Cynthia J Guidos

Cynthia J Guidos

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Cynthia J Guidos

Cynthia J Guidos

Publications by authors named "Cynthia J Guidos"

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39Publications

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Method for Tagging Antibodies with Metals for Mass Cytometry Experiments.

Methods Mol Biol 2019 ;1989:47-54

The Hospital for Sick Children Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-9454-0_4DOI Listing
March 2020

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.

Clin Cancer Res 2018 11 31;24(22):5685-5696. Epub 2018 Jul 31.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0554DOI Listing
November 2018

CD8 T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity.

Immunity 2018 10 9;49(4):678-694.e5. Epub 2018 Oct 9.

Princess Margaret Cancer Center, University Health Network, Toronto, ON, M5G 2M9 Canada; Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8 Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183034
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http://dx.doi.org/10.1016/j.immuni.2018.08.002DOI Listing
October 2018

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.

Cell Rep 2018 10;25(3):702-714.e6

Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276789PMC
October 2018

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.

Blood 2016 06 31;127(24):3054-61. Epub 2016 Mar 31.

The Leucegene Project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; and Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1182/blood-2016-03-705053DOI Listing
June 2016

In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency.

PLoS Genet 2015 Jun 9;11(6):e1005288. Epub 2015 Jun 9.

Program in Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1005288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461263PMC
June 2015

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection.

Nat Immunol 2015 Apr 2;16(4):397-405. Epub 2015 Mar 2.

1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Canada. [2] Department of Immunology, University of Toronto, Toronto, Canada.

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http://www.nature.com/articles/ni.3122
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http://dx.doi.org/10.1038/ni.3122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368453PMC
April 2015

Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.

Sci Transl Med 2014 May;6(236):236ra62

Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3008661DOI Listing
May 2014

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Blood 2011 Apr 3;117(17):4449-59. Epub 2011 Mar 3.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-06-29
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http://dx.doi.org/10.1182/blood-2010-06-290049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673751PMC
April 2011

Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors.

Blood 2011 Jan 19;117(4):1184-95. Epub 2010 Nov 19.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 101 College Street, Toronto, Ontario, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-07-29
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http://dx.doi.org/10.1182/blood-2010-07-296616DOI Listing
January 2011

Lunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo.

J Immunol 2010 Oct 15;185(8):4609-17. Epub 2010 Sep 15.

Program in Stem Cell and Developmental Biology, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1002008
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http://dx.doi.org/10.4049/jimmunol.1002008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579566PMC
October 2010

Functions of notch signaling in the immune system: consensus and controversies.

Annu Rev Immunol 2010 ;28:343-65

Hospital for Sick Children Research Institute, Department of Immunology, University of Toronto, Ontario, Canada.

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http://www.annualreviews.org/doi/10.1146/annurev.immunol.021
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http://dx.doi.org/10.1146/annurev.immunol.021908.132719DOI Listing
May 2010

Regulation of Notch signaling during T- and B-cell development by O-fucose glycans.

Immunol Rev 2009 Jul;230(1):201-15

Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2009.00791.xDOI Listing
July 2009

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.

Immunity 2009 Feb 12;30(2):254-63. Epub 2009 Feb 12.

Hospital for Sick Children Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.immuni.2008.12.016DOI Listing
February 2009

Chromosomal reinsertion of broken RSS ends during T cell development.

J Exp Med 2007 Oct 4;204(10):2293-303. Epub 2007 Sep 4.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1084/jem.20070583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118463PMC
October 2007

ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes.

Blood 2007 Mar 31;109(5):1887-96. Epub 2006 Oct 31.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, University of Toronto, ON, Canada.

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http://www.bloodjournal.org/content/109/5/1887.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-05-02
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http://dx.doi.org/10.1182/blood-2006-05-020917DOI Listing
March 2007

Synergy between the pre-T cell receptor and Notch: cementing the alphabeta lineage choice.

Authors:
Cynthia J Guidos

J Exp Med 2006 Oct 25;203(10):2233-7. Epub 2006 Sep 25.

Program in Developmental Biology, Hospital for Sick Children Research Institute, and Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1084/jem.20060998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118108PMC
October 2006

Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.

Nat Immunol 2006 Jun 14;7(6):634-43. Epub 2006 May 14.

Program in Developmental Biology, Hospital for Sick Children Research Institute, and Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://www.nature.com/articles/ni1345
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http://dx.doi.org/10.1038/ni1345DOI Listing
June 2006

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.

Mol Cancer Res 2006 May;4(5):311-8

Program in Developmental Biology, Hospital for Sick Children Research Institute, Toronto Medical Discovery Tower Building (East Tower), Room 14-312, 101 College Street, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0258DOI Listing
May 2006

Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions.

Immunol Rev 2006 Feb;209:76-94

Program in Developmental Biology, Hospital for Sick Children Research Institute, and Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/j.0105-2896.2006.00360.x
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http://dx.doi.org/10.1111/j.0105-2896.2006.00360.xDOI Listing
February 2006

ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.

Immunol Rev 2006 Feb;209:142-58

Program in Developmental Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/j.0105-2896.2006.00361.x
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http://dx.doi.org/10.1111/j.0105-2896.2006.00361.xDOI Listing
February 2006

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development.

Nat Immunol 2005 Jul 12;6(7):671-9. Epub 2005 Jun 12.

Program in Developmental Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1038/ni1217DOI Listing
July 2005

Fine-tuning Notch1 activation by endocytosis and glycosylation.

Semin Immunol 2003 Apr;15(2):99-106

Program in Developmental Biology, Department of Immunology, University of Toronto, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1016/s1044-5323(03)00006-xDOI Listing
April 2003

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

Cancer Cell 2003 Jan;3(1):37-50

Program in Developmental Biology, The Hospital for Sick Children and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s1535-6108(02)00236-2DOI Listing
January 2003

Notch signaling in lymphocyte development.

Authors:
Cynthia J Guidos

Semin Immunol 2002 Dec;14(6):395-404

Program in Developmental Biology, Hospital for Sick Children Research Institute, Room 8104, 555 University Avenue, Ont., Toronto, Canada M5G 1X8.

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http://dx.doi.org/10.1016/s104453230200074xDOI Listing
December 2002

Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification.

J Immunol 2002 Apr;168(7):3173-80

Arthur and Sonia Labatt Brain Tumor Research Center and Program in Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.168.7.3173DOI Listing
April 2002