Publications by authors named "Dafydd G Thomas"

100Publications

PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression.

Transl Oncol 2020 Jul 15;13(7):100776. Epub 2020 May 15.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

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July 2020

Enhancing the Radiation Response in KRAS Mutant Colorectal Cancers Using the c-Met Inhibitor Crizotinib.

Transl Oncol 2019 Feb 6;12(2):209-216. Epub 2018 Nov 6.

University of Michigan Medical School, Department of Radiation Oncology, Ann Arbor, MI, USA.

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February 2019

Gynecologic melanomas: A clinicopathologic and molecular analysis.

Gynecol Oncol 2017 11 24;147(2):351-357. Epub 2017 Aug 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:

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November 2017

Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.

Hum Pathol 2016 12 21;58:161-170. Epub 2016 Sep 21.

Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109; Michigan Center for Translational Pathology, Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109; Michigan Center for Translational Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109. Electronic address:

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December 2016

Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.

Cancer Res 2016 09 30;76(17):5040-53. Epub 2016 Jun 30.

Translational Oncology Program, The University of Michigan, Ann Arbor, Michigan. Department of Pediatrics, and Communicable Diseases, The University of Michigan, Ann Arbor, Michigan. Department of Pathology, The University of Michigan, Ann Arbor, Michigan.

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September 2016

Heterogeneous estrogen receptor expression in circulating tumor cells suggests diverse mechanisms of fulvestrant resistance.

Mol Oncol 2016 08 29;10(7):1078-85. Epub 2016 Apr 29.

Breast Oncology Program of the Comprehensive Cancer Center and the Department of Internal Medicine, University of Michigan Health and Hospital System, Ann Arbor, MI, 48109, USA.

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August 2016

Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):E6882-8. Epub 2015 Nov 30.

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; Department of Cell and Molecular Biology, University of Michigan, Ann Arbor, MI 48109; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109

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December 2015

Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma.

Lab Invest 2015 Nov 17;95(11):1278-90. Epub 2015 Aug 17.

Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.

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November 2015

The role of Dickkopf-3 overexpression in esophageal adenocarcinoma.

J Thorac Cardiovasc Surg 2015 Aug 8;150(2):377-385.e2. Epub 2015 May 8.

Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich. Electronic address:

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August 2015

Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor-positive breast cancer.

Clin Cancer Res 2015 Jun 7;21(11):2487-98. Epub 2014 Nov 7.

Breast Oncology Program of the Comprehensive Cancer Center and the Department of Internal Medicine, University of Michigan Health and Hospital System, Ann Arbor, Michigan.

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June 2015

Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma.

Arch Pathol Lab Med 2014 Nov;138(11):1507-13

From the Department of Pathology (Drs Jorns and Thomas) and Comprehensive Cancer Center (Mr Healy and Ms Daignault), University of Michigan, Ann Arbor; the Genome Institute (Ms Vickery and Dr Mardis) and Division of Oncology (Ms Snider and Drs Davies and Ellis), Washington University School of Medicine, St Louis, Missouri; and the Department of Laboratory Medicine and Pathology (Dr Visscher), Mayo Medical Laboratories, Rochester, Minnesota.

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November 2014

CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression.

Mod Pathol 2015 Jan 20;28(1):57-68. Epub 2014 Jun 20.

1] Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA [2] Department of Dermatology, University of Michigan Health System, Ann Arbor, MI, USA.

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January 2015

TGM2: a cell surface marker in esophageal adenocarcinomas.

J Thorac Oncol 2014 Jun;9(6):872-81

*Thoracic Surgery, Department of Surgery; †Department Radiation Oncology; ‡Department of Biomedical Engineering; §Department of Mechanical Engineering; ‖Division of Gastroenterology in Department of Internal Medicine; and ¶Department of Pathology, University of Michigan, Ann Arbor, MI.

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June 2014

Comparative analysis of rosacea and cutaneous lupus erythematosus: histopathologic features, T-cell subsets, and plasmacytoid dendritic cells.

J Am Acad Dermatol 2014 Jul 20;71(1):100-7. Epub 2014 Mar 20.

Department of Pathology, University of Michigan, Ann Arbor, Michigan; Department of Dermatology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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July 2014

Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.

Mol Cancer Res 2014 Jun 20;12(6):953-64. Epub 2014 Mar 20.

Authors' Affiliations: Departments of Pediatrics and Communicable Diseases, Pathology, University of Michigan, Ann Arbor, Michigan

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June 2014

Comparative evaluation of strategies for quantifying signaling pathway proteins in Ewing sarcoma.

Appl Immunohistochem Mol Morphol 2014 Sep;22(8):593-9

*Department of Pediatrics, University of Chicago, Chicago, IL Departments of ¶Pediatrics §Pathology, San Francisco School of Medicine, University of California, San Francisco, CA Departments of †Pathology ∥Pediatrics, University of Michigan Medical School, Ann Arbor, MI ‡OncoPlex Diagnostics, Rockville, MD.

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September 2014

Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.

J Surg Res 2014 Mar 18;187(1):6-13. Epub 2013 Dec 18.

Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan. Electronic address:

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March 2014

CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells.

Lung Cancer 2013 Dec 23;82(3):477-84. Epub 2013 Sep 23.

Department of Surgery, Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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December 2013

Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma.

Mol Cancer Ther 2013 Sep 26;12(9):1701-14. Epub 2013 Jun 26.

Corresponding Author: Nicholas S. Duesbery, Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, 333 Bostwick Ave., NE, Grand Rapids, MI 49503.

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September 2013

Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors.

Am J Clin Pathol 2013 Jun;139(6):771-9

Michigan Center for Translational Pathology, Department of Pathology,University of Michigan Medical School, Ann Arbor, MI 48104-5054, USA.

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June 2013

Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis.

J Invest Dermatol 2013 Nov 30;133(11):2585-2592. Epub 2013 Apr 30.

Department of Internal Medicine, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan, USA; Department of Epidemiology, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan, USA; Department of Human Genetics, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

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November 2013

Diagnostic evaluation of metastatic rhabdomyosarcoma in effusion specimens.

Diagn Cytopathol 2013 Nov 15;41(11):955-9. Epub 2013 Apr 15.

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.

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November 2013

Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma.

Int J Clin Exp Pathol 2012 16;5(4):347-55. Epub 2012 Apr 16.

Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.

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October 2012

Characterization of vitamin D receptor (VDR) in lung adenocarcinoma.

Lung Cancer 2012 Aug 6;77(2):265-71. Epub 2012 May 6.

Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.

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August 2012

A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.

Clin Cancer Res 2012 Jun 25;18(12):3352-65. Epub 2012 Apr 25.

Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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June 2012

Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma.

Eur J Cancer 2012 Jun 21;48(9):1347-53. Epub 2012 Apr 21.

Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109-5848, United States.

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June 2012

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.

Proc Natl Acad Sci U S A 2012 Mar 28;109(11):4251-6. Epub 2012 Feb 28.

Department of Surgery, Department of Pathology, and Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

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March 2012

p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system.

Histopathology 2012 Mar 19;60(4):597-608. Epub 2012 Jan 19.

Department of Pathology, University of Michigan Medical Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0602, USA.

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March 2012

Stromal LRP1 in lung adenocarcinoma predicts clinical outcome.

Clin Cancer Res 2011 Apr 15;17(8):2426-33. Epub 2011 Feb 15.

Departments of Neurology, University of Michigan; and Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA.

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April 2011

CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.

Clin Cancer Res 2011 Feb 17;17(4):817-26. Epub 2010 Dec 17.

Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2011

Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features.

Am J Surg Pathol 2010 Jun;34(6):844-51

Department of Pathology, University of Michigan, Ann Arbor, MI 48109-0054, USA.

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June 2010

Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.

Clin Cancer Res 2010 Apr 23;16(7):2009-21. Epub 2010 Mar 23.

Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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April 2010

Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups.

Cancer 2009 Sep;115(18):4186-95

Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0054, USA.

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September 2009

Differential protein mapping of ovarian serous adenocarcinomas: identification of potential markers for distinct tumor stage.

J Proteome Res 2009 Mar;8(3):1452-63

Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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March 2009

Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma.

J Clin Endocrinol Metab 2009 Jan 14;94(1):204-12. Epub 2008 Oct 14.

Department of Internal Medicine-Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, USA.

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January 2009

Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.

Neoplasia 2006 Dec;8(12):1062-71

Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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December 2006

Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma.

Mod Pathol 2006 May;19(5):659-68

Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109-0054, USA.

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May 2006

Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition.

Pediatr Blood Cancer 2006 May;46(5):614-23

Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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May 2006

Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants.

Clin Cancer Res 2004 Sep;10(17):5708-16

Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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September 2004

L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma.

Neoplasia 2004 Jan-Feb;6(1):74-84

Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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October 2004