Dafydd G Thomas

Dafydd G Thomas

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Dafydd G Thomas

Dafydd G Thomas

Publications by authors named "Dafydd G Thomas"

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Gynecologic melanomas: A clinicopathologic and molecular analysis.

Gynecol Oncol 2017 11 24;147(2):351-357. Epub 2017 Aug 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.08.023DOI Listing
November 2017

Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.

Hum Pathol 2016 12 21;58:161-170. Epub 2016 Sep 21.

Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109; Michigan Center for Translational Pathology, Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109; Michigan Center for Translational Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125884PMC
December 2016

Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.

Cancer Res 2016 09 30;76(17):5040-53. Epub 2016 Jun 30.

Translational Oncology Program, The University of Michigan, Ann Arbor, Michigan. Department of Pediatrics, and Communicable Diseases, The University of Michigan, Ann Arbor, Michigan. Department of Pathology, The University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010452PMC
September 2016

Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):E6882-8. Epub 2015 Nov 30.

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; Department of Cell and Molecular Biology, University of Michigan, Ann Arbor, MI 48109; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109

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http://dx.doi.org/10.1073/pnas.1507899112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687560PMC
December 2015

The role of Dickkopf-3 overexpression in esophageal adenocarcinoma.

J Thorac Cardiovasc Surg 2015 Aug 8;150(2):377-385.e2. Epub 2015 May 8.

Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515149PMC
August 2015

Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor-positive breast cancer.

Clin Cancer Res 2015 Jun 7;21(11):2487-98. Epub 2014 Nov 7.

Breast Oncology Program of the Comprehensive Cancer Center and the Department of Internal Medicine, University of Michigan Health and Hospital System, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516625PMC
June 2015

CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression.

Mod Pathol 2015 Jan 20;28(1):57-68. Epub 2014 Jun 20.

1] Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA [2] Department of Dermatology, University of Michigan Health System, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/modpathol.2014.83DOI Listing
January 2015

Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma.

Arch Pathol Lab Med 2014 Nov;138(11):1507-13

From the Department of Pathology (Drs Jorns and Thomas) and Comprehensive Cancer Center (Mr Healy and Ms Daignault), University of Michigan, Ann Arbor; the Genome Institute (Ms Vickery and Dr Mardis) and Division of Oncology (Ms Snider and Drs Davies and Ellis), Washington University School of Medicine, St Louis, Missouri; and the Department of Laboratory Medicine and Pathology (Dr Visscher), Mayo Medical Laboratories, Rochester, Minnesota.

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http://dx.doi.org/10.5858/arpa.2013-0621-OADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327939PMC
November 2014

Comparative evaluation of strategies for quantifying signaling pathway proteins in Ewing sarcoma.

Appl Immunohistochem Mol Morphol 2014 Sep;22(8):593-9

*Department of Pediatrics, University of Chicago, Chicago, IL Departments of ¶Pediatrics §Pathology, San Francisco School of Medicine, University of California, San Francisco, CA Departments of †Pathology ∥Pediatrics, University of Michigan Medical School, Ann Arbor, MI ‡OncoPlex Diagnostics, Rockville, MD.

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http://dx.doi.org/10.1097/PAI.0b013e3182a8d4bbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148473PMC
September 2014

Comparative analysis of rosacea and cutaneous lupus erythematosus: histopathologic features, T-cell subsets, and plasmacytoid dendritic cells.

J Am Acad Dermatol 2014 Jul 20;71(1):100-7. Epub 2014 Mar 20.

Department of Pathology, University of Michigan, Ann Arbor, Michigan; Department of Dermatology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2014.01.892DOI Listing
July 2014

Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.

Mol Cancer Res 2014 Jun 20;12(6):953-64. Epub 2014 Mar 20.

Authors' Affiliations: Departments of Pediatrics and Communicable Diseases, Pathology, University of Michigan, Ann Arbor, Michigan

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058379PMC
June 2014

TGM2: a cell surface marker in esophageal adenocarcinomas.

J Thorac Oncol 2014 Jun;9(6):872-81

*Thoracic Surgery, Department of Surgery; †Department Radiation Oncology; ‡Department of Biomedical Engineering; §Department of Mechanical Engineering; ‖Division of Gastroenterology in Department of Internal Medicine; and ¶Department of Pathology, University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1097/JTO.0000000000000229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170218PMC
June 2014

Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.

J Surg Res 2014 Mar 18;187(1):6-13. Epub 2013 Dec 18.

Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00224804130218
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http://dx.doi.org/10.1016/j.jss.2013.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073630PMC
March 2014

CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells.

Lung Cancer 2013 Dec 23;82(3):477-84. Epub 2013 Sep 23.

Department of Surgery, Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.lungcan.2013.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073640PMC
December 2013

Diagnostic evaluation of metastatic rhabdomyosarcoma in effusion specimens.

Diagn Cytopathol 2013 Nov 15;41(11):955-9. Epub 2013 Apr 15.

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/dc.22987DOI Listing
November 2013

Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis.

J Invest Dermatol 2013 Nov 30;133(11):2585-2592. Epub 2013 Apr 30.

Department of Internal Medicine, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan, USA; Department of Epidemiology, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan, USA; Department of Human Genetics, University of Michigan Medical School and School of Public Health, Ann Arbor, Michigan, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/jid.2013.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267221PMC
November 2013

Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma.

Mol Cancer Ther 2013 Sep 26;12(9):1701-14. Epub 2013 Jun 26.

Corresponding Author: Nicholas S. Duesbery, Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, 333 Bostwick Ave., NE, Grand Rapids, MI 49503.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769440PMC
September 2013

Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors.

Am J Clin Pathol 2013 Jun;139(6):771-9

Michigan Center for Translational Pathology, Department of Pathology,University of Michigan Medical School, Ann Arbor, MI 48104-5054, USA.

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http://dx.doi.org/10.1309/AJCPN4L1BMRQPEITDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662488PMC
June 2013

Ewing sarcoma of the kidney: case series and literature review of an often overlooked entity in the diagnosis of primary renal tumors.

Urology 2013 Feb;81(2):347-53

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5848, USA.

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http://dx.doi.org/10.1016/j.urology.2012.10.016DOI Listing
February 2013

Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma.

Int J Clin Exp Pathol 2012 16;5(4):347-55. Epub 2012 Apr 16.

Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365819PMC
October 2012

Characterization of vitamin D receptor (VDR) in lung adenocarcinoma.

Lung Cancer 2012 Aug 6;77(2):265-71. Epub 2012 May 6.

Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.

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http://dx.doi.org/10.1016/j.lungcan.2012.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396768PMC
August 2012

Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma.

Eur J Cancer 2012 Jun 21;48(9):1347-53. Epub 2012 Apr 21.

Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109-5848, United States.

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http://dx.doi.org/10.1016/j.ejca.2012.03.022DOI Listing
June 2012

A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.

Clin Cancer Res 2012 Jun 25;18(12):3352-65. Epub 2012 Apr 25.

Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042205PMC
June 2012

p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system.

Histopathology 2012 Mar 19;60(4):597-608. Epub 2012 Jan 19.

Department of Pathology, University of Michigan Medical Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0602, USA.

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http://dx.doi.org/10.1111/j.1365-2559.2011.04093.xDOI Listing
March 2012

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.

Proc Natl Acad Sci U S A 2012 Mar 28;109(11):4251-6. Epub 2012 Feb 28.

Department of Surgery, Department of Pathology, and Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1011989109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306720PMC
March 2012

Stromal LRP1 in lung adenocarcinoma predicts clinical outcome.

Clin Cancer Res 2011 Apr 15;17(8):2426-33. Epub 2011 Feb 15.

Departments of Neurology, University of Michigan; and Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079007PMC
April 2011

CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.

Clin Cancer Res 2011 Feb 17;17(4):817-26. Epub 2010 Dec 17.

Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058389PMC
February 2011

Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features.

Am J Surg Pathol 2010 Jun;34(6):844-51

Department of Pathology, University of Michigan, Ann Arbor, MI 48109-0054, USA.

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http://dx.doi.org/10.1097/PAS.0b013e3181db34d8DOI Listing
June 2010

Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.

Clin Cancer Res 2010 Apr 23;16(7):2009-21. Epub 2010 Mar 23.

Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953959PMC
April 2010

Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups.

Cancer 2009 Sep;115(18):4186-95

Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0054, USA.

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http://doi.wiley.com/10.1002/cncr.24486
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http://dx.doi.org/10.1002/cncr.24486DOI Listing
September 2009

Differential protein mapping of ovarian serous adenocarcinomas: identification of potential markers for distinct tumor stage.

J Proteome Res 2009 Mar;8(3):1452-63

Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://pubs.acs.org/doi/abs/10.1021/pr800820z
Publisher Site
http://dx.doi.org/10.1021/pr800820zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693455PMC
March 2009

Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma.

J Clin Endocrinol Metab 2009 Jan 14;94(1):204-12. Epub 2008 Oct 14.

Department of Internal Medicine-Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, USA.

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http://dx.doi.org/10.1210/jc.2008-1456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630877PMC
January 2009

Comparative proteomics analysis of Barrett metaplasia and esophageal adenocarcinoma using two-dimensional liquid mass mapping.

Mol Cell Proteomics 2007 Jun 8;6(6):987-99. Epub 2006 Jul 8.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/mcp.M600175-MCP200DOI Listing
June 2007

Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.

Neoplasia 2006 Dec;8(12):1062-71

Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1593/neo.05832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783715PMC
December 2006

Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons.

Cancer 2006 Aug;107(3):554-62

Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109-0054, USA.

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http://dx.doi.org/10.1002/cncr.22019DOI Listing
August 2006

Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition.

Pediatr Blood Cancer 2006 May;46(5):614-23

Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/pbc.20454DOI Listing
May 2006

Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma.

Mod Pathol 2006 May;19(5):659-68

Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109-0054, USA.

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http://dx.doi.org/10.1038/modpathol.3800569DOI Listing
May 2006

Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma.

Cancer 2005 Feb;103(4):830-8

Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109-0602, USA.

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http://dx.doi.org/10.1002/cncr.20847DOI Listing
February 2005

Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants.

Clin Cancer Res 2004 Sep;10(17):5708-16

Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0468DOI Listing
September 2004

Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.

Cancer Res 2004 Mar;64(6):2047-53

Department of Pediatrics and Infectious Diseases, Division of Pediatric Hematology/Oncology, University of Michigan Medical Center, L2110 Women's Hospital, 0238, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0238, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-3096DOI Listing
March 2004