Daan van Aalten

Daan van Aalten

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Daan van Aalten

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An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase.

Eur J Hum Genet 2020 Feb 20. Epub 2020 Feb 20.

Division of Gene Regulation and Expression and School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/s41431-020-0589-9DOI Listing
February 2020

O-GlcNAcase contributes to cognitive function in .

J Biol Chem 2020 Feb 24. Epub 2020 Feb 24.

School of Life Sciences, University of Dundee, United Kingdom.

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http://dx.doi.org/10.1074/jbc.RA119.010312DOI Listing
February 2020

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation.

Nat Struct Mol Biol 2019 11 6;26(11):1071-1077. Epub 2019 Nov 6.

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/s41594-019-0325-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858883PMC
November 2019

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability.

Proc Natl Acad Sci U S A 2019 07 11;116(30):14961-14970. Epub 2019 Jul 11.

Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1900065116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660750PMC
July 2019

Evidence for substrate-assisted catalysis in -acetylphosphoglucosamine mutase.

Biochem J 2018 08 16;475(15):2547-2557. Epub 2018 Aug 16.

Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BCJ20180172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096347PMC
August 2018

Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors.

Bioconjug Chem 2018 06 10;29(6):1834-1840. Epub 2018 May 10.

Division of Gene Regulation and Expression, School of Life Sciences , University of Dundee , DD1 5EH Dundee , U.K.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016062PMC
June 2018

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies.

Chemistry 2018 May 30;24(28):7264-7272. Epub 2018 Apr 30.

Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009, Zaragoza, Spain.

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http://dx.doi.org/10.1002/chem.201801083DOI Listing
May 2018

Effects of hypo--GlcNAcylation on development.

J Biol Chem 2018 05 27;293(19):7209-7221. Epub 2018 Mar 27.

From the Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom

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http://dx.doi.org/10.1074/jbc.RA118.002580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950000PMC
May 2018

The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix.

Cell Chem Biol 2018 05 29;25(5):513-518.e4. Epub 2018 Mar 29.

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967971PMC
May 2018

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

Nature 2018 04 11;556(7701):381-385. Epub 2018 Apr 11.

MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.

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http://www.nature.com/articles/s41586-018-0026-1
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http://dx.doi.org/10.1038/s41586-018-0026-1DOI Listing
April 2018

Inhibitors against Fungal Cell Wall Remodeling Enzymes.

ChemMedChem 2018 01 12;13(2):128-132. Epub 2017 Dec 12.

Institute of Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, BIFI-IQFR (CSIC) Joint Unit, Campus Rio Ebro, Zaragoza, Aragón, Spain.

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http://dx.doi.org/10.1002/cmdc.201700720DOI Listing
January 2018

A mutant O-GlcNAcase enriches Drosophila developmental regulators.

Nat Chem Biol 2017 Aug 12;13(8):882-887. Epub 2017 Jun 12.

MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nchembio.2404DOI Listing
August 2017

Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry.

ACS Chem Biol 2017 08 28;12(8):2078-2084. Epub 2017 Jun 28.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics Centre, Utrecht University , Padualaan 8, 3584 CH, Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/acschembio.7b00371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565903PMC
August 2017

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats.

Open Biol 2017 06;7(6)

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK

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http://dx.doi.org/10.1098/rsob.170078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493779PMC
June 2017

Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4.

Sci Rep 2017 05 11;7(1):1746. Epub 2017 May 11.

Faculty of Chemistry, Biotechnology, and Food Science, The Norwegian University of Life Sciences, Ås, 1432, Norway.

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http://dx.doi.org/10.1038/s41598-017-02043-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431758PMC
May 2017

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins.

Biochem J 2016 06 5;473(12):1693-702. Epub 2016 Apr 5.

School of Life Sciences, University of Dundee, Dundee DD1 4HN, U.K. Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, U.K.

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http://dx.doi.org/10.1042/BCJ20160092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901358PMC
June 2016

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.

Nat Immunol 2016 06 25;17(6):712-20. Epub 2016 Apr 25.

Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/ni.3439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900450PMC
June 2016

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes.

Genes Dev 2016 Apr 7;30(8):960-72. Epub 2016 Apr 7.

Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland;

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http://dx.doi.org/10.1101/gad.275925.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840301PMC
April 2016

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations.

J Am Chem Soc 2016 Mar 1;138(10):3325-32. Epub 2016 Mar 1.

Departament de Química Inorgànica i Orgànica and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona , Martí i Franquès 1, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/jacs.5b10092DOI Listing
March 2016

O-GlcNAc transferase inhibitors: current tools and future challenges.

Biochem Soc Trans 2016 Feb;44(1):88-93

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K. Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BST20150189DOI Listing
February 2016

Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum.

J Biol Chem 2015 Dec 21;290(51):30291-305. Epub 2015 Oct 21.

From the Division of Molecular Microbiology and Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, DD1 5EH Dundee, Scotland, United Kingdom and

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http://dx.doi.org/10.1074/jbc.M115.689596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683255PMC
December 2015

Dual functionality of O-GlcNAc transferase is required for Drosophila development.

Open Biol 2015 Dec;5(12):150234

MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK Division of Molecular Microbiology, University of Dundee, Dundee, UK

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http://dx.doi.org/10.1098/rsob.150234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703063PMC
December 2015

The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

Nat Struct Mol Biol 2015 Sep 3;22(9):744-750. Epub 2015 Aug 3.

MRC Protein Phosphorylation and Ubiquitylation Unit and College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nsmb.3063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979681PMC
September 2015

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

EMBO Rep 2015 Aug 25;16(8):939-54. Epub 2015 Jun 25.

MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences University of Dundee, Dundee, UK College of Medicine, Dentistry & Nursing University of Dundee, Dundee, UK

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http://dx.doi.org/10.15252/embr.201540352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552487PMC
August 2015

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.

Nat Commun 2015 Jul 20;6:7807. Epub 2015 Jul 20.

1] Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University Freiburg, D-79104 Freiburg, Germany [2] Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs-University Freiburg, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1038/ncomms8807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518317PMC
July 2015

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.

ACS Chem Biol 2015 Jun 27;10(6):1425-34. Epub 2015 Feb 27.

†Division of Molecular Microbiology, ‡Division of Biological Chemistry and Drug Discovery, §MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/cb5008647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477619PMC
June 2015

The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System.

J Biol Chem 2015 May 16;290(19):11969-82. Epub 2015 Mar 16.

From the Division of Molecular Microbiology and MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.628750
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http://dx.doi.org/10.1074/jbc.M114.628750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424335PMC
May 2015

O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?

J Biol Chem 2014 Dec 21;289(50):34433-9. Epub 2014 Oct 21.

From the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and Division of Molecular Microbiology, College of Life Sciences, University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom

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http://dx.doi.org/10.1074/jbc.R114.609198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263850PMC
December 2014

A structural and biochemical model of processive chitin synthesis.

J Biol Chem 2014 Aug 18;289(33):23020-8. Epub 2014 Jun 18.

From the Division of Molecular Microbiology, MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom

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http://dx.doi.org/10.1074/jbc.M114.563353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132801PMC
August 2014

Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors.

FEBS Lett 2014 Aug 22;588(17):3282-90. Epub 2014 Jul 22.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom. Electronic address:

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http://doi.wiley.com/10.1016/j.febslet.2014.07.015
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http://dx.doi.org/10.1016/j.febslet.2014.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158421PMC
August 2014

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors.

Biochem J 2014 Feb;457(3):497-502

‡Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20131272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927924PMC
February 2014

Chemical tools to probe cellular O-GlcNAc signalling.

Biochem J 2013 Nov;456(1):1-12

*Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20131081DOI Listing
November 2013

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

ACS Chem Biol 2013 Sep 18;8(9):1981-7. Epub 2013 Jul 18.

Division of Biological Chemistry and Drug Discovery, ‡Division of Molecular Microbiology, and §MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee , Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/cb400411xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780468PMC
September 2013

Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis.

Open Biol 2013 Sep 11;3(9):130022. Epub 2013 Sep 11.

Division of Molecular Microbiology, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1098/rsob.130022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787745PMC
September 2013

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Mol Microbiol 2013 Aug 5;89(3):479-93. Epub 2013 Jul 5.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1111/mmi.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888555PMC
August 2013

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm.

Proc Natl Acad Sci U S A 2013 Aug 31;110(33):13600-5. Epub 2013 Jul 31.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1306390110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746881PMC
August 2013

A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription.

EMBO J 2013 Mar 12;32(5):612-3. Epub 2013 Feb 12.

MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/emboj.2013.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590992PMC
March 2013

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.

J Proteome Res 2013 Feb 18;12(2):927-36. Epub 2013 Jan 18.

Chair for Proteomics and Bioanalytics, Center of Life and Food Sciences, Weihenstephan, Technische Universität München, Freising, Germany.

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http://pubs.acs.org/doi/10.1021/pr300967y
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http://dx.doi.org/10.1021/pr300967yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946622PMC
February 2013

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

Biochem J 2012 Aug;446(1):149-57

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20120377
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http://dx.doi.org/10.1042/BJ20120377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513709PMC
August 2012

Structural and biochemical characterization of a trapped coenzyme A adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1.

Acta Crystallogr D Biol Crystallogr 2012 Aug 17;68(Pt 8):1019-29. Epub 2012 Jul 17.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S0907444912019592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413214PMC
August 2012

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

J Biol Chem 2012 Jun 5;287(27):22483-96. Epub 2012 Apr 5.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow St., Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M112.352773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391087PMC
June 2012

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Jun 23;68(Pt 6):705-8. Epub 2012 May 23.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309112017915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370916PMC
June 2012

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.

EMBO J 2012 Mar 3;31(6):1394-404. Epub 2012 Feb 3.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/emboj.2012.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321193PMC
March 2012

Synergy of peptide and sugar in O-GlcNAcase substrate recognition.

Chem Biol 2012 Feb;19(2):173-8

Division of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2012.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476531PMC
February 2012

Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila.

Sci Signal 2011 Dec 20;4(204):ra89. Epub 2011 Dec 20.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1126/scisignal.2002335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660836PMC
December 2011

Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases.

ACS Med Chem Lett 2011 Jun 23;2(6):428-32. Epub 2011 Mar 23.

Division of Molecular Microbiology and Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland.

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http://dx.doi.org/10.1021/ml200008bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018065PMC
June 2011

Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.

Chem Biol 2011 May;18(5):569-79

Centre for Immunity, Infection and Evolution, and the Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1016/j.chembiol.2011.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115046PMC
May 2011

Substrate and product analogues as human O-GlcNAc transferase inhibitors.

Amino Acids 2011 Mar 17;40(3):781-92. Epub 2010 Jul 17.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1007/s00726-010-0688-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040809PMC
March 2011

Charge-surrounded pockets and electrostatic interactions with small ions modulate the activity of retroviral fusion proteins.

PLoS Pathog 2011 Feb 3;7(2):e1001268. Epub 2011 Feb 3.

The Biomedical Research Institute, College of Medicine, Ninewells Hospital, The University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1371/journal.ppat.1001268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033372PMC
February 2011

Pseudokinases-remnants of evolution or key allosteric regulators?

Curr Opin Struct Biol 2010 12 10;20(6):772-81. Epub 2010 Nov 10.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 1090, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.sbi.2010.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014569PMC
December 2010

Natural product-guided discovery of a fungal chitinase inhibitor.

Chem Biol 2010 Dec;17(12):1275-81

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2010.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518266PMC
December 2010

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases.

Chem Biol 2010 Nov;17(11):1250-5

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2010.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032886PMC
November 2010

An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold.

Tetrahedron 2010 Sep;66(39-3):7838-7849

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1016/j.tet.2010.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956484PMC
September 2010

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds.

FEBS Lett 2010 Feb 16;584(4):694-700. Epub 2009 Dec 16.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1016/j.febslet.2009.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828546PMC
February 2010

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase.

Biochem J 2010 Feb 24;426(3):281-92. Epub 2010 Feb 24.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20091351
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http://dx.doi.org/10.1042/BJ20091351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518269PMC
February 2010

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Science 2009 Dec 5;326(5960):1707-11. Epub 2009 Nov 5.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1126/science.1178377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518268PMC
December 2009

SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation.

Adv Exp Med Biol 2009 ;611:143-4

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1007/978-0-387-73657-0_64DOI Listing
June 2009

Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs.

Adv Exp Med Biol 2009 ;611:525-6

Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1007/978-0-387-73657-0_229DOI Listing
June 2009

Molecular mechanisms of yeast cell wall glucan remodeling.

J Biol Chem 2009 Mar 19;284(13):8461-9. Epub 2008 Dec 19.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M807990200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659204PMC
March 2009

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold.

Org Biomol Chem 2009 Jan 13;7(2):259-68. Epub 2008 Nov 13.

Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK.

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http://dx.doi.org/10.1039/b815077jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657367PMC
January 2009

Structure of the OSR1 kinase, a hypertension drug target.

Proteins 2008 Dec;73(4):1082-7

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1002/prot.22238DOI Listing
December 2008

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.

Biochem J 2008 Oct;415(2):217-23

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20081000DOI Listing
October 2008

Structural insights into mechanism and specificity of O-GlcNAc transferase.

EMBO J 2008 Oct 25;27(20):2780-8. Epub 2008 Sep 25.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/emboj.2008.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556091PMC
October 2008

Molecular mechanisms of O-GlcNAcylation.

Curr Opin Struct Biol 2008 Oct 6;18(5):551-7. Epub 2008 Oct 6.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.sbi.2008.09.005DOI Listing
October 2008

Putting glycobiology on a structural footing.

Curr Opin Struct Biol 2008 Oct 1;18(5):525-6. Epub 2008 Oct 1.

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http://linkinghub.elsevier.com/retrieve/pii/S0959440X0800130
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http://dx.doi.org/10.1016/j.sbi.2008.09.002DOI Listing
October 2008

Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope.

Retrovirology 2008 Aug 4;5:70. Epub 2008 Aug 4.

The Biomedical Research Centre, College of Medicine, Ninewells Hospital, The University, Dundee, DD1 9SY, Scotland, UK.

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http://dx.doi.org/10.1186/1742-4690-5-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533354PMC
August 2008

Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.

Chem Biol 2008 Aug;15(8):799-807

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2008.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568864PMC
August 2008

Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.

Chem Biol 2008 Mar;15(3):295-301

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2008.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764403PMC
March 2008

Glucose-6-phosphate as a probe for the glucosamine-6-phosphate N-acetyltransferase Michaelis complex.

FEBS Lett 2007 Dec 20;581(29):5597-600. Epub 2007 Nov 20.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1016/j.febslet.2007.10.065DOI Listing
December 2007

Structural insights into the recognition of substrates and activators by the OSR1 kinase.

EMBO Rep 2007 Sep 17;8(9):839-45. Epub 2007 Aug 17.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/sj.embor.7401048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973955PMC
September 2007

Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors.

Chem Biol 2007 May;14(5):589-99

Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1016/j.chembiol.2007.03.015DOI Listing
May 2007

High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand.

Proteins 2007 Jan;66(1):229-38

Biocenter Oulu and Department of Biochemistry, University of Oulu, FIN-90014, Finland.

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http://dx.doi.org/10.1002/prot.21124DOI Listing
January 2007

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.

J Am Chem Soc 2006 Dec;128(51):16484-5

Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://davapc1.bioch.dundee.ac.uk/pdf/glcnacstatin.pdf
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http://pubs.acs.org/doi/abs/10.1021/ja066743n
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December 2006

Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b.

J Biol Chem 2006 Oct 8;281(43):32774-83. Epub 2006 Aug 8.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M601714200
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October 2006