Dale E Bredesen

Dale E Bredesen

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Dale E Bredesen

Dale E Bredesen

Publications by authors named "Dale E Bredesen"

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A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.

Sci Rep 2018 12 4;8(1):17574. Epub 2018 Dec 4.

The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41598-018-35687-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279743PMC
December 2018

Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease.

Mol Neurobiol 2018 Jun 6;55(6):5243-5254. Epub 2017 Sep 6.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.

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http://dx.doi.org/10.1007/s12035-017-0757-2DOI Listing
June 2018

Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease.

Mol Cell Neurosci 2017 09 15;83:83-91. Epub 2017 Jul 15.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.07.002DOI Listing
September 2017

Ayurvedic Profiling of Alzheimer's Disease.

Altern Ther Health Med 2017 May 27;23(3):46-50. Epub 2017 Feb 27.

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May 2017

sAβPPα is a Potent Endogenous Inhibitor of BACE1.

J Alzheimers Dis 2015 ;47(3):545-55

Buck Institute for Research on Aging, Novato, CA, USA.

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http://dx.doi.org/10.3233/JAD-150282DOI Listing
July 2016

Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic.

Authors:
Dale E Bredesen

Aging (Albany NY) 2016 Feb;8(2):304-13

Easton Laboratories for Neurodegenerative Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789584PMC
http://dx.doi.org/10.18632/aging.100896DOI Listing
February 2016

Direct Transcriptional Effects of Apolipoprotein E.

J Neurosci 2016 Jan;36(3):685-700

Buck Institute for Research on Aging, Novato, California 94945, and

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http://dx.doi.org/10.1523/JNEUROSCI.3562-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719010PMC
January 2016

Metabolic profiling distinguishes three subtypes of Alzheimer's disease.

Authors:
Dale E Bredesen

Aging (Albany NY) 2015 Aug;7(8):595-600

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095, USA.

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http://www.impactaging.com/papers/v7/n8/pdf/100801.pdf
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http://impactaging.com/papers/v7/n8/full/100801.html
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586104PMC
http://dx.doi.org/10.18632/aging.100801DOI Listing
August 2015

ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment.

FASEB J 2015 Jul 24;29(7):2681-9. Epub 2015 Mar 24.

*Department of Surgery and Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; and Department of Biostatistics, University of California, Los Angeles, School of Public Health, Los Angeles, California, USA.

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http://www.fasebj.org/doi/10.1096/fj.14-264218
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http://dx.doi.org/10.1096/fj.14-264218DOI Listing
July 2015

Dynamic self-guiding analysis of Alzheimer's disease.

Oncotarget 2015 Jun;6(16):14092-122

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546454PMC
http://dx.doi.org/10.18632/oncotarget.4221DOI Listing
June 2015

Correction to hunter-killer peptide (HKP) for targeted therapy.

J Med Chem 2015 Feb 10;58(4):2045. Epub 2015 Feb 10.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00034DOI Listing
February 2015

Alzheimer's Model Develops Early ADHD Syndrome.

J Neurol Neurophysiol 2015;6(6):1-6

Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA ; Department of Neurology, University of California, Los Angeles, CA 90095.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704098PMC
January 2015

Reversal of cognitive decline: a novel therapeutic program.

Authors:
Dale E Bredesen

Aging (Albany NY) 2014 Sep;6(9):707-17

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095. Buck Institute for Research on Aging, Novato, CA 94945.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920PMC
http://dx.doi.org/10.18632/aging.100690DOI Listing
September 2014

The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.

Brain Res 2014 Mar 31;1551:25-44. Epub 2013 Dec 31.

Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA; Department of Neurology, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2013.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001856PMC
March 2014

Next generation therapeutics for Alzheimer's disease.

EMBO Mol Med 2013 Jun 23;5(6):795-8. Epub 2013 May 23.

Buck Institute for Research on Aging, Novato, CA, USA.

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http://dx.doi.org/10.1002/emmm.201202307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779441PMC
June 2013

The small co-chaperone p23 overexpressing transgenic mouse.

J Neurosci Methods 2013 Jan 27;212(2):190-4. Epub 2012 Sep 27.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2012.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562756PMC
January 2013

Induction of the C-terminal proteolytic cleavage of AβPP by statins.

J Alzheimers Dis 2011 ;25(1):51-7

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.3233/JAD-2011-101857DOI Listing
June 2012

Ayurvedic medicinal plants for Alzheimer's disease: a review.

Alzheimers Res Ther 2012 Jun 29;4(3):22. Epub 2012 Jun 29.

The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://dx.doi.org/10.1186/alzrt125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506936PMC
June 2012

Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.

PLoS One 2011 9;6(12):e28530. Epub 2011 Dec 9.

College of Pharmacy, Touro University - California, Vallejo, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028530PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235131PMC
April 2012

Signaling via amyloid precursor-like proteins APLP1 and APLP2.

J Alzheimers Dis 2011 ;23(4):689-99

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.3233/JAD-2010-101470DOI Listing
March 2012

The small chaperone protein p23 and its cleaved product p19 in cellular stress.

J Mol Neurosci 2012 Feb 21;46(2):303-14. Epub 2011 Jun 21.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA.

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http://dx.doi.org/10.1007/s12031-011-9574-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246043PMC
February 2012

Importance of the caspase cleavage site in amyloid-β protein precursor.

J Alzheimers Dis 2010 ;22(1):57-63

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.3233/JAD-2010-100537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968071PMC
August 2011

Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.

J Mol Neurosci 2011 Jun 20;44(2):91-102. Epub 2011 Jan 20.

The Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1007/s12031-010-9489-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084943PMC
June 2011

Dependence receptors: from basic research to drug development.

Sci Signal 2011 Jan 25;4(157):mr2. Epub 2011 Jan 25.

Apoptose, Cancer et Développement, CNRS UMR5538, Centre Léon Bérard, University of Lyon, Lyon 69008, France. dbredesen@buckinstitute

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http://dx.doi.org/10.1126/scisignal.2001521DOI Listing
January 2011

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience.

Behav Brain Res 2010 Jan 12;206(2):202-7. Epub 2009 Sep 12.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, United States.

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http://dx.doi.org/10.1016/j.bbr.2009.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783897PMC
January 2010

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.

Free Radic Biol Med 2010 Jan 23;48(1):136-44. Epub 2009 Oct 23.

Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818480PMC
January 2010

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.

J Neurosci 2010 Jan;30(1):372-81

Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5341-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064502PMC
January 2010

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.

Biochem Biophys Res Commun 2009 Oct 11;388(2):450-5. Epub 2009 Aug 11.

Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838490PMC
October 2009

Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.

J Mol Neurosci 2009 Sep 15;39(1-2):157-68. Epub 2009 Jan 15.

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1007/s12031-008-9170-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745484PMC
September 2009

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence.

Authors:
Dale E Bredesen

Mol Neurodegener 2009 Jun 26;4:27. Epub 2009 Jun 26.

Buck Institute for Age Research, 8001 Redwood Blvd,, Novato, CA USA 94945.

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http://dx.doi.org/10.1186/1750-1326-4-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709109PMC
June 2009

Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.

Neuromolecular Med 2008 5;10(4):333-42. Epub 2008 Sep 5.

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1007/s12017-008-8047-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818083PMC
April 2009

Hunter-killer peptide (HKP) for targeted therapy.

J Med Chem 2008 Oct;51(19):5887-92

College of Pharmacy, Touro University, Mare Island, Vallejo, California 94592, USA.

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http://dx.doi.org/10.1021/jm800495uDOI Listing
October 2008

Programmed cell death mechanisms in neurological disease.

Authors:
Dale E Bredesen

Curr Mol Med 2008 May;8(3):173-86

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, California 94945, USA.

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http://dx.doi.org/10.2174/156652408784221315DOI Listing
May 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation.

Neuromolecular Med 2007 ;9(3):255-63

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755584PMC
http://dx.doi.org/10.1007/s12017-007-8007-9DOI Listing
December 2007

APP-based neuroprotective strategies.

Curr Alzheimer Res 2007 Dec;4(5):541-3

Buck Institute for Age Research and University of California, San Francisco, USA.

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http://dx.doi.org/10.2174/156720507783018253DOI Listing
December 2007

A calpain-like protease inhibits autophagic cell death.

Autophagy 2007 Sep-Oct;3(5):519-22. Epub 2007 Feb 23.

Buck Institute for Age Research, Novato, California 94945, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749617PMC
http://dx.doi.org/10.4161/auto.4052DOI Listing
November 2007

Neurogenesis in the adult brain: implications for Alzheimer's disease.

CNS Neurol Disord Drug Targets 2007 Oct;6(5):303-10

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.2174/187152707783220938DOI Listing
October 2007

The PDZ domain as a complex adaptive system.

PLoS One 2007 Sep 26;2(9):e953. Epub 2007 Sep 26.

The Buck Institute for Age Research, Novato, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978516PMC
September 2007

A novel motif identified in dependence receptors.

PLoS One 2007 May 23;2(5):e463. Epub 2007 May 23.

Buck Institute for Age Research, Novato, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000463PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866245PMC
May 2007

An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.

J Mol Recognit 2007 Jan-Feb;20(1):39-50

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1002/jmr.809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847359PMC
April 2007

Key note lecture: toward a mechanistic taxonomy for cell death programs.

Authors:
Dale E Bredesen

Stroke 2007 Feb;38(2 Suppl):652-60

Buck Institute for Age Research, CA 94945, USA.

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http://dx.doi.org/10.1161/01.STR.0000257802.82826.a7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885420PMC
February 2007

An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.

J Mol Recognit 2007 Jan-Feb;20(1):39-50

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1002/jmr.809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847359PMC
April 2007

Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing.

FEBS Lett 2006 Jun 9;580(15):3739-45. Epub 2006 Jun 9.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://doi.wiley.com/10.1016/j.febslet.2006.05.066
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http://dx.doi.org/10.1016/j.febslet.2006.05.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847410PMC
June 2006

Developmental shift in the apostat: comparison of neurones and astrocytes.

FEBS Lett 2005 Nov 11;579(27):6147-50. Epub 2005 Oct 11.

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.febslet.2005.09.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847358PMC
November 2005

Improved prediction of critical residues for protein function based on network and phylogenetic analyses.

BMC Bioinformatics 2005 Aug 26;6:213. Epub 2005 Aug 26.

Buck Institute For Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.

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http://dx.doi.org/10.1186/1471-2105-6-213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208857PMC
August 2005

Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex.

Neuromolecular Med 2004 ;5(3):205-18

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://dx.doi.org/10.1385/NMM:5:3:205DOI Listing
May 2005

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration.

Curr Opin Cell Biol 2004 Dec;16(6):653-62

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945-1400, USA.

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http://dx.doi.org/10.1016/j.ceb.2004.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970707PMC
December 2004

Toward a mechanistic taxonomy of cell death programs.

Authors:
Dale E Bredesen

J Alzheimers Dis 2004 Dec;6(6 Suppl):S3-6

Buck Institute and UCSF, USA.

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http://dx.doi.org/10.3233/jad-2004-6s613DOI Listing
December 2004

The non-existent aging program: how does it work?

Authors:
Dale E Bredesen

Aging Cell 2004 Oct;3(5):255-9

Buck Institute for Age Research, University of California, San Francisco, 8001 Redwood Blvd, Novato, CA 94949, USA.

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http://dx.doi.org/10.1111/j.1474-9728.2004.00121.xDOI Listing
October 2004

Rebuttal to Austad: 'Is aging programmed?

Authors:
Dale E Bredesen

Aging Cell 2004 Oct;3(5):261-2

Buck Institute for Age Research, University of California, San Francisco, 8001 Redwood Blvd, Novato, CA 94949, USA.

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http://dx.doi.org/10.1111/j.1474-9728.2004.00120.xDOI Listing
October 2004

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.

Proc Natl Acad Sci U S A 2004 Sep 30;101(36):13363-7. Epub 2004 Aug 30.

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1073/pnas.0403678101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516572PMC
September 2004

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

Nature 2004 Sep;431(7004):80-4

Apoptosis/Differentiation Laboratory-Equipe labellisée La Ligue-Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France.

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http://dx.doi.org/10.1038/nature02788DOI Listing
September 2004

Target-assisted iterative screening of phage surface display cDNA libraries.

Methods Mol Biol 2004 ;264:47-60

Buck Institute for Age Research, Novato, CA, USA.

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http://dx.doi.org/10.1385/1-59259-759-9:047DOI Listing
July 2004

Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

J Biol Chem 2004 Apr 9;279(17):17543-53. Epub 2004 Feb 9.

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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http://dx.doi.org/10.1074/jbc.M312363200DOI Listing
April 2004

Apoptosis and dependence receptors: a molecular basis for cellular addiction.

Physiol Rev 2004 Apr;84(2):411-30

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1152/physrev.00027.2003DOI Listing
April 2004

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

Cytokine Growth Factor Rev 2003 Jun-Aug;14(3-4):225-39

The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945-1400, USA.

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http://dx.doi.org/10.1016/s1359-6101(03)00018-2DOI Listing
February 2004

Molecular components of a cell death pathway activated by endoplasmic reticulum stress.

J Biol Chem 2004 Jan 15;279(1):177-87. Epub 2003 Oct 15.

The Buck Institute for Age Research, Novato, California 94945, USA.

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http://dx.doi.org/10.1074/jbc.M304490200DOI Listing
January 2004

Meeting report: cellular dependence--old concept, new mechanisms.

Sci STKE 2003 Dec 16;2003(213):pe55. Epub 2003 Dec 16.

Centre Genetique Moleculaire et Cellulaire, Equipe Labellisée "La Ligue," CNRS UMR5534, University of Lyon, Lyon, France.

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http://dx.doi.org/10.1126/stke.2132003pe55DOI Listing
December 2003

Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes.

Ann Neurol 2003 Dec;54(6):781-9

Department of Neurosciences, University of California-San Diego, 9500 Gilman Drive, Mail Code 0691, La Jolla, CA 92093-0691, USA.

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http://dx.doi.org/10.1002/ana.10761DOI Listing
December 2003

Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.

J Neurochem 2003 Nov;87(3):733-41

Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.02059.xDOI Listing
November 2003

Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice.

Neurobiol Dis 2003 Oct;14(1):52-62

Buck Institute for Age Research, Novato, CA, USA.

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http://dx.doi.org/10.1016/s0969-9961(03)00086-xDOI Listing
October 2003

An artificially designed pore-forming protein with anti-tumor effects.

J Biol Chem 2003 Sep 14;278(37):35311-6. Epub 2003 May 14.

Program on Cancer and Aging, The Buck Institute, Novato, California 94945, USA.

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http://dx.doi.org/10.1074/jbc.M300474200DOI Listing
September 2003

Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.

J Biol Chem 2003 Sep 26;278(36):34102-9. Epub 2003 Jun 26.

Buck Institute for Age Research, Novato, California 94945, USA.

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http://dx.doi.org/10.1074/jbc.M305264200DOI Listing
September 2003

Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

J Biol Chem 2003 Apr 28;278(15):13325-32. Epub 2003 Jan 28.

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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http://dx.doi.org/10.1074/jbc.M211398200DOI Listing
April 2003

PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.

Neuromolecular Med 2002 ;1(3):153-70

Buck Institute for Age Research, Novato, CA 94945-1400, USA.

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http://dx.doi.org/10.1385/NMM:1:3:153DOI Listing
January 2003

Caspase cleavage of members of the amyloid precursor family of proteins.

J Neurochem 2002 Jul;82(2):283-94

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.00970.xDOI Listing
July 2002

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.

J Biol Chem 2002 Jun 27;277(24):21836-42. Epub 2002 Mar 27.

Buck Institute for Age Research, Novato, California 94945 and the Department of Medicine III, Johannes Gutenberg University, Mainz D-55101, Germany.

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http://dx.doi.org/10.1074/jbc.M202726200DOI Listing
June 2002