Publications by authors named "Dae-Sik Lim"

98Publications

YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice.

Cancer Res 2020 Nov 8;80(21):4768-4779. Epub 2020 Sep 8.

Department of Biological Sciences, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-20-0907DOI Listing
November 2020

WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.

Mol Cells 2020 May;43(5):491-499

Department of Biological Sciences, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

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http://dx.doi.org/10.14348/molcells.2020.0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264477PMC
May 2020

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth.

Genes Dev 2020 01 12;34(1-2):72-86. Epub 2019 Dec 12.

Department of Pharmacology, Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1101/gad.331546.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938666PMC
January 2020

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.

J Mol Cell Biol 2019 12;11(11):1006-1017

Department of Biological Sciences, KAIST 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.1093/jmcb/mjz013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927243PMC
December 2019

A MST1-FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis.

Nat Commun 2019 02 19;10(1):838. Epub 2019 Feb 19.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea.

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http://dx.doi.org/10.1038/s41467-019-08773-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381131PMC
February 2019

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.

Circ Res 2019 01;124(2):292-305

From the Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark (S.I., W.M., S. Sciarretta, M.A., P.Z., R.M., N.F., S.-i.O., M.N., D.P.D.R., L.-H.X., J.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645688PMC
January 2019

YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis.

Circ Res 2019 01;124(2):225-242

From the Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon (H.C., J.H.A., D.-S.L., G.Y.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31370
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313707DOI Listing
January 2019

SURF4 has oncogenic potential in NIH3T3 cells.

Biochem Biophys Res Commun 2018 07 21;502(1):43-47. Epub 2018 May 21.

Department of Medical Science, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea; Department of Biological Sciences, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183117
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http://dx.doi.org/10.1016/j.bbrc.2018.05.116DOI Listing
July 2018

Insulin receptor substrate 2: a bridge between Hippo and AKT pathways.

BMB Rep 2018 May;51(5):209-210

National Creative Research Initiatives Center, Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988573PMC
http://dx.doi.org/10.5483/bmbrep.2018.51.5.095DOI Listing
May 2018

YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC.

Cancer Res 2018 06 18;78(12):3306-3320. Epub 2018 Apr 18.

National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3487DOI Listing
June 2018

BIG2-ARF1-RhoA-mDia1 Signaling Regulates Dendritic Golgi Polarization in Hippocampal Neurons.

Mol Neurobiol 2018 Oct 17;55(10):7701-7716. Epub 2018 Feb 17.

Department of Microbiology and Molecular Biology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea.

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http://dx.doi.org/10.1007/s12035-018-0954-7DOI Listing
October 2018

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.

J Clin Invest 2018 03 5;128(3):1010-1025. Epub 2018 Feb 5.

National Creative Research Initiatives Center, Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

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http://dx.doi.org/10.1172/JCI95802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824861PMC
March 2018

Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition.

Sci Rep 2018 01 17;8(1):942. Epub 2018 Jan 17.

Department of Biological Sciences, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

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http://dx.doi.org/10.1038/s41598-018-19637-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772645PMC
January 2018

Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.

Dev Cell 2018 01 14;44(1):13-28.e3. Epub 2017 Dec 14.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760287PMC
January 2018

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.

J Clin Invest 2017 Sep 14;127(9):3441-3461. Epub 2017 Aug 14.

Center for Vascular Research, Institute for Basic Science, Daejeon, South Korea.

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http://dx.doi.org/10.1172/JCI93825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669570PMC
September 2017

Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma.

Biochem Biophys Res Commun 2017 09 3;491(2):493-499. Epub 2017 Jul 3.

Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.07.007DOI Listing
September 2017

Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling.

EMBO J 2017 09 3;36(17):2510-2528. Epub 2017 Jul 3.

Department of Biological Sciences, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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http://dx.doi.org/10.15252/embj.201696089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579353PMC
September 2017

The novel YAP target gene, SGK1, upregulates TAZ activity by blocking GSK3β-mediated TAZ destabilization.

Biochem Biophys Res Commun 2017 08 17;490(3):650-656. Epub 2017 Jun 17.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea; National Creative Research Center for Cell Division and Differentiation, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X173122
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http://dx.doi.org/10.1016/j.bbrc.2017.06.092DOI Listing
August 2017

Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival.

Stem Cell Res 2017 04 27;20:42-49. Epub 2017 Feb 27.

Division of Cardiovascular Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376382PMC
April 2017

NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.

Mol Cell Biol 2017 04 31;37(8). Epub 2017 Mar 31.

Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan

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http://dx.doi.org/10.1128/MCB.00424-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376635PMC
April 2017

MRTF potentiates TEAD-YAP transcriptional activity causing metastasis.

EMBO J 2017 02 27;36(4):520-535. Epub 2016 Dec 27.

National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea

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http://dx.doi.org/10.15252/embj.201695137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694947PMC
February 2017

Prostaglandin E Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.

Gastroenterology 2017 02 15;152(3):616-630. Epub 2016 Nov 15.

Biomedical Research Center, Asan Institute for Life Sciences, Seoul, South Korea; Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285392PMC
February 2017

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis.

Sci Rep 2016 08 23;6:31931. Epub 2016 Aug 23.

Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.1038/srep31931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994041PMC
August 2016

The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation.

Biochem Biophys Res Commun 2016 10 28;479(2):152-158. Epub 2016 Jul 28.

Cancer Institute of Chungnam National University, Daejeon 35015, South Korea; Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.111DOI Listing
October 2016

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

Nat Commun 2016 06 30;7:11961. Epub 2016 Jun 30.

National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.1038/ncomms11961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931324PMC
June 2016

The SRF-YAP-IL6 axis promotes breast cancer stemness.

Cell Cycle 2016 05;15(10):1311-2

a Department of Biological Sciences , Korea Advanced Institute of Science and Technology , Daejeon , Korea.

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http://dx.doi.org/10.1080/15384101.2016.1161994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916404PMC
May 2016

Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance.

Biochem Biophys Res Commun 2016 05 20;474(1):154-160. Epub 2016 Apr 20.

Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.04.089DOI Listing
May 2016

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2.

Oncotarget 2016 Apr;7(17):24063-75

National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

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http://dx.doi.org/10.18632/oncotarget.8211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029684PMC
April 2016

A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness.

Nat Commun 2015 Dec 16;6:10186. Epub 2015 Dec 16.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1038/ncomms10186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703869PMC
December 2015

Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.

EMBO Rep 2016 Jan 23;17(1):64-78. Epub 2015 Nov 23.

National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea

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http://dx.doi.org/10.15252/embr.201540809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718409PMC
January 2016

Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.

Arterioscler Thromb Vasc Biol 2016 Jan 19;36(1):86-96. Epub 2015 Nov 19.

Department of Pediatrics (C.P., H.S.C.), Children's Heart Research and Outcomes Center (C.P.), Molecular and Systems Pharmacology Program (C.P.), Emory University School of Medicine, Atlanta; Department of Pharmacology, College of Medicine, University of Illinois at Chicago, IL (T.M.K., N.U., M.U-F.); School of Chemical Engineering, Sungkyunkwan University, Korea (S.H.B.); School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea (B-S.K.); Korea Advanced Institute of Science and Technology, Korea (D.J.L., D-S.L.); RIKEN BioResource Center, Japan (H.M.); the Departments of Pathology and Immunology (T-J.L., F.L., K.C.), Ophthalmology and Visual Sciences (R.N., I.P-R., R.S.A.), Developmental Biology (S.S.O., D.M.O.), Biochemistry and Molecular Biophysics (B. C.), Developmental, Regenerative, and Stem cell Biology Program (D.M.O., R.S.A., K.C.), Washington University School of Medicine, MO.

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http://atvb.ahajournals.org/content/36/1/86.full.pdf
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http://atvb.ahajournals.org/lookup/doi/10.1161/ATVBAHA.115.3
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http://dx.doi.org/10.1161/ATVBAHA.115.306430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690812PMC
January 2016

Mouse Hepatic Tumor Vascular Imaging by Experimental Selective Angiography.

PLoS One 2015 1;10(7):e0131687. Epub 2015 Jul 1.

Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131687PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489182PMC
April 2016

Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila.

PLoS Genet 2015 May 21;11(5):e1005263. Epub 2015 May 21.

National Creative Research Initiatives Center for Energy Homeostasis Regulation, Seoul National University, Seoul, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Republic of Korea; School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1371/journal.pgen.1005263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440640PMC
May 2015

Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

Cell Rep 2015 Apr 2;11(2):270-82. Epub 2015 Apr 2.

National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.015DOI Listing
April 2015

Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation.

J Bone Miner Res 2015 Sep 31;30(9):1597-607. Epub 2015 May 31.

Department of Pharmacology, Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea.

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http://dx.doi.org/10.1002/jbmr.2503DOI Listing
September 2015

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.

Nat Cell Biol 2015 Apr 9;17(4):500-10. Epub 2015 Mar 9.

Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/ncb3111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380774PMC
April 2015

The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.

Nat Commun 2014 Nov 4;5:5370. Epub 2014 Nov 4.

Department of Biological Sciences, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.

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http://dx.doi.org/10.1038/ncomms6370DOI Listing
November 2014

The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.

J Biol Chem 2014 Aug 17;289(35):24275-88. Epub 2014 Jul 17.

From the Institute of Cardiovascular Sciences, University of Manchester and Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M114.562405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148857PMC
August 2014

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response.

Nat Commun 2014 ;5:3315

Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey 07103, USA.

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http://www.nature.com/articles/ncomms4315
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http://dx.doi.org/10.1038/ncomms4315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962829PMC
November 2015

Reversing the intractable nature of pancreatic cancer by selectively targeting ALDH-high, therapy-resistant cancer cells.

PLoS One 2013 23;8(10):e78130. Epub 2013 Oct 23.

Graduate School of Medical Science and Engineering, South Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078130PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806801PMC
February 2015

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.

Nat Med 2013 Nov 20;19(11):1478-88. Epub 2013 Oct 20.

1] Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA. [2] Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

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http://www.nature.com/articles/nm.3322
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http://dx.doi.org/10.1038/nm.3322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823824PMC
November 2013

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

Proc Natl Acad Sci U S A 2013 Jul 1;110(29):12066-71. Epub 2013 Jul 1.

Laboratory of Cell Death and Human Diseases, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.

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http://dx.doi.org/10.1073/pnas.1300894110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718122PMC
July 2013

SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage.

Cell Rep 2013 Jun 20;3(6):2075-87. Epub 2013 Jun 20.

National Creative Initiatives Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseoung-D, Yuseong-G, Daejeon 305-701, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053763PMC
http://dx.doi.org/10.1016/j.celrep.2013.05.029DOI Listing
June 2013

cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.

EMBO J 2013 May 3;32(11):1543-55. Epub 2013 May 3.

National Creative Research Initiatives Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305-701, Republic of Korea.

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http://dx.doi.org/10.1038/emboj.2013.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671250PMC
May 2013

Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis.

Proc Natl Acad Sci U S A 2013 May 25;110(19):7732-7. Epub 2013 Apr 25.

Department of Biological Sciences, National Creative Research Initiatives Center, Biomedical Research Center, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1073/pnas.1220603110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651464PMC
May 2013

RASSF Family Proteins.

Mol Biol Int 2012 10;2012:938916. Epub 2012 Dec 10.

JG Brown Cancer Center, University of Louisville, 417 CTR Building, 505 S. Hancock Street, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1155/2012/938916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523567PMC
January 2013

Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1.

Free Radic Biol Med 2012 Dec 17;53(12):2335-43. Epub 2012 Oct 17.

Laboratory of Cell Death and Human Diseases, School of Life Sciences, South Korea; School of Pharmacy, Korea University, Seoul 136-701, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.527DOI Listing
December 2012

Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.

Cancer Res 2012 Oct 27;72(20):5386-95. Epub 2012 Aug 27.

Authors' Affiliations: Department of Biological Sciences, National Creative Research Initiatives Center, Graduate School of Nanoscience and Technology (WCU), Korea Advanced Institute of Science and Technology, Daejeon, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3956DOI Listing
October 2012

ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling.

Blood 2012 Apr 17;119(14):3295-305. Epub 2012 Feb 17.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2012-01-403766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321855PMC
April 2012

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice.

EMBO J 2012 Mar 6;31(5):1147-59. Epub 2012 Jan 6.

Department of Biological Sciences, National Creative Research Initiatives Center, Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

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http://dx.doi.org/10.1038/emboj.2011.480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297990PMC
March 2012

The Er71 is an important regulator of hematopoietic stem cells in adult mice.

Stem Cells 2011 Mar;29(3):539-48

National Creative Research Initiatives Center, Department of Biological Sciences, Graduate School of Nanoscience and Technology (WCU), Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, Korea.

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http://dx.doi.org/10.1002/stem.597DOI Listing
March 2011

Retrotransposon-specific DNA hypomethylation and two-step loss-of-imprinting during WW45 haploinsufficiency-induced hepatocarcinogenesis.

Biochem Biophys Res Commun 2011 Jan 14;404(2):728-34. Epub 2010 Dec 14.

National Creative Research Initiatives Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea.

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http://dx.doi.org/10.1016/j.bbrc.2010.12.052DOI Listing
January 2011

Male-like sexual behavior of female mouse lacking fucose mutarotase.

BMC Genet 2010 Jul 7;11:62. Epub 2010 Jul 7.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong-Gu, Daejon 305-701, Korea.

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http://dx.doi.org/10.1186/1471-2156-11-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912782PMC
July 2010

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.

Proc Natl Acad Sci U S A 2010 May 19;107(18):8248-53. Epub 2010 Apr 19.

Department of Biological Sciences, Graduate School of Medical Science and Engineering, National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1073/pnas.0912203107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889558PMC
May 2010

MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment.

Curr Biol 2010 Mar 18;20(5):416-22. Epub 2010 Feb 18.

Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1016/j.cub.2009.12.054DOI Listing
March 2010

The protease inhibitor, elafin, induces p53-dependent apoptosis in human melanoma cells.

Int J Cancer 2010 Sep;127(6):1308-20

Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

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http://dx.doi.org/10.1002/ijc.25125DOI Listing
September 2010

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.

Biochem Biophys Res Commun 2010 Jan 4;391(1):969-73. Epub 2009 Dec 4.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2009.11.175DOI Listing
January 2010

Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.

PLoS One 2009 Nov 24;4(11):e8011. Epub 2009 Nov 24.

Department of Biological Sciences, National Research Laboratory of Molecular Genetics, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008011PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776980PMC
November 2009

Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody.

Cancer Res 2009 Nov 3;69(22):8540-4. Epub 2009 Nov 3.

National Research Laboratory for Genomic Stability, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1554DOI Listing
November 2009

Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.

Mol Cell Biol 2009 Dec 28;29(23):6309-20. Epub 2009 Sep 28.

National Research Laboratory of Molecular Genetics, Department of Biological Science, KAIST, Daejeon 305-701, South Korea.

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http://dx.doi.org/10.1128/MCB.00551-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786698PMC
December 2009

SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.

Gastroenterology 2009 Nov 15;137(5):1816-26.e1-10. Epub 2009 Aug 15.

Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1053/j.gastro.2009.08.005DOI Listing
November 2009

Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function.

Mol Cells 2009 Jun 12;27(6):697-701. Epub 2009 Jun 12.

Department of Microbiology, Chungnam National University, Daejeon 305-764, Korea.

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http://dx.doi.org/10.1007/s10059-009-0083-2DOI Listing
June 2009

Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity.

Cancer Res 2009 Mar 10;69(6):2314-23. Epub 2009 Mar 10.

National Research Laboratory for Genomic Stability, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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March 2009

A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death.

Biochem Biophys Res Commun 2009 Jan 28;378(3):332-7. Epub 2008 Nov 28.

Department of Molecular Science and Technology, College of Natural Sciences, Ajou University, San 5 Wonchun-Dong, Yeongtong-Gu, Suwon 443-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.079DOI Listing
January 2009

An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner.

Biochem Biophys Res Commun 2009 Jan 25;378(3):326-31. Epub 2008 Nov 25.

Department of Molecular Science and Technology, College of Natural Sciences, Ajou University, Suwon 443-749, Daejeon 305-701, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.057DOI Listing
January 2009

Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1.

J Biol Chem 2008 Nov 12;283(47):32344-51. Epub 2008 Sep 12.

Department of Biology, Chungnam National University, Daejeon 305-764, Korea.

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http://dx.doi.org/10.1074/jbc.M804199200DOI Listing
November 2008

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.

EMBO J 2008 Jul 19;27(13):1863-74. Epub 2008 Jun 19.

National Research Laboratory for Genomic Stability, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1038/emboj.2008.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486425PMC
July 2008

A crucial role of WW45 in developing epithelial tissues in the mouse.

EMBO J 2008 Apr 27;27(8):1231-42. Epub 2008 Mar 27.

National Research Laboratory, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

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http://dx.doi.org/10.1038/emboj.2008.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367404PMC
April 2008

Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway.

Proc Natl Acad Sci U S A 2007 May 21;104(22):9236-41. Epub 2007 May 21.

Magnetic Resonance Team, Korea Basic Science Institute, 804-1 Yangchung-Ri, Ochang, Chungbuk 363-883, Korea.

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http://dx.doi.org/10.1073/pnas.0610716104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890478PMC
May 2007

Mouse emi1 has an essential function in mitotic progression during early embryogenesis.

Mol Cell Biol 2006 Jul;26(14):5373-81

Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseoung-dong, Yuseong-gu, Daejeon 305-701, South Korea.

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http://dx.doi.org/10.1128/MCB.00043-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592703PMC
July 2006

Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.

FEBS J 2006 Apr;273(8):1630-6

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong-D, Yuseong-G, Daejeon.

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http://dx.doi.org/10.1111/j.1742-4658.2006.05191.xDOI Listing
April 2006

Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

Cancer Res 2006 Mar;66(5):2562-9

Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-2951DOI Listing
March 2006

T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells.

Brain Res 2005 Aug;1054(1):22-9

Biomedical Research Center, Korea Institute of Science and Technology, Seoul, Korea.

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http://dx.doi.org/10.1016/j.brainres.2005.05.010DOI Listing
August 2005

RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer.

Int J Cancer 2005 Jul;115(4):575-81

Cancer Research Center, Center for Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1002/ijc.20916DOI Listing
July 2005

The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles.

J Biol Chem 2005 Feb 16;280(5):3920-7. Epub 2004 Nov 16.

Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseoung-D, Yuseong-G, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1074/jbc.M409115200DOI Listing
February 2005

Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.

Mol Cancer Res 2004 Jun;2(6):362-9

Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, Room 406, CSRB Building, 533 Bolivar Street, New Orleans, LA 70112, USA.

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June 2004

Control of APC-Cdc20 by the tumor suppressor RASSF1A.

Cell Cycle 2004 May 25;3(5):574-6. Epub 2004 May 25.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon.

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May 2004

Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns.

J Cancer Res Clin Oncol 2004 Apr 23;130(4):225-34. Epub 2004 Jan 23.

National Cancer Center, 809 Madu-dong, Ilsan-gu, 411-764, Goyang, Gyeonggi, Korea.

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http://dx.doi.org/10.1007/s00432-003-0522-yDOI Listing
April 2004

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex.

Nat Cell Biol 2004 Feb 25;6(2):129-37. Epub 2004 Jan 25.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Guseoung-D, Yuseong-G, Daejeon 305-701, Korea.

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http://dx.doi.org/10.1038/ncb1091DOI Listing
February 2004

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Mol Cancer Res 2003 Jul;1(9):674-81

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

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July 2003

Association of hepatitis B virus polymerase with promyelocytic leukemia nuclear bodies mediated by the S100 family protein p11.

Biochem Biophys Res Commun 2003 Jun;305(4):1049-56

Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawallkok-dong, Sungbuk-ku, Seoul 136-791, South Korea.

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http://dx.doi.org/10.1016/s0006-291x(03)00881-7DOI Listing
June 2003

Construction of two pGEM-7Zf(+) phagemid T-tail vectors using AhdI-restriction endonuclease sites for direct cloning of PCR products.

Plasmid 2002 Sep;48(2):160-3

Graduate School of Biotechnology, Korea University, Seoul 136-701, South Korea.

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http://dx.doi.org/10.1016/s0147-619x(02)00122-1DOI Listing
September 2002

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.

Mol Cell Biol 2002 Feb;22(4):1049-59

Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134638PMC
http://dx.doi.org/10.1128/mcb.22.4.1049-1059.2002DOI Listing
February 2002