Publications by authors named "D Y Xing"

1,559 Publications

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Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial.

Nutrients 2021 Nov 9;13(11). Epub 2021 Nov 9.

Human Clinical Research Facility, Exercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.

This study examined the effects of acute paraxanthine (PXN) ingestion on markers of cognition, executive function, and psychomotor vigilance. In a randomized, double blind, placebo-controlled, crossover, and counterbalanced manner, 13 healthy male and female participants were randomly assigned to consume a placebo (PLA) or 200 mg of PXN (ENFINITY™, Ingenious Ingredients, L.P.). Participants completed stimulant sensitivity and side effect questionnaires and then performed the Berg Wisconsin Card Sorting Test (BCST), the Go/No-Go test (GNG), the Sternberg task test (STT), and the psychomotor vigilance task test (PVTT). Participants then ingested one capsule of PLA or PXN treatment. Participants completed side effect and cognitive function tests after 1, 2, 3, 4, 5, and 6 h after ingestion of the supplement. After 7 days, participants repeated the experiment while consuming the alternative treatment. Data were analyzed by general linear model (GLM) univariate analyses with repeated measures using body mass as a covariate, and by assessing mean and percent changes from baseline with 95% confidence intervals (CIs) expressed as means (LL, UL). PXN decreased BCST errors (PXN -4.7 [-0.2, -9.20], = 0.04; PXN -17.5% [-36.1, 1.0], = 0.06) and perseverative errors (PXN -2.2 [-4.2, -0.2], = 0.03; PXN -32.8% [-64.4, 1.2], = 0.04) at hour 6. GNG analysis revealed some evidence that PXN ingestion better maintained mean accuracy over time and Condition R Round 2 response time (e.g., PXN -25.1 [-52.2, 1.9] ms, = 0.07 faster than PLA at 1 h), suggesting better sustained attention. PXN ingestion improved STT two-letter length absent and present reaction times over time as well as improving six-letter length absent reaction time after 2 h (PXN -86.5 ms [-165, -7.2], = 0.03; PXN -9.0% [-18.1, 0.2], = 0.05), suggesting that PXN enhanced the ability to store and retrieve random information of increasing complexity from short-term memory. A moderate treatment x time effect size (η = 0.08) was observed in PVTT, where PXN sustained vigilance during Trial 2 after 2 h (PXN 840 ms [103, 1576], = 0.03) and 4 h (PXN 1466 ms [579, 2353], = 0.002) compared to PL. As testing progressed, the response time improved during the 20 trials and over the course of the 6 h experiment in the PXN treatment, whereas it significantly increased in the PL group. The results suggest that acute PXN ingestion (200 mg) may affect some measures of short-term memory, reasoning, and response time to cognitive challenges and help sustain attention.
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http://dx.doi.org/10.3390/nu13113980DOI Listing
November 2021

Effects of Inositol-Enhanced Bonded Arginine Silicate Ingestion on Cognitive and Executive Function in Gamers.

Nutrients 2021 Oct 24;13(11). Epub 2021 Oct 24.

Exercise & Sport Nutrition Laboratory, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.

Inositol stabilized arginine silicate (ASI) ingestion has been reported to increase nitric oxide levels while inositol (I) has been reported to enhance neurotransmission. The current study examined whether acute ASI + I (Inositol-enhanced bonded arginine silicate) ingestion affects cognitive function in e-sport gamers. In a double blind, randomized, placebo controlled, and crossover trial, 26 healthy male (n = 18) and female (n = 8) experienced gamers (23 ± 5 years, 171 ± 11 cm, 71.1 ± 14 kg, 20.7 ± 3.5 kg/m) were randomly assigned to consume 1600 mg of ASI + I (nooLVL, Nutrition 21) or 1600 mg of a maltodextrin placebo (PLA). Prior to testing, participants recorded their diet, refrained from consuming atypical amounts of stimulants and foods high in arginine and nitrates, and fasted for 8 h. During testing sessions, participants completed stimulant sensitivity questionnaires and performed cognitive function tests (i.e., Berg-Wisconsin Card Sorting task test, Go/No-Go test, Sternberg Task Test, Psychomotor Vigilance Task Test, Cambridge Brain Sciences Reasoning and Concentration test) and a light reaction test. Participants then ingested treatments in a randomized manner. Fifteen minutes following ingestion, participants repeated tests (Pre-Game). Participants then played their favorite video game for 1-h and repeated the battery of tests (Post-Game). Participants observed a 7-14-day washout period and then replicated the study with the alternative treatment. Data were analyzed by General Linear Model (GLM) univariate analyses with repeated measures using weight as a covariate, paired -tests (not adjusted to weight), and mean changes from baseline with 95% Confidence Intervals (CI). Pairwise comparison revealed that there was a significant improvement in Sternberg Mean Present Reaction Time (ASI + I vs. PLA; < 0.05). In Post-Game assessments, 4-letter Absent Reaction Time ( < 0.05), 6-letter Present Reaction Time ( < 0.01), 6-letter Absent Reaction Time ( < 0.01), Mean Present Reaction Time ( < 0.02), and Mean Absent Reaction Time ( < 0.03) were improved with ASI + I vs. PLA. There was a non-significant trend in Pre-Game Sternberg 4-letter Present Reaction time in ASI + I vs. PLA ( < 0.07). ASI + I ingestion better maintained changes in Go/No-Go Mean Accuracy and Reaction Time, Psychomotor Vigilance Task Reaction Time, and Cambridge Post-Game Visio-spatial Processing and Planning. Results provide evidence that ASI + I ingestion prior to playing video games may enhance some measures of short-term and working memory, reaction time, reasoning, and concentration in experienced gamers.
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http://dx.doi.org/10.3390/nu13113758DOI Listing
October 2021

Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists.

Cancers (Basel) 2021 Nov 15;13(22). Epub 2021 Nov 15.

Oliver Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, VIC 3079, Australia.

Radiotherapy plays an important role of managing head and neck squamous cell carcinoma (HNSCC). Concurrent radiotherapy with radiosensitizing cisplastin chemotherapy is the standard of care (SOC) for non-operable locally advanced HNSCC. Cetuximab, a monoclonal antibody of epidermal growth factor receptor, was the most extensively studied targeted therapy as a chemo-sparing agent that was used concurrently with radiotherapy. Immunotherapy is used in the treatment of metastatic HNSCC. There is evidence to support the synergistic effect when combining radiotherapy with immunotherapy to potentiate anti-tumor immune response. There has been increasing interest to incorporate immune checkpoint inhibitor (ICI) with radiotherapy in the curative setting for HNSCC. In this review, we discuss the latest evidence that supports concurrent radiotherapy with cisplatin which remains the SOC for locally advanced HNSCC (LA-HNSCC). Cetuximab is suitable for patients who are not fit for cisplatin. We then summarize the clinical trials that incorporate ICI with radiotherapy for LA-HNSCC in concurrent, neoadjuvant, and adjuvant settings. We also discuss the potential of combining immunotherapy with radiotherapy as a treatment de-escalating strategy in HPV-associated oropharyngeal carcinoma. Finally, the pre-clinical and clinical evidence of the abscopal effect when combining stereotactic body radiotherapy with ICIs is presented.
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http://dx.doi.org/10.3390/cancers13225716DOI Listing
November 2021

Global Research Trends in Revision Total Knee Arthroplasty: A Bibliometric and Visualized Study.

Indian J Orthop 2021 Oct 10;55(5):1335-1347. Epub 2021 Mar 10.

Arthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044 China.

Background: Revision total knee arthroplasty (TKA) is a longstanding area of research interest in orthopedics due to its increasing global demand and associated technical challenges. The present study aims to analyze and present the current state of research and trends in this active field.

Methods: Articles on revision TKA published from inception to 2018 were retrieved from Web of Science. Bibliometric analysis was conducted using the metadata of the included articles. Visualized analysis was conducted using VOSviewer software to reveal global trends in revision TKA research, through analyses of bibliographic coupling, co-authorship, co-citation and co-occurrence.

Results: A total of 6027 articles were included. The number of publications and relative research interest in the field of revision TKA displayed strong upward growth over the time period examined. The USA had the highest number of citations for publications in this field, as well as the highest H-index. Studies in the field could be categorized into five clusters: prosthesis design, periprosthetic fracture, periprosthetic joint infection, risk factors for revision TKA, and survivorship of implants. Studies focused on infection and risk factors for revision TKA are likely to become the most popular research topics in the field.

Conclusion: Global trends over the past few years suggest that the field of revision TKA research will continue to grow and lead to increasing rates of publication output over the coming years. Future developments in the field will likely include more preventative and etiological studies relating to revision TKA.
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http://dx.doi.org/10.1007/s43465-021-00390-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586134PMC
October 2021

Anomalous Superconducting Proximity Effect in Bi Se /FeSe Te Thin-Film Heterojunctions.

Adv Mater 2021 Nov 24:e2107799. Epub 2021 Nov 24.

National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

Superconducting proximity effect (SPE) induces superconductivity transition in the otherwise non superconducting thin-film in proximity with a superconductor. The SPE usually occurs in real space and decays exponentially with the film thickness. Herein, we unveiled an abnormal SPE in a topological insulator (TI)/superconductor heterostructure, which is attributed to the topologically protected surface state. Surprisingly, such abnormal SPE occurs in momentum space regardless the TI film thickness, as long as the topological surface states are robust and form a continuous conduction loop. Combining transport measurements and scanning tunneling microscopy/spectroscopy techniques, we explored the SPE in Bi Se /FeSe Te heterostructures, where Bi Se is an ideal three-dimensional topological insulator and FeSe Te a typical iron-based superconductor. As the thickness of the Bi Se thin-film exceeds 400 nanometers, there still exits SPE-induced superconductivity on the surface of Bi Se thin-film with a transition temperature T not less than 10 K. Such an extraordinary behavior is induced by the unique properties of topologically protected surface states of Bi Se . This research will deepen the understanding of important role of topologically protected surface states in the SPE. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202107799DOI Listing
November 2021
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