Cynthia Ju

Cynthia Ju

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Cynthia Ju

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Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms.

Liver Int 2019 May 2;39(5):788-801. Epub 2019 Apr 2.

Department of Anesthesia, McGovern Medical School at UT Health, Houston, Texas.

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http://dx.doi.org/10.1111/liv.14091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483869PMC
May 2019

TARBP2 inhibits IRF7 activation by suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.

Mol Immunol 2019 05 27;109:116-125. Epub 2019 Mar 27.

Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Life Science, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, Jiangxi, 330022, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2019.02.019DOI Listing
May 2019

THO Complex Subunit 7 Homolog Negatively Regulates Cellular Antiviral Response against RNA Viruses by Targeting TBK1.

Viruses 2019 Feb 15;11(2). Epub 2019 Feb 15.

Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Life Science, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang 330022, Jiangxi, China.

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http://dx.doi.org/10.3390/v11020158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410154PMC
February 2019

Orchestrating liver repair: A newly discovered function of hepatic iNKT cells.

Hepatology 2018 08 18;68(2):773-775. Epub 2018 May 18.

Department of Anesthesiology McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX.

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http://dx.doi.org/10.1002/hep.29828DOI Listing
August 2018

Fibroblast growth factors 19 and 21 in acute liver damage.

Ann Transl Med 2018 Jun;6(12):257

Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.

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http://dx.doi.org/10.21037/atm.2018.05.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046301PMC
June 2018

Role of gp91 in hepatic macrophage programming and alcoholic liver disease.

Hepatol Commun 2017 10 11;1(8):765-779. Epub 2017 Aug 11.

Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus Aurora CO.

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http://dx.doi.org/10.1002/hep4.1078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678917PMC
October 2017

IL-1 receptor like 1 protects against alcoholic liver injury by limiting NF-κB activation in hepatic macrophages.

J Hepatol 2017 Sep 21. Epub 2017 Sep 21.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.08.023DOI Listing
September 2017

Role of hepatic macrophages in alcoholic liver disease.

J Investig Med 2016 08 5;64(6):1075-7. Epub 2016 Jul 5.

Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1136/jim-2016-000210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495184PMC
August 2016

Hypoxia-inducible factors as molecular targets for liver diseases.

J Mol Med (Berl) 2016 06 20;94(6):613-27. Epub 2016 Apr 20.

Department of Anesthesiology and Organ Protection Program, School of Medicine, University of Colorado, Auroa, Colorado, 800045, USA.

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http://dx.doi.org/10.1007/s00109-016-1408-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879168PMC
June 2016

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies.

Cell Mol Immunol 2016 05 24;13(3):316-27. Epub 2016 Feb 24.

Department of Medicine III, University Hospital Aachen, Aachen, Germany.

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http://dx.doi.org/10.1038/cmi.2015.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856798PMC
May 2016

Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration.

Cell Mol Immunol 2016 Mar 9;13(2):206-16. Epub 2015 Feb 9.

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/cmi.2015.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786627PMC
March 2016

Interaction of AIM with insulin-like growth factor-binding protein-4.

Int J Mol Med 2015 Sep 26;36(3):833-8. Epub 2015 Jun 26.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://dx.doi.org/10.3892/ijmm.2015.2262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533773PMC
September 2015

Intrahepatic antiviral quantification in a patient undergoing orthotopic cadaveric liver transplantation.

J Antimicrob Chemother 2015 Jan 11;70(1):315-7. Epub 2014 Sep 11.

Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA

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http://dx.doi.org/10.1093/jac/dku334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267500PMC
January 2015

Development of a screening assay to evaluate the potential of drugs to cause immune-mediated hypersensitivity reactions.

J Immunotoxicol 2014 Apr-Jun;11(2):110-5. Epub 2013 Jun 14.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus , Aurora, CO , USA and.

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http://dx.doi.org/10.3109/1547691X.2013.803269DOI Listing
December 2014

Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding.

PLoS One 2014 20;9(1):e80949. Epub 2014 Jan 20.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080949PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896335PMC
December 2014

Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.

Proc Natl Acad Sci U S A 2014 Dec 24;111(50):E5420-8. Epub 2014 Nov 24.

Laboratory of Physiologic Studies, Section on Neuroendocrinology, and

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http://dx.doi.org/10.1073/pnas.1419901111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273328PMC
December 2014

Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas.

Front Immunol 2014 25;5:587. Epub 2014 Nov 25.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver , Aurora, CO , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243558PMC
December 2014

Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice.

J Leukoc Biol 2014 Oct 16;96(4):657-65. Epub 2014 Jul 16.

Skaggs School of Pharmacy and Pharmaceutical Sciences and Integrated Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA;

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http://dx.doi.org/10.1189/jlb.6A0114-004RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163632PMC
October 2014

Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.

J Immunol 2014 Sep 25;193(5):2512-8. Epub 2014 Jul 25.

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135042PMC
http://dx.doi.org/10.4049/jimmunol.1400588DOI Listing
September 2014

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity.

Mol Pharmacol 2014 Jun 28;85(6):849-57. Epub 2014 Mar 28.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado (C.-H.C., D.A.D., D.S., Q.Y., D.S.B., C.J., D.R.); and School of Chemistry, University of Nottingham, Nottingham, United Kingdom (R.R.A.K., C.J.M.).

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http://dx.doi.org/10.1124/mol.113.090654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014664PMC
June 2014

PKCs: pernicious kinase culprits in acetaminophen pathogenesis.

Hepatology 2014 Apr 28;59(4):1229-31. Epub 2014 Feb 28.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO.

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http://dx.doi.org/10.1002/hep.26923DOI Listing
April 2014

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.

Biochem Pharmacol 2013 Sep 19;86(6):836-43. Epub 2013 Jul 19.

Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210011, China.

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http://dx.doi.org/10.1016/j.bcp.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863645PMC
September 2013

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

Nat Med 2013 Sep 18;19(9):1132-40. Epub 2013 Aug 18.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1038/nm.3265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050982PMC
September 2013

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.

Hepatology 2013 Apr 18;57(4):1575-84. Epub 2013 Jan 18.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://doi.wiley.com/10.1002/hep.26134
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http://dx.doi.org/10.1002/hep.26134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622784PMC
April 2013

Current challenges and controversies in drug-induced liver injury.

Drug Saf 2012 Dec;35(12):1099-117

Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.2165/11632970-000000000-00000DOI Listing
December 2012

Role of immune reactions in drug-induced liver injury (DILI).

Drug Metab Rev 2012 Feb 12;44(1):107-15. Epub 2012 Jan 12.

Skaggs School of Pharmacy, University of Colorado Denver, Aurora, USA.

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http://dx.doi.org/10.3109/03602532.2011.645579DOI Listing
February 2012

Involvement of natural killer T cells in halothane-induced liver injury in mice.

Biochem Pharmacol 2010 Jul 30;80(2):255-61. Epub 2010 Mar 30.

Department of Pharmaceutical Sciences, University of Colorado Denver, USA.

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http://dx.doi.org/10.1016/j.bcp.2010.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888538PMC
July 2010

Mechanisms of immune-mediated liver injury.

Toxicol Sci 2010 Jun 13;115(2):307-21. Epub 2010 Jan 13.

Center for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1093/toxsci/kfq009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871750PMC
June 2010

Generation of T cell responses targeting the reactive metabolite of halothane in mice.

Toxicol Lett 2010 May 13;194(3):79-85. Epub 2010 Feb 13.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, United States.

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http://dx.doi.org/10.1016/j.toxlet.2010.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866171PMC
May 2010

Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice.

Toxicol Lett 2010 Apr 1;194(1-2):34-41. Epub 2010 Feb 1.

Department of Pharmaceutical Sciences, University of Colorado Denver, Denver, CO, USA.

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http://dx.doi.org/10.1016/j.toxlet.2010.01.020DOI Listing
April 2010

Lactoferrin protects against concanavalin A-induced liver injury in mice.

Liver Int 2010 Apr 29;30(4):623-32. Epub 2010 Jan 29.

Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1111/j.1478-3231.2009.02199.xDOI Listing
April 2010

Drug-induced liver injury.

Handb Exp Pharmacol 2010 (196):3-27

Department of Pharmaceutical Sciences, University of Colorado Denver, C238-P15, Research Complex 2, 12700 East 19th Avenue, Room 3007, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1007/978-3-642-00663-0_1DOI Listing
March 2010

Lactoferrin protects against acetaminophen-induced liver injury in mice.

Hepatology 2010 Mar;51(3):1007-16

Department of Pharmaceutical Sciences, University of Colorado, Denver, CO 80045, USA.

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http://dx.doi.org/10.1002/hep.23476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908515PMC
March 2010

The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice.

Toxicol Lett 2010 Feb 1;192(3):387-94. Epub 2009 Dec 1.

Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.toxlet.2009.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822049PMC
February 2010

Effect of polyI:C cotreatment on halothane-induced liver injury in mice.

Hepatology 2009 Jan;49(1):215-26

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA.

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http://doi.wiley.com/10.1002/hep.22585
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http://dx.doi.org/10.1002/hep.22585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636554PMC
January 2009

The role of haptic macrophages in regulation of idiosyncratic drug reactions.

Authors:
Cynthia Ju

Toxicol Pathol 2009 Jan 26;37(1):12-7. Epub 2009 Jan 26.

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA.

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http://dx.doi.org/10.1177/0192623308329475DOI Listing
January 2009

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury.

J Leukoc Biol 2008 Dec 19;84(6):1410-21. Epub 2008 Aug 19.

Department of Pharmaceutical Sciences, University of Colorado Denver, 4200 East 9th Avenue, Denver, CO 80262, USA.

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http://dx.doi.org/10.1189/jlb.0308173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614594PMC
December 2008

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.

Hepatology 2008 Sep;48(3):978-90

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA.

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http://doi.wiley.com/10.1002/hep.22395
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http://dx.doi.org/10.1002/hep.22395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600585PMC
September 2008

Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo.

Mol Pharmacol 2008 Jun 11;73(6):1769-75. Epub 2008 Mar 11.

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Ave., Denver, CO 80262, USA.

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http://dx.doi.org/10.1124/mol.107.043273DOI Listing
June 2008

Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury.

Hepatology 2007 Jan;45(1):159-69

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1002/hep.21493DOI Listing
January 2007

Role of neutrophils in a mouse model of halothane-induced liver injury.

Hepatology 2006 Dec;44(6):1421-31

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1002/hep.21425DOI Listing
December 2006

Mechanisms of drug-induced liver injury.

AAPS J 2006 Feb 3;8(1):E48-54. Epub 2006 Feb 3.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C-238, Denver, CO 80262, USA.

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http://dx.doi.org/10.1208/aapsj080106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751423PMC
February 2006

Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions.

Toxicology 2005 Apr;209(2):109-12

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/j.tox.2004.12.017DOI Listing
April 2005

Immunological mechanisms of drug-induced liver injury.

Authors:
Cynthia Ju

Curr Opin Drug Discov Devel 2005 Jan;8(1):38-43

University of Colorado Health Sciences Center, Department of Pharmaceutical Sciences, Denver, CO 80262, USA.

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January 2005

Tolerogenic role of Kupffer cells in allergic reactions.

Chem Res Toxicol 2003 Dec;16(12):1514-9

Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1021/tx0341761DOI Listing
December 2003

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.

Chem Res Toxicol 2002 Dec;15(12):1504-13

Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

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December 2002

Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions.

Curr Opin Allergy Clin Immunol 2002 Aug;2(4):307-15

Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, NHLBI/NIH, 9000 Rockville Pike, Building 10, Room 8N110, Bethesda, MD 20892-2760, USA.

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August 2002