Dr Cynthia Picard, PhD - Douglas Mental Health University Institute

Dr Cynthia Picard

PhD

Douglas Mental Health University Institute

Montreal | Canada

ORCID logohttps://orcid.org/0000-0003-1107-6839

Dr Cynthia Picard, PhD - Douglas Mental Health University Institute

Dr Cynthia Picard

PhD

Introduction

Primary Affiliation: Douglas Mental Health University Institute - Montreal , Canada

Education

Sep 2012
Université de Montréal
Ph.D.
Biochemistry

Publications

13Publications

91Reads

1Profile Views

32PubMed Central Citations

Association of PPP2R1A with Alzheimer's disease and specific cognitive domains.

Neurobiol Aging 2019 Jul 2;81:234-243. Epub 2019 Jul 2.

Douglas Hospital Research Centre, Montréal, Canada; Centre for the Studies on the Prevention of Alzheimer's Disease, Montréal, Canada; McGill University, Montréal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.06.008DOI Listing
July 2019
5.013 Impact Factor

Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation.

Alzheimers Dement 2019 Jul 4;15(7):951-960. Epub 2019 Jun 4.

Douglas Mental Health University Institute, Montréal, Québec, Canada; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.jalz.2019.03.012DOI Listing
July 2019
9 Reads
12.407 Impact Factor

CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's disease.

Alzheimers Dement 2018 06 19;14(6):787-796. Epub 2018 Jan 19.

Douglas Mental Health University Institute, Montréal, Québec, Canada; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Québec, Canada; McGill University, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.12.004DOI Listing
June 2018
1 Read
12.410 Impact Factor

Alterations in cholesterol metabolism-related genes in sporadic Alzheimer's disease.

Neurobiol Aging 2018 06 9;66:180.e1-180.e9. Epub 2018 Feb 9.

Centre for Studies on the Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, Montreal, Quebec, Canada; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.018DOI Listing
June 2018
6 Reads
5.013 Impact Factor

Isoprenoids and tau pathology in sporadic Alzheimer's disease.

Neurobiol Aging 2018 05 2;65:132-139. Epub 2018 Feb 2.

Douglas Mental Health University Institute, McGill University, Montreal, Canada; Center for Studies on the Prevention of Alzheimer's Disease, McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.012DOI Listing
May 2018
2 Reads
1 Citation
5.013 Impact Factor

TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer's Disease and in Response to Hippocampal Deafferentation in Rodents.

Journal of Alzheimer's disease : JAD

One important aspect in Alzheimer's disease pathology is the presence of chronic inflammation. Considering its role as a key receptor in the microglial innate immune system, TLR4 was shown to regulate the binding and phagocytosis of amyloid plaques by microglia in several mouse models of amyloidosis, as well as the production of pro-inflammatory cytokines. To our knowledge, TLR4 and its association with cytokines have not been thoroughly examined in the brains of subjects affected with Alzheimer's disease. Using quantitative reverse transcription polymerase chain reaction (qRT-PCR) in postmortem human brains, we observed increased expression for the TLR4 and TNF genes (p = 0.001 and p = 0.025, respectively), as well as a trend for higher IL6 gene expression in the frontal cortex of AD subjects when compared to age-matched controls. Similarly, using a mouse model of hippocampal deafferentation without amyloidosis, (i.e., the entorhinal cortex lesioned mouse), we observed significant increases in the expression of both the Tlr4 (p = 0.0367 and p = 0.0193 compared to sham-lesioned mice or to the contralateral side, respectively) and Il1b (p = 0.0055 and p = 0.0066 compared to sham-lesioned mice or to the contralateral side, respectively) genes in the deafferentation phase, but not during the ensuing reinnervation process. In conclusion, we suggest that the modulation of cytokines by TLR4 is differentially regulated whether by the presence of amyloid plaques or by the ongoing deafferentation process.

https://doi.org/10.3233/JAD-171160

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January 2018

E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes.

PLoS One 2016 1;11(11):e0165951. Epub 2016 Nov 1.

Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Hospital Research Center, Montréal, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165951PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089553PMC
June 2017
3 Reads
2 Citations
3.234 Impact Factor

Epistasis analysis links immune cascades and cerebral amyloidosis.

J Neuroinflammation 2015 Dec 1;12:227. Epub 2015 Dec 1.

Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, 6825 LaSalle Blvd, H4H 1R3, Montreal, QC, Canada.

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http://dx.doi.org/10.1186/s12974-015-0436-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666175PMC
December 2015
46 Reads
6 Citations
5.410 Impact Factor

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease.

Neurobiol Aging 2014 Sep 15;35 Suppl 2:S3-10. Epub 2014 May 15.

Centre for Studies on the Prevention of Alzheimer's disease, Verdun, Quebec, Canada; Molecular Neurobiology Unit, Douglas Mental Health University Institute, Research Centre, Verdun, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140289PMC
September 2014
3 Reads
18 Citations
5.013 Impact Factor

Nuclear accumulation of prohibitin 1 in osteoarthritic chondrocytes down-regulates PITX1 expression.

Arthritis Rheum 2013 Apr;65(4):993-1003

Sainte-Justine University Hospital Research Center and University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/art.37837DOI Listing
April 2013
2 Reads
2 Citations
7.764 Impact Factor

New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis.

Clin Orthop Relat Res 2007 Sep;462:59-66

Research Centre, Sainte-Justine University Hospital, Montreal, Canada.

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http://dx.doi.org/10.1097/BLO.0b013e3180d09d9cDOI Listing
September 2007
6 Reads
3 Citations
2.770 Impact Factor

Top co-authors

Judes Poirier
Judes Poirier

McGill University

8
Justin Miron
Justin Miron

Douglas Mental Health University Institute

5
Doris Dea
Doris Dea

McGill University

4
Louise Theroux
Louise Theroux

University of British Columbia

3
Alain Moreau
Alain Moreau

Université François Rabelais

3
John Breitner
John Breitner

University of Washington

3
DaShen Wang
DaShen Wang

Sainte-Justine University Hospital Research Center and University of Montreal

2
Patrick Lavigne
Patrick Lavigne

Maisonneuve-Rosemont Hospital

2
Martin Pellicelli
Martin Pellicelli

Université de Montréal

2