Cell Biol 2014 Oct 28;55:288-97. Epub 2014 Sep 28.

Lady Davis Institute and Segal Cancer Center of the Sir Mortimer B. Davis Jewish General Hospital, Department of Medicine and Oncology, McGill University, Montreal, QC, Canada H3T 1E2. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725140030
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http://dx.doi.org/10.1016/j.biocel.2014.09.021DOI Listing
October 2014

Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.

J Biol Chem 2014 Sep 11;289(39):27246-63. Epub 2014 Aug 11.

Pharmacology, From the Departments of Physiology and Biophysics and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 and

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http://dx.doi.org/10.1074/jbc.M114.590240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175357PMC
September 2014

Pannexin channels and their links to human disease.

Biochem J 2014 Aug;461(3):371-81

*Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada, N6A 5C1.

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http://dx.doi.org/10.1042/BJ20140447DOI Listing
August 2014

Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing.

J Invest Dermatol 2014 Jul 12;134(7):2026-2035. Epub 2014 Feb 12.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada; Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1038/jid.2014.86DOI Listing
July 2014

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels.

Dis Model Mech 2014 May 13;7(5):561-9. Epub 2014 Mar 13.

Department of Physiology and Pharmacology, The University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1242/dmm.013813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007407PMC
May 2014

Syndromic and non-syndromic disease-linked Cx43 mutations.

Authors:
Dale W Laird

FEBS Lett 2014 Apr 14;588(8):1339-48. Epub 2014 Jan 14.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2013.12.022DOI Listing
April 2014

Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologies.

J Cell Sci 2014 Apr 12;127(Pt 8):1751-64. Epub 2014 Feb 12.

Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1242/jcs.138230DOI Listing
April 2014

Myogenic bladder defects in mouse models of human oculodentodigital dysplasia.

Biochem J 2014 Feb;457(3):441-9

‡Division of Cardiology, New York University School of Medicine, New York, NY 10016, U.S.A.

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http://dx.doi.org/10.1042/BJ20130810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457304PMC
February 2014

Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo.

J Biol Chem 2014 Jan 2;289(3):1592-603. Epub 2013 Dec 2.

From the Departments of Anatomy and Cell Biology and.

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http://dx.doi.org/10.1074/jbc.M113.507228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894339PMC
January 2014

Autosomal recessive GJA1 (Cx43) gene mutations cause oculodentodigital dysplasia by distinct mechanisms.

J Cell Sci 2013 Jul 19;126(Pt 13):2857-66. Epub 2013 Apr 19.

Department of Anatomy and Cell Biology, University of Western Ontario, London ON N6A-5C1, Canada.

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http://dx.doi.org/10.1242/jcs.123315DOI Listing
July 2013

Gap junction remodeling in skin repair following wounding and disease.

Physiology (Bethesda) 2013 May;28(3):190-8

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1152/physiol.00058.2012DOI Listing
May 2013

The biochemistry and function of pannexin channels.

Biochim Biophys Acta 2013 Jan 28;1828(1):15-22. Epub 2012 Jan 28.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbamem.2012.01.017DOI Listing
January 2013

Expression of pannexin isoforms in the systemic murine arterial network.

J Vasc Res 2012 26;49(5):405-16. Epub 2012 Jun 26.

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1159/000338758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482510PMC
October 2012

Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia.

Mol Biol Cell 2012 Sep 18;23(17):3312-21. Epub 2012 Jul 18.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1091/mbc.E12-02-0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431933PMC
September 2012

Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype.

J Biol Chem 2012 Aug 29;287(34):29184-93. Epub 2012 Jun 29.

Department of Anatomy and Cell BiologyUniversity of Western Ontario, London, Ontario N6A-5C1, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436541PMC
August 2012

The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation.

Exp Dermatol 2012 Aug;21(8):612-8

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1111/j.1600-0625.2012.01532.xDOI Listing
August 2012

Pannexin1 and Pannexin3 exhibit distinct localization patterns in human skin appendages and are regulated during keratinocyte differentiation and carcinogenesis.

Cell Commun Adhes 2012 Aug 4;19(3-4):45-53. Epub 2012 Sep 4.

Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.3109/15419061.2012.712575DOI Listing
August 2012

Introductory paper of the special issue on gap junctions in honor of Ross Johnson.

J Membr Biol 2012 Jun;245(5-6):217-9

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800, Box 19024, Seattle, WA 98109, USA.

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http://link.springer.com/10.1007/s00232-012-9486-7
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June 2012

The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells.

Graefes Arch Clin Exp Ophthalmol 2012 Apr 3;250(4):515-22. Epub 2011 Dec 3.

Department of Ophthalmology, University of Western Ontario, Ivey Eye Institute, St. Joseph's Hospital, 268 Grosvenor Street, London, ON, Canada.

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http://link.springer.com/10.1007/s00417-011-1871-x
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April 2012

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes.

J Bone Miner Res 2011 Dec;26(12):2911-22

Department of Cellular and Physiological Science, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/jbmr.509DOI Listing
December 2011

The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia.

J Invest Dermatol 2011 Nov 30;131(11):2197-204. Epub 2011 Jun 30.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1038/jid.2011.183DOI Listing
November 2011

Pannexin channels are not gap junction hemichannels.

Channels (Austin) 2011 May-Jun;5(3):193-7. Epub 2011 May 1.

National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/chan.5.3.15765DOI Listing
October 2011

Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain.

J Biol Chem 2011 Aug 9;286(31):27639-53. Epub 2011 Jun 9.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/jbc.M111.260711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149355PMC
August 2011

Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.

J Biol Chem 2011 Jul 23;286(30):26277-86. Epub 2011 May 23.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M111.260562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143590PMC
July 2011

Evaluation of mammary gland development and function in mouse models.

J Vis Exp 2011 Jul 21(53). Epub 2011 Jul 21.

Department of Anatomy and Cell Biology, University of Western Ontario.

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http://dx.doi.org/10.3791/2828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196158PMC
July 2011

Ocular pathology relevant to glaucoma in a Gja1(Jrt/+) mouse model of human oculodentodigital dysplasia.

Invest Ophthalmol Vis Sci 2011 Jun 1;52(6):3539-47. Epub 2011 Jun 1.

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1167/iovs.10-6399DOI Listing
June 2011

Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.

Mol Reprod Dev 2011 Feb;78(2):124-38

INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada.

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http://dx.doi.org/10.1002/mrd.21280DOI Listing
February 2011

Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40.

Free Radic Biol Med 2010 Sep 9;49(6):1008-13. Epub 2010 Jun 9.

Lawson Health Research Institute, Critical Illness Research, London, ON, Canada.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.06.005DOI Listing
September 2010

Implications and challenges of connexin connections to cancer.

Nat Rev Cancer 2010 06;10(6):435-41

Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T-1Z3, Canada.

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http://dx.doi.org/10.1038/nrc2841DOI Listing
June 2010

Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged.

Biol Reprod 2010 May 20;82(5):837-47. Epub 2010 Jan 20.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.109.081406DOI Listing
May 2010

The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.

Cancer Res 2010 May 20;70(10):4222-32. Epub 2010 Apr 20.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3281DOI Listing
May 2010

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.

J Cell Sci 2010 Apr 23;123(Pt 8):1363-72. Epub 2010 Mar 23.

Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1242/jcs.056093DOI Listing
April 2010

Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.

J Biol Chem 2010 Mar 10;285(12):9147-60. Epub 2010 Jan 10.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.082008
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838334PMC
March 2010

The gap junction proteome and its relationship to disease.

Authors:
Dale W Laird

Trends Cell Biol 2010 Feb 26;20(2):92-101. Epub 2009 Nov 26.

Department of Anatomy and Cell Biology, and Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1016/j.tcb.2009.11.001DOI Listing
February 2010

Optical and biochemical dissection of connexin and disease-linked connexin mutants in 3D organotypic epidermis.

Methods Mol Biol 2010 ;585:313-34

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.

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January 2010

Glycosylation regulates pannexin intermixing and cellular localization.

Mol Biol Cell 2009 Oct 19;20(20):4313-23. Epub 2009 Aug 19.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1091/mbc.e09-01-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762227PMC
October 2009

Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia.

Dis Model Mech 2009 Mar-Apr;2(3-4):157-67. Epub 2009 Feb 23.

Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.000935
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650217PMC
August 2009

A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse.

Biol Reprod 2009 Jun 28;80(6):1099-106. Epub 2009 Jan 28.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.108.071969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849809PMC
June 2009

Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques.

J Cell Sci 2009 Feb 27;122(Pt 4):554-62. Epub 2009 Jan 27.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1242/jcs.036970DOI Listing
February 2009

Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

Cardiovasc Res 2008 Dec 4;80(3):385-95. Epub 2008 Aug 4.

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1093/cvr/cvn203DOI Listing
December 2008

ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation.

J Bone Miner Res 2008 Jun;23(6):928-38

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1359/jbmr.080217DOI Listing
June 2008

Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia.

Dev Biol 2008 Jun 8;318(2):312-22. Epub 2008 Apr 8.

Department of Anatomy and Cell Biology, Dental Science Building, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ydbio.2008.03.033DOI Listing
June 2008

Diverse subcellular distribution profiles of pannexin 1 and pannexin 3.

Cell Commun Adhes 2008 May;15(1):133-42

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1080/15419060802014115DOI Listing
May 2008

Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes.

Mol Biol Cell 2008 Mar 27;19(3):912-28. Epub 2007 Dec 27.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://www.molbiolcell.org/doi/10.1091/mbc.e07-06-0596
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262971PMC
March 2008

Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression.

Proc Natl Acad Sci U S A 2008 Mar 12;105(12):4763-8. Epub 2008 Mar 12.

Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226-8501, Japan.

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http://dx.doi.org/10.1073/pnas.0708451105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290751PMC
March 2008

Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease.

Authors:
Dale W Laird

J Biol Chem 2008 Feb 18;283(6):2997-3001. Epub 2007 Dec 18.

Departments of Anatomy & Cell Biology and Physiology & Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/jbc.R700041200DOI Listing
February 2008

The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress.

Invest Ophthalmol Vis Sci 2008 Feb;49(2):800-6

Department of Ophthalmology, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1167/iovs.07-0717DOI Listing
February 2008

Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins.

J Cell Sci 2007 Nov 9;120(Pt 21):3772-83. Epub 2007 Oct 9.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A 5C1, Canada.

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http://dx.doi.org/10.1242/jcs.009514DOI Listing
November 2007

Connexin levels regulate keratinocyte differentiation in the epidermis.

J Biol Chem 2007 Oct 10;282(41):30171-80. Epub 2007 Aug 10.

Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, N6A 5C1, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M703623200
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October 2007

Connexins and gap junctions in mammary gland development and breast cancer progression.

J Membr Biol 2007 Aug 28;218(1-3):107-21. Epub 2007 Jul 28.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1007/s00232-007-9052-xDOI Listing
August 2007

Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia.

J Biol Chem 2007 Jun 9;282(26):19190-202. Epub 2007 Apr 9.

Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/jbc.M609653200DOI Listing
June 2007

Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26.

J Membr Biol 2007 Jun 20;217(1-3):93-104. Epub 2007 Jul 20.

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada.

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June 2007