Publications by authors named "Daiwei Wang"

14 Publications

  • Page 1 of 1

Commiphoranes K-O, New Terpenoids from Resina Commiphora and Their Anti-Inflammatory Activities.

Chem Biodivers 2021 Jul 2;18(7):e2100265. Epub 2021 Jun 2.

Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.

Commiphorane K (1), a new dinorditerpenoid, commiphoranes L-N (2-4), three new germacrane-type sesquiterpenoids, and commiphorane O (5), one new guaiane-type sesquiterpenoid, were isolated from Resina Commiphora. Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4 was confirmed by X-ray crystallography. Compounds 2-5 were evaluated for their anti-inflammatory activities. The result shows that compound 2 suppresses lipopolysaccharide (LPS)-stimulated production of TNF-α in RAW264.7 cells in a dose-dependent manner.
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http://dx.doi.org/10.1002/cbdv.202100265DOI Listing
July 2021

Stable metal anodes enabled by a labile organic molecule bonded to a reduced graphene oxide aerogel.

Proc Natl Acad Sci U S A 2020 Dec 16;117(48):30135-30141. Epub 2020 Nov 16.

Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA 16802;

Metallic anodes (lithium, sodium, and zinc) are attractive for rechargeable battery technologies but are plagued by an unfavorable metal-electrolyte interface that leads to nonuniform metal deposition and an unstable solid-electrolyte interphase (SEI). Here we report the use of electrochemically labile molecules to regulate the electrochemical interface and guide even lithium deposition and a stable SEI. The molecule, benzenesulfonyl fluoride, was bonded to the surface of a reduced graphene oxide aerogel. During metal deposition, this labile molecule not only generates a metal-coordinating benzenesulfonate anion that guides homogeneous metal deposition but also contributes lithium fluoride to the SEI to improve Li surface passivation. Consequently, high-efficiency lithium deposition with a low nucleation overpotential was achieved at a high current density of 6.0 mA cm A Li|LiCoO cell had a capacity retention of 85.3% after 400 cycles, and the cell also tolerated low-temperature (-10 °C) operation without additional capacity fading. This strategy was applied to sodium and zinc anodes as well.
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http://dx.doi.org/10.1073/pnas.2001837117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720105PMC
December 2020

Proteomic Analysis of Serum Differentially Expressed Proteins Between Allergic Bronchopulmonary Aspergillosis and Asthma.

Mycopathologia 2021 Mar 12;186(1):1-13. Epub 2020 Nov 12.

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Background: Allergic bronchopulmonary aspergillosis (ABPA) constantly develops in asthmatics, which has not been fully investigated.

Objectives: This study aimed to investigate serum differentially expressed proteins (DEPs) between ABPA and asthma using the new approach isobaric tags by relative and absolute quantitation (iTRAQ).

Methods: Each 16 serum samples from ABPA or asthmatic subjects were pooled and screened using iTRAQ. After bioinformatic analysis, five candidate DEPs were validated in the enlarged serum samples from additional 21 ABPA, 31 asthmatic and 20 healthy subjects using ELISA. A receiver operating characteristic (ROC) curve was used to estimate the diagnostic power of carnosine dipeptidase 1 (CNDP1).

Results: A total of 29 DEPs were screened out between ABPA and asthmatic groups. Over half of them were enriched in proteolysis and regulation of protein metabolic process. Further verification showed serum levels of immunoglobulin heavy constant gamma 1, α-1-acid glycoprotein 1, corticosteroid-binding globulin and vitronectin were neither differentially altered between ABPA and asthma nor consistent with the proteomic analysis. Only serum CNDP1 was significantly decreased in ABPA patients, compared with asthmatics and healthy controls (P < 0.01 and P < 0.05). The ROC analysis determined 10.73 ng/mL as the cutoff value of CNDP1, which could distinguish ABPA among asthmatics (AUC 0.770, 95%CI 0.632-0.875, P < 0.001).

Conclusions: This study firstly identified serological DEPs between ABPA and asthma using the new technique iTRAQ. Serum CNDP1 might assist the differential diagnosis of ABPA from asthma and serve as a new pathogenetic factor in fungal colonization and sensitization.
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http://dx.doi.org/10.1007/s11046-020-00506-0DOI Listing
March 2021

Coexisting overexpression of STOML1 and STOML2 proteins may be associated with pathology of oral squamous cell carcinoma.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jun 8;129(6):591-599.e3. Epub 2020 May 8.

Center for Research and Technology of Precision Medicine, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, China. Electronic address:

Objective: The present study aimed to investigate the expression and co-localization of stomatin-like protein-1 (STOML1) and stomatin-like protein-2 (STOML2) in oral squamous cell carcinoma (OSCC) tissues in situ and evaluate their pathologic roles in OSCC.

Study Design: STOML1 and STOML2 in human OSCC tissues (n = 109) and normal oral/paracancerous tissues (n = 19) were detected by using multiple immunohistochemistry (IHC) staining. Positive staining scores and clinicopathologic features during the OSCC process were analyzed.

Results: STOML1 and STOML2 were significantly overexpressed in OSCC tissues compared with normal oral tissue/paracancerous tissues (P < .0001 and P < .0001, respectively). Furthermore, both STOML1 and STOML2 were positively associated with pathologic tumor (T) stages. Positive signals of both STOML1 and STOML2 were mainly localized to the cell membrane and the cytoplasm, whereas those of STOML1 were also expressed in the cell nucleus.

Conclusions: Our results indicated that overexpression of STOML1 and STOML2 was significantly associated with T1 and T2 stages of OSCC. STOML1 and STOML2 were mainly co-localized at the cell membrane and the cytoplasm. These findings suggested that either STOML1 or STOML2 may play critical roles in OSCC development and may serve as potential diagnostic biomarkers and therapeutic targets.
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http://dx.doi.org/10.1016/j.oooo.2020.01.011DOI Listing
June 2020

TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis.

Int J Biol Sci 2020 10;16(7):1180-1193. Epub 2020 Feb 10.

Center for Research and Technology of Precision Medicine, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, China.

This study focused on investigating the relationships of TAF1L expression and clinical features or pathological stages of oral squamous cell carcinoma (OSCC), and its potential roles of TAF1L on OSCC development. Western blot and immunohistochemical staining were used to detect TAF1L expression in OSCC tissues and cells. Effects of TAF1L on OSCC cells were examined by cell proliferation assay, wound healing assay, transwell chamber assay, flow cytometry analysis and siRNA technique. Cellular key proteins related to cell autophagy and apoptosis were evaluated by Western blot and immunofluorescent staining. Moreover, functions of TAF1L on OSCC process were observed in nude mouse model. Testing results showed that expression of TAF1L protein was higher in OSCC tissues than that in normal oral epithelial or paracancerous tissues. Additionally, the level of TAF1L protein expression was upregulated in OSCC cell lines, compared to that in normal oral epithelial cells. Furthermore, cell proliferation, migration, autophagy and apoptosis were modulated post siRNA- treatment . Especially, TAF1L knockdown-induced apoptotic activation on OSCC cells could be rescued by autophagic activator (Rapamycin). Moreover, that overexpression of TAF1L protein could promote the growth of OSCC cell xenografts was confirmed in nude mouse model. Taken together, it suggests that TAF1L may facilitate OSCC cells to escape cell apoptosis via autophagic activation for enhancing OSCC development.
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http://dx.doi.org/10.7150/ijbs.41148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053316PMC
February 2020

A new approach to both high safety and high performance of lithium-ion batteries.

Sci Adv 2020 Feb 28;6(9):eaay7633. Epub 2020 Feb 28.

Electrochemical Engine Center and Department of Mechanical Engineering, Pennsylvania State University, University Park, PA 16802, USA.

We present a novel concept to achieve high performance and high safety simultaneously by passivating a Li-ion cell and then self-heating before use. By adding a small amount of triallyl phosphate in conventional electrolytes, we show that resistances of the passivated cells can increase by ~5×, thereby ensuring high safety and thermal stability. High power before battery operation is delivered by self-heating to an elevated temperature such as 60°C within tens of seconds. The present approach of building a resistive cell with highly stable materials and then delivering high power on demand through rapid thermal stimulation leads to a revolutionary route to high safety when batteries are not in use and high battery performance upon operation.
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http://dx.doi.org/10.1126/sciadv.aay7633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048421PMC
February 2020

Supremely elastic gel polymer electrolyte enables a reliable electrode structure for silicon-based anodes.

Nat Commun 2019 12 6;10(1):5586. Epub 2019 Dec 6.

Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Silicon-based materials are promising anodes for next-generation lithium-ion batteries, owing to their high specific capacities. However, the huge volume expansion and shrinkage during cycling result in severe displacement of silicon particles and structural collapse of electrodes. Here we report the use of a supremely elastic gel polymer electrolyte to address this problem and realize long-term stable cycling of silicon monoxide anodes. The high elasticity of the gel polymer electrolyte is attributed to the use of a unique copolymer consisting of a soft ether domain and a hard cyclic ring domain. Consequently, the displacement of silicon monoxide particles and volume expansion of the electrode were effectively reduced, and the damage caused by electrode cracking is alleviated. A SiO|LiNiCoMnO cell shows 70.0% capacity retention in 350 cycles with a commercial-level reversible capacity of 3.0 mAh cm and an average Coulombic efficiency of 99.9%.
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http://dx.doi.org/10.1038/s41467-019-13434-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898440PMC
December 2019

Polymer-inorganic solid-electrolyte interphase for stable lithium metal batteries under lean electrolyte conditions.

Nat Mater 2019 04 11;18(4):384-389. Epub 2019 Mar 11.

Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA, USA.

The solid-electrolyte interphase (SEI) is pivotal in stabilizing lithium metal anodes for rechargeable batteries. However, the SEI is constantly reforming and consuming electrolyte with cycling. The rational design of a stable SEI is plagued by the failure to control its structure and stability. Here we report a molecular-level SEI design using a reactive polymer composite, which effectively suppresses electrolyte consumption in the formation and maintenance of the SEI. The SEI layer consists of a polymeric lithium salt, lithium fluoride nanoparticles and graphene oxide sheets, as evidenced by cryo-transmission electron microscopy, atomic force microscopy and surface-sensitive spectroscopies. This structure is different from that of a conventional electrolyte-derived SEI and has excellent passivation properties, homogeneity and mechanical strength. The use of the polymer-inorganic SEI enables high-efficiency Li deposition and stable cycling of 4 V Li|LiNiCoMnO cells under lean electrolyte, limited Li excess and high capacity conditions. The same approach was also applied to design stable SEI layers for sodium and zinc anodes.
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http://dx.doi.org/10.1038/s41563-019-0305-8DOI Listing
April 2019

Salt-Based Organic-Inorganic Nanocomposites: Towards A Stable Lithium Metal/Li GeP S Solid Electrolyte Interface.

Angew Chem Int Ed Engl 2018 Oct 17;57(41):13608-13612. Epub 2018 Sep 17.

Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Solid-state Li metal battery technology is attractive, owing to the high energy density, long lifespans, and better safety. A key obstacle in this technology is the unstable Li/solid-state electrolyte (SSE) interface involving electrolyte reduction by Li. Herein we report a novel approach based on the use of a nanocomposite consisting of organic elastomeric salts (LiO-(CH O) -Li) and inorganic nanoparticle salts (LiF, -NSO -Li, Li O), which serve as an interphase to protect Li GeP S (LGPS), a highly conductive but reducible SSE. The nanocomposite is formed in situ on Li via the electrochemical decomposition of a liquid electrolyte, thus having excellent chemical and electrochemical stability, affinity for Li and LGPS, and limited interfacial resistance. XPS depth profiling and SEM show that the nanocomposite effectively restrained the reduction of LGPS. Stable Li electrodeposition over 3000 h and a 200 cycle life for a full cell were achieved.
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http://dx.doi.org/10.1002/anie.201807304DOI Listing
October 2018

Self-Formed Hybrid Interphase Layer on Lithium Metal for High-Performance Lithium-Sulfur Batteries.

ACS Nano 2018 02 2;12(2):1500-1507. Epub 2018 Feb 2.

Department of Mechanical and Nuclear Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.

Lithium-sulfur (Li-S) batteries are promising candidates for high-energy storage devices due to high theoretical capacities of both the sulfur cathode and lithium (Li) metal anode. Considerable efforts have been devoted to improving sulfur cathodes. However, issues associated with Li anodes, such as low Coulombic efficiency (CE) and growth of Li dendrites, remain unsolved due to unstable solid-electrolyte interphase (SEI) and lead to poor capacity retention and a short cycling life of Li-S batteries. In this work, we demonstrate a facile and effective approach to fabricate a flexible and robust hybrid SEI layer through co-deposition of aromatic-based organosulfides and inorganic Li salts using poly(sulfur-random-1,3-diisopropenylbenzene) as an additive in an electrolyte. The aromatic-based organic components with planar backbone conformation and π-π interaction in the SEI layers can improve the toughness and flexibility to promote stable and high efficient Li deposition/dissolution. The as-formed durable SEI layer can inhibit dendritic Li growth, enhance Li deposition/dissolution CE (99.1% over 420 cycles), and in turn enable Li-S batteries with good cycling stability (1000 cycles) and slow capacity decay. This work demonstrates a route to address the issues associated with Li metal anodes and promote the development of high-energy rechargeable Li metal batteries.
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http://dx.doi.org/10.1021/acsnano.7b08035DOI Listing
February 2018

Exceptionally High Ionic Conductivity in Na P As S with Improved Moisture Stability for Solid-State Sodium-Ion Batteries.

Adv Mater 2017 Apr 20;29(16). Epub 2017 Feb 20.

Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

A Na-ion solid-state electrolyte, Na P As S , is developed with an exceptionally high conductivity of 1.46 mS cm at 25 °C and enhanced moisture stability. Dual effects of alloying element As (lattice expansion and a weaker AsS bond strength) are responsible for the superior conductivity. Improved moisture stability is regulated by shifting low-energy moisture reactions to high-energy ones due to As.
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http://dx.doi.org/10.1002/adma.201605561DOI Listing
April 2017

The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics.

Dev Cell 2016 10 29;39(1):61-74. Epub 2016 Sep 29.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No. 3 Zhongguancun South Road, Haidian District, Beijing 100190, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. Electronic address:

For adaptation to complex cellular functions, dynamic cytoskeletal networks are required. There are two major components of the cytoskeleton, microtubules and actin filaments, which form an intricate network maintaining an exquisite cooperation to build the physical basis for their cellular function. However, little is known about the molecular mechanism underlying their synergism. Here, we show that in Caco2 epithelial cells, noncentrosomal microtubules crosstalk with F-actin through their minus ends and contribute to the regulation of focal adhesion size and cell migration. We demonstrate that ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. Those noncentrosomal microtubules cooperate with actin filaments through retrograde flow to keep their length and orientation perpendicular to the cell edge as well as regulate focal adhesion size and cell migration.
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http://dx.doi.org/10.1016/j.devcel.2016.09.003DOI Listing
October 2016

Linear multivariate evaluation models for spatial perception of soundscape.

J Acoust Soc Am 2015 Nov;138(5):2860-70

The Queen's College, University of Oxford, Oxford, United Kingdom.

Soundscape is a sound environment that emphasizes the awareness of auditory perception and social or cultural understandings. The case of spatial perception is significant to soundscape. However, previous studies on the auditory spatial perception of the soundscape environment have been limited. Based on 21 native binaural-recorded soundscape samples and a set of auditory experiments for subjective spatial perception (SSP), a study of the analysis among semantic parameters, the inter-aural-cross-correlation coefficient (IACC), A-weighted-equal sound-pressure-level (L(eq)), dynamic (D), and SSP is introduced to verify the independent effect of each parameter and to re-determine some of their possible relationships. The results show that the more noisiness the audience perceived, the worse spatial awareness they received, while the closer and more directional the sound source image variations, dynamics, and numbers of sound sources in the soundscape are, the better the spatial awareness would be. Thus, the sensations of roughness, sound intensity, transient dynamic, and the values of Leq and IACC have a suitable range for better spatial perception. A better spatial awareness seems to promote the preference slightly for the audience. Finally, setting SSPs as functions of the semantic parameters and Leq-D-IACC, two linear multivariate evaluation models of subjective spatial perception are proposed.
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http://dx.doi.org/10.1121/1.4934272DOI Listing
November 2015

Intensification and spatial homogenization of coastal upwelling under climate change.

Nature 2015 Feb;518(7539):390-4

Sustainability and Data Sciences Laboratory, Department of Civil and Environmental Engineering, Northeastern University, Boston, Massachusetts 02115, USA.

The timing and strength of wind-driven coastal upwelling along the eastern margins of major ocean basins regulate the productivity of critical fisheries and marine ecosystems by bringing deep and nutrient-rich waters to the sunlit surface, where photosynthesis can occur. How coastal upwelling regimes might change in a warming climate is therefore a question of vital importance. Although enhanced land-ocean differential heating due to greenhouse warming has been proposed to intensify coastal upwelling by strengthening alongshore winds, analyses of observations and previous climate models have provided little consensus on historical and projected trends in coastal upwelling. Here we show that there are strong and consistent changes in the timing, intensity and spatial heterogeneity of coastal upwelling in response to future warming in most Eastern Boundary Upwelling Systems (EBUSs). An ensemble of climate models shows that by the end of the twenty-first century the upwelling season will start earlier, end later and become more intense at high but not low latitudes. This projected increase in upwelling intensity and duration at high latitudes will result in a substantial reduction of the existing latitudinal variation in coastal upwelling. These patterns are consistent across three of the four EBUSs (Canary, Benguela and Humboldt, but not California). The lack of upwelling intensification and greater uncertainty associated with the California EBUS may reflect regional controls associated with the atmospheric response to climate change. Given the strong linkages between upwelling and marine ecosystems, the projected changes in the intensity, timing and spatial structure of coastal upwelling may influence the geographical distribution of marine biodiversity.
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http://dx.doi.org/10.1038/nature14235DOI Listing
February 2015
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