Publications by authors named "Dale E Bredesen"

98Publications

Alzheimer's disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics.

Authors:
Alexei Kurakin Dale E Bredesen

Aging (Albany NY) 2020 Sep 21;12(18):17815-17844. Epub 2020 Sep 21.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

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September 2020

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.

Authors:
Jesus Campagna Patricia Spilman Barbara Jagodzinska Dongsheng Bai Asa Hatami Chunni Zhu Tina Bilousova Michael Jun Chris Jean Elias Johnny Pham Gregory Cole Mary Jo LaDu Michael E Jung Dale E Bredesen Varghese John

Sci Rep 2018 12 4;8(1):17574. Epub 2018 Dec 4.

The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.

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December 2018

Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease.

Authors:
Veena Theendakara Clare A Peters-Libeu Dale E Bredesen Rammohan V Rao

Mol Neurobiol 2018 Jun 6;55(6):5243-5254. Epub 2017 Sep 6.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.

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June 2018

Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease.

Authors:
Veena Theendakara Dale E Bredesen Rammohan V Rao

Mol Cell Neurosci 2017 09 15;83:83-91. Epub 2017 Jul 15.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA. Electronic address:

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September 2017

Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production.

Authors:
Karen S Poksay Douglas J Sheffler Patricia Spilman Jesus Campagna Barbara Jagodzinska Olivier Descamps Olivia Gorostiza Alex Matalis Michael Mullenix Dale E Bredesen Nicholas D P Cosford Varghese John

Front Pharmacol 2017 15;8:46. Epub 2017 Feb 15.

Drug Discovery Lab, Department of Neurology, University of California, Los Angeles CA, USA.

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February 2017

Ayurvedic Profiling of Alzheimer's Disease.

Authors:
Dale E Bredesen Rammohan V Rao

Altern Ther Health Med 2017 May 27;23(3):46-50. Epub 2017 Feb 27.

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May 2017

Reversal of cognitive decline in Alzheimer's disease.

Authors:
Dale E Bredesen Edwin C Amos Jonathan Canick Mary Ackerley Cyrus Raji Milan Fiala Jamila Ahdidan

Aging (Albany NY) 2016 06;8(6):1250-8

Brainreader, Horsens, Denmark.

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June 2016

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.

Authors:
Patricia R Spilman Veronique Corset Olivia Gorostiza Karen S Poksay Veronica Galvan Junli Zhang Rammohan Rao Clare Peters-Libeu Jon Vincelette Andrew McGeehan Melita Dvorak-Ewell Janine Beyer Jesus Campagna Krystof Bankiewicz Patrick Mehlen Varghese John Dale E Bredesen

J Alzheimers Dis 2016 03;52(1):223-42

Buck Institute for Research on Aging, Novato, CA, USA.

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March 2016

Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic.

Authors:
Dale E Bredesen

Aging (Albany NY) 2016 Feb;8(2):304-13

Easton Laboratories for Neurodegenerative Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095, USA.

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February 2016

Direct Transcriptional Effects of Apolipoprotein E.

Authors:
Veena Theendakara Clare A Peters-Libeu Patricia Spilman Karen S Poksay Dale E Bredesen Rammohan V Rao

J Neurosci 2016 Jan;36(3):685-700

Buck Institute for Research on Aging, Novato, California 94945, and

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January 2016

Alzheimer's Model Develops Early ADHD Syndrome.

Authors:
Qiang Zhang Guiping Du V John Pankaj Kapahi Dale E Bredesen

J Neurol Neurophysiol 2015;6(6):1-6

Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA ; Department of Neurology, University of California, Los Angeles, CA 90095.

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January 2015

sAβPPα is a Potent Endogenous Inhibitor of BACE1.

Authors:
Clare Peters-Libeu Jesus Campagna Michael Mitsumori Karen S Poksay Patricia Spilman Alex Sabogal Dale E Bredesen Varghese John

J Alzheimers Dis 2015 ;47(3):545-55

Buck Institute for Research on Aging, Novato, CA, USA.

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July 2016

Metabolic profiling distinguishes three subtypes of Alzheimer's disease.

Authors:
Dale E Bredesen

Aging (Albany NY) 2015 Aug;7(8):595-600

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095, USA.

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August 2015

Dynamic self-guiding analysis of Alzheimer's disease.

Authors:
Alexei Kurakin Dale E Bredesen

Oncotarget 2015 Jun;6(16):14092-122

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA, USA.

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June 2015

ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment.

Authors:
Milan Fiala Ramesh C Halder Bien Sagong Olivia Ross James Sayre Verna Porter Dale E Bredesen

FASEB J 2015 Jul 24;29(7):2681-9. Epub 2015 Mar 24.

*Department of Surgery and Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; and Department of Biostatistics, University of California, Los Angeles, School of Public Health, Los Angeles, California, USA.

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July 2015

Correction to hunter-killer peptide (HKP) for targeted therapy.

Authors:
H Michael Ellerby Dale E Bredesen Satoshi Fujimura Varghese John

J Med Chem 2015 Feb 10;58(4):2045. Epub 2015 Feb 10.

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February 2015

Reversal of cognitive decline: a novel therapeutic program.

Authors:
Dale E Bredesen

Aging (Albany NY) 2014 Sep;6(9):707-17

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095. Buck Institute for Research on Aging, Novato, CA 94945.

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September 2014

Paradoxical effect of TrkA inhibition in Alzheimer's disease models.

Authors:
Qiang Zhang Olivier Descamps Matthew J Hart Karen S Poksay Patricia Spilman Darci J Kane Olivia Gorostiza Varghese John Dale E Bredesen

J Alzheimers Dis 2014 ;40(3):605-617

Buck Institute for Research on Aging, Novato, CA, USA.

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December 2014

The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.

Authors:
Patricia Spilman Olivier Descamps Olivia Gorostiza Clare Peters-Libeu Karen S Poksay Alexander Matalis Jesus Campagna Alexander Patent Rammohan Rao Varghese John Dale E Bredesen

Brain Res 2014 Mar 31;1551:25-44. Epub 2013 Dec 31.

Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA; Department of Neurology, University of California, San Francisco, CA 94143, USA. Electronic address:

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March 2014

Neuroprotective Sirtuin ratio reversed by ApoE4.

Authors:
Veena Theendakara Alexander Patent Clare A Peters Libeu Brittany Philpot Sonia Flores Olivier Descamps Karen S Poksay Qiang Zhang Gabriellee Cailing Matthew Hart Varghese John Rammohan V Rao Dale E Bredesen

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18303-8. Epub 2013 Oct 21.

The Buck Institute for Research on Aging, Novato, CA 94945.

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November 2013

AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease.

Authors:
Olivier Descamps Patricia Spilman Qiang Zhang Clare P Libeu Karen Poksay Olivia Gorostiza Jesus Campagna Barbara Jagodzinska Dale E Bredesen Varghese John

J Alzheimers Dis 2013 ;37(2):343-55

Buck Institute for Research on Aging, Novato, CA, USA.

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April 2014

Next generation therapeutics for Alzheimer's disease.

Authors:
Dale E Bredesen Varghese John

EMBO Mol Med 2013 Jun 23;5(6):795-8. Epub 2013 May 23.

Buck Institute for Research on Aging, Novato, CA, USA.

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June 2013

No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease.

Authors:
Sung W Choi Akos A Gerencser Ryan Ng James M Flynn Simon Melov Steven R Danielson Bradford W Gibson David G Nicholls Dale E Bredesen Martin D Brand

J Neurosci 2012 Nov;32(47):16775-84

Buck Institute Research on Aging, Novato, California 94945, USA.

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November 2012

The small co-chaperone p23 overexpressing transgenic mouse.

Authors:
Junli Zhang Patricia Spilman Sylvia Chen Olivia Gorostiza Alex Matalis Kayvan Niazi Dale E Bredesen Rammohan V Rao

J Neurosci Methods 2013 Jan 27;212(2):190-4. Epub 2012 Sep 27.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA.

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January 2013

Moonlighting peptides with emerging function.

Authors:
Jonathan G Rodríguez Plaza Amanda Villalón Rojas Sur Herrera Georgina Garza-Ramos Alfredo Torres Larios Carlos Amero Gabriela Zarraga Granados Manuel Gutiérrez Aguilar María Teresa Lara Ortiz Carlos Polanco Gonzalez Salvador Uribe Carvajal Roberto Coria Antonio Peña Díaz Dale E Bredesen Susana Castro-Obregon Gabriel del Rio

PLoS One 2012 13;7(7):e40125. Epub 2012 Jul 13.

Biochemistry and Structural Biology Department, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México DF, México.

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March 2013

Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain.

Authors:
Clare A Peters Libeu Olivier Descamps Qiang Zhang Varghese John Dale E Bredesen

PLoS One 2012 29;7(6):e40027. Epub 2012 Jun 29.

Buck Institute for Research on Aging, Novato, California, United States of America.

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November 2012

Ayurvedic medicinal plants for Alzheimer's disease: a review.

Authors:
Rammohan V Rao Olivier Descamps Varghese John Dale E Bredesen

Alzheimers Res Ther 2012 Jun 29;4(3):22. Epub 2012 Jun 29.

The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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June 2012

Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?

Authors:
Rukhsana Sultana Renã A S Robinson Miranda Bader Lange Ada Fiorini Veronica Galvan Joanna Fombonne Austin Baker Olivia Gorostiza Junli Zhang Jian Cai William M Pierce Dale E Bredesen D Allan Butterfield

Antioxid Redox Signal 2012 Dec 6;17(11):1507-14. Epub 2012 Jun 6.

Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506, USA.

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December 2012

Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.

Authors:
David T Madden Diana Davila-Kruger Simon Melov Dale E Bredesen

PLoS One 2011 9;6(12):e28530. Epub 2011 Dec 9.

College of Pharmacy, Touro University - California, Vallejo, California, United States of America.

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April 2012

Endogenously EGFP-Labeled Mouse Embryonic Stem Cells.

Authors:
Junli Zhang Rammohan V Rao Patricia Spilman Julie Mangada Lin Xie Cathy Vitelli Olivia F Gorostiza David T Madden Xianmin Zeng Kunlin Jin Matthew J Hart Dale E Bredesen Veronica Galvan

Aging Dis 2011 Feb;2(1):18-29

Touro University College of Pharmacy, Vallejo, CA 94592, USA.

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February 2011

The small chaperone protein p23 and its cleaved product p19 in cellular stress.

Authors:
Karen S Poksay Surita Banwait Danielle Crippen Xiao Mao Dale E Bredesen Rammohan V Rao

J Mol Neurosci 2012 Feb 21;46(2):303-14. Epub 2011 Jun 21.

The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA.

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February 2012

Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides.

Authors:
Clare Peters Libeu Karen S Poksay Varghese John Dale E Bredesen

J Alzheimers Dis 2011 ;25(3):547-66

Buck Institute for Age Research, Novato, CA 94945, USA.

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November 2011

Induction of the C-terminal proteolytic cleavage of AβPP by statins.

Authors:
Olivier Descamps Qiang Zhang Varghese John Dale E Bredesen

J Alzheimers Dis 2011 ;25(1):51-7

Buck Institute for Age Research, Novato, CA 94945, USA.

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June 2012

Dependence receptors: from basic research to drug development.

Authors:
Patrick Mehlen Dale E Bredesen

Sci Signal 2011 Jan 25;4(157):mr2. Epub 2011 Jan 25.

Apoptose, Cancer et Développement, CNRS UMR5538, Centre Léon Bérard, University of Lyon, Lyon 69008, France. dbredesen@buckinstitute

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January 2011

Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.

Authors:
Karen S Poksay David T Madden Anna K Peter Kayvan Niazi Surita Banwait Danielle Crippen Dale E Bredesen Rammohan V Rao

J Mol Neurosci 2011 Jun 20;44(2):91-102. Epub 2011 Jan 20.

The Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.

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June 2011

Signaling via amyloid precursor-like proteins APLP1 and APLP2.

Authors:
Mark E Orcholski Qiang Zhang Dale E Bredesen

J Alzheimers Dis 2011 ;23(4):689-99

Buck Institute for Age Research, Novato, CA 94945, USA.

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March 2012

Importance of the caspase cleavage site in amyloid-β protein precursor.

Authors:
Dale E Bredesen Varghese John Veronica Galvan

J Alzheimers Dis 2010 ;22(1):57-63

Buck Institute for Age Research, Novato, CA 94945, USA.

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August 2011

Identification of new modulators and protein alterations in non-apoptotic programmed cell death.

Authors:
Sabina Sperandio Karen S Poksay Birgit Schilling Danielle Crippen Bradford W Gibson Dale E Bredesen

J Cell Biochem 2010 Dec;111(6):1401-12

Buck Institute for Age Research, Novato, California 94945, USA.

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December 2010

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.

Authors:
Julie A Harris Nino Devidze Brian Halabisky Iris Lo Myo T Thwin Gui-Qiu Yu Dale E Bredesen Eliezer Masliah Lennart Mucke

J Neurosci 2010 Jan;30(1):372-81

Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA.

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January 2010

Novel mediators of amyloid precursor protein signaling.

Authors:
Andrzej Swistowski Qiang Zhang Mark E Orcholski Danielle Crippen Cathy Vitelli Alexei Kurakin Dale E Bredesen

J Neurosci 2009 Dec;29(50):15703-12

Buck Institute for Age Research, Novato, California 94945, USA.

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December 2009

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.

Authors:
D Allan Butterfield Veronica Galvan Miranda Bader Lange Huidong Tang Renã A Sowell Patricia Spilman Joanna Fombonne Olivia Gorostiza Junli Zhang Rukhsana Sultana Dale E Bredesen

Free Radic Biol Med 2010 Jan 23;48(1):136-44. Epub 2009 Oct 23.

Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.

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January 2010

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience.

Authors:
Junli Zhang Olivia F Gorostiza Huidong Tang Dale E Bredesen Veronica Galvan

Behav Brain Res 2010 Jan 12;206(2):202-7. Epub 2009 Sep 12.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, United States.

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January 2010

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.

Authors:
Sun Ah Park Gideon M Shaked Dale E Bredesen Edward H Koo

Biochem Biophys Res Commun 2009 Oct 11;388(2):450-5. Epub 2009 Aug 11.

Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

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October 2009

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence.

Authors:
Dale E Bredesen

Mol Neurodegener 2009 Jun 26;4:27. Epub 2009 Jun 26.

Buck Institute for Age Research, 8001 Redwood Blvd,, Novato, CA USA 94945.

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June 2009

Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.

Authors:
Joanna Fombonne Shahrooz Rabizadeh Surita Banwait Patrick Mehlen Dale E Bredesen

Ann Neurol 2009 Mar;65(3):294-303

The Buck Institute for Age Research, Novato, CA 94945, USA.

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March 2009

Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.

Authors:
Shankar J Chinta Karen S Poksay Gaayatri Kaundinya Matthew Hart Dale E Bredesen Julie K Andersen Rammohan V Rao

J Mol Neurosci 2009 Sep 15;39(1-2):157-68. Epub 2009 Jan 15.

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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September 2009

Hunter-killer peptide (HKP) for targeted therapy.

Authors:
H Michael Ellerby Dale E Bredesen Satoshi Fujimura Varghese John

J Med Chem 2008 Oct;51(19):5887-92

College of Pharmacy, Touro University, Mare Island, Vallejo, California 94592, USA.

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October 2008

Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.

Authors:
Shankar J Chinta Anand Rane Karen S Poksay Dale E Bredesen Julie K Andersen Rammohan V Rao

Neuromolecular Med 2008 5;10(4):333-42. Epub 2008 Sep 5.

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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April 2009

Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin.

Authors:
Jason Bakhshi Lee Weinstein Karen S Poksay Brian Nishinaga Dale E Bredesen Rammohan V Rao

Apoptosis 2008 Jul;13(7):904-14

Terra Linda High School, 320 Nova Albion Way, San Rafael, CA 94903, USA.

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July 2008

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.

Authors:
Veronica Galvan Junli Zhang Olivia F Gorostiza Surita Banwait Wei Huang Marina Ataie Huidong Tang Dale E Bredesen

Behav Brain Res 2008 Aug 8;191(2):246-55. Epub 2008 Apr 8.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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August 2008

Programmed cell death mechanisms in neurological disease.

Authors:
Dale E Bredesen

Curr Mol Med 2008 May;8(3):173-86

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, California 94945, USA.

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May 2008

C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease.

Authors:
Surita Banwait Veronica Galvan Junli Zhang Olivia F Gorostiza Marina Ataie Wei Huang Danielle Crippen Edward H Koo Dale E Bredesen

J Alzheimers Dis 2008 Feb;13(1):1-16

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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February 2008

APP-based neuroprotective strategies.

Authors:
Dale E Bredesen Shahrooz Rabizadeh

Curr Alzheimer Res 2007 Dec;4(5):541-3

Buck Institute for Age Research and University of California, San Francisco, USA.

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December 2007

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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February 2008

Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985.

Authors:
Robert M Levy Dale E Bredesen Mark L Rosenblum

J Neurosurg 2007 Dec;107(6):1253-73; discussion 1251

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December 2007

Neurogenesis in the adult brain: implications for Alzheimer's disease.

Authors:
Veronica Galvan Dale E Bredesen

CNS Neurol Disord Drug Targets 2007 Oct;6(5):303-10

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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October 2007

Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.

Authors:
Thuy-Vi V Nguyen Veronica Galvan Wei Huang Surita Banwait Huidong Tang Junli Zhang Dale E Bredesen

J Neurochem 2008 Feb 6;104(4):1065-80. Epub 2007 Nov 6.

Buck Institute for Age Research, Novato, California 94945, USA.

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February 2008

Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation.

Authors:
Veronika Stoka Vito Turk Dale E Bredesen

Neuromolecular Med 2007 ;9(3):255-63

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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December 2007

The PDZ domain as a complex adaptive system.

Authors:
Alexei Kurakin Andrzej Swistowski Susan C Wu Dale E Bredesen

PLoS One 2007 Sep 26;2(9):e953. Epub 2007 Sep 26.

The Buck Institute for Age Research, Novato, California, USA.

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September 2007

Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex.

Authors:
Veronica Galvan Surita Banwait Patricia Spilman Olivia F Gorostiza Alyson Peel Marina Ataie Danielle Crippen Wei Huang Gurleen Sidhu Hidenori Ichijo Dale E Bredesen

Neurobiol Dis 2007 Oct 3;28(1):65-75. Epub 2007 Jul 3.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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October 2007

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

Authors:
Jessica E Young Launce Gouw Stephanie Propp Bryce L Sopher Jillian Taylor Amy Lin Evan Hermel Anna Logvinova Sylvia F Chen Shiming Chen Dale E Bredesen Ray Truant Louis J Ptacek Albert R La Spada Lisa M Ellerby

J Biol Chem 2007 Oct 23;282(41):30150-60. Epub 2007 Jul 23.

Buck Institute for Age Research, Novato, California, 94945, USA.

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October 2007

A novel motif identified in dependence receptors.

Authors:
Gabriel del Rio Darci J Kane Keith D Ball Dale E Bredesen

PLoS One 2007 May 23;2(5):e463. Epub 2007 May 23.

Buck Institute for Age Research, Novato, California, United States of America.

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May 2007

Efficient identification of critical residues based only on protein structure by network analysis.

Authors:
Michael P Cusack Boris Thibert Dale E Bredesen Gabriel Del Rio

PLoS One 2007 May 9;2(5):e421. Epub 2007 May 9.

Buck Institute for Age Research, Novato, California, United States of America.

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May 2007

A calpain-like protease inhibits autophagic cell death.

Authors:
David T Madden Lotti Egger Dale E Bredesen

Autophagy 2007 Sep-Oct;3(5):519-22. Epub 2007 Feb 23.

Buck Institute for Age Research, Novato, California 94945, USA.

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November 2007

Key note lecture: toward a mechanistic taxonomy for cell death programs.

Authors:
Dale E Bredesen

Stroke 2007 Feb;38(2 Suppl):652-60

Buck Institute for Age Research, CA 94945, USA.

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February 2007

Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

Authors:
Michael J Saganich Brock E Schroeder Veronica Galvan Dale E Bredesen Edward H Koo Stephen F Heinemann

J Neurosci 2006 Dec;26(52):13428-36

Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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December 2006

An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.

Authors:
Alexei Kurakin Dale E Bredesen

J Mol Recognit 2007 Jan-Feb;20(1):39-50

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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April 2007

An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.

Authors:
Alexei Kurakin Dale E Bredesen

J Mol Recognit 2007 Jan-Feb;20(1):39-50

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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April 2007

Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing.

Authors:
Veronika Stoka Vito Turk Dale E Bredesen

FEBS Lett 2006 Jun 9;580(15):3739-45. Epub 2006 Jun 9.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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June 2006

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

Authors:
Veronica Galvan Olivia F Gorostiza Surita Banwait Marina Ataie Anna V Logvinova Sandhya Sitaraman Elaine Carlson Sarah A Sagi Nathalie Chevallier Kunlin Jin David A Greenberg Dale E Bredesen

Proc Natl Acad Sci U S A 2006 May 25;103(18):7130-5. Epub 2006 Apr 25.

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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May 2006

Developmental shift in the apostat: comparison of neurones and astrocytes.

Authors:
Veronika Stoka Sylvia F Chen Vito Turk Dale E Bredesen

FEBS Lett 2005 Nov 11;579(27):6147-50. Epub 2005 Oct 11.

Buck Institute for Age Research, Novato, CA 94945, USA.

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November 2005

Improved prediction of critical residues for protein function based on network and phylogenetic analyses.

Authors:
Boris Thibert Dale E Bredesen Gabriel del Rio

BMC Bioinformatics 2005 Aug 26;6:213. Epub 2005 Aug 26.

Buck Institute For Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.

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August 2005

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.

Authors:
Barbara A Cottrell Veronica Galvan Surita Banwait Olivia Gorostiza Christian R Lombardo Tristan Williams Birgit Schilling Alyson Peel Bradford Gibson Edward H Koo Christopher D Link Dale E Bredesen

Ann Neurol 2005 Aug;58(2):277-89

Buck Institute for Age Research, Novato, CA 94945, USA.

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August 2005

Toward a mechanistic taxonomy of cell death programs.

Authors:
Dale E Bredesen

J Alzheimers Dis 2004 Dec;6(6 Suppl):S3-6

Buck Institute and UCSF, USA.

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December 2004

Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex.

Authors:
Alyson L Peel Noah Sorscher Joseph Y Kim Veronica Galvan Sylvia Chen Dale E Bredesen

Neuromolecular Med 2004 ;5(3):205-18

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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May 2005

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration.

Authors:
Rammohan V Rao Dale E Bredesen

Curr Opin Cell Biol 2004 Dec;16(6):653-62

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945-1400, USA.

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December 2004

Rebuttal to Austad: 'Is aging programmed?

Authors:
Dale E Bredesen

Aging Cell 2004 Oct;3(5):261-2

Buck Institute for Age Research, University of California, San Francisco, 8001 Redwood Blvd, Novato, CA 94949, USA.

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October 2004

The non-existent aging program: how does it work?

Authors:
Dale E Bredesen

Aging Cell 2004 Oct;3(5):255-9

Buck Institute for Age Research, University of California, San Francisco, 8001 Redwood Blvd, Novato, CA 94949, USA.

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October 2004

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

Authors:
Laetitia Mazelin Agnès Bernet Christelle Bonod-Bidaud Laurent Pays Ségolène Arnaud Christian Gespach Dale E Bredesen Jean-Yves Scoazec Patrick Mehlen

Nature 2004 Sep;431(7004):80-4

Apoptosis/Differentiation Laboratory-Equipe labellisée La Ligue-Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France.

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September 2004

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.

Authors:
Kunlin Jin Veronica Galvan Lin Xie Xiao Ou Mao Olivia F Gorostiza Dale E Bredesen David A Greenberg

Proc Natl Acad Sci U S A 2004 Sep 30;101(36):13363-7. Epub 2004 Aug 30.

Buck Institute for Age Research, Novato, CA 94945, USA.

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September 2004

Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.

Authors:
Yuichi Hashimoto Yuka Kaneko Emi Tsukamoto Harald Frankowski Keisuke Kouyama Yoshiko Kita Takako Niikura Sadakazu Aiso Dale E Bredesen Masaaki Matsuoka Ikuo Nishimoto

J Neurochem 2004 Aug;90(3):549-58

Department of Pharmacology, KEIO University School of Medicine, Shinanomachi, Tokyo, Japan.

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August 2004

Apoptosis and dependence receptors: a molecular basis for cellular addiction.

Authors:
Dale E Bredesen Patrick Mehlen Shahrooz Rabizadeh

Physiol Rev 2004 Apr;84(2):411-30

The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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April 2004

Target-assisted iterative screening of phage surface display cDNA libraries.

Authors:
Alexei Kurakin Susan Wu Dale E Bredesen

Methods Mol Biol 2004 ;264:47-60

Buck Institute for Age Research, Novato, CA, USA.

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July 2004

Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

Authors:
Susana Castro-Obregón Rammohan V Rao Gabriel del Rio Sylvia F Chen Karen S Poksay Shahrooz Rabizadeh Sabino Vesce Xiao-Khun Zhang Raymond A Swanson Dale E Bredesen

J Biol Chem 2004 Apr 9;279(17):17543-53. Epub 2004 Feb 9.

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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April 2004

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme.

Authors:
Takanori Yokota Makoto Miyagishi Taro Hino Ryusuke Matsumura Andrea Tasinato Makoto Urushitani Rammohan V Rao Ryosuke Takahashi Dale E Bredesen Kazunari Taira Hidehiro Mizusawa Tasinato Andrea

Biochem Biophys Res Commun 2004 Jan;314(1):283-91

Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan.

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January 2004

Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes.

Authors:
Daniel C Lu Gideon M Shaked Eliezer Masliah Dale E Bredesen Edward H Koo

Ann Neurol 2003 Dec;54(6):781-9

Department of Neurosciences, University of California-San Diego, 9500 Gilman Drive, Mail Code 0691, La Jolla, CA 92093-0691, USA.

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December 2003

Meeting report: cellular dependence--old concept, new mechanisms.

Authors:
Patrick Mehlen Dale E Bredesen

Sci STKE 2003 Dec 16;2003(213):pe55. Epub 2003 Dec 16.

Centre Genetique Moleculaire et Cellulaire, Equipe Labellisée "La Ligue," CNRS UMR5534, University of Lyon, Lyon, France.

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December 2003

Molecular components of a cell death pathway activated by endoplasmic reticulum stress.

Authors:
Rammohan V Rao Karen S Poksay Susana Castro-Obregon Birgit Schilling Richard H Row Gabriel del Rio Bradford W Gibson H Michael Ellerby Dale E Bredesen

J Biol Chem 2004 Jan 15;279(1):177-87. Epub 2003 Oct 15.

The Buck Institute for Age Research, Novato, California 94945, USA.

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January 2004

Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.

Authors:
Daniel C Lu Salvador Soriano Dale E Bredesen Edward H Koo

J Neurochem 2003 Nov;87(3):733-41

Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA.

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November 2003

Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice.

Authors:
Alyson L Peel Dale E Bredesen

Neurobiol Dis 2003 Oct;14(1):52-62

Buck Institute for Age Research, Novato, CA, USA.

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October 2003

Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.

Authors:
Alexei V Kurakin Susan Wu Dale E Bredesen

J Biol Chem 2003 Sep 26;278(36):34102-9. Epub 2003 Jun 26.

Buck Institute for Age Research, Novato, California 94945, USA.

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September 2003

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

Authors:
Shahrooz Rabizadeh Dale E Bredesen

Cytokine Growth Factor Rev 2003 Jun-Aug;14(3-4):225-39

The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945-1400, USA.

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February 2004

An artificially designed pore-forming protein with anti-tumor effects.

Authors:
H Michael Ellerby Sannamu Lee Lisa M Ellerby Sylvia Chen Taira Kiyota Gabriel del Rio Gohsuke Sugihara Yan Sun Dale E Bredesen Wadih Arap Renata Pasqualini

J Biol Chem 2003 Sep 14;278(37):35311-6. Epub 2003 May 14.

Program on Cancer and Aging, The Buck Institute, Novato, California 94945, USA.

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September 2003

Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

Authors:
Veronica Galvan Anna Logvinova Sabina Sperandio Hidenori Ichijo Dale E Bredesen

J Biol Chem 2003 Apr 28;278(15):13325-32. Epub 2003 Jan 28.

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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April 2003

Caspase cleavage of members of the amyloid precursor family of proteins.

Authors:
Veronica Galvan Sylvia Chen Daniel Lu Anna Logvinova Paul Goldsmith Edward H Koo Dale E Bredesen

J Neurochem 2002 Jul;82(2):283-94

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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July 2002

PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.

Authors:
Harald Frankowski Susana Castro-Obregon Gabriel del Rio Rammohan V Rao Dale E Bredesen

Neuromolecular Med 2002 ;1(3):153-70

Buck Institute for Age Research, Novato, CA 94945-1400, USA.

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January 2003

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78.

Authors:
Rammohan V Rao Alyson Peel Anna Logvinova Gabriel del Rio Evan Hermel Takanori Yokota Paul C Goldsmith Lisa M Ellerby H Michael Ellerby Dale E Bredesen

FEBS Lett 2002 Mar;514(2-3):122-8

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.

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March 2002

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.

Authors:
Rammohan V Rao Susana Castro-Obregon Harald Frankowski Martin Schuler Veronica Stoka Gabriel del Rio Dale E Bredesen H Michael Ellerby

J Biol Chem 2002 Jun 27;277(24):21836-42. Epub 2002 Mar 27.

Buck Institute for Age Research, Novato, California 94945 and the Department of Medicine III, Johannes Gutenberg University, Mainz D-55101, Germany.

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June 2002

Targeting the prostate for destruction through a vascular address.

Authors:
Wadih Arap Wolfgang Haedicke Michele Bernasconi Renate Kain Daniel Rajotte Stanislaw Krajewski H Michael Ellerby Dale E Bredesen Renata Pasqualini Erkki Ruoslahti

Proc Natl Acad Sci U S A 2002 Feb;99(3):1527-31

Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA.

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February 2002