Cynthia Wolberger

Cynthia Wolberger

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Cynthia Wolberger

Publications by authors named "Cynthia Wolberger"

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Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.

Biochemistry 2020 Mar 24;59(8):921-932. Epub 2020 Feb 24.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21210-2185, United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00993DOI Listing
March 2020

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome.

Elife 2020 Jan 10;9. Epub 2020 Jan 10.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.53199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039682PMC
January 2020

Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases.

Curr Opin Struct Biol 2019 12 21;59:98-106. Epub 2019 Jun 21.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888998PMC
December 2019

Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage.

Methods Enzymol 2019 26;618:1-27. Epub 2019 Feb 26.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917205PMC
November 2019

Competition Assay for Measuring Deubiquitinating Enzyme Substrate Affinity.

Methods Mol Biol 2018 ;1844:59-70

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://link.springer.com/10.1007/978-1-4939-8706-1_5
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http://dx.doi.org/10.1007/978-1-4939-8706-1_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917206PMC
May 2019

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.

Cell 2019 03 11;176(6):1490-1501.e12. Epub 2019 Feb 11.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498860PMC
March 2019

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics.

Elife 2019 01 25;8. Epub 2019 Jan 25.

Program in Molecular Biophysics, Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, United States.

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https://elifesciences.org/articles/40988
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http://dx.doi.org/10.7554/eLife.40988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372288PMC
January 2019

OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination.

J Biol Chem 2018 11 3;293(47):18285-18295. Epub 2018 Oct 3.

From the Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185 and

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http://dx.doi.org/10.1074/jbc.RA118.004677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254341PMC
November 2018

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.

EMBO Rep 2018 10 27;19(10). Epub 2018 Aug 27.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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http://dx.doi.org/10.15252/embr.201745680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172466PMC
October 2018

Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.

J Am Chem Soc 2018 08 24;140(30):9478-9485. Epub 2018 Jul 24.

Department of Pharmacology and Molecular Sciences , Johns Hopkins University School of Medicine , Baltimore , Maryland 21205 , United States.

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http://dx.doi.org/10.1021/jacs.8b03572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070418PMC
August 2018

Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins.

Nat Commun 2018 08 8;9(1):3154. Epub 2018 Aug 8.

Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.

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http://dx.doi.org/10.1038/s41467-018-05628-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082840PMC
August 2018

RAP80, ubiquitin and SUMO in the DNA damage response.

J Mol Med (Berl) 2017 08 5;95(8):799-807. Epub 2017 Jul 5.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://link.springer.com/10.1007/s00109-017-1561-1
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http://dx.doi.org/10.1007/s00109-017-1561-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570449PMC
August 2017

A Tunable Brake for HECT Ubiquitin Ligases.

Mol Cell 2017 May;66(3):345-357.e6

Department of Pharmacology and Molecular Sciences, John Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, John Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489419PMC
May 2017

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.

Chem Sci 2017 May 5;8(5):4027-4034. Epub 2017 Apr 5.

Schulich Faculty of Chemistry , Technion-Israel Institute of Technology , Haifa 3200008 , Israel . Email:

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http://dx.doi.org/10.1039/c7sc00488eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434752PMC
May 2017

Mutations that Allow SIR2 Orthologs to Function in a NAD-Depleted Environment.

Cell Rep 2017 03;18(10):2310-2319

Glenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173021
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http://dx.doi.org/10.1016/j.celrep.2017.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407064PMC
March 2017

Recognition of ubiquitinated nucleosomes.

Curr Opin Struct Biol 2017 02 4;42:75-82. Epub 2016 Dec 4.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373988PMC
February 2017

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

J Mol Biol 2016 11 24;428(23):4639-4650. Epub 2016 Sep 24.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115946PMC
November 2016

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.

Biochemistry 2016 07 22;55(26):3658-66. Epub 2016 Jun 22.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102067PMC
July 2016

Structural basis for acyl-group discrimination by human Gcn5L2.

Acta Crystallogr D Struct Biol 2016 07 23;72(Pt 7):841-8. Epub 2016 Jun 23.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1107/S2059798316007907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932917PMC
July 2016

The Substrate Specificity of Sirtuins.

Annu Rev Biochem 2016 Jun 18;85:405-29. Epub 2016 Apr 18.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850.

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http://dx.doi.org/10.1146/annurev-biochem-060815-014537DOI Listing
June 2016

Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.

Angew Chem Int Ed Engl 2016 Apr 9;55(16):4972-6. Epub 2016 Mar 9.

Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.

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http://dx.doi.org/10.1002/anie.201600638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944388PMC
April 2016

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Authors:
Huaying Zhao Rodolfo Ghirlando Carlos Alfonso Fumio Arisaka Ilan Attali David L Bain Marina M Bakhtina Donald F Becker Gregory J Bedwell Ahmet Bekdemir Tabot M D Besong Catherine Birck Chad A Brautigam William Brennerman Olwyn Byron Agnieszka Bzowska Jonathan B Chaires Catherine T Chaton Helmut Cölfen Keith D Connaghan Kimberly A Crowley Ute Curth Tina Daviter William L Dean Ana I Díez Christine Ebel Debra M Eckert Leslie E Eisele Edward Eisenstein Patrick England Carlos Escalante Jeffrey A Fagan Robert Fairman Ron M Finn Wolfgang Fischle José García de la Torre Jayesh Gor Henning Gustafsson Damien Hall Stephen E Harding José G Hernández Cifre Andrew B Herr Elizabeth E Howell Richard S Isaac Shu-Chuan Jao Davis Jose Soon-Jong Kim Bashkim Kokona Jack A Kornblatt Dalibor Kosek Elena Krayukhina Daniel Krzizike Eric A Kusznir Hyewon Kwon Adam Larson Thomas M Laue Aline Le Roy Andrew P Leech Hauke Lilie Karolin Luger Juan R Luque-Ortega Jia Ma Carrie A May Ernest L Maynard Anna Modrak-Wojcik Yee-Foong Mok Norbert Mücke Luitgard Nagel-Steger Geeta J Narlikar Masanori Noda Amanda Nourse Tomas Obsil Chad K Park Jin-Ku Park Peter D Pawelek Erby E Perdue Stephen J Perkins Matthew A Perugini Craig L Peterson Martin G Peverelli Grzegorz Piszczek Gali Prag Peter E Prevelige Bertrand D E Raynal Lenka Rezabkova Klaus Richter Alison E Ringel Rose Rosenberg Arthur J Rowe Arne C Rufer David J Scott Javier G Seravalli Alexandra S Solovyova Renjie Song David Staunton Caitlin Stoddard Katherine Stott Holger M Strauss Werner W Streicher John P Sumida Sarah G Swygert Roman H Szczepanowski Ingrid Tessmer Ronald T Toth Ashutosh Tripathy Susumu Uchiyama Stephan F W Uebel Satoru Unzai Anna Vitlin Gruber Peter H von Hippel Christine Wandrey Szu-Huan Wang Steven E Weitzel Beata Wielgus-Kutrowska Cynthia Wolberger Martin Wolff Edward Wright Yu-Sung Wu Jacinta M Wubben Peter Schuck

PLoS One 2015 21;10(5):e0126420. Epub 2015 May 21.

Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, United States of America.

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https://kops.uni-konstanz.de/bitstream/handle/123456789/3152
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http://dx.plos.org/10.1371/journal.pone.0126420
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440767PMC
February 2016

Structural basis for histone H2B deubiquitination by the SAGA DUB module.

Science 2016 Feb;351(6274):725-8

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/science.aac5681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863942PMC
February 2016

Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.

Nucleic Acids Res 2015 Oct 18;43(18):9039-50. Epub 2015 Aug 18.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA

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http://dx.doi.org/10.1093/nar/gkv845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605308PMC
October 2015

Nucleosome competition reveals processive acetylation by the SAGA HAT module.

Proc Natl Acad Sci U S A 2015 Oct 23;112(40):E5461-70. Epub 2015 Sep 23.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205

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http://dx.doi.org/10.1073/pnas.1508449112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603478PMC
October 2015

Structure of the yeast Bre1 RING domain.

Proteins 2015 Jun 29;83(6):1185-90. Epub 2015 Apr 29.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland, 21205.

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http://dx.doi.org/10.1002/prot.24812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452286PMC
June 2015

Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198.

PLoS One 2014 18;9(8):e105271. Epub 2014 Aug 18.

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136804PMC
April 2015

Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.

J Mol Biol 2015 Apr 17;427(8):1765-78. Epub 2014 Dec 17.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380536PMC
April 2015

Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.

Protein Sci 2014 Dec 1;23(12):1686-97. Epub 2014 Oct 1.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205-2185.

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http://dx.doi.org/10.1002/pro.2546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253809PMC
December 2014

The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.

Mol Cell Proteomics 2014 Nov 8;13(11):2896-910. Epub 2014 Aug 8.

From the ‡Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; §Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205;

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http://dx.doi.org/10.1074/mcp.M114.038174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223480PMC
November 2014

Mechanisms for regulating deubiquitinating enzymes.

Protein Sci 2014 Apr 12;23(4):344-53. Epub 2014 Feb 12.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205.

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http://dx.doi.org/10.1002/pro.2415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970886PMC
April 2014

New insights into ubiquitin E3 ligase mechanism.

Nat Struct Mol Biol 2014 Apr;21(4):301-7

1] Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nsmb.2780DOI Listing
April 2014

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.

Nat Struct Mol Biol 2013 Sep 18;20(9):1033-9. Epub 2013 Aug 18.

1] Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Howard Hughes Medical Institute, Baltimore, Maryland, USA. [3] [4].

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http://dx.doi.org/10.1038/nsmb.2655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941643PMC
September 2013

A new RING tossed into an old HAT.

Structure 2013 Sep;21(9):1479-81

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.str.2013.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836368PMC
September 2013

A new DUB makes linear ubiquitin a party to its own destruction.

Cell 2013 Jun;153(6):1189-91

Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, Hadassah Medical School, Hebrew University, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.cell.2013.05.018DOI Listing
June 2013

A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants.

J Mass Spectrom 2013 May;48(5):608-15

Middle Atlantic Mass Spectrometry Laboratory, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1002/jms.3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784001PMC
May 2013

Biochemistry: Sirtuin on a high-fat diet.

Nature 2013 Apr;496(7443):41-2

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http://dx.doi.org/10.1038/496041aDOI Listing
April 2013

A conserved asparagine has a structural role in ubiquitin-conjugating enzymes.

Nat Chem Biol 2013 Mar 6;9(3):154-6. Epub 2013 Jan 6.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nchembio.1159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578109PMC
March 2013

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

Sci Signal 2012 Dec 4;5(253):ra88. Epub 2012 Dec 4.

Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scisignal.2003485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131685PMC
December 2012

A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity.

Structure 2012 Aug 5;20(8):1414-24. Epub 2012 Jul 5.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205-2185, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09692126120021
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http://dx.doi.org/10.1016/j.str.2012.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423971PMC
August 2012

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):E916-25. Epub 2012 Apr 2.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1121471109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341040PMC
April 2012

The mechanism of OTUB1-mediated inhibition of ubiquitination.

Nature 2012 Feb 22;483(7391):618-22. Epub 2012 Feb 22.

Department of Biophysics and Biophysical Chemistry and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature10911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319311PMC
February 2012

A new chapter in the transcription SAGA.

Curr Opin Struct Biol 2011 Dec 18;21(6):767-74. Epub 2011 Oct 18.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0959440X110016
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http://dx.doi.org/10.1016/j.sbi.2011.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232345PMC
December 2011

A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins.

Anal Biochem 2011 Nov 2;418(1):102-10. Epub 2011 Jul 2.

Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute and the Johns Hopkins University School of Medicine, Baltimore, MD 21202, USA.

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http://dx.doi.org/10.1016/j.ab.2011.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178097PMC
November 2011

Structure of Sir2Tm bound to a propionylated peptide.

Protein Sci 2011 Jan;20(1):131-9

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1002/pro.544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047069PMC
January 2011

Structural insights into the assembly and function of the SAGA deubiquitinating module.

Science 2010 May 15;328(5981):1025-9. Epub 2010 Apr 15.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/science.1190049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220450PMC
May 2010

Side chain specificity of ADP-ribosylation by a sirtuin.

FEBS J 2009 Dec 6;276(23):7159-76. Epub 2009 Nov 6.

Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07427.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805772PMC
December 2009

Structure-based mechanism of ADP-ribosylation by sirtuins.

J Biol Chem 2009 Nov 30;284(48):33654-61. Epub 2009 Sep 30.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/jbc.M109.024521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785207PMC
November 2009

The structure and conformation of Lys63-linked tetraubiquitin.

J Mol Biol 2009 Oct 4;392(5):1117-24. Epub 2009 Aug 4.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.07.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762427PMC
October 2009

Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5.

J Mol Biol 2009 Sep 17;392(2):452-64. Epub 2009 Jul 17.

Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763353PMC
September 2009

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.

J Mol Biol 2009 Mar 13;386(4):1011-23. Epub 2009 Jan 13.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.12.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682458PMC
March 2009

Structural insights into intermediate steps in the Sir2 deacetylation reaction.

Structure 2008 Sep;16(9):1368-77

Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.str.2008.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590790PMC
September 2008

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.

J Mol Biol 2008 Jul 17;380(3):520-31. Epub 2008 May 17.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.04.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516966PMC
July 2008

Identification of a new nicotinamide binding site in a sirtuin: a reassessment.

Mol Cell 2007 Dec;28(6):1102-3

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.12.006DOI Listing
December 2007

N-lysine propionylation controls the activity of propionyl-CoA synthetase.

J Biol Chem 2007 Oct 7;282(41):30239-45. Epub 2007 Aug 7.

Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M704409200DOI Listing
October 2007

The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins.

Protein Sci 2007 Jul 13;16(7):1308-15. Epub 2007 Jun 13.

Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.

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http://doi.wiley.com/10.1110/ps.072803507
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http://dx.doi.org/10.1110/ps.072803507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206682PMC
July 2007

Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH.

J Mol Biol 2007 Mar 29;367(1):204-11. Epub 2006 Dec 29.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360601755
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http://dx.doi.org/10.1016/j.jmb.2006.12.065DOI Listing
March 2007

The biochemistry of sirtuins.

Annu Rev Biochem 2006 ;75:435-65

Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1146/annurev.biochem.74.082803.133500DOI Listing
February 2007

Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.

Nat Struct Mol Biol 2006 Oct 17;13(10):915-20. Epub 2006 Sep 17.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://www.nature.com/articles/nsmb1148
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http://dx.doi.org/10.1038/nsmb1148DOI Listing
October 2006

Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide.

Structure 2006 Aug;14(8):1231-40

Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1016/j.str.2006.06.006DOI Listing
August 2006

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

Nat Struct Mol Biol 2006 Jul 18;13(7):661-2. Epub 2006 Jun 18.

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nsmb1114DOI Listing
July 2006

The structural basis of sirtuin substrate affinity.

Biochemistry 2006 Jun;45(24):7511-21

Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1021/bi0526332DOI Listing
June 2006

How does the histone code work?

Biochem Cell Biol 2005 Aug;83(4):468-76

Department of Biology, Syracuse University, NY 13244, USA.

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http://dx.doi.org/10.1139/o05-137DOI Listing
August 2005

Getting a grip on O-acetyl-ADP-ribose.

Nat Struct Mol Biol 2005 Jul;12(7):560-1

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http://dx.doi.org/10.1038/nsmb0705-560DOI Listing
July 2005

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.

Mol Cell 2005 Mar;17(6):855-68

Howard Hughes Medical Institute, Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.02.022DOI Listing
March 2005

Regulated nucleosome mobility and the histone code.

Nat Struct Mol Biol 2004 Nov;11(11):1037-43

Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nsmb851DOI Listing
November 2004

Arm-domain interactions can provide high binding cooperativity.

Protein Sci 2004 Oct;13(10):2829-31

Biology Department, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1110/ps.04908404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2286541PMC
October 2004

Structural basis for the mechanism and regulation of Sir2 enzymes.

Mol Cell 2004 Mar;13(5):639-48

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA.

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http://dx.doi.org/10.1016/s1097-2765(04)00082-6DOI Listing
March 2004

A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

EMBO J 2003 Oct;22(19):5241-50

Department of Biochemistry and Molecular Biology/Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/emboj/cdg501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC204484PMC
October 2003

Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior.

Genes Dev 2003 Aug;17(16):2060-72

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.

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http://dx.doi.org/10.1101/gad.1103303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196259PMC
August 2003

Insights into nonspecific binding of homeodomains from a structure of MATalpha2 bound to DNA.

Proteins 2003 Jun;51(4):544-51

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.

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http://dx.doi.org/10.1002/prot.10375DOI Listing
June 2003

Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera.

Protein Sci 2003 Feb;12(2):306-12

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://doi.wiley.com/10.1110/ps.0219103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312416PMC
http://dx.doi.org/10.1110/ps.0219103DOI Listing
February 2003

A Hoogsteen base pair embedded in undistorted B-DNA.

Nucleic Acids Res 2002 Dec;30(23):5244-52

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137974PMC
http://dx.doi.org/10.1093/nar/gkf661DOI Listing
December 2002

Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships.

J Biol Chem 2002 Nov 6;277(47):45529-36. Epub 2002 Sep 6.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.

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http://dx.doi.org/10.1074/jbc.M206327200DOI Listing
November 2002

A core nucleosome surface crucial for transcriptional silencing.

Nat Genet 2002 Oct 16;32(2):273-9. Epub 2002 Sep 16.

Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/ng982DOI Listing
October 2002

Structure of a Sir2 enzyme bound to an acetylated p53 peptide.

Mol Cell 2002 Sep;10(3):523-35

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00628-7DOI Listing
September 2002

SIR2 family of NAD(+)-dependent protein deacetylases.

Methods Enzymol 2002 ;353:282-300

Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)53056-1DOI Listing
August 2002

Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2.

Structure 2002 Jul;10(7):961-71

Department of Biophysics and Biophysical Chemistry, John Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/s0969-2126(02)00790-6DOI Listing
July 2002