Dale J Kempf

Dale J Kempf

UNVERIFIED PROFILE

Are you Dale J Kempf?   Register this Author

Register author
Dale J Kempf

Dale J Kempf

Publications by authors named "Dale J Kempf"

Are you Dale J Kempf?   Register this Author

69Publications

1778Reads

23Profile Views

Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.

Acta Crystallogr F Struct Biol Commun 2017 03 21;73(Pt 3):116-122. Epub 2017 Feb 21.

AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X17001601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349304PMC
March 2017

P1-substituted symmetry-based human immunodeficiency virus protease inhibitors with potent antiviral activity against drug-resistant viruses.

J Med Chem 2011 Oct 21;54(20):7094-104. Epub 2011 Sep 21.

Antiviral Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm201109t
Publisher Site
http://dx.doi.org/10.1021/jm201109tDOI Listing
October 2011

Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.

Bioorg Med Chem Lett 2011 Mar 13;21(6):1876-9. Epub 2011 Jan 13.

Department of Antiviral Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2010.12.067DOI Listing
March 2011

Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease.

Antimicrob Agents Chemother 2010 Nov 30;54(11):4903-6. Epub 2010 Aug 30.

Abbott Molecular, 1300 East Touhy Avenue, Des Plaines, IL 60018-3315, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00906-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976162PMC
November 2010

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia.

Arch Toxicol 2010 Apr 6;84(4):263-70. Epub 2010 Mar 6.

Abbott Laboratories Global Pharmaceuticals Research and Development, 100 Abbott Park Rd, Abbott Park, IL 60064-6123, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00204-010-0527-7DOI Listing
April 2010

Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.

J Med Chem 2009 Dec;52(23):7604-17

Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm9005115DOI Listing
December 2009

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.

Bioorg Med Chem Lett 2009 Sep 30;19(18):5444-8. Epub 2009 Jul 30.

Abbott Laboratories, Departments of Antiviral Research (D-R4CQ), Building AP-52, 200 Abbott Park Road, Abbott Park, IL 60064-3537, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.07.118DOI Listing
September 2009

Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir.

J Med Chem 2009 May;52(9):2964-70

Antiviral Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm900080gDOI Listing
May 2009

Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.

Antimicrob Agents Chemother 2008 Apr 22;52(4):1337-44. Epub 2008 Jan 22.

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01132-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292532PMC
April 2008

Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.

Bioorg Med Chem Lett 2008 Apr 4;18(8):2735-8. Epub 2008 Mar 4.

Antiviral Research, Global Pharmaceutical Research, and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.02.064DOI Listing
April 2008

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor.

Bioorg Med Chem Lett 2008 Apr 26;18(8):2745-50. Epub 2008 Feb 26.

Global Pharmaceutical Research and Development, Antiviral Research, 200 Abbott Park Road, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.02.053DOI Listing
April 2008

A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.

Drug Metab Dispos 2008 Mar 20;36(3):500-7. Epub 2007 Dec 20.

Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064-6104, USA.

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.107.019547
Publisher Site
http://dx.doi.org/10.1124/dmd.107.019547DOI Listing
March 2008

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.

Bioorg Med Chem Lett 2008 Mar 18;18(5):1692-5. Epub 2008 Jan 18.

Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, AP-52N, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.01.048DOI Listing
March 2008

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy.

Proc Natl Acad Sci U S A 2008 Mar 10;105(10):3879-84. Epub 2008 Mar 10.

HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0800050105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268833PMC
March 2008

Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.

Bioorg Med Chem Lett 2008 Jan 28;18(2):568-70. Epub 2007 Nov 28.

Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.11.088DOI Listing
January 2008

Predictive genotypic algorithm for virologic response to lopinavir-ritonavir in protease inhibitor-experienced patients.

Antimicrob Agents Chemother 2007 Sep 18;51(9):3067-74. Epub 2007 Jun 18.

Global Pharmaceutical Research and Development, Abbott, 100 Abbott Park Rd., R436 AP9A-2, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00388-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043245PMC
September 2007

Identification and structural characterization of I84C and I84A mutations that are associated with high-level resistance to human immunodeficiency virus protease inhibitors and impair viral replication.

Antimicrob Agents Chemother 2007 Feb 13;51(2):732-5. Epub 2006 Nov 13.

Global Pharmaceutical Research and Development, Department R4CQ, Building AP52N, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL 60064-6217, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00690-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797770PMC
February 2007

Relationship between adherence and the development of resistance in antiretroviral-naive, HIV-1-infected patients receiving lopinavir/ritonavir or nelfinavir.

J Infect Dis 2005 Jun 12;191(12):2046-52. Epub 2005 May 12.

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/jid/article-lookup/doi/10.1086/4303
Publisher Site
http://dx.doi.org/10.1086/430387DOI Listing
June 2005

Oximinoarylsulfonamides as potent HIV protease inhibitors.

Bioorg Med Chem Lett 2005 May;15(9):2275-8

Abbott Laboratories, GPRD, D-47D, Building AP52N, 200 Abbott Park Road, Abbott Park, IL 60064-3501, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.03.008DOI Listing
May 2005

An 'inside-the-box' approach to drug resistance.

Chem Biol 2004 Oct;11(10):1327-8

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2004.09.006DOI Listing
October 2004

Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.

Bioorg Med Chem Lett 2004 Aug;14(15):4075-8

Abbott Laboratories, Infectious Disease Research, Dept. R47D, Building AP52N, 200 Abbott Park Road, Abbott Park, IL 60064-6217, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.05.036DOI Listing
August 2004

Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

J Infect Dis 2004 Jan 31;189(1):51-60. Epub 2003 Dec 31.

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/380509DOI Listing
January 2004

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.

Bioorg Med Chem Lett 2003 Nov;13(21):3657-60

Pharmaceutical Products Division, Abbott Laboratories, D-47D, AP52, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2003.08.043DOI Listing
November 2003

Characterization of resistant HIV variants generated by in vitro passage with lopinavir/ritonavir.

Antiviral Res 2003 Aug;59(3):173-80

Global Pharmaceutical Research Development, Department R47D, Abbott Laboratories, Building AP52N, 200 Abbott Park Road, Abbott Park, IL 60064-6217, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0166-3542(03)00107-4DOI Listing
August 2003

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships.

Bioorg Med Chem Lett 2002 Nov;12(21):3101-3

Pharmaceutical Discovery, R47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0960-894x(02)00643-1DOI Listing
November 2002

Enantioselective synthesis of antiinfluenza compound A-315675.

J Org Chem 2002 Aug;67(16):5445-53

Infectious Disease Research Division, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo0162890DOI Listing
August 2002

In vitro antiviral interaction of lopinavir with other protease inhibitors.

Antimicrob Agents Chemother 2002 Jul;46(7):2249-53

Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127306PMC
http://dx.doi.org/10.1128/aac.46.7.2249-2253.2002DOI Listing
July 2002

Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).

Bioorg Med Chem Lett 2002 Apr;12(8):1185-7

Pharmaceutical Discovery, D47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0960-894x(02)00134-8DOI Listing
April 2002